DE60135504D1 - Isotop-kodierte ionisierung-förderende reagenzien zur hochdurchsatz protein identifikation und quantifikation mit massenspectrometrie - Google Patents
Isotop-kodierte ionisierung-förderende reagenzien zur hochdurchsatz protein identifikation und quantifikation mit massenspectrometrieInfo
- Publication number
- DE60135504D1 DE60135504D1 DE60135504T DE60135504T DE60135504D1 DE 60135504 D1 DE60135504 D1 DE 60135504D1 DE 60135504 T DE60135504 T DE 60135504T DE 60135504 T DE60135504 T DE 60135504T DE 60135504 D1 DE60135504 D1 DE 60135504D1
- Authority
- DE
- Germany
- Prior art keywords
- icier
- increase
- ionization
- maldi
- cysteine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/13—Tracers or tags
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24264500P | 2000-10-23 | 2000-10-23 | |
PCT/US2001/050744 WO2002046770A2 (en) | 2000-10-23 | 2001-10-22 | Isotope-coded ionization-enhancing reagents (icier) for high-throughput protein identification and quantitation using matrix-assisted laser desorption ionization mass spectrometry |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60135504D1 true DE60135504D1 (de) | 2008-10-02 |
Family
ID=22915621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60135504T Expired - Fee Related DE60135504D1 (de) | 2000-10-23 | 2001-10-22 | Isotop-kodierte ionisierung-förderende reagenzien zur hochdurchsatz protein identifikation und quantifikation mit massenspectrometrie |
Country Status (8)
Country | Link |
---|---|
US (1) | US6905879B2 (de) |
EP (1) | EP1415161B1 (de) |
JP (1) | JP4141834B2 (de) |
AT (1) | ATE405839T1 (de) |
AU (2) | AU2002241732B2 (de) |
CA (1) | CA2426728A1 (de) |
DE (1) | DE60135504D1 (de) |
WO (1) | WO2002046770A2 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE344456T1 (de) * | 2000-05-05 | 2006-11-15 | Purdue Research Foundation | Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen |
AU4338502A (en) * | 2000-10-23 | 2002-06-24 | Genetics Inst | Acid-labile isotope-coded extractant (alice) and its use in quantitative mass spectrometric analysis of protein mixtures |
AU2002341862C1 (en) | 2001-09-27 | 2009-01-29 | Purdue Research Foundation | Controlling isotope effects during fractionation of analytes |
EP1475632B1 (de) * | 2002-02-14 | 2013-05-22 | Ajinomoto Co., Inc. | Verfahren zur analyse einer aminofunktionellen verbindung und analytisches reagens |
US7846748B2 (en) * | 2002-12-02 | 2010-12-07 | The University Of North Carolina At Chapel Hill | Methods of quantitation and identification of peptides and proteins |
CA2488584C (en) | 2003-01-30 | 2011-10-11 | Applera Corporation | Methods, mixtures, kits and compositions pertaining to analyte determination |
GB0314209D0 (en) * | 2003-06-19 | 2003-07-23 | Amersham Biosciences Ab | Novel MS reagents |
CN1809753B (zh) * | 2003-07-29 | 2010-10-20 | 索尔瓦药物有限公司 | 通过二维凝胶电泳分析包含生理可接受消化酶混合物的方法 |
WO2005052563A1 (en) * | 2003-11-20 | 2005-06-09 | Indiana University Research And Technology Corporation | Peptide derivatization for enhancing protein identification by mass spectrometry |
TW200535417A (en) * | 2003-12-08 | 2005-11-01 | Oxford Gene Tech Ip Ltd | Mass spectrometry of arginine-containing peptides |
US20050148087A1 (en) | 2004-01-05 | 2005-07-07 | Applera Corporation | Isobarically labeled analytes and fragment ions derived therefrom |
WO2005075993A1 (en) * | 2004-02-10 | 2005-08-18 | Korea Basic Science Institute | Selective labeling agent for phosphoproteome analysis and phosphorylated site analysis |
BRPI0614746A2 (pt) * | 2005-08-09 | 2011-04-12 | Univ Sunderland | partìculas de sìlica hidrofóbicas, métodos de fabricação e uso das mesmas, assim como métodos de detecção e/ou identificação de uma impressão digital ou outra massa ou depósito hidrofóbico |
KR101081053B1 (ko) * | 2008-07-18 | 2011-11-07 | 포항공과대학교 산학협력단 | 가변질량 라벨링제와 이를 이용한 아미노산 서열 및 단백질정량 동시 분석방법 |
WO2013035513A1 (ja) * | 2011-09-09 | 2013-03-14 | 株式会社島津製作所 | 親水性チオールプローブ |
CN102495127B (zh) * | 2011-11-11 | 2013-09-04 | 暨南大学 | 一种基于概率统计模型的蛋白质二级质谱鉴定方法 |
US10035823B2 (en) | 2014-09-29 | 2018-07-31 | The Regents Of The University Of California | Compositions for expanding regulatory T cells (TREG), and treating autoimmune and inflammatory diseases and conditions |
KR101746535B1 (ko) | 2015-07-27 | 2017-06-13 | 서강대학교산학협력단 | Maldi-tof 질량분석방법을 이용한 고분자내 올리고머의 정량분석 방법 |
CN112326852B (zh) * | 2020-11-06 | 2021-07-27 | 吉林大学 | 一种1-芘甲醛的应用及生物小分子的检测方法 |
CN113267554A (zh) * | 2021-05-14 | 2021-08-17 | 谱天(天津)生物科技有限公司 | 一种用于评估蛋白质组还原烷基化效率的质控方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5045694A (en) | 1989-09-27 | 1991-09-03 | The Rockefeller University | Instrument and method for the laser desorption of ions in mass spectrometry |
US4977320A (en) | 1990-01-22 | 1990-12-11 | The Rockefeller University | Electrospray ionization mass spectrometer with new features |
US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
US5245186A (en) | 1991-11-18 | 1993-09-14 | The Rockefeller University | Electrospray ion source for mass spectrometry |
WO1993024834A1 (en) | 1992-05-29 | 1993-12-09 | The Rockefeller University | Method and product for the sequence determination of peptides using a mass spectrometer |
US5792664A (en) | 1992-05-29 | 1998-08-11 | The Rockefeller University | Methods for producing and analyzing biopolymer ladders |
ATE253126T1 (de) | 1998-08-25 | 2003-11-15 | Univ Washington | Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen |
US6629040B1 (en) * | 1999-03-19 | 2003-09-30 | University Of Washington | Isotope distribution encoded tags for protein identification |
WO2001094935A2 (en) * | 2000-06-09 | 2001-12-13 | Mds Proteomics, Inc. | Labeling of proteomic samples during proteolysis for quantitation and sample multiplexing |
AU4338502A (en) | 2000-10-23 | 2002-06-24 | Genetics Inst | Acid-labile isotope-coded extractant (alice) and its use in quantitative mass spectrometric analysis of protein mixtures |
-
2001
- 2001-10-22 WO PCT/US2001/050744 patent/WO2002046770A2/en active IP Right Grant
- 2001-10-22 JP JP2002548456A patent/JP4141834B2/ja not_active Expired - Fee Related
- 2001-10-22 AT AT01988424T patent/ATE405839T1/de not_active IP Right Cessation
- 2001-10-22 CA CA002426728A patent/CA2426728A1/en not_active Abandoned
- 2001-10-22 AU AU2002241732A patent/AU2002241732B2/en not_active Ceased
- 2001-10-22 DE DE60135504T patent/DE60135504D1/de not_active Expired - Fee Related
- 2001-10-22 AU AU4173202A patent/AU4173202A/xx active Pending
- 2001-10-22 EP EP01988424A patent/EP1415161B1/de not_active Expired - Lifetime
- 2001-10-22 US US10/044,708 patent/US6905879B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6905879B2 (en) | 2005-06-14 |
CA2426728A1 (en) | 2002-06-13 |
EP1415161B1 (de) | 2008-08-20 |
ATE405839T1 (de) | 2008-09-15 |
EP1415161A2 (de) | 2004-05-06 |
AU2002241732B2 (en) | 2007-07-12 |
WO2002046770A3 (en) | 2004-02-26 |
US20030054570A1 (en) | 2003-03-20 |
JP4141834B2 (ja) | 2008-08-27 |
WO2002046770A2 (en) | 2002-06-13 |
JP2004534205A (ja) | 2004-11-11 |
AU4173202A (en) | 2002-06-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |