JP7547215B2 - テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 - Google Patents
テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 Download PDFInfo
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- JP7547215B2 JP7547215B2 JP2020566737A JP2020566737A JP7547215B2 JP 7547215 B2 JP7547215 B2 JP 7547215B2 JP 2020566737 A JP2020566737 A JP 2020566737A JP 2020566737 A JP2020566737 A JP 2020566737A JP 7547215 B2 JP7547215 B2 JP 7547215B2
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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| JP2024146283A JP2024178188A (ja) | 2018-05-30 | 2024-08-28 | テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 |
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| US201962822365P | 2019-03-22 | 2019-03-22 | |
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| GC201937662 | 2019-05-28 | ||
| GC2019-37662 | 2019-05-28 | ||
| PCT/US2019/034515 WO2019232126A1 (en) | 2018-05-30 | 2019-05-30 | Compositions and methods for increasing tetrahydrobiopterin plasma exposure |
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| JP2021525746A JP2021525746A (ja) | 2021-09-27 |
| JPWO2019232126A5 JPWO2019232126A5 (https=) | 2022-06-03 |
| JP2021525746A5 JP2021525746A5 (https=) | 2022-06-03 |
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| JP2024146283A Pending JP2024178188A (ja) | 2018-05-30 | 2024-08-28 | テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 |
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| US (2) | US12257252B2 (https=) |
| EP (1) | EP3801534B1 (https=) |
| JP (2) | JP7547215B2 (https=) |
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| US11072614B2 (en) | 2016-11-29 | 2021-07-27 | Ptc Therapeutics Mp, Inc. | Polymorphs of sepiapterin and salts thereof |
| US11130760B2 (en) | 2016-11-29 | 2021-09-28 | Ptc Therapeutics Mp, Inc. | Polymorphic form of sepiapterin |
| JP7811085B2 (ja) | 2017-09-01 | 2026-02-04 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
| EP3801536B1 (en) * | 2018-05-30 | 2024-07-17 | PTC Therapeutics MP, Inc. | Administration of sepiapterin without food for use in a method for increasing sepiapterin plasma exposure |
| CN112654356A (zh) | 2018-05-30 | 2021-04-13 | Ptc医疗Mp公司 | 增加四氢生物蝶呤血浆暴露的组合物和方法 |
| CA3165636A1 (en) * | 2020-01-24 | 2021-07-29 | Neil Smith | Methods for treating parkinson's disease with sepiapterin |
| US12298026B1 (en) | 2021-04-12 | 2025-05-13 | W. L. Gore & Associates, Inc. | Latent energy transfer laminate for plate pack core |
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| JP2010523708A (ja) | 2007-04-11 | 2010-07-15 | バイオマリン ファーマシューティカル インコーポレイテッド | テトラヒドロビオプテリンを投与する方法、関連する組成物および測定方法 |
| WO2011132435A1 (ja) | 2010-04-22 | 2011-10-27 | 学校法人日本大学 | 脳機能障害予防・改善用の薬剤及び飲食物 |
| US20130108694A1 (en) | 2011-11-02 | 2013-05-02 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
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| JPS5925323A (ja) | 1982-03-03 | 1984-02-09 | 鐘淵化学工業株式会社 | プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤 |
| US5910304A (en) | 1982-12-13 | 1999-06-08 | Texas A&M University System | Low-dose oral administration of interferons |
| CA1320905C (en) | 1986-11-06 | 1993-08-03 | Joseph M. Cummins | Treatment of immuno-resistant disease |
| CA2228970A1 (en) | 1995-08-18 | 1997-02-27 | Donald W. Landry | Detection of organic compounds through regulation of antibody-catalyzed reactions |
| US6036949A (en) | 1998-03-05 | 2000-03-14 | Amarillo Biosciences, Inc. | Treatment of fibromyalgia with low doses of interferon |
| US8188043B2 (en) | 1999-07-28 | 2012-05-29 | The Board Of Trustees Of The Leland Stanford Jr. University | Nicotine in therapeutic angiogenesis and vasculogenesis |
| FR2859996B1 (fr) | 2003-09-19 | 2006-02-03 | Aventis Pharma Sa | Solvat acetonique du dimethoxy docetaxel et son procede de preparation |
| EP1696877A4 (en) | 2003-11-13 | 2010-06-09 | Gen Hospital Corp | PROCESS FOR PAIN TREATMENT |
| US7732599B2 (en) | 2003-11-17 | 2010-06-08 | Biomarin Pharmaceutical Inc. | Process for preparing tetrahydrobiopterin and analogs of tetrahydrobiopterin |
| CA2678125C (en) | 2003-11-17 | 2014-10-14 | Merck Eprova Ag | Crystalline forms of (6r)-l-erythro-tetrahydrobiopterin dihydrochloride |
| KR20070005550A (ko) | 2003-11-17 | 2007-01-10 | 바이오마린 파머수티컬 인크. | 대사 장애 치료를 위한 조성물 및 방법 |
| WO2006055511A2 (en) | 2004-11-17 | 2006-05-26 | Biomarin Pharmaceutical Inc. | Stable tablet formulation of tetrahydrobiopterin |
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| US20110144117A1 (en) | 2008-08-12 | 2011-06-16 | Orpha Swiss Gmbh | Pharmaceutical Dosage Form Containing Tetrahydrobiopterin |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| CA2828685C (en) | 2011-03-01 | 2018-05-29 | Rubicon Research Private Limited | Stable compositions of tetrahydrobiopterin |
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| US11130760B2 (en) | 2016-11-29 | 2021-09-28 | Ptc Therapeutics Mp, Inc. | Polymorphic form of sepiapterin |
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| JP7811085B2 (ja) | 2017-09-01 | 2026-02-04 | ピーティーシー セラピューティクス エムピー，インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
| CN112654356A (zh) | 2018-05-30 | 2021-04-13 | Ptc医疗Mp公司 | 增加四氢生物蝶呤血浆暴露的组合物和方法 |
| AU2019277372B2 (en) * | 2018-05-30 | 2024-12-19 | Ptc Therapeutics Mp, Inc. | Pharmaceutically acceptable salts of sepiapterin |
| EP3801536B1 (en) | 2018-05-30 | 2024-07-17 | PTC Therapeutics MP, Inc. | Administration of sepiapterin without food for use in a method for increasing sepiapterin plasma exposure |
| IL290321B1 (en) | 2019-08-05 | 2026-04-01 | Ptc Therapeutics Inc | Use of spiapterin and its metabolites for radiation exposure treatment |
| IL291565B1 (en) | 2019-09-25 | 2026-04-01 | Ptc Therapeutics Inc | Method for treating phenylalanine irregularity |
-
2019
- 2019-05-30 CN CN201980050730.3A patent/CN112654356A/zh active Pending
- 2019-05-30 MX MX2020012980A patent/MX2020012980A/es unknown
- 2019-05-30 WO PCT/US2019/034515 patent/WO2019232126A1/en not_active Ceased
- 2019-05-30 EP EP19810058.8A patent/EP3801534B1/en active Active
- 2019-05-30 JP JP2020566737A patent/JP7547215B2/ja active Active
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- 2019-05-30 BR BR112020024329-9A patent/BR112020024329A2/pt unknown
- 2019-05-30 FI FIEP19810058.8T patent/FI3801534T3/fi active
- 2019-05-30 DK DK19810058.8T patent/DK3801534T3/da active
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2024
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2025
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010523708A (ja) | 2007-04-11 | 2010-07-15 | バイオマリン ファーマシューティカル インコーポレイテッド | テトラヒドロビオプテリンを投与する方法、関連する組成物および測定方法 |
| WO2011132435A1 (ja) | 2010-04-22 | 2011-10-27 | 学校法人日本大学 | 脳機能障害予防・改善用の薬剤及び飲食物 |
| US20130108694A1 (en) | 2011-11-02 | 2013-05-02 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
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| Title |
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| 医薬品の臨床薬物動態試験について，医薬審発第七九六号，各都道府県衛生主管部（局）長あて厚生労働省医薬局審査管理課長通知，2001年06月01日 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024178188A (ja) | 2024-12-24 |
| FI3801534T3 (fi) | 2026-04-14 |
| US20210161901A1 (en) | 2021-06-03 |
| US12257252B2 (en) | 2025-03-25 |
| JP2021525746A (ja) | 2021-09-27 |
| EP3801534B1 (en) | 2026-02-18 |
| DK3801534T3 (da) | 2026-03-30 |
| BR112020024329A2 (pt) | 2021-02-23 |
| CN112654356A (zh) | 2021-04-13 |
| US20250195529A1 (en) | 2025-06-19 |
| MX2020012980A (es) | 2021-04-29 |
| CA3102105A1 (en) | 2019-12-05 |
| EP3801534A4 (en) | 2022-03-16 |
| EP3801534A1 (en) | 2021-04-14 |
| WO2019232126A1 (en) | 2019-12-05 |
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