MX2022006991A - Arn guía antisentido con región funcional añadida para editar arn blanco. - Google Patents

Arn guía antisentido con región funcional añadida para editar arn blanco.

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Publication number
MX2022006991A
MX2022006991A MX2022006991A MX2022006991A MX2022006991A MX 2022006991 A MX2022006991 A MX 2022006991A MX 2022006991 A MX2022006991 A MX 2022006991A MX 2022006991 A MX2022006991 A MX 2022006991A MX 2022006991 A MX2022006991 A MX 2022006991A
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MX
Mexico
Prior art keywords
rna
target rna
functional region
editing target
antisense
Prior art date
Application number
MX2022006991A
Other languages
English (en)
Inventor
Eiji Yoshimi
Yukari Moriya
Mariko MANDA
Takayasu Gotoh
Takatomo Arai
Original Assignee
Astellas Pharma Inc
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Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2022006991A publication Critical patent/MX2022006991A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract

Objeto: Proporcionar un ARN guía antisentido para editar un ARN blanco mediante ADAR. Solución: Un ARN guía antisentido para editar un ARN blanco mediante ADAR, que contiene al menos una región funcional y una región antisentido que es complementaria a una parte del ARN blanco y puede formar una cadena doble con el ARN blanco, en la que la al menos una región funcional está unida a la región antisentido y en la que el ARN guía no contiene sustancialmente una secuencia base de reclutamiento de ADAR. Dibujo seleccionado: Ninguna.
MX2022006991A 2019-12-09 2020-12-08 Arn guía antisentido con región funcional añadida para editar arn blanco. MX2022006991A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019222437 2019-12-09
PCT/JP2020/045707 WO2021117729A1 (ja) 2019-12-09 2020-12-08 標的ｒｎａを編集するための機能性領域を付加したアンチセンス型ガイドｒｎａ

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MX2022006991A true MX2022006991A (es) 2022-08-25

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MX2022006991A MX2022006991A (es) 2019-12-09 2020-12-08 Arn guía antisentido con región funcional añadida para editar arn blanco.

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US (1) US20230059753A1 (es)
EP (1) EP4074825A1 (es)
JP (1) JPWO2021117729A1 (es)
KR (1) KR20220111322A (es)
CN (1) CN114787357A (es)
AU (1) AU2020399673A1 (es)
BR (1) BR112022011277A2 (es)
CA (1) CA3161264A1 (es)
CO (1) CO2022009538A2 (es)
IL (1) IL293671A (es)
MX (1) MX2022006991A (es)
TW (1) TW202136508A (es)
WO (1) WO2021117729A1 (es)

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JP2023504314A (ja) 2019-12-02 2023-02-02 シェイプ セラピューティクス インコーポレイテッド 治療的編集
EP4139453A1 (en) * 2020-04-22 2023-03-01 Shape Therapeutics Inc. Compositions and methods using snrna components
US20240150754A1 (en) 2020-12-25 2024-05-09 Astellas Pharma Inc. Guide rna for editing polyadenylation signal sequence of target rna
CA3236122A1 (en) * 2021-10-27 2023-05-04 Shape Therapeutics Inc. Engineered rnas
WO2023077128A1 (en) * 2021-10-29 2023-05-04 Board Of Regents, The University Of Texas System Shielded small nucleotides for intracellular barcoding
WO2023152371A1 (en) 2022-02-14 2023-08-17 Proqr Therapeutics Ii B.V. Guide oligonucleotides for nucleic acid editing in the treatment of hypercholesterolemia
WO2023196853A1 (en) * 2022-04-05 2023-10-12 Astellas Gene Therapies, Inc. Compositions and methods for the treatment of muscular dystrophies
WO2023214512A1 (ja) * 2022-05-06 2023-11-09 学校法人常翔学園 人工ｒｎａ分子
WO2024013360A1 (en) 2022-07-15 2024-01-18 Proqr Therapeutics Ii B.V. Chemically modified oligonucleotides for adar-mediated rna editing
WO2024013361A1 (en) 2022-07-15 2024-01-18 Proqr Therapeutics Ii B.V. Oligonucleotides for adar-mediated rna editing and use thereof
WO2024044282A1 (en) * 2022-08-24 2024-02-29 Shape Therapeutics Inc. Engineered constructs for increased transcription of rna payloads
WO2024078345A1 (zh) * 2022-10-11 2024-04-18 广州瑞风生物科技有限公司 snRNA核酸分子及其应用
GB202215614D0 (en) 2022-10-21 2022-12-07 Proqr Therapeutics Ii Bv Heteroduplex rna editing oligonucleotide complexes

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CN102264898B (zh) * 2008-10-23 2013-10-16 国立大学法人东京大学 微小rna的功能抑制方法
GB201412802D0 (en) * 2014-07-18 2014-09-03 Univ London Queen Mary Method
WO2016097212A1 (en) 2014-12-17 2016-06-23 Proqr Therapeutics Ii B.V. Targeted rna editing
US10550393B2 (en) 2015-03-06 2020-02-04 Tagcyx Biotechnologies Method for stabilizing DNA aptamers
US11390865B2 (en) 2015-07-14 2022-07-19 Fukuoka University Method for introducing site-directed RNA mutation, target editing guide RNA used in the method and target RNA-target editing guide RNA complex
DE102015012522B3 (de) 2015-09-26 2016-06-02 Eberhard Karls Universität Tübingen Verfahren und Substanzen zur gerichteten RNA-Editierung
SG10201913477UA (en) 2016-04-29 2020-02-27 Univ Nanyang Tech G-quadruplex-containing antisense oligonucleotides
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KR102501980B1 (ko) 2016-09-01 2023-02-20 프로큐알 테라퓨틱스 Ⅱ 비.브이. 화학적으로 변형된 단일 가닥 rna-편집 올리고뉴클레오타이드
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JP7333508B2 (ja) * 2017-12-06 2023-08-25 学校法人福岡大学 オリゴヌクレオチド、その製造方法及び標的ｒｎａの部位特異的編集方法
WO2019111957A1 (ja) 2017-12-06 2019-06-13 学校法人福岡大学 オリゴヌクレオチド、その製造方法及び標的ｒｎａの部位特異的編集方法

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CN114787357A (zh) 2022-07-22
JPWO2021117729A1 (es) 2021-06-17
CA3161264A1 (en) 2021-06-17
KR20220111322A (ko) 2022-08-09
US20230059753A1 (en) 2023-02-23
CO2022009538A2 (es) 2022-07-19
TW202136508A (zh) 2021-10-01
EP4074825A1 (en) 2022-10-19
IL293671A (en) 2022-08-01
BR112022011277A2 (pt) 2022-09-06
AU2020399673A1 (en) 2022-07-28
WO2021117729A1 (ja) 2021-06-17

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