MX2022001869A - Metodo para la caracterizacion de polipeptidos que se unen a complejos de peptido:mhc. - Google Patents

Metodo para la caracterizacion de polipeptidos que se unen a complejos de peptido:mhc.

Info

Publication number
MX2022001869A
MX2022001869A MX2022001869A MX2022001869A MX2022001869A MX 2022001869 A MX2022001869 A MX 2022001869A MX 2022001869 A MX2022001869 A MX 2022001869A MX 2022001869 A MX2022001869 A MX 2022001869A MX 2022001869 A MX2022001869 A MX 2022001869A
Authority
MX
Mexico
Prior art keywords
peptide
characterization
binding polypeptides
mhc binding
mhc
Prior art date
Application number
MX2022001869A
Other languages
English (en)
Inventor
Sebastian Bunk
Toni Weinschenk
Jens Fritsche
Oliver Schoor
Heiko Schuster
Felix Unverdorben
Meike Hutt
Martin Hofmann
Linus Backert
Gisela Schimmack
Florian Schwörer
Original Assignee
Immatics Biotechnologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immatics Biotechnologies Gmbh filed Critical Immatics Biotechnologies Gmbh
Publication of MX2022001869A publication Critical patent/MX2022001869A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56977—HLA or MHC typing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539—MHC-molecules, e.g. HLA-molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención concierne a un método para la caracterización de polipéptidos que se unen a complejos de péptido:MHC, p. ej. Mediante espectrometría de masas y un análisis del espacio peptídico reconocido, es decir, con el fin de identificar péptidos que puedan ser unidos en el contexto de su presentación por el MHC, y aquellos que no puedan serlo.
MX2022001869A 2019-08-13 2020-08-12 Metodo para la caracterizacion de polipeptidos que se unen a complejos de peptido:mhc. MX2022001869A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962886225P 2019-08-13 2019-08-13
DE102019121834 2019-08-13
PCT/EP2020/072674 WO2021028503A1 (en) 2019-08-13 2020-08-12 Method for the characterization of peptide:mhc binding polypeptides

Publications (1)

Publication Number Publication Date
MX2022001869A true MX2022001869A (es) 2022-03-11

Family

ID=72088088

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022001869A MX2022001869A (es) 2019-08-13 2020-08-12 Metodo para la caracterizacion de polipeptidos que se unen a complejos de peptido:mhc.

Country Status (16)

Country Link
US (1) US20210048442A1 (es)
EP (1) EP4014043A1 (es)
JP (1) JP2022547794A (es)
KR (1) KR20220044485A (es)
CN (1) CN114375397A (es)
AU (1) AU2020330717A1 (es)
BR (1) BR112022002699A2 (es)
CA (1) CA3150546A1 (es)
CL (1) CL2022000352A1 (es)
CO (1) CO2022001531A2 (es)
CR (1) CR20220065A (es)
IL (1) IL289209A (es)
MX (1) MX2022001869A (es)
PE (1) PE20220564A1 (es)
TW (1) TW202120925A (es)
WO (1) WO2021028503A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102375218B1 (ko) 2016-12-08 2022-03-17 이매틱스 바이오테크놀로지스 게엠베하 T 세포 수용체 및 이를 사용하는 면역 요법
WO2024033332A1 (en) 2022-08-08 2024-02-15 Immatics Biotechnologies Gmbh Guided positional scanning method

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2336775A3 (en) * 1999-12-06 2013-03-20 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
WO2005076009A2 (en) 2004-01-28 2005-08-18 Immatics Biotechnologies Gmbh Method for identifying and quantifying of tumour-associated peptides
GB201006360D0 (en) 2010-04-16 2010-06-02 Immatics Biotechnologies Gmbh Method for differentially quantifying naturally processed HLA-restricted peptides for cancer, autoimmune and infectious diseases immunotherapy development
EA201390011A1 (ru) 2010-07-28 2013-07-30 Иммьюнокор Лтд. Т-клеточные рецепторы
WO2012104843A1 (en) 2011-02-06 2012-08-09 Yeda Research And Development Co.Ltd. At The Weizmann Institute Of Science Affinity maturated t cell receptors and use thereof
GB201309469D0 (en) * 2013-05-28 2013-07-10 Imcyse Sa Detection of CD4+ T lymphocytes
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
GB201423361D0 (en) 2014-12-30 2015-02-11 Immatics Biotechnologies Gmbh Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides
NL2014935B1 (en) 2015-06-08 2017-02-03 Applied Immune Tech Ltd T cell receptor like antibodies having fine specificity.
GB201520592D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
EP3925972A1 (en) 2016-04-08 2021-12-22 Adaptimmune Ltd T cell receptors
CA3036992A1 (en) 2016-09-16 2018-03-22 Memorial Sloan Kettering Cancer Center Methods and compositions for t-cell epitope screening
DE102018122546B3 (de) * 2018-09-14 2019-12-05 Immatics Biotechnologies Gmbh Verfahren zum Hochdurchsatz-Peptid-MHC-Affinitätsscreening für TCR-Liganden

Also Published As

Publication number Publication date
JP2022547794A (ja) 2022-11-16
US20210048442A1 (en) 2021-02-18
PE20220564A1 (es) 2022-04-13
WO2021028503A8 (en) 2022-04-07
AU2020330717A1 (en) 2022-02-03
CN114375397A (zh) 2022-04-19
CR20220065A (es) 2022-05-04
EP4014043A1 (en) 2022-06-22
KR20220044485A (ko) 2022-04-08
CL2022000352A1 (es) 2022-09-23
WO2021028503A1 (en) 2021-02-18
CO2022001531A2 (es) 2022-06-21
BR112022002699A2 (pt) 2022-05-31
TW202120925A (zh) 2021-06-01
IL289209A (en) 2022-02-01
CA3150546A1 (en) 2021-02-18

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