KR20230096110A - 고형 종양을 표적화하는 멀티플렉스화된 조작 iPSC 및 면역 효과기 세포 - Google Patents

고형 종양을 표적화하는 멀티플렉스화된 조작 iPSC 및 면역 효과기 세포 Download PDF

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KR20230096110A
KR20230096110A KR1020237018628A KR20237018628A KR20230096110A KR 20230096110 A KR20230096110 A KR 20230096110A KR 1020237018628 A KR1020237018628 A KR 1020237018628A KR 20237018628 A KR20237018628 A KR 20237018628A KR 20230096110 A KR20230096110 A KR 20230096110A
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cell
cells
receptor
car
tcr
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바흐람 발라메르
톰 티. 리
비-후에이 양
목타르 프리바디
치아-웨이 창
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페이트 세러퓨틱스, 인코포레이티드
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KR1020237018628A 2020-11-04 2021-11-04 고형 종양을 표적화하는 멀티플렉스화된 조작 iPSC 및 면역 효과기 세포 Pending KR20230096110A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063109842P 2020-11-04 2020-11-04
US63/109,842 2020-11-04
US202163228490P 2021-08-02 2021-08-02
US63/228,490 2021-08-02
PCT/US2021/072255 WO2022099297A1 (en) 2020-11-04 2021-11-04 Multiplexed engineered ipsc and immune effector cells targeting solid tumors

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KR20230096110A true KR20230096110A (ko) 2023-06-29

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US (1) US20230381235A1 (https=)
EP (1) EP4240834A4 (https=)
JP (1) JP2023549098A (https=)
KR (1) KR20230096110A (https=)
AU (1) AU2021376382A1 (https=)
CA (1) CA3196555A1 (https=)
IL (1) IL302481A (https=)
MX (1) MX2023004326A (https=)
WO (1) WO2022099297A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230118887A (ko) 2020-12-03 2023-08-14 센츄리 쎄라퓨틱스 인코포레이티드 유전자 조작 세포 및 이의 용도
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AR124414A1 (es) 2020-12-18 2023-03-22 Century Therapeutics Inc Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable
US20230288405A1 (en) * 2022-01-20 2023-09-14 3T Biosciences, Inc. T cell receptor (tcr) compositions and methods for optimizing antigen reactive t-cells
AU2023273018A1 (en) * 2022-05-18 2024-11-14 Seattle Children's Hospital (dba Seattle Children's Research Institute) Production and/or delivery of multispecific binding agents
GB202208545D0 (en) * 2022-06-10 2022-07-27 Adaptimmune Ltd Production of immune cells
WO2025064828A1 (en) * 2023-09-20 2025-03-27 Kure.Ai, Inc. Methods and reagents to improve cell therapy with the creation of novel car-targeting mr1 protein
GB202318950D0 (en) * 2023-12-12 2024-01-24 Adaptimmune Ltd Production of immune cells

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Publication number Priority date Publication date Assignee Title
GB201717578D0 (en) * 2017-10-26 2017-12-13 Univ College Cardiff Consultants Ltd Novel T-cell receptor
CA3177757A1 (en) * 2018-02-16 2019-08-22 Kite Pharma, Inc. Modified pluripotent stem cells and methods of making and use
WO2019204683A1 (en) * 2018-04-19 2019-10-24 Board Of Regents, The University Of Texas System T cell receptors with mage-b2 specificity and uses thereof
EP3632460A1 (en) * 2018-10-05 2020-04-08 St. Anna Kinderkrebsforschung A group of chimeric antigen receptors (cars)
KR20210139472A (ko) * 2019-04-11 2021-11-22 페이트 세러퓨틱스, 인코포레이티드 조작된 iPSC 및 면역 효과기 세포에서의 CD3 재구성
US20220213198A1 (en) * 2019-05-22 2022-07-07 The Council Of The Queensland Institute Of Medical Research Method of treatment

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