MX2021001923A - Metodos para la secuenciacion de proteinas de novo. - Google Patents

Metodos para la secuenciacion de proteinas de novo.

Info

Publication number
MX2021001923A
MX2021001923A MX2021001923A MX2021001923A MX2021001923A MX 2021001923 A MX2021001923 A MX 2021001923A MX 2021001923 A MX2021001923 A MX 2021001923A MX 2021001923 A MX2021001923 A MX 2021001923A MX 2021001923 A MX2021001923 A MX 2021001923A
Authority
MX
Mexico
Prior art keywords
mass
amino acid
sets
peptide
peptide ions
Prior art date
Application number
MX2021001923A
Other languages
English (en)
Spanish (es)
Inventor
Yuan Mao
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2021001923A publication Critical patent/MX2021001923A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/28—Static spectrometers
    • H01J49/30—Static spectrometers using magnetic analysers, e.g. Dempster spectrometer
    • H01J49/305—Static spectrometers using magnetic analysers, e.g. Dempster spectrometer with several sectors in tandem

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Evolutionary Biology (AREA)
  • Organic Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Computation (AREA)
  • Optics & Photonics (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Public Health (AREA)
  • Software Systems (AREA)
  • Databases & Information Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Signal Processing (AREA)
  • Epidemiology (AREA)
MX2021001923A 2018-08-17 2019-08-16 Metodos para la secuenciacion de proteinas de novo. MX2021001923A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862719292P 2018-08-17 2018-08-17
PCT/US2019/046821 WO2020037205A1 (en) 2018-08-17 2019-08-16 Methods for de novo protein sequencing

Publications (1)

Publication Number Publication Date
MX2021001923A true MX2021001923A (es) 2021-04-28

Family

ID=67851219

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021001923A MX2021001923A (es) 2018-08-17 2019-08-16 Metodos para la secuenciacion de proteinas de novo.

Country Status (14)

Country Link
US (2) US11047863B2 (https=)
EP (1) EP3837553A1 (https=)
JP (1) JP2021534408A (https=)
KR (1) KR20210045449A (https=)
CN (1) CN112601962A (https=)
AU (1) AU2019320814A1 (https=)
BR (1) BR112021002029A2 (https=)
CA (1) CA3107963A1 (https=)
EA (1) EA202190550A1 (https=)
IL (1) IL280628A (https=)
MX (1) MX2021001923A (https=)
SG (1) SG11202100740YA (https=)
WO (1) WO2020037205A1 (https=)
ZA (1) ZA202100694B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210045449A (ko) * 2018-08-17 2021-04-26 리제너론 파아마슈티컬스, 인크. 새로운 단백질 서열분석 방법
AU2019380606B2 (en) 2018-11-15 2026-04-23 Quantum-Si Incorporated Methods and compositions for protein sequencing
US20210148922A1 (en) * 2019-10-28 2021-05-20 Quantum-Si Incorporated Methods of single-polypeptide sequencing and reconstruction
EP4143579A2 (en) 2020-05-20 2023-03-08 Quantum-si Incorporated Methods and compositions for protein sequencing
KR102691545B1 (ko) * 2023-12-28 2024-08-05 충남대학교 산학협력단 안정동위원소가 표지된 내부 표준 펩타이드를 이용한 질량분석 기반의 표적 펩타이드의 정량 방법

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824556A (en) * 1997-06-11 1998-10-20 Tarr; George E. Peptide mass ladders generated using carbon disulfide
US6962818B2 (en) * 2000-10-19 2005-11-08 Target Discovery Mass defect labeling for the determination of oligomer sequences
US20040185448A1 (en) * 2003-03-20 2004-09-23 Viorica Lopez-Avila Methods and devices for performing matrix assisted laser desorption/lonization protocols
JP4832168B2 (ja) * 2006-06-02 2011-12-07 株式会社日立ハイテクノロジーズ デノボシーケンス解析方法，解析ソフト，解析ソフトを記憶した記憶媒体，試薬キット
GB2448562B (en) * 2006-10-24 2012-02-22 Bruker Daltonik Gmbh Top-down protein analysis in mass spectrometers with ion traps
GB0723183D0 (en) * 2007-11-23 2008-01-09 Micromass Ltd Mass spectrometer
ATE460666T1 (de) * 2008-01-15 2010-03-15 Univ Utrecht Holding Bv Verfahren zur bestimmung der aminosäurensequenz von peptiden
CN101298611B (zh) * 2008-06-12 2011-06-15 北京生命科学研究所 衣原体蛋白酶体样活性因子的活性片段及其表达方法
MY192182A (en) 2009-06-26 2022-08-04 Regeneron Pharma Readily isolated bispecific antibodies with native immunoglobulin format
JP2011112562A (ja) * 2009-11-27 2011-06-09 Mitsubishi Chemicals Corp ペプチド末端の同定方法
US8455624B2 (en) * 2011-06-03 2013-06-04 University Of South Alabama Methods and compositions for detecting endometrial or ovarian cancer
JP6281349B2 (ja) 2014-03-19 2018-02-21 株式会社島津製作所 質量分析用ペプチド混合物試料の調製方法
WO2015185592A2 (en) * 2014-06-03 2015-12-10 Dsm Ip Assets B.V. Proline-specific endoprotease and use thereof
US9719078B1 (en) * 2014-06-15 2017-08-01 Darryl J. Pappin Proteases for the production of N-terminal argininyl- and lysinyl-peptides and methods of use in protein analysis
WO2016004233A2 (en) * 2014-07-01 2016-01-07 Expression Pathology, Inc. Srm assays to chemotherapy targets
SG11201800894SA (en) * 2015-08-03 2018-03-28 Shimadzu Corp Method for parallel quantification of protein variant
US11807671B2 (en) * 2016-11-16 2023-11-07 Auckland Uniservices Limited Methods for protein ligation and uses thereof
WO2019246140A1 (en) * 2018-06-18 2019-12-26 Emory University Parallel enzyme digestion for protein biomarker detection
KR20210045449A (ko) * 2018-08-17 2021-04-26 리제너론 파아마슈티컬스, 인크. 새로운 단백질 서열분석 방법

Also Published As

Publication number Publication date
BR112021002029A2 (pt) 2021-05-25
EP3837553A1 (en) 2021-06-23
US11047863B2 (en) 2021-06-29
SG11202100740YA (en) 2021-02-25
US20210278414A1 (en) 2021-09-09
EA202190550A1 (ru) 2021-04-23
JP2021534408A (ja) 2021-12-09
CA3107963A1 (en) 2020-02-20
CN112601962A (zh) 2021-04-02
US20200057073A1 (en) 2020-02-20
KR20210045449A (ko) 2021-04-26
IL280628A (en) 2021-03-25
AU2019320814A1 (en) 2021-02-18
US12000840B2 (en) 2024-06-04
WO2020037205A1 (en) 2020-02-20
ZA202100694B (en) 2023-03-29

Similar Documents

Publication Publication Date Title
MX2021001923A (es) Metodos para la secuenciacion de proteinas de novo.
JP4913587B2 (ja) ペプチドおよびタンパク質定量法
Reeks et al. Deep venomics of the Pseudonaja genus reveals inter-and intra-specific variation
Gallego et al. Titin-derived peptides as processing time markers in dry-cured ham
Dada et al. Characterization of acidic and basic variants of IgG1 therapeutic monoclonal antibodies based on non‐denaturing IEF fractionation
ATE495447T1 (de) Peptidantikörperdepletion und anwendung zur probenvorbereitung für massenspektrometrie
US12061204B2 (en) Method to map protein landscapes
JP2021534408A5 (https=)
RU2014148769A (ru) Композиции и способы, включающие последовательности, характеризующиеся мегануклеазной активностью
Mamone et al. Characterization of wheat gliadin proteins by combined two‐dimensional gel electrophoresis and tandem mass spectrometry
WO2003074992A3 (en) Phosphorylated proteins and uses related thereto
MX2023009995A (es) Composiciones que incluyen adyuvantes de sbi y metodos para usarlos.
WO2021021964A3 (en) Methods of quantifying frataxin and frataxin fusion proteins
MX2018009339A (es) Métodos para la identificación y análisis de secuencias de aminoácidos de las proteínas.
Lomonte et al. First crotoxin-like phospholipase A2 complex from a New World non-rattlesnake species: Nigroviriditoxin, from the arboreal Neotropical snake Bothriechis nigroviridis
Samyn et al. Functional proteome analysis of the banana plant (Musa spp.) using de novo sequence analysis of derivatized peptides
WO2021028503A8 (en) Method for the characterization of peptide:mhc binding polypeptides
JP2023501478A5 (https=)
Simó et al. Capillary electrophoresis‐mass spectrometry of peptides from enzymatic protein hydrolysis: Simulation and optimization
CN104034791A (zh) 一种基于cid与etd质谱谱图融合的多肽从头测序方法
Artamonova et al. Mass spectrometric analysis of affinity-purified proteasomes from the human myelogenous leukemia K562 cell line
WO2016150853A1 (en) Retention time standard
WO2019217727A3 (en) Methods for proteome labeling
Engidawork et al. Protein chemical identification and characterization of the human variants of far upstream element binding protein in medulloblastoma DAOY cell line
Villar et al. Systematic characterization of phosphorylation sites in NFATc2 by linear ion trap mass spectrometry