BR112022022400A2 - Síntese de intermediários de álcool vinílico protegidos - Google Patents

Síntese de intermediários de álcool vinílico protegidos

Info

Publication number
BR112022022400A2
BR112022022400A2 BR112022022400A BR112022022400A BR112022022400A2 BR 112022022400 A2 BR112022022400 A2 BR 112022022400A2 BR 112022022400 A BR112022022400 A BR 112022022400A BR 112022022400 A BR112022022400 A BR 112022022400A BR 112022022400 A2 BR112022022400 A2 BR 112022022400A2
Authority
BR
Brazil
Prior art keywords
synthesis
vinyl alcohol
alcohol intermediates
compound
protected vinyl
Prior art date
Application number
BR112022022400A
Other languages
English (en)
Inventor
G Smith Austin
Huang Liang
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BR112022022400A2 publication Critical patent/BR112022022400A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/18—[b, e]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

SÍNTESE DE INTERMEDIÁRIOS DE ÁLCOOL VINÍLICO PROTEGIDOS. São proporcionados aqui processos para sintetizar intermediários úteis na preparação de inibidores de Mcl-1. Em particular são proporcionados aqui processos para sintetizar o composto D, em que OPG e R1 são descritos aqui. O composto D pode ser útil na síntese do composto A1, ou um seu sal ou solvato, ou do composto A2 ou um seu sal ou solvato.
BR112022022400A 2020-05-06 2021-04-27 Síntese de intermediários de álcool vinílico protegidos BR112022022400A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063020862P 2020-05-06 2020-05-06
PCT/US2021/029271 WO2021225823A1 (en) 2020-05-06 2021-04-27 Synthesis of vinylic protected alcohol intermediates

Publications (1)

Publication Number Publication Date
BR112022022400A2 true BR112022022400A2 (pt) 2022-12-13

Family

ID=75914617

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022022400A BR112022022400A2 (pt) 2020-05-06 2021-04-27 Síntese de intermediários de álcool vinílico protegidos

Country Status (12)

Country Link
US (1) US20230174496A1 (pt)
EP (1) EP4146636A1 (pt)
JP (1) JP2023524263A (pt)
KR (1) KR20230006550A (pt)
CN (1) CN115485268A (pt)
AU (1) AU2021268569A1 (pt)
BR (1) BR112022022400A2 (pt)
CA (1) CA3181214A1 (pt)
CL (1) CL2022003051A1 (pt)
IL (1) IL297520A (pt)
MX (1) MX2022013871A (pt)
WO (1) WO2021225823A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112020021648A2 (pt) 2018-05-14 2021-01-26 Gilead Sciences, Inc. inibidores de mcl-1
TWI778443B (zh) 2019-11-12 2022-09-21 美商基利科學股份有限公司 Mcl1抑制劑
KR20220105661A (ko) 2019-11-26 2022-07-27 길리애드 사이언시즈, 인코포레이티드 Mcl1 억제제를 제조하기 위한 방법 및 중간체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3474B1 (ar) * 2014-08-29 2020-07-05 Amgen Inc مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
US11306107B2 (en) * 2016-02-25 2022-04-19 Amgen Inc. Compounds that inhibit MCL-1 protein
JP6453507B2 (ja) 2017-03-30 2019-01-16 アムジエン・インコーポレーテツド Ｍｃｌ−１タンパク質を阻害する化合物
KR20220105661A (ko) * 2019-11-26 2022-07-27 길리애드 사이언시즈, 인코포레이티드 Mcl1 억제제를 제조하기 위한 방법 및 중간체

Also Published As

Publication number Publication date
US20230174496A1 (en) 2023-06-08
MX2022013871A (es) 2022-11-30
CN115485268A (zh) 2022-12-16
IL297520A (en) 2022-12-01
KR20230006550A (ko) 2023-01-10
CA3181214A1 (en) 2021-11-11
AU2021268569A1 (en) 2022-12-15
JP2023524263A (ja) 2023-06-09
EP4146636A1 (en) 2023-03-15
WO2021225823A1 (en) 2021-11-11
CL2022003051A1 (es) 2023-07-07

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