MX2022013871A - Sintesis de productos intermedios de alcohol protegido vinilico. - Google Patents
Sintesis de productos intermedios de alcohol protegido vinilico.Info
- Publication number
- MX2022013871A MX2022013871A MX2022013871A MX2022013871A MX2022013871A MX 2022013871 A MX2022013871 A MX 2022013871A MX 2022013871 A MX2022013871 A MX 2022013871A MX 2022013871 A MX2022013871 A MX 2022013871A MX 2022013871 A MX2022013871 A MX 2022013871A
- Authority
- MX
- Mexico
- Prior art keywords
- vinylic
- synthesis
- protected alcohol
- alcohol intermediates
- compound
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000002348 vinylic group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000002194 synthesizing effect Effects 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- SFHYNDMGZXWXBU-LIMNOBDPSA-N 6-amino-2-[[(e)-(3-formylphenyl)methylideneamino]carbamoylamino]-1,3-dioxobenzo[de]isoquinoline-5,8-disulfonic acid Chemical compound O=C1C(C2=3)=CC(S(O)(=O)=O)=CC=3C(N)=C(S(O)(=O)=O)C=C2C(=O)N1NC(=O)N\N=C\C1=CC=CC(C=O)=C1 SFHYNDMGZXWXBU-LIMNOBDPSA-N 0.000 abstract 1
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 abstract 1
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D267/18—[b, e]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
En el presente documento se proporcionan procesos para sintetizar intermedios útiles para preparar inhibidores de Mcl-1. En particular, se proporcionan en el presente documento la sintetización del compuesto D, en donde OPG y R1 se describen en el presente documento. El compuesto D puede ser útil para sintetizar el compuesto A1, o una sal o solvato del mismo, y el compuesto A2, o una sal o solvato del mismo. (ver Fórmulas).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063020862P | 2020-05-06 | 2020-05-06 | |
| PCT/US2021/029271 WO2021225823A1 (en) | 2020-05-06 | 2021-04-27 | Synthesis of vinylic protected alcohol intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022013871A true MX2022013871A (es) | 2022-11-30 |
Family
ID=75914617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022013871A MX2022013871A (es) | 2020-05-06 | 2021-04-27 | Sintesis de productos intermedios de alcohol protegido vinilico. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230174496A1 (es) |
| EP (1) | EP4146636A1 (es) |
| JP (1) | JP2023524263A (es) |
| KR (1) | KR20230006550A (es) |
| CN (1) | CN115485268B (es) |
| AU (1) | AU2021268569B2 (es) |
| BR (1) | BR112022022400A2 (es) |
| CA (1) | CA3181214A1 (es) |
| CL (1) | CL2022003051A1 (es) |
| IL (1) | IL297520A (es) |
| MX (1) | MX2022013871A (es) |
| WO (1) | WO2021225823A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3793565B1 (en) | 2018-05-14 | 2022-01-05 | Gilead Sciences, Inc. | Mcl-1 inhibitors |
| TWI778443B (zh) | 2019-11-12 | 2022-09-21 | 美商基利科學股份有限公司 | Mcl1抑制劑 |
| AU2020391106B2 (en) | 2019-11-26 | 2024-03-21 | Gilead Sciences, Inc. | Processes and intermediates for preparing MCL1 inhibitors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3474B1 (ar) | 2014-08-29 | 2020-07-05 | Amgen Inc | مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1 |
| WO2017147410A1 (en) * | 2016-02-25 | 2017-08-31 | Amgen Inc. | Compounds that inhibit mcl-1 protein |
| JP6453507B2 (ja) * | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
| AU2020391106B2 (en) * | 2019-11-26 | 2024-03-21 | Gilead Sciences, Inc. | Processes and intermediates for preparing MCL1 inhibitors |
-
2021
- 2021-04-27 EP EP21725656.9A patent/EP4146636A1/en active Pending
- 2021-04-27 AU AU2021268569A patent/AU2021268569B2/en active Active
- 2021-04-27 CA CA3181214A patent/CA3181214A1/en active Pending
- 2021-04-27 KR KR1020227042139A patent/KR20230006550A/ko active Search and Examination
- 2021-04-27 JP JP2022566655A patent/JP2023524263A/ja active Pending
- 2021-04-27 WO PCT/US2021/029271 patent/WO2021225823A1/en active Application Filing
- 2021-04-27 MX MX2022013871A patent/MX2022013871A/es unknown
- 2021-04-27 CN CN202180032830.0A patent/CN115485268B/zh active Active
- 2021-04-27 IL IL297520A patent/IL297520A/en unknown
- 2021-04-27 US US17/918,607 patent/US20230174496A1/en active Pending
- 2021-04-27 BR BR112022022400A patent/BR112022022400A2/pt unknown
-
2022
- 2022-11-04 CL CL2022003051A patent/CL2022003051A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021268569A1 (en) | 2022-12-15 |
| CL2022003051A1 (es) | 2023-07-07 |
| BR112022022400A2 (pt) | 2022-12-13 |
| EP4146636A1 (en) | 2023-03-15 |
| AU2021268569B2 (en) | 2024-06-13 |
| CA3181214A1 (en) | 2021-11-11 |
| US20230174496A1 (en) | 2023-06-08 |
| WO2021225823A1 (en) | 2021-11-11 |
| KR20230006550A (ko) | 2023-01-10 |
| CN115485268A (zh) | 2022-12-16 |
| JP2023524263A (ja) | 2023-06-09 |
| CN115485268B (zh) | 2024-06-18 |
| IL297520A (en) | 2022-12-01 |
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