MX2021008525A - Polipeptidos de interleucina-34 (il-34) mutados y sus usos en terapia. - Google Patents

Polipeptidos de interleucina-34 (il-34) mutados y sus usos en terapia.

Info

Publication number
MX2021008525A
MX2021008525A MX2021008525A MX2021008525A MX2021008525A MX 2021008525 A MX2021008525 A MX 2021008525A MX 2021008525 A MX2021008525 A MX 2021008525A MX 2021008525 A MX2021008525 A MX 2021008525A MX 2021008525 A MX2021008525 A MX 2021008525A
Authority
MX
Mexico
Prior art keywords
polypeptides
interleukin
therapy
mutated
cytokine
Prior art date
Application number
MX2021008525A
Other languages
English (en)
Inventor
Ignacio Anegon
Carole Guillonneau
Erwan Mortier
Agnès Quemener
Original Assignee
Univ Nantes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Nantes filed Critical Univ Nantes
Publication of MX2021008525A publication Critical patent/MX2021008525A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2334—Interleukin-34 (IL-34)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
    • C12N2506/115—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells from monocytes, from macrophages

Abstract

La interleucina-34 es una citocina que participa en la diferenciación y supervivencia de macrófagos, monocitos y células dendríticas en respuesta a la inflamación. La participación de IL-34 se ha mostrado en áreas tan diversas como protección neuronal, enfermedades autoinmunes, infecciones, cáncer y trasplantes. Un trabajo reciente también ha demostrado un nuevo y posible papel terapéutico para la IL-34 como mediador de la tolerancia al trasplante de citocinas secretadas por Treg Foxp3+. Los inventores generaron ahora nuevos polipéptidos de IL-34 mutados que pueden utilizarse como agonistas o antagonistas.
MX2021008525A 2019-01-15 2020-01-15 Polipeptidos de interleucina-34 (il-34) mutados y sus usos en terapia. MX2021008525A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19305046 2019-01-15
PCT/EP2020/050920 WO2020148338A1 (en) 2019-01-15 2020-01-15 Mutated interleukin-34 (il-34) polypeptides and uses thereof in therapy

Publications (1)

Publication Number Publication Date
MX2021008525A true MX2021008525A (es) 2021-11-12

Family

ID=65228484

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021008525A MX2021008525A (es) 2019-01-15 2020-01-15 Polipeptidos de interleucina-34 (il-34) mutados y sus usos en terapia.

Country Status (12)

Country Link
US (1) US20220098264A1 (es)
EP (1) EP3911670A1 (es)
JP (1) JP2022517029A (es)
KR (1) KR20210121077A (es)
CN (1) CN113508129A (es)
AU (1) AU2020208909A1 (es)
BR (1) BR112021013944A8 (es)
CA (1) CA3126741A1 (es)
IL (1) IL284868A (es)
MX (1) MX2021008525A (es)
SG (1) SG11202107606VA (es)
WO (1) WO2020148338A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115819614B (zh) * 2022-06-21 2024-02-23 四川大学华西医院 一种基于il34的嵌合抗原受体免疫细胞制备及其应用
WO2023246908A1 (zh) * 2022-06-21 2023-12-28 四川大学华西医院 靶向csf1r的嵌合抗原受体免疫细胞制备及其应用

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Also Published As

Publication number Publication date
BR112021013944A8 (pt) 2021-12-21
JP2022517029A (ja) 2022-03-03
EP3911670A1 (en) 2021-11-24
KR20210121077A (ko) 2021-10-07
SG11202107606VA (en) 2021-08-30
CA3126741A1 (en) 2020-07-23
IL284868A (en) 2021-08-31
AU2020208909A1 (en) 2021-07-29
US20220098264A1 (en) 2022-03-31
WO2020148338A1 (en) 2020-07-23
CN113508129A (zh) 2021-10-15
BR112021013944A2 (es) 2021-11-21

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