MX2020012980A - Composiciones y métodos para incrementar la exposición plasmática de tetrahidrobiopterina. - Google Patents
Composiciones y métodos para incrementar la exposición plasmática de tetrahidrobiopterina.Info
- Publication number
- MX2020012980A MX2020012980A MX2020012980A MX2020012980A MX2020012980A MX 2020012980 A MX2020012980 A MX 2020012980A MX 2020012980 A MX2020012980 A MX 2020012980A MX 2020012980 A MX2020012980 A MX 2020012980A MX 2020012980 A MX2020012980 A MX 2020012980A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- compositions
- plasma exposure
- tetrahydrobiopterin
- increasing
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 title 1
- 229960004617 sapropterin Drugs 0.000 title 1
- VPVOXUSPXFPWBN-UHFFFAOYSA-N L-sepiapterin Natural products N1=C(N)NC(=O)C2=C1NCC(C(=O)C(O)C)=N2 VPVOXUSPXFPWBN-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- VPVOXUSPXFPWBN-VKHMYHEASA-N sepiapterin Chemical compound N1C(N)=NC(=O)C2=C1NCC(C(=O)[C@@H](O)C)=N2 VPVOXUSPXFPWBN-VKHMYHEASA-N 0.000 abstract 1
- 229940126478 sepiapterin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862677926P | 2018-05-30 | 2018-05-30 | |
| US201862771397P | 2018-11-26 | 2018-11-26 | |
| US201962822365P | 2019-03-22 | 2019-03-22 | |
| GC201937662 | 2019-05-28 | ||
| PCT/US2019/034515 WO2019232126A1 (en) | 2018-05-30 | 2019-05-30 | Compositions and methods for increasing tetrahydrobiopterin plasma exposure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020012980A true MX2020012980A (es) | 2021-04-29 |
Family
ID=68699016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020012980A MX2020012980A (es) | 2018-05-30 | 2019-05-30 | Composiciones y métodos para incrementar la exposición plasmática de tetrahidrobiopterina. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US12257252B2 (https=) |
| EP (1) | EP3801534B1 (https=) |
| JP (2) | JP7547215B2 (https=) |
| CN (1) | CN112654356A (https=) |
| BR (1) | BR112020024329A2 (https=) |
| CA (1) | CA3102105A1 (https=) |
| DK (1) | DK3801534T3 (https=) |
| FI (1) | FI3801534T3 (https=) |
| MX (1) | MX2020012980A (https=) |
| WO (1) | WO2019232126A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11072614B2 (en) | 2016-11-29 | 2021-07-27 | Ptc Therapeutics Mp, Inc. | Polymorphs of sepiapterin and salts thereof |
| US11130760B2 (en) | 2016-11-29 | 2021-09-28 | Ptc Therapeutics Mp, Inc. | Polymorphic form of sepiapterin |
| JP7811085B2 (ja) | 2017-09-01 | 2026-02-04 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
| EP3801536B1 (en) * | 2018-05-30 | 2024-07-17 | PTC Therapeutics MP, Inc. | Administration of sepiapterin without food for use in a method for increasing sepiapterin plasma exposure |
| CN112654356A (zh) | 2018-05-30 | 2021-04-13 | Ptc医疗Mp公司 | 增加四氢生物蝶呤血浆暴露的组合物和方法 |
| CA3165636A1 (en) * | 2020-01-24 | 2021-07-29 | Neil Smith | Methods for treating parkinson's disease with sepiapterin |
| US12298026B1 (en) | 2021-04-12 | 2025-05-13 | W. L. Gore & Associates, Inc. | Latent energy transfer laminate for plate pack core |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5925323A (ja) | 1982-03-03 | 1984-02-09 | 鐘淵化学工業株式会社 | プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤 |
| US5910304A (en) | 1982-12-13 | 1999-06-08 | Texas A&M University System | Low-dose oral administration of interferons |
| CA1320905C (en) | 1986-11-06 | 1993-08-03 | Joseph M. Cummins | Treatment of immuno-resistant disease |
| CA2228970A1 (en) | 1995-08-18 | 1997-02-27 | Donald W. Landry | Detection of organic compounds through regulation of antibody-catalyzed reactions |
| US6036949A (en) | 1998-03-05 | 2000-03-14 | Amarillo Biosciences, Inc. | Treatment of fibromyalgia with low doses of interferon |
| US8188043B2 (en) | 1999-07-28 | 2012-05-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
| FR2859996B1 (fr) | 2003-09-19 | 2006-02-03 | Aventis Pharma Sa | Solvat acetonique du dimethoxy docetaxel et son procede de preparation |
| EP1696877A4 (en) | 2003-11-13 | 2010-06-09 | Gen Hospital Corp | PROCESS FOR PAIN TREATMENT |
| US7732599B2 (en) | 2003-11-17 | 2010-06-08 | Biomarin Pharmaceutical Inc. | Process for preparing tetrahydrobiopterin and analogs of tetrahydrobiopterin |
| CA2678125C (en) | 2003-11-17 | 2014-10-14 | Merck Eprova Ag | Crystalline forms of (6r)-l-erythro-tetrahydrobiopterin dihydrochloride |
| KR20070005550A (ko) | 2003-11-17 | 2007-01-10 | 바이오마린 파머수티컬 인크. | 대사 장애 치료를 위한 조성물 및 방법 |
| WO2006055511A2 (en) | 2004-11-17 | 2006-05-26 | Biomarin Pharmaceutical Inc. | Stable tablet formulation of tetrahydrobiopterin |
| CA2588994A1 (en) | 2004-12-08 | 2006-06-15 | Biomarin Pharmaceutical Inc. | Methods and compositions for the treatment of pulmonary hypertension of the newborn |
| US7582799B2 (en) | 2005-04-28 | 2009-09-01 | Shiratori Pharmaceutical Co., Ltd. | Method for producing hydrazone derivatives |
| US20080075666A1 (en) | 2006-08-25 | 2008-03-27 | Dudley Samuel C Jr | Methods and compositions for treating diastolic dysfunction |
| WO2008128049A2 (en) | 2007-04-11 | 2008-10-23 | Biomarin Pharmaceutical Inc. | Methods of administering tetrahydrobiopterin, associated compositions, and methods of measuring |
| US20110144117A1 (en) | 2008-08-12 | 2011-06-16 | Orpha Swiss Gmbh | Pharmaceutical Dosage Form Containing Tetrahydrobiopterin |
| EP2562176B1 (en) | 2010-04-22 | 2018-08-15 | Nihon University | Medicinal agent and beverage/food for preventing cerebral dysfunction and improving same |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| CA2828685C (en) | 2011-03-01 | 2018-05-29 | Rubicon Research Private Limited | Stable compositions of tetrahydrobiopterin |
| US9216178B2 (en) * | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
| IN2014DN09053A (https=) | 2012-05-07 | 2015-05-22 | Shiratori Pharm | |
| US10365267B2 (en) | 2014-10-31 | 2019-07-30 | Children's Medical Center Corporation | Methods and assays relating to sepiapterin reductase inhibition |
| US11130760B2 (en) | 2016-11-29 | 2021-09-28 | Ptc Therapeutics Mp, Inc. | Polymorphic form of sepiapterin |
| US11072614B2 (en) * | 2016-11-29 | 2021-07-27 | Ptc Therapeutics Mp, Inc. | Polymorphs of sepiapterin and salts thereof |
| JP7811085B2 (ja) | 2017-09-01 | 2026-02-04 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
| CN112654356A (zh) | 2018-05-30 | 2021-04-13 | Ptc医疗Mp公司 | 增加四氢生物蝶呤血浆暴露的组合物和方法 |
| AU2019277372B2 (en) * | 2018-05-30 | 2024-12-19 | Ptc Therapeutics Mp, Inc. | Pharmaceutically acceptable salts of sepiapterin |
| EP3801536B1 (en) | 2018-05-30 | 2024-07-17 | PTC Therapeutics MP, Inc. | Administration of sepiapterin without food for use in a method for increasing sepiapterin plasma exposure |
| IL290321B1 (en) | 2019-08-05 | 2026-04-01 | Ptc Therapeutics Inc | Use of spiapterin and its metabolites for radiation exposure treatment |
| IL291565B1 (en) | 2019-09-25 | 2026-04-01 | Ptc Therapeutics Inc | Method for treating phenylalanine irregularity |
-
2019
- 2019-05-30 CN CN201980050730.3A patent/CN112654356A/zh active Pending
- 2019-05-30 MX MX2020012980A patent/MX2020012980A/es unknown
- 2019-05-30 WO PCT/US2019/034515 patent/WO2019232126A1/en not_active Ceased
- 2019-05-30 EP EP19810058.8A patent/EP3801534B1/en active Active
- 2019-05-30 JP JP2020566737A patent/JP7547215B2/ja active Active
- 2019-05-30 US US17/059,632 patent/US12257252B2/en active Active
- 2019-05-30 CA CA3102105A patent/CA3102105A1/en active Pending
- 2019-05-30 BR BR112020024329-9A patent/BR112020024329A2/pt unknown
- 2019-05-30 FI FIEP19810058.8T patent/FI3801534T3/fi active
- 2019-05-30 DK DK19810058.8T patent/DK3801534T3/da active
-
2024
- 2024-08-28 JP JP2024146283A patent/JP2024178188A/ja active Pending
-
2025
- 2025-03-04 US US19/070,026 patent/US20250195529A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024178188A (ja) | 2024-12-24 |
| FI3801534T3 (fi) | 2026-04-14 |
| US20210161901A1 (en) | 2021-06-03 |
| US12257252B2 (en) | 2025-03-25 |
| JP2021525746A (ja) | 2021-09-27 |
| EP3801534B1 (en) | 2026-02-18 |
| DK3801534T3 (da) | 2026-03-30 |
| BR112020024329A2 (pt) | 2021-02-23 |
| CN112654356A (zh) | 2021-04-13 |
| JP7547215B2 (ja) | 2024-09-09 |
| US20250195529A1 (en) | 2025-06-19 |
| CA3102105A1 (en) | 2019-12-05 |
| EP3801534A4 (en) | 2022-03-16 |
| EP3801534A1 (en) | 2021-04-14 |
| WO2019232126A1 (en) | 2019-12-05 |
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