MX2022006799A - Fusion de recombinasas especificas del sitio para una edicion genomica eficiente y especifica. - Google Patents
Fusion de recombinasas especificas del sitio para una edicion genomica eficiente y especifica.Info
- Publication number
- MX2022006799A MX2022006799A MX2022006799A MX2022006799A MX2022006799A MX 2022006799 A MX2022006799 A MX 2022006799A MX 2022006799 A MX2022006799 A MX 2022006799A MX 2022006799 A MX2022006799 A MX 2022006799A MX 2022006799 A MX2022006799 A MX 2022006799A
- Authority
- MX
- Mexico
- Prior art keywords
- recombinases
- recombinase
- site
- recombinase enzyme
- fusion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19214152.1A EP3831939A1 (en) | 2019-12-06 | 2019-12-06 | Fusion of site-specific recombinases for efficient and specific genome editing |
| PCT/EP2020/084489 WO2021110846A1 (en) | 2019-12-06 | 2020-12-03 | Fusion of site-specific recombinases for efficient and specific genome editing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022006799A true MX2022006799A (es) | 2022-09-07 |
Family
ID=68808195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022006799A MX2022006799A (es) | 2019-12-06 | 2020-12-03 | Fusion de recombinasas especificas del sitio para una edicion genomica eficiente y especifica. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20250243473A1 (https=) |
| EP (2) | EP3831939A1 (https=) |
| JP (1) | JP7702149B2 (https=) |
| CN (1) | CN115427558A (https=) |
| AU (1) | AU2020396214B2 (https=) |
| CA (1) | CA3163359A1 (https=) |
| MX (1) | MX2022006799A (https=) |
| WO (1) | WO2021110846A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI3638776T3 (fi) | 2017-06-14 | 2025-12-09 | Univ Dresden Tech | Menetelmiä ja välineitä genomien geneettiseen muokkaamiseen hyödyntäen suunnittelu-DNA:ta rekombinoivia entsyymejä |
| EP4433584A1 (en) * | 2021-11-15 | 2024-09-25 | Technische Universität Dresden | Site-specific recombinases for efficient and specific genome editing |
| US20250145973A1 (en) * | 2023-10-16 | 2025-05-08 | Technische Universität Dresden Körperschaft Des Öffentlichen Rechts | Conditioned dna modifying enzyme comprising heterologous dna binding domain |
| WO2026022363A1 (en) | 2024-07-25 | 2026-01-29 | Technische Universität Dresden Körperschaft Des Öffentlichen Rechts | Modifying nucleic acid sequences having asymmetric target sites |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981830A (en) | 1997-05-30 | 1999-11-09 | Schering Aktiengesellschaft | Knockout mice and their progeny with a disrupted hepsin gene |
| ES2256972T3 (es) * | 1997-11-18 | 2006-07-16 | Pioneer Hi-Bred International, Inc. | Metodo novedoso para la integracion de un adn foraneo dentro de genomas de eucariotas. |
| GB0029375D0 (en) * | 2000-12-01 | 2001-01-17 | Total Fina Elf | Substrate linked directed evolution (slide) |
| US20060014264A1 (en) * | 2004-07-13 | 2006-01-19 | Stowers Institute For Medical Research | Cre/lox system with lox sites having an extended spacer region |
| EP1942192A1 (en) | 2007-01-08 | 2008-07-09 | Heinrich-Pette-Institut für experimentelle Virologie und Immunologie | Use of a tailored recombinase for the treatment of retroviral infections |
| EP2576798B1 (en) | 2010-05-27 | 2016-04-27 | Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts - | Tailored recombinase for recombining asymmetric target sites in a plurality of retrovirus strains |
| CN111254500B (zh) * | 2012-12-10 | 2024-01-23 | 分析生物科学有限公司 | 靶向基因组分析的方法 |
| EP2993229A1 (en) * | 2014-09-02 | 2016-03-09 | Heinrich-Pette-Institut Leibniz-Institut für experimentelle Virologie-Stiftung bürgerlichen Rechts - | Well-tolerated and highly specific tailored recombinase for recombining asymmetric target sites in a plurality of retrovirus strains |
| US10017832B2 (en) * | 2015-08-25 | 2018-07-10 | Washington University | Compositions and methods for site specific recombination at asymmetric sites |
| FI3638776T3 (fi) | 2017-06-14 | 2025-12-09 | Univ Dresden Tech | Menetelmiä ja välineitä genomien geneettiseen muokkaamiseen hyödyntäen suunnittelu-DNA:ta rekombinoivia entsyymejä |
| KR20250133994A (ko) * | 2018-05-09 | 2025-09-09 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iia 변이체 및 그의 사용 방법 |
-
2019
- 2019-12-06 EP EP19214152.1A patent/EP3831939A1/en not_active Withdrawn
-
2020
- 2020-12-03 WO PCT/EP2020/084489 patent/WO2021110846A1/en not_active Ceased
- 2020-12-03 CA CA3163359A patent/CA3163359A1/en active Pending
- 2020-12-03 AU AU2020396214A patent/AU2020396214B2/en active Active
- 2020-12-03 CN CN202080095838.7A patent/CN115427558A/zh active Pending
- 2020-12-03 MX MX2022006799A patent/MX2022006799A/es unknown
- 2020-12-03 US US17/780,136 patent/US20250243473A1/en active Pending
- 2020-12-03 EP EP20816214.9A patent/EP4069834A1/en active Pending
- 2020-12-03 JP JP2022533406A patent/JP7702149B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20250243473A1 (en) | 2025-07-31 |
| WO2021110846A1 (en) | 2021-06-10 |
| CA3163359A1 (en) | 2021-06-10 |
| AU2020396214A1 (en) | 2022-06-16 |
| AU2020396214B2 (en) | 2025-10-30 |
| EP4069834A1 (en) | 2022-10-12 |
| CN115427558A (zh) | 2022-12-02 |
| JP7702149B2 (ja) | 2025-07-03 |
| JP2023504826A (ja) | 2023-02-07 |
| EP3831939A1 (en) | 2021-06-09 |
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