ATE460666T1 - Verfahren zur bestimmung der aminosäurensequenz von peptiden - Google Patents
Verfahren zur bestimmung der aminosäurensequenz von peptidenInfo
- Publication number
- ATE460666T1 ATE460666T1 AT08150294T AT08150294T ATE460666T1 AT E460666 T1 ATE460666 T1 AT E460666T1 AT 08150294 T AT08150294 T AT 08150294T AT 08150294 T AT08150294 T AT 08150294T AT E460666 T1 ATE460666 T1 AT E460666T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- peptide
- determining
- acid sequence
- peptides
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 7
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 150000001413 amino acids Chemical group 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 4
- 150000002500 ions Chemical class 0.000 abstract 4
- 230000002797 proteolythic effect Effects 0.000 abstract 4
- 101800001442 Peptide pr Proteins 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108010033276 Peptide Fragments Proteins 0.000 abstract 1
- 102000007079 Peptide Fragments Human genes 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1
- 230000027756 respiratory electron transport chain Effects 0.000 abstract 1
- 238000004885 tandem mass spectrometry Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6818—Sequencing of polypeptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08150294A EP2081025B1 (de) | 2008-01-15 | 2008-01-15 | Verfahren zur Bestimmung der Aminosäurensequenz von Peptiden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE460666T1 true ATE460666T1 (de) | 2010-03-15 |
Family
ID=39183025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08150294T ATE460666T1 (de) | 2008-01-15 | 2008-01-15 | Verfahren zur bestimmung der aminosäurensequenz von peptiden |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8338122B2 (de) |
| EP (1) | EP2081025B1 (de) |
| AT (1) | ATE460666T1 (de) |
| DE (1) | DE602008000796D1 (de) |
| WO (1) | WO2009090188A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE460666T1 (de) | 2008-01-15 | 2010-03-15 | Univ Utrecht Holding Bv | Verfahren zur bestimmung der aminosäurensequenz von peptiden |
| WO2014029497A1 (en) | 2012-08-20 | 2014-02-27 | Merz Pharma Gmbh & Co. Kgaa | Novel method for the manufacturing of recombinant proteins harbouring an n-terminal lysine |
| CN103852513B (zh) * | 2012-11-29 | 2016-01-06 | 中国科学院计算技术研究所 | 一种基于hcd与etd质谱图的肽段从头测序方法及系统 |
| CN105102977A (zh) | 2012-12-26 | 2015-11-25 | 奎斯特诊断投资公司 | 通过质谱法的c肽检测 |
| AU2014337263B2 (en) | 2013-10-16 | 2019-12-12 | Outlook Therapeutics, Inc. | Buffer formulations for enhanced antibody stability |
| EP3247718B1 (de) | 2015-01-21 | 2021-09-01 | Outlook Therapeutics, Inc. | Modulation von ladungsvarianten in einer monoklonalen antikörperzusammensetzung |
| JP2019505780A (ja) * | 2015-12-30 | 2019-02-28 | フィト エヌフェー | 質量分析法に基づく生体高分子の構造決定方法 |
| EP3411401A1 (de) | 2016-02-03 | 2018-12-12 | Oncobiologics, Inc. | Pufferformulierungen für verstärkte antikörperstabilität |
| MX2018009339A (es) * | 2016-02-04 | 2019-01-10 | Oncobiologics Inc | Métodos para la identificación y análisis de secuencias de aminoácidos de las proteínas. |
| US20190343963A1 (en) * | 2016-04-22 | 2019-11-14 | Medimmune Limited | Conjugated protease targeting moieties |
| JP2021534408A (ja) * | 2018-08-17 | 2021-12-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｄｅ ｎｏｖｏタンパク質シークエンシングのための方法 |
| US11726096B2 (en) * | 2018-10-04 | 2023-08-15 | Regeneron Pharmaceuticals, Inc. | Fast protein sequencing |
| TWI863941B (zh) | 2018-11-15 | 2024-12-01 | 美商寬騰矽公司 | 用於蛋白質定序之方法及組合物 |
| BR112022007937A2 (pt) * | 2019-10-28 | 2022-08-30 | Quantum Si Inc | Métodos de sequenciamento e reconstrução de um único polipeptídeo |
| AU2021276522A1 (en) | 2020-05-20 | 2023-01-05 | Quantum-Si Incorporated | Methods and compositions for protein sequencing |
| EP4405687A1 (de) * | 2021-09-22 | 2024-07-31 | DH Technologies Development Pte. Ltd. | Ms/ms-basierte identifizierung von trisulfidbindungen |
| WO2024161325A1 (en) * | 2023-02-01 | 2024-08-08 | Dh Technologies Development Pte. Ltd. | Systems and methods for improved sequence coverage in analysis of large polypeptides |
| CN116930369B (zh) * | 2023-07-27 | 2025-12-26 | 黑龙江飞鹤乳业有限公司 | 用于乳蛋白水解多肽分析的方法 |
| CN118033144A (zh) * | 2024-01-22 | 2024-05-14 | 中国人民解放军军事科学院军事医学研究院 | 一种基于子离子类型可辨识且子离子全覆盖的直读型蛋白质和蛋白质组精准从头测序方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060141632A1 (en) * | 2000-07-25 | 2006-06-29 | The Procter & Gamble Co. | New methods and kits for sequencing polypeptides |
| US20040121477A1 (en) * | 2002-12-20 | 2004-06-24 | Thompson Dean R. | Method for improving data dependent ion selection in tandem mass spectroscopy of protein digests |
| US7371514B2 (en) * | 2004-07-16 | 2008-05-13 | Agilent Technologies, Inc. | Serial derivatization of peptides for de novo sequencing using tandem mass spectrometry |
| ATE460666T1 (de) | 2008-01-15 | 2010-03-15 | Univ Utrecht Holding Bv | Verfahren zur bestimmung der aminosäurensequenz von peptiden |
-
2008
- 2008-01-15 AT AT08150294T patent/ATE460666T1/de not_active IP Right Cessation
- 2008-01-15 DE DE602008000796T patent/DE602008000796D1/de active Active
- 2008-01-15 EP EP08150294A patent/EP2081025B1/de not_active Not-in-force
-
2009
- 2009-01-14 US US12/735,373 patent/US8338122B2/en not_active Expired - Fee Related
- 2009-01-14 WO PCT/EP2009/050365 patent/WO2009090188A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US8338122B2 (en) | 2012-12-25 |
| EP2081025B1 (de) | 2010-03-10 |
| US20100311098A1 (en) | 2010-12-09 |
| WO2009090188A1 (en) | 2009-07-23 |
| EP2081025A1 (de) | 2009-07-22 |
| EP2081025A9 (de) | 2009-09-30 |
| DE602008000796D1 (de) | 2010-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |