MX2023000057A - Metodo para preparar intermediarios de compuesto de uracilo que contiene isoxazolina. - Google Patents
Metodo para preparar intermediarios de compuesto de uracilo que contiene isoxazolina.Info
- Publication number
- MX2023000057A MX2023000057A MX2023000057A MX2023000057A MX2023000057A MX 2023000057 A MX2023000057 A MX 2023000057A MX 2023000057 A MX2023000057 A MX 2023000057A MX 2023000057 A MX2023000057 A MX 2023000057A MX 2023000057 A MX2023000057 A MX 2023000057A
- Authority
- MX
- Mexico
- Prior art keywords
- uracil compound
- containing uracil
- isoxazoline
- preparing
- intermediates
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- -1 uracil compound Chemical class 0.000 title abstract 4
- WEQPBCSPRXFQQS-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole Chemical compound C1CC=NO1 WEQPBCSPRXFQQS-UHFFFAOYSA-N 0.000 title abstract 3
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Natural products O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 title abstract 3
- 229940035893 uracil Drugs 0.000 title abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 2
- WJAFQSJKHIPRDX-UPHRSURJSA-N (z)-3-amino-4,4,4-trifluorobut-2-enoic acid Chemical compound FC(F)(F)C(/N)=C/C(O)=O WJAFQSJKHIPRDX-UPHRSURJSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- 230000002363 herbicidal effect Effects 0.000 abstract 1
- 239000004009 herbicide Substances 0.000 abstract 1
- 239000000413 hydrolysate Substances 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 230000035484 reaction time Effects 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 238000010025 steaming Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0235—Nitrogen containing compounds
- B01J31/0244—Nitrogen containing compounds with nitrogen contained as ring member in aromatic compounds or moieties, e.g. pyridine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se refiere a un método de preparación de una clase de intermediarios de herbicidas, en particular a un método para preparar un intermediario de un compuesto de uracilo que contiene isooxazolina, que comprende: hacer reaccionar el éster metílico del ácido 3-amino-4,4,4-trifluorocrotónico con carbamato de arilo sustituido; en un proceso de reacción, evaporando continuamente agua y el subproducto de alcohol en el sistema; y realizar el procesamiento para obtener el intermediario del compuesto de uracilo que contiene isooxazolina. En el método de la presente invención, se mejoran la selectividad de la reacción y la proporción de utilización de las materias primas; se reducen los productos de hidrólisis, las impurezas y el alquitrán; el tiempo de reacción se acorta considerablemente; y se mejora la productividad. Además, después de una recristalización de los productos crudos, se puede obtener un producto intermediario con una pureza superior al 97% y el rendimiento cuantitativo puede ser superior al 85%, lo que es adecuado para la producción industrial.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010633453.3A CN113880823B (zh) | 2020-07-02 | 2020-07-02 | 一种制备含异噁唑啉脲嘧啶类化合物中间体的方法 |
| PCT/CN2021/103484 WO2022002117A1 (zh) | 2020-07-02 | 2021-06-30 | 一种制备含异恶唑啉脲嘧啶类化合物中间体的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023000057A true MX2023000057A (es) | 2023-02-01 |
Family
ID=79012719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023000057A MX2023000057A (es) | 2020-07-02 | 2021-06-30 | Metodo para preparar intermediarios de compuesto de uracilo que contiene isoxazolina. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20230265084A1 (es) |
| EP (1) | EP4177251A4 (es) |
| JP (1) | JP7553690B2 (es) |
| CN (1) | CN113880823B (es) |
| AU (1) | AU2021301939B2 (es) |
| BR (1) | BR112023000039A2 (es) |
| CA (1) | CA3184712A1 (es) |
| IL (1) | IL299619A (es) |
| MX (1) | MX2023000057A (es) |
| WO (1) | WO2022002117A1 (es) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19543676A1 (de) | 1995-05-03 | 1996-11-07 | Bayer Ag | Verfahren zur Herstellung von substituierten Aryluracilen |
| HUP0004151A3 (en) * | 1997-10-27 | 2001-12-28 | Isk Americas Inc Concord | Herbicidal substituted benzene derivatives, intermediates, preparation and use thereof |
| AU2001260607A1 (en) * | 2000-05-24 | 2001-12-03 | Nissan Chemical Industries Ltd. | Nitrile compounds and process for their preparation |
| JP2002193914A (ja) | 2000-05-24 | 2002-07-10 | Nissan Chem Ind Ltd | ニトリル化合物およびその製造方法 |
| US20020010334A1 (en) | 2000-06-30 | 2002-01-24 | Xun Li | Processes to prepare pyrimidinediones |
| CN105753853B (zh) | 2014-12-16 | 2020-08-04 | 沈阳中化农药化工研发有限公司 | 一种含异恶唑啉的脲嘧啶类化合物及其用途 |
| CN110818644B (zh) * | 2018-08-08 | 2022-08-23 | 沈阳中化农药化工研发有限公司 | 一种异恶唑啉羧酸酯类化合物和应用 |
-
2020
- 2020-07-02 CN CN202010633453.3A patent/CN113880823B/zh active Active
-
2021
- 2021-06-30 BR BR112023000039A patent/BR112023000039A2/pt unknown
- 2021-06-30 AU AU2021301939A patent/AU2021301939B2/en active Active
- 2021-06-30 EP EP21834558.5A patent/EP4177251A4/en active Pending
- 2021-06-30 JP JP2023500282A patent/JP7553690B2/ja active Active
- 2021-06-30 CA CA3184712A patent/CA3184712A1/en active Pending
- 2021-06-30 US US18/004,147 patent/US20230265084A1/en active Pending
- 2021-06-30 IL IL299619A patent/IL299619A/en unknown
- 2021-06-30 MX MX2023000057A patent/MX2023000057A/es unknown
- 2021-06-30 WO PCT/CN2021/103484 patent/WO2022002117A1/zh active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021301939A1 (en) | 2023-03-02 |
| CN113880823B (zh) | 2023-12-12 |
| US20230265084A1 (en) | 2023-08-24 |
| WO2022002117A1 (zh) | 2022-01-06 |
| CN113880823A (zh) | 2022-01-04 |
| CA3184712A1 (en) | 2022-01-06 |
| EP4177251A4 (en) | 2024-07-10 |
| IL299619A (en) | 2023-03-01 |
| AU2021301939B2 (en) | 2024-06-27 |
| EP4177251A1 (en) | 2023-05-10 |
| JP2023532363A (ja) | 2023-07-27 |
| BR112023000039A2 (pt) | 2023-01-31 |
| JP7553690B2 (ja) | 2024-09-18 |
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