MX2021016093A - Composicion farmaceutica para tratar un tumor. - Google Patents
Composicion farmaceutica para tratar un tumor.Info
- Publication number
- MX2021016093A MX2021016093A MX2021016093A MX2021016093A MX2021016093A MX 2021016093 A MX2021016093 A MX 2021016093A MX 2021016093 A MX2021016093 A MX 2021016093A MX 2021016093 A MX2021016093 A MX 2021016093A MX 2021016093 A MX2021016093 A MX 2021016093A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical composition
- treating tumor
- pharmaceutically acceptable
- acceptable salt
- composition containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Abstract
Una administración combinada de una composición liposómica que comprende Eribulina o una sal farmacéuticamente aceptable de la misma y un antagonista de PD-1 presenta un efecto antitumoral inesperado.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019138041 | 2019-07-26 | ||
US16/835,719 US11083705B2 (en) | 2019-07-26 | 2020-03-31 | Pharmaceutical composition for treating tumor |
PCT/JP2020/028663 WO2021020336A1 (ja) | 2019-07-26 | 2020-07-27 | 腫瘍治療用医薬組成物 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021016093A true MX2021016093A (es) | 2022-02-03 |
Family
ID=74187564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021016093A MX2021016093A (es) | 2019-07-26 | 2020-07-27 | Composicion farmaceutica para tratar un tumor. |
Country Status (14)
Country | Link |
---|---|
US (2) | US11083705B2 (es) |
EP (1) | EP3970745A4 (es) |
JP (1) | JPWO2021020336A1 (es) |
KR (1) | KR20220041044A (es) |
CN (1) | CN113993545A (es) |
AU (1) | AU2020323402A1 (es) |
BR (1) | BR112021026170A2 (es) |
CA (1) | CA3143486A1 (es) |
IL (1) | IL289213A (es) |
MA (1) | MA55982A (es) |
MX (1) | MX2021016093A (es) |
TW (1) | TW202118486A (es) |
WO (1) | WO2021020336A1 (es) |
ZA (1) | ZA202110686B (es) |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5551683B2 (es) | 1972-10-23 | 1980-12-25 | ||
US5736155A (en) | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
GB9126209D0 (en) | 1991-12-10 | 1992-02-12 | Orion Yhtymae Oy | Drug formulations for parenteral use |
PT695169E (pt) | 1993-04-22 | 2003-04-30 | Skyepharma Inc | Lipossomas multivesiculares de ciclodextrina encapsulando compostos farmacologicos e metodos para a sua utilizacao |
FR2736056B1 (fr) | 1995-06-29 | 1997-08-08 | Commissariat Energie Atomique | Derives de cyclodextrines, leur preparation et leur utilisation pour incorporer des molecules hydrophobes dans des systemes de tensioactifs organises |
US6051251A (en) | 1997-11-20 | 2000-04-18 | Alza Corporation | Liposome loading method using a boronic acid compound |
US8097648B2 (en) | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
PT1087960E (pt) | 1998-06-17 | 2011-06-17 | Eisai R&D Man Co Ltd | Análogos macrocíclicos e métodos de sua utilização e preparação |
US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
US6593308B2 (en) | 1999-12-03 | 2003-07-15 | The Regents Of The University Of California | Targeted drug delivery with a hyaluronan ligand |
CN1116875C (zh) | 2000-10-19 | 2003-08-06 | 南京振中生物工程有限公司 | 紫杉醇脂质组合物及其制备方法 |
ES2290333T3 (es) | 2001-11-13 | 2008-02-16 | Celator Pharmaceuticals, Inc. | Composiciones de vehiculos lipidicos y metodos para la retencion mejorada de farmacos. |
JP4555569B2 (ja) | 2001-11-13 | 2010-10-06 | セレーター ファーマシューティカルズ, インコーポレイテッド | 増強された血中安定性を有する脂質キャリア組成物 |
EP3287144A1 (en) | 2002-07-03 | 2018-02-28 | ONO Pharmaceutical Co., Ltd. | Immunopotentiating compositions |
DE10255106A1 (de) | 2002-11-24 | 2004-06-09 | Novosom Ag | Liposomale Glucocorticoide |
AU2003298738A1 (en) | 2002-11-26 | 2004-06-18 | Su-Ming Chiang | Liposomal formulations |
CN101899114A (zh) | 2002-12-23 | 2010-12-01 | 惠氏公司 | 抗pd-1抗体及其用途 |
ES2337563T3 (es) | 2002-12-31 | 2010-04-27 | Zydus Bsv Pharma Private Limited | Liposomas no pegilados de circulacion duradera. |
ES2729974T3 (es) | 2003-01-23 | 2019-11-07 | Ono Pharmaceutical Co | Anticuerpo específico de PD-1 y CD3 humanas |
JPWO2004089419A1 (ja) | 2003-04-04 | 2006-07-06 | 国立大学法人 東京大学 | 抗mt−mmpモノクローナル抗体含有脂質膜構造体 |
US6747011B1 (en) | 2003-06-04 | 2004-06-08 | A.P. Group, Inc. | Antitumor drugs and methods |
US20050129753A1 (en) | 2003-11-14 | 2005-06-16 | Gabizon Alberto A. | Method for drug loading in liposomes |
EP1710244A4 (en) | 2004-01-29 | 2009-06-17 | Eisai R&D Man Co Ltd | METHOD FOR STABILIZING A MACROLIDE COVERAGE |
KR101223366B1 (ko) | 2004-05-03 | 2013-01-16 | 헤르메스 바이오사이언스, 인코포레이티드 | 약물 전달에 유용한 리포좀 |
US7811602B2 (en) | 2004-05-17 | 2010-10-12 | Tekmira Pharmaceuticals Corporation | Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof |
EP2949652B1 (en) | 2004-06-03 | 2019-08-07 | Eisai R&D Management Co., Ltd. | Intermediates for the preparation of halichondrin B |
CN101072588B (zh) | 2004-10-06 | 2012-11-28 | 不列颠哥伦比亚抗癌机构 | 用于治疗癌症的具有改善的药物保留的脂质体 |
CA2970873C (en) | 2005-05-09 | 2022-05-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
CN104356236B (zh) | 2005-07-01 | 2020-07-03 | E.R.施贵宝&圣斯有限责任公司 | 抗程序性死亡配体1(pd-l1)的人单克隆抗体 |
TWI373473B (en) | 2005-09-02 | 2012-10-01 | Otsuka Pharma Co Ltd | Anticancer agent |
CN101209243B (zh) | 2006-12-29 | 2010-12-08 | 石药集团中奇制药技术(石家庄)有限公司 | 一种脂质体药物及其制备方法 |
US20090196913A1 (en) | 2007-05-11 | 2009-08-06 | Ken Shi Kun Huang | Anti-Alpha-V Immunoliposome Composition, Methods, and Uses |
EP3222634A1 (en) | 2007-06-18 | 2017-09-27 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor pd-1 |
WO2009046308A1 (en) | 2007-10-03 | 2009-04-09 | Eisai R & D Management Co., Ltd. | Intermediates and methods for the synthesis of halichondrin b analogs |
US20090196918A1 (en) | 2008-02-01 | 2009-08-06 | University Of Kentucky Research Foundation | Liposomal formulations of hydrophobic lactone drugs in the presence of metal ions |
EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
KR20110074850A (ko) | 2008-08-25 | 2011-07-04 | 앰플리뮨, 인크. | Pd-1 길항제 및 그의 사용 방법 |
AU2009296392B2 (en) | 2008-09-26 | 2016-06-02 | Dana-Farber Cancer Institute, Inc. | Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor |
PE20120341A1 (es) | 2008-12-09 | 2012-04-24 | Genentech Inc | Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t |
JP5622719B2 (ja) | 2009-03-30 | 2014-11-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | リポソーム組成物の製造方法 |
DK2415470T3 (en) | 2009-03-30 | 2016-09-19 | Eisai R&D Man Co Ltd | liposome |
JP5388735B2 (ja) | 2009-07-21 | 2014-01-15 | 浜松ホトニクス株式会社 | マイクロチャンネルプレート |
WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
RU2579511C2 (ru) | 2010-01-26 | 2016-04-10 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производные фуро[3,2-в]пирана, применимые в синтезе аналогов |
SG193489A1 (en) | 2011-03-18 | 2013-10-30 | Eisai R&D Man Co Ltd | Methods and compositions for predicting response to eribulin |
TR201810298T4 (tr) | 2011-03-31 | 2018-08-27 | Merck Sharp & Dohme | İnsan programlı ölüm reseptörü PD-1'e karşı antikorların stabil formülasyonları ve ilgili tedaviler. |
WO2012139039A2 (en) | 2011-04-08 | 2012-10-11 | British Columbia Cancer Agency Branch | Bisphenol compounds and methods for their use |
CA2842306A1 (en) | 2011-07-19 | 2013-01-24 | Stc.Unm | Intraperitoneally-administered nanocarriers that release their therapeutic load based on the inflammatory environment of cancers |
MY193562A (en) | 2011-08-01 | 2022-10-19 | Genentech Inc | Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors |
RU2689977C2 (ru) | 2012-12-04 | 2019-05-30 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Применение эрибулина для лечения рака молочной железы |
US20160067337A1 (en) | 2013-03-14 | 2016-03-10 | Bristol-Myers Squibb Company | Combination of dr5 agonist and anti-pd-1 antagonist and methods of use |
WO2014193898A1 (en) | 2013-05-31 | 2014-12-04 | Merck Sharp & Dohme Corp. | Combination therapies for cancer |
RU2672585C2 (ru) | 2013-06-26 | 2018-11-16 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Применение эрибулина и ленватиниба в качестве комбинированной терапии для лечения рака |
EP3046543A1 (en) | 2013-09-18 | 2016-07-27 | Stc.Unm | Torroidal mesoporous silica nanoparticles (tmsnps) and related protocells |
US9457019B2 (en) | 2013-11-07 | 2016-10-04 | Deciphera Pharmaceuticals, Llc | Methods for inhibiting tie-2 kinase useful in the treatment of cancer |
WO2015095784A1 (en) | 2013-12-19 | 2015-06-25 | Luminus Biosciences, Inc. | Solid nanoparticle formulation of microtubule inhibitors with reduced ostwald ripening for oral administration |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
US20170071903A1 (en) | 2014-03-03 | 2017-03-16 | Eisai R&D Management Co., Ltd. | Use of eribulin and mtor inhibitors as combination therapy for the treatment of cancer |
WO2015134605A1 (en) | 2014-03-05 | 2015-09-11 | Bristol-Myers Squibb Company | Treatment of renal cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent |
JP6648040B2 (ja) | 2014-05-28 | 2020-02-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | がん治療のための併用療法としてのエリブリン及びポリ(adpリボース)ポリメラーゼ(parp)阻害剤の使用 |
CN105640935A (zh) | 2014-11-12 | 2016-06-08 | 天津市汉康医药生物技术有限公司 | 供注射用甲磺酸艾日布林药物组合物 |
CN107810013B (zh) | 2015-03-04 | 2021-04-02 | 默沙东公司 | 用于治疗癌症的pd-1拮抗剂和艾立布林的组合 |
WO2017188350A1 (ja) | 2016-04-28 | 2017-11-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍の成長を抑制する方法 |
KR20190082782A (ko) | 2016-10-14 | 2019-07-10 | 머크 샤프 앤드 돔 코포레이션 | 요로상피암을 치료하기 위한 pd-1 길항제 및 에리불린의 조합 |
AR112603A1 (es) * | 2017-07-10 | 2019-11-20 | Lilly Co Eli | Anticuerpos biespecíficos inhibidores de punto de control |
-
2020
- 2020-03-31 US US16/835,719 patent/US11083705B2/en active Active
- 2020-07-24 TW TW109125099A patent/TW202118486A/zh unknown
- 2020-07-27 CA CA3143486A patent/CA3143486A1/en active Pending
- 2020-07-27 JP JP2021535323A patent/JPWO2021020336A1/ja active Pending
- 2020-07-27 BR BR112021026170A patent/BR112021026170A2/pt unknown
- 2020-07-27 MX MX2021016093A patent/MX2021016093A/es unknown
- 2020-07-27 MA MA055982A patent/MA55982A/fr unknown
- 2020-07-27 AU AU2020323402A patent/AU2020323402A1/en active Pending
- 2020-07-27 CN CN202080042486.9A patent/CN113993545A/zh active Pending
- 2020-07-27 KR KR1020217041665A patent/KR20220041044A/ko unknown
- 2020-07-27 EP EP20847524.4A patent/EP3970745A4/en active Pending
- 2020-07-27 WO PCT/JP2020/028663 patent/WO2021020336A1/ja unknown
-
2021
- 2021-02-19 US US17/180,107 patent/US20210177802A1/en not_active Abandoned
- 2021-12-20 ZA ZA2021/10686A patent/ZA202110686B/en unknown
- 2021-12-21 IL IL289213A patent/IL289213A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3970745A1 (en) | 2022-03-23 |
EP3970745A4 (en) | 2023-07-19 |
MA55982A (fr) | 2022-03-23 |
US20210023047A1 (en) | 2021-01-28 |
KR20220041044A (ko) | 2022-03-31 |
TW202118486A (zh) | 2021-05-16 |
US11083705B2 (en) | 2021-08-10 |
BR112021026170A2 (pt) | 2022-02-15 |
CA3143486A1 (en) | 2021-02-04 |
CN113993545A (zh) | 2022-01-28 |
ZA202110686B (en) | 2022-09-28 |
US20210177802A1 (en) | 2021-06-17 |
JPWO2021020336A1 (es) | 2021-02-04 |
WO2021020336A1 (ja) | 2021-02-04 |
AU2020323402A1 (en) | 2022-01-27 |
IL289213A (en) | 2022-02-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JOP20190186A1 (ar) | مركب كينازولين | |
MX2021000887A (es) | Compuestos espiroheterociclicos y metodos de uso de los mismos para el tratamiento de cancer. | |
WO2020106647A3 (en) | Combination therapy including a krasg12c inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers | |
PH12019502245A1 (en) | Compounds that inhibit mcl-1 protein | |
MX2021004639A (es) | Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para uso en el tratamiento de tumores solidos. | |
BR112019024525A2 (pt) | composto, sal farmaceuticamente aceitável e formulação farmacêutica de inibidores de kras c12c | |
MX2019013954A (es) | Inhibidores covalentes de kras. | |
MX2018000777A (es) | Compuestos de quinazolina sustituido y su uso como inhibidores de proteinas kras, hras y/o nras mutantes g12c. | |
MX2021001807A (es) | Combinacion de un inhibidor de histona desacetilasa y un inhibidor de proteina cinasa y uso farmaceutico de la misma. | |
JO3474B1 (ar) | مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1 | |
WO2015194764A3 (ko) | 피리미딘-2,4-디아민 유도체 및 이를 유효성분으로 함유하는 항암용 약학적 조성물 | |
MX2022013051A (es) | Agentes quimioterapéuticos de éteres macrocíclicos heteroaromáticos. | |
MX2023008954A (es) | Inhibidores de los receptores erbb. | |
MA39765A (fr) | Formulation pharmaceutique d'un inhibiteur de la kinase pan-raf, ses procédés de préparation, et procédés d'utilisation | |
MX2021015543A (es) | Derivado de pirimidina que inhibe el crecimiento de celulas cancerosas y uso medicinal del mismo. | |
MX2022009612A (es) | Combinacion de bi853520 con farmacos quimioterapeuticos. | |
MX2021015770A (es) | Inhibidores macrociclicos de mcl-1. | |
EA035519B9 (ru) | 1,3,4-тиадиазольные соединения и их применение в лечении рака | |
MX2022006853A (es) | Macrociclos para uso en el tratamiento de enfermedades. | |
PH12018502360A1 (en) | 2-anilinopyrimidine derivatives as therapeutic agents for treatment of brain cancers | |
PH12019501642A1 (en) | Novel compounds and their use in the treatment of schistosomiasis | |
TR201906476T4 (tr) | Farmasötik formülasyonlar. | |
MX2021016093A (es) | Composicion farmaceutica para tratar un tumor. | |
MX2022015659A (es) | Compuesto de alquenil pirimidina, metodo de preparacion del mismo y aplicacion del mismo. | |
MX2022004739A (es) | Compuesto novedoso y composicion farmaceutica para prevencion o tratamiento de cancer que comprende el mismo. |