MX2022011988A - Nuevos lipidos y composiciones de nanopartículas de estos. - Google Patents
Nuevos lipidos y composiciones de nanopartículas de estos.Info
- Publication number
- MX2022011988A MX2022011988A MX2022011988A MX2022011988A MX2022011988A MX 2022011988 A MX2022011988 A MX 2022011988A MX 2022011988 A MX2022011988 A MX 2022011988A MX 2022011988 A MX2022011988 A MX 2022011988A MX 2022011988 A MX2022011988 A MX 2022011988A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- nanoparticle compositions
- novel lipids
- capsid
- lipids
- Prior art date
Links
- 150000002632 lipids Chemical class 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000002105 nanoparticle Substances 0.000 title abstract 2
- 108020005202 Viral DNA Proteins 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Obesity (AREA)
- Nanotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
En la presente se proporcionan lípidos que tienen la Fórmula (I): (VER FORMULA) y sales farmacéuticamente aceptables de estos, en donde R1 , R2 , a y b son como se definen en la presente. Se proporcionan además en la presente, composiciones de nanopartículas lipídicas (LNP) que comprenden lípidos que tienen la Fórmula (I) y un vector no viral libre de cápside (por ejemplo, ADNce). En un aspecto de cualquiera de los aspectos o modalidades de la presente, estas LNP pueden usarse para suministrar un vector de ADN no viral libre de cápside a un sitio diana de interés (por ejemplo, célula, tejido, órgano y similares).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063000990P | 2020-03-27 | 2020-03-27 | |
PCT/US2021/024413 WO2021195529A2 (en) | 2020-03-27 | 2021-03-26 | Novel lipids and nanoparticle compositions thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022011988A true MX2022011988A (es) | 2023-01-04 |
Family
ID=77890624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022011988A MX2022011988A (es) | 2020-03-27 | 2021-03-26 | Nuevos lipidos y composiciones de nanopartículas de estos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230159459A1 (es) |
EP (1) | EP4125821A2 (es) |
JP (1) | JP2023518985A (es) |
KR (1) | KR20220160647A (es) |
CN (1) | CN115916163A (es) |
AU (1) | AU2021241696A1 (es) |
BR (1) | BR112022019369A2 (es) |
CA (1) | CA3173126A1 (es) |
IL (1) | IL296763A (es) |
MX (1) | MX2022011988A (es) |
WO (1) | WO2021195529A2 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3114699A1 (en) | 2018-10-09 | 2020-04-16 | The University Of British Columbia | Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto |
CN116437964A (zh) * | 2020-07-17 | 2023-07-14 | 世代生物公司 | 用于将多核苷酸封装成减小尺寸的脂质纳米颗粒以及其新型调配物的方法 |
AU2021385572A1 (en) | 2020-11-25 | 2023-06-22 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
WO2023121964A1 (en) * | 2021-12-20 | 2023-06-29 | Beam Therapeutics Inc. | Nanomaterials comprising disulfides |
WO2023190164A1 (ja) * | 2022-03-28 | 2023-10-05 | 日油株式会社 | アリールエステルを含むカルボン酸の製造方法及びカチオン性脂質の製造方法 |
CN116082184B (zh) * | 2023-04-12 | 2023-06-30 | 山东大学 | 基于环己二胺的可电离脂质、脂质纳米颗粒及其制备方法与应用 |
CN117964577A (zh) * | 2024-03-29 | 2024-05-03 | 天津全和诚生物技术有限公司 | 阳离子脂质化合物、其制备方法、包含其的组合物及应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4775523B1 (ja) * | 2010-10-05 | 2011-09-21 | トヨタ自動車株式会社 | 推定装置および推定方法 |
JP7075256B2 (ja) * | 2018-03-28 | 2022-05-25 | 三菱重工業株式会社 | 配管の余寿命評価方法 |
-
2021
- 2021-03-26 IL IL296763A patent/IL296763A/en unknown
- 2021-03-26 CN CN202180037847.5A patent/CN115916163A/zh active Pending
- 2021-03-26 WO PCT/US2021/024413 patent/WO2021195529A2/en active Application Filing
- 2021-03-26 MX MX2022011988A patent/MX2022011988A/es unknown
- 2021-03-26 US US17/913,498 patent/US20230159459A1/en active Pending
- 2021-03-26 KR KR1020227037604A patent/KR20220160647A/ko unknown
- 2021-03-26 CA CA3173126A patent/CA3173126A1/en active Pending
- 2021-03-26 JP JP2022558110A patent/JP2023518985A/ja active Pending
- 2021-03-26 BR BR112022019369A patent/BR112022019369A2/pt unknown
- 2021-03-26 AU AU2021241696A patent/AU2021241696A1/en active Pending
- 2021-03-26 EP EP21776608.8A patent/EP4125821A2/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20220160647A (ko) | 2022-12-06 |
WO2021195529A2 (en) | 2021-09-30 |
CN115916163A (zh) | 2023-04-04 |
BR112022019369A2 (pt) | 2022-12-13 |
AU2021241696A1 (en) | 2022-12-01 |
EP4125821A2 (en) | 2023-02-08 |
IL296763A (en) | 2022-11-01 |
US20230159459A1 (en) | 2023-05-25 |
JP2023518985A (ja) | 2023-05-09 |
CA3173126A1 (en) | 2021-09-30 |
WO2021195529A3 (en) | 2021-11-18 |
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