MX2022003291A - Vectores de adn sinteticos y metodos de uso. - Google Patents
Vectores de adn sinteticos y metodos de uso.Info
- Publication number
- MX2022003291A MX2022003291A MX2022003291A MX2022003291A MX2022003291A MX 2022003291 A MX2022003291 A MX 2022003291A MX 2022003291 A MX2022003291 A MX 2022003291A MX 2022003291 A MX2022003291 A MX 2022003291A MX 2022003291 A MX2022003291 A MX 2022003291A
- Authority
- MX
- Mexico
- Prior art keywords
- dna vectors
- methods
- dna
- synthetic dna
- subject
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
Abstract
Se proporciona en la presente vectores de ADN aislados que comprenden un gen heterólogo, en donde el vector de ADN está desprovisto de ADN plasmídico bacteriano y/o firmas bacterianas, que pueden anular la persistencia in vivo. La invención también presenta composiciones farmacéuticas (composiciones farmacéuticas no inmunogénicas) incluido los vectores de ADN de la invención, que se pueden usar para inducción de la expresión episomática a largo plazo de un gen heterólogo en un sujeto. La invención implica métodos para tratar un sujeto al administrar los vectores de ADN de la invención, incluidos métodos para tratar trastornos asociados con un defecto en un gen objetivo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962902084P | 2019-09-18 | 2019-09-18 | |
PCT/US2020/051507 WO2021055760A1 (en) | 2019-09-18 | 2020-09-18 | Synthetic dna vectors and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022003291A true MX2022003291A (es) | 2022-09-09 |
Family
ID=74884687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022003291A MX2022003291A (es) | 2019-09-18 | 2020-09-18 | Vectores de adn sinteticos y metodos de uso. |
Country Status (12)
Country | Link |
---|---|
US (6) | US20210330817A1 (es) |
EP (1) | EP4031168A4 (es) |
JP (1) | JP2022549138A (es) |
KR (1) | KR20220128607A (es) |
CN (1) | CN115066255A (es) |
AU (1) | AU2020351204A1 (es) |
CA (1) | CA3151464A1 (es) |
GB (1) | GB2606844A (es) |
IL (1) | IL291437A (es) |
MX (1) | MX2022003291A (es) |
TW (1) | TW202124722A (es) |
WO (1) | WO2021055760A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2019233901A1 (en) * | 2018-03-15 | 2020-09-17 | Intergalactic Therapeutics, Inc. | Synthetic DNA vectors and methods of use |
CN116479022A (zh) * | 2018-12-12 | 2023-07-25 | 中南大学 | 一种重组car19-il24基因、慢病毒载体、car19-il24-t细胞及应用 |
GB2606844A (en) | 2019-09-18 | 2022-11-23 | Intergalactic Therapeutics Inc | Synthetic DNA vectors and methods of use |
EP4288553A1 (en) * | 2021-02-02 | 2023-12-13 | University of Massachusetts | Inverted terminal repeats from aav serotypes 8 and rh.39 in gene therapy vectors |
WO2023049937A2 (en) * | 2021-09-27 | 2023-03-30 | Intergalactic Therapeutics, Inc. | Synthetic production of circular dna vectors |
WO2023064934A1 (en) * | 2021-10-15 | 2023-04-20 | Intergalactic Therapeutics, Inc. | Respiratory delivery of therapeutic agents |
WO2023122625A2 (en) * | 2021-12-20 | 2023-06-29 | Intergalactic Therapeutics, Inc. | Production of gene therapy vector in engineered bacteria |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2488641A (en) * | 1947-06-17 | 1949-11-22 | Herschel V Seawright | Revolving display rack for showcases |
US6027722A (en) | 1990-10-25 | 2000-02-22 | Nature Technology Corporation | Vectors for gene transfer |
US5478745A (en) | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
US6825012B2 (en) * | 1995-02-23 | 2004-11-30 | Gencell S.A. | DNA molecules, preparation and use in gene therapy |
FR2731014B1 (fr) | 1995-02-23 | 1997-03-28 | Rhone Poulenc Rorer Sa | Molecules d'adn, preparation et utilisation en therapie genique |
US5994104A (en) | 1996-11-08 | 1999-11-30 | Royal Free Hospital School Of Medicine | Interleukin-12 fusion protein |
US7030098B2 (en) | 1999-03-12 | 2006-04-18 | The Board Of Trustees Of The Leland Stanford Junior University | DNA vaccination for treatment of autoimmune disease |
NZ515645A (en) | 1999-05-28 | 2004-07-30 | Cambrex Bio Science Baltimore | Methods of purifying plasmid DNA mixture containing host cell impurities |
WO2002020814A1 (en) | 2000-09-08 | 2002-03-14 | The General Hospital Corporation | Self-rearranging dna vectors |
US20070196838A1 (en) | 2000-12-08 | 2007-08-23 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
US20030082559A1 (en) | 2001-01-19 | 2003-05-01 | David Beach | Methods and reagents for amplification and manipulation of vector and target nucleic acid sequences |
FR2821855B1 (fr) * | 2001-03-09 | 2004-04-02 | Cayla | Genes synthetiques et plasmides bacteriens depourvus de cpg |
RU2005106999A (ru) | 2002-08-29 | 2005-08-27 | Дзе Борд Оф Трастиз Оф Дзе Лелэнд Стэнфорд Джуниор Юниверсити (Us) | Кольцевые векторы нуклеиновой кислоты и способы их создания и использования |
US7595303B1 (en) | 2002-09-05 | 2009-09-29 | University Of South Florida | Genetic adjuvants for immunotherapy |
US20050069991A1 (en) * | 2003-03-25 | 2005-03-31 | Hyman Edward D. | Method for plasmid preparation by conversion of open circular plasmid to supercoiled plasmid |
AT412400B (de) | 2003-05-08 | 2005-02-25 | Mayrhofer Peter Mag Dr | Minicircle-herstellung |
US8802643B1 (en) | 2003-05-30 | 2014-08-12 | University Of South Florida | Method for the treatment of malignancies |
EP1486567A1 (en) | 2003-06-11 | 2004-12-15 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Improved adeno-associated virus (AAV) vector for gene therapy |
EP1781800B1 (en) | 2004-08-19 | 2013-06-19 | Nature Technology Corp. | Process for plasmid dna fermentation |
US20080305142A1 (en) | 2004-12-11 | 2008-12-11 | Cytogenix, Inc. | Cell Free Biosynthesis of High-Quality Nucleic Acid and Uses Thereof |
US7622252B2 (en) | 2005-06-10 | 2009-11-24 | Baylor College Of Medicine | Generation of minicircle DNA with physiological supercoiling |
WO2007018744A2 (en) | 2005-08-03 | 2007-02-15 | Cytogenix, Inc. | Cell-free biosynthesis of nucleic acid |
US20080318283A1 (en) | 2006-02-01 | 2008-12-25 | Clague P. Hodgson | Fermentation Process for Continuous Plasmid Dna Production |
US9017966B2 (en) | 2007-05-23 | 2015-04-28 | Nature Technology Corporation | E. coli plasmid DNA production |
US9109012B2 (en) | 2007-05-29 | 2015-08-18 | Nature Technology Corporation | Vectors and method for genetic immunization |
EP2262899A1 (en) | 2008-04-02 | 2010-12-22 | Fondazione Telethon | Method of treating genetic disorders |
US8945885B2 (en) | 2008-07-03 | 2015-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Minicircle DNA vector preparations and methods of making and using the same |
US8921072B2 (en) | 2008-09-02 | 2014-12-30 | General Electric Compnay | Methods to generate DNA mini-circles |
US9045759B2 (en) | 2009-01-21 | 2015-06-02 | James Arthur Williams | DNA plasmids with improved copy number |
GB0901593D0 (en) | 2009-01-30 | 2009-03-11 | Touchlight Genetics Ltd | Production of closed linear DNA |
EP2488641B1 (en) | 2009-10-16 | 2019-01-23 | Baylor College Of Medicine | Supercoiled minicircle dna for gene therapy applications |
US9506082B2 (en) | 2010-04-12 | 2016-11-29 | Nature Technology Corporation | Eukaryotic expression vectors resistant to transgene silencing |
GB201013153D0 (en) | 2010-08-04 | 2010-09-22 | Touchlight Genetics Ltd | Primer for production of closed linear DNA |
EP2439276A1 (de) * | 2010-10-05 | 2012-04-11 | Rentschler Biotechnologie GmbH | Verfahren zur semi-synthetischen Herstellung hochreiner "MiniCircle" DNA-Vektoren aus Plasmiden |
EP2500434A1 (en) | 2011-03-12 | 2012-09-19 | Association Institut de Myologie | Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery |
EA026926B1 (ru) | 2011-12-12 | 2017-05-31 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Композиции, содержащие улучшенные генетические конструкции il-12, вакцины, иммунотерапевтические составы и способы их применения |
WO2013119371A2 (en) | 2012-02-10 | 2013-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Mini-intronic plasmid vectors |
US20140350087A9 (en) | 2012-03-22 | 2014-11-27 | Halozyme, Inc. | Oncovector Nucleic Acid Molecules and Methods of Use |
US20140056868A1 (en) | 2012-05-30 | 2014-02-27 | University of Washington Center for Commercialization | Supercoiled MiniVectors as a Tool for DNA Repair, Alteration and Replacement |
WO2014077863A1 (en) | 2012-11-19 | 2014-05-22 | Nature Technology Corporation | Replicative minicircle vectors with improved expression |
MX2015007575A (es) | 2012-12-13 | 2016-03-15 | Univ Pennsylvania | Construcciones de anticuerpos de adn y metodo para utilizarlas. |
US9701981B2 (en) | 2013-03-15 | 2017-07-11 | The Board Of Trustees Of The Leland Stanford Junior University | Nucleosome-excluding sequences (NES) as a DNA spacer in vectors results in prolonged transgene expression in eukaryotic cells |
GB201307075D0 (en) | 2013-04-19 | 2013-05-29 | Mayrhofer Peter | Plasmid for minicircle production |
CA2910427C (en) | 2013-05-10 | 2024-02-20 | Sangamo Biosciences, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
CN104342453A (zh) | 2013-08-06 | 2015-02-11 | 深圳先进技术研究院 | 含基因工程抗体基因表达盒的微环dna重组母质粒、含该表达盒的微环dna及应用 |
US9827308B2 (en) | 2014-12-10 | 2017-11-28 | Wisconsin Alumni Research Foundation | Mini-intronic plasmid DNA vaccines in combination with LAG3 blockade |
CN107208102B (zh) * | 2015-01-27 | 2021-07-06 | 豪夫迈·罗氏有限公司 | 重组hbv cccdna、其产生方法及其用途 |
WO2016126987A1 (en) | 2015-02-04 | 2016-08-11 | Twist Bioscience Corporation | Compositions and methods for synthetic gene assembly |
DK3286311T3 (da) | 2015-03-26 | 2021-05-17 | Oncosec Medical Inc | Fremgangsmåde til behandling af maligniteter |
AU2016260401B2 (en) | 2015-05-14 | 2022-05-19 | St. Jude Children's Research Hospital, Inc. | Nucleic acid molecules containing spacers and methods of use thereof |
WO2017050884A1 (en) * | 2015-09-22 | 2017-03-30 | Julius-Maximilians-Universität Würzburg | A method for high level and stable gene transfer in lymphocytes |
WO2017087900A1 (en) | 2015-11-19 | 2017-05-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for correction of heritable ocular disease |
SG11201805162VA (en) | 2015-12-18 | 2018-07-30 | Oncosec Medical Inc | Plasmid constructs for heterologous protein expression and methods of use |
EP3205356A1 (en) | 2016-02-10 | 2017-08-16 | Onkoloski Institut Ljubljana | Plasmid expression vector encoding human interleukin 12 under transcriptional control of p21 promoter and without antibiotic resistance for cancer gene therapy and other uses thereof |
CN109195636B (zh) | 2016-03-03 | 2022-07-05 | 马萨诸塞大学 | 用于非病毒基因转移的末端封闭型线性双链体dna |
US10077459B2 (en) | 2016-05-04 | 2018-09-18 | General Electric Company | Cell-free protein expression using rolling circle amplification product |
US11060137B2 (en) | 2016-12-14 | 2021-07-13 | Codex Dna, Inc. | Methods for assembling DNA molecules |
RU2752611C2 (ru) | 2017-02-28 | 2021-07-29 | Орикиро Дженомикс, Инк. | Способ репликации или амплификации кольцевой днк |
US20180305701A1 (en) * | 2017-03-14 | 2018-10-25 | Baylor College Of Medicine | Targeting minivectors to specific tissue using shape |
AU2018238422A1 (en) | 2017-03-21 | 2019-10-03 | Martin Biel | Gene therapy for the treatment of CNGB1-linked retinitis pigmentosa |
EP3606544A4 (en) | 2017-04-05 | 2021-04-07 | University of Massachusetts | MINI-GENE THERAPY |
CN108728465A (zh) | 2017-04-14 | 2018-11-02 | 深圳新诺微环生物科技有限公司 | 一种表达靶细胞-效应细胞桥接器的微环dna载体及其制备方法和应用 |
US20200123566A1 (en) | 2017-06-13 | 2020-04-23 | Oncosec Medical Incorporated | Multigene construct for immune-modulatory protein expression and methods of use |
CN110914414A (zh) * | 2017-06-14 | 2020-03-24 | 德累斯顿工业大学 | 利用设计dna重组酶遗传改变基因组的方法与手段 |
MA50100A (fr) * | 2017-09-08 | 2020-07-15 | Generation Bio Co | Adn à extrémité fermée (cedna) modifié |
WO2019057774A1 (en) | 2017-09-19 | 2019-03-28 | Deutsches Krebsforschungszentrum | NON-INTEGRATING DNA VECTORS FOR THE GENETIC MODIFICATION OF CELLS |
DK3456821T4 (da) | 2017-09-19 | 2024-04-15 | Deutsches Krebsforsch | Ikke-integrerende dna-vektorer til genetisk modifikation af celler |
US20200048716A1 (en) | 2017-11-03 | 2020-02-13 | Twister Biotech, Inc | Using minivectors to treat ovarian cancer |
AU2019233901A1 (en) * | 2018-03-15 | 2020-09-17 | Intergalactic Therapeutics, Inc. | Synthetic DNA vectors and methods of use |
JP2021518150A (ja) | 2018-03-21 | 2021-08-02 | ネイチャー テクノロジー コーポレーション | 生成が改良されたウイルス及び非ウイルスのナノプラスミドベクター |
MA52709A (fr) | 2018-05-23 | 2021-03-31 | Modernatx Inc | Administration d'adn |
WO2020077159A1 (en) | 2018-10-10 | 2020-04-16 | The Johns Hopkins University | POLY(Beta-AMINO ESTER) NANOPARTICLES FOR THE NON-VIRAL DELIVERY OF PLASMID DNA FOR GENE EDITING AND RETINAL GENE THERAPY |
WO2020101828A2 (en) | 2018-10-12 | 2020-05-22 | Children's Hospital Medical Center | Modular expression systems for gene expression and methods of using same |
US20210383891A1 (en) | 2018-10-19 | 2021-12-09 | New England Biolabs, Inc. | Improved Ordered Assembly of Multiple DNA Fragments |
CN109402168A (zh) | 2018-10-30 | 2019-03-01 | 深圳新诺微环生物科技有限公司 | 微环dna表达连接her2阳性细胞与效应细胞的桥接分子及其应用 |
TW202039537A (zh) | 2018-11-27 | 2020-11-01 | 美商昂科賽克醫療公司 | 用於治療癌症之質體建構體和使用方法 |
CN111378677A (zh) | 2018-12-27 | 2020-07-07 | 南京中科游子生物技术研究院有限公司 | 一种dna组装的方法及其应用 |
US20220090090A1 (en) | 2019-01-15 | 2022-03-24 | University Of Marlyland, Baltimore County | A method for assembling circular and linear dna molecules in an ordered manner |
EP3931319A1 (en) | 2019-02-28 | 2022-01-05 | ProteoNic Biotechnology IP B.V. | Self-immolative plasmid backbone |
EP3956453A4 (en) | 2019-04-19 | 2023-02-22 | University of Massachusetts | GENE THERAPIES FOR USHER SYNDROME (USH1B) |
WO2020214796A1 (en) | 2019-04-19 | 2020-10-22 | University Of Massachusetts | Gene therapies for usher syndrome (ush2a) |
AU2020257392A1 (en) | 2019-04-19 | 2021-11-18 | University Of Massachusetts | Gene therapies for Stargardt disease (ABCA4) |
CN110564751A (zh) | 2019-09-03 | 2019-12-13 | 深圳新诺微环生物科技有限公司 | 微环dna疫苗设计及应用 |
CN110684798A (zh) | 2019-09-03 | 2020-01-14 | 深圳新诺微环生物科技有限公司 | 肌肉靶向的微环dna基因治疗 |
GB2606844A (en) | 2019-09-18 | 2022-11-23 | Intergalactic Therapeutics Inc | Synthetic DNA vectors and methods of use |
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2020
- 2020-09-18 GB GB2204355.8A patent/GB2606844A/en active Pending
- 2020-09-18 CN CN202080080113.0A patent/CN115066255A/zh active Pending
- 2020-09-18 CA CA3151464A patent/CA3151464A1/en active Pending
- 2020-09-18 WO PCT/US2020/051507 patent/WO2021055760A1/en unknown
- 2020-09-18 KR KR1020227012373A patent/KR20220128607A/ko unknown
- 2020-09-18 AU AU2020351204A patent/AU2020351204A1/en active Pending
- 2020-09-18 JP JP2022517337A patent/JP2022549138A/ja active Pending
- 2020-09-18 TW TW109132490A patent/TW202124722A/zh unknown
- 2020-09-18 MX MX2022003291A patent/MX2022003291A/es unknown
- 2020-09-18 EP EP20866548.9A patent/EP4031168A4/en active Pending
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2021
- 2021-07-01 US US17/365,805 patent/US20210330817A1/en not_active Abandoned
- 2021-07-01 US US17/365,846 patent/US11766490B2/en active Active
- 2021-07-01 US US17/365,808 patent/US11324839B2/en active Active
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2022
- 2022-02-18 US US17/675,899 patent/US11602569B2/en active Active
- 2022-03-16 IL IL291437A patent/IL291437A/en unknown
- 2022-11-18 US US18/057,032 patent/US11684680B2/en active Active
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2023
- 2023-04-27 US US18/308,457 patent/US20230270888A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210330817A1 (en) | 2021-10-28 |
EP4031168A1 (en) | 2022-07-27 |
WO2021055760A1 (en) | 2021-03-25 |
AU2020351204A1 (en) | 2022-04-21 |
US20230270888A1 (en) | 2023-08-31 |
GB202204355D0 (en) | 2022-05-11 |
US20220168451A1 (en) | 2022-06-02 |
CA3151464A1 (en) | 2021-03-25 |
TW202124722A (zh) | 2021-07-01 |
EP4031168A4 (en) | 2023-10-11 |
GB2606844A (en) | 2022-11-23 |
US11324839B2 (en) | 2022-05-10 |
US20210322576A1 (en) | 2021-10-21 |
JP2022549138A (ja) | 2022-11-24 |
US20210322579A1 (en) | 2021-10-21 |
US11602569B2 (en) | 2023-03-14 |
IL291437A (en) | 2022-05-01 |
US20230089543A1 (en) | 2023-03-23 |
US11766490B2 (en) | 2023-09-26 |
KR20220128607A (ko) | 2022-09-21 |
US11684680B2 (en) | 2023-06-27 |
CN115066255A (zh) | 2022-09-16 |
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