MX2021002135A - Secuencia génica de gtpasa similar a dineína mitocondrial de tipo ii humana recombinante y usos de esta. - Google Patents

Secuencia génica de gtpasa similar a dineína mitocondrial de tipo ii humana recombinante y usos de esta.

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Publication number
MX2021002135A
MX2021002135A MX2021002135A MX2021002135A MX2021002135A MX 2021002135 A MX2021002135 A MX 2021002135A MX 2021002135 A MX2021002135 A MX 2021002135A MX 2021002135 A MX2021002135 A MX 2021002135A MX 2021002135 A MX2021002135 A MX 2021002135A
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Mexico
Prior art keywords
nucleic acid
gtpase
human type
mitochondrial dynein
dynein
Prior art date
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MX2021002135A
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English (en)
Inventor
Bin Li
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Wuhan Neurophth Biotechnology Ltd Company
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Publication date
Application filed by Wuhan Neurophth Biotechnology Ltd Company filed Critical Wuhan Neurophth Biotechnology Ltd Company
Publication of MX2021002135A publication Critical patent/MX2021002135A/es

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    • C12Y306/03—Hydrolases acting on acid anhydrides (3.6) acting on acid anhydrides; catalysing transmembrane movement of substances (3.6.3)
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    • C12Y306/05005—Dynamin GTPase (3.6.5.5)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract

Una secuencia génica de GTPasa similar a dineína mitocondrial de tipo II humana recombinante que tiene una secuencia de nucleótidos que se muestra en la SEQ ID NO: 1 y su uso. Un ácido nucleico de fusión que comprende un ácido nucleico que codifica GTPasa similar a dineína mitocondrial de tipo II humana. Un vector de expresión recombinante que comprende el ácido nucleico o un ácido nucleico de fusión. Un transformante por el cual el ácido nucleico o el ácido nucleico de fusión se introduce en un hospedador. Un modelo de ADOA de mamífero no humano basado en la inactivación del gen de la GTPasa similar a dineína mitocondrial de tipo II, que puede mejorar de manera efectiva las manifestaciones patológicas de ADOA usando un vector de expresión recombinante que codifica la GTPasa similar a dineína mitocondrial de tipo II humana. El nivel de expresión del ácido nucleico que codifica la GTPasa similar a dineína mitocondrial de tipo II humana es mayor, por lo tanto, más GTPasa similar a dineína mitocondrial de tipo II humana se puede obtener en la mitocondria, lo que puede tratar mejor las enfermedades oculares como ADOA.
MX2021002135A 2018-08-23 2019-08-23 Secuencia génica de gtpasa similar a dineína mitocondrial de tipo ii humana recombinante y usos de esta. MX2021002135A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810968173.0A CN110857440B (zh) 2018-08-23 2018-08-23 重组人ⅱ型线粒体动力蛋白样gtp酶基因序列及其应用
PCT/CN2019/102352 WO2020038473A1 (zh) 2018-08-23 2019-08-23 重组人ⅱ型线粒体动力蛋白样gtp酶基因序列及其应用

Publications (1)

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MX2021002135A true MX2021002135A (es) 2021-06-23

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Country Link
US (1) US11459584B2 (es)
EP (1) EP3851535A4 (es)
JP (1) JP7285022B2 (es)
KR (1) KR102612148B1 (es)
CN (1) CN110857440B (es)
AU (1) AU2019323501B2 (es)
BR (1) BR112021002566A2 (es)
CA (1) CA3110153A1 (es)
MX (1) MX2021002135A (es)
SG (1) SG11202101236WA (es)
WO (1) WO2020038473A1 (es)

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* Cited by examiner, † Cited by third party
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CN110857440B (zh) 2018-08-23 2021-02-19 武汉纽福斯生物科技有限公司 重组人ⅱ型线粒体动力蛋白样gtp酶基因序列及其应用
CN111849998A (zh) * 2020-07-29 2020-10-30 武汉纽福斯生物科技有限公司 编码人卵黄状黄斑病蛋白1的核酸分子及其应用
CN117904156A (zh) * 2022-10-17 2024-04-19 武汉纽福斯生物科技有限公司 人线粒体动力蛋白样gtp酶及应用

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CN110857440B (zh) 2021-02-19
WO2020038473A1 (zh) 2020-02-27
CA3110153A1 (en) 2020-02-27
JP7285022B2 (ja) 2023-06-01
AU2019323501B2 (en) 2023-08-03
EP3851535A4 (en) 2022-12-14
US20210180086A1 (en) 2021-06-17
EP3851535A1 (en) 2021-07-21
AU2019323501A1 (en) 2021-02-25
US11459584B2 (en) 2022-10-04
KR102612148B1 (ko) 2023-12-12
CN110857440A (zh) 2020-03-03
BR112021002566A2 (pt) 2021-06-22
SG11202101236WA (en) 2021-03-30
JP2021533801A (ja) 2021-12-09
KR20210049131A (ko) 2021-05-04

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