MX2020006098A - Lisinas y sus derivados con actividad bactericida contra pseudomona aeruginosa, en la presencia de suero humano. - Google Patents

Lisinas y sus derivados con actividad bactericida contra pseudomona aeruginosa, en la presencia de suero humano.

Info

Publication number
MX2020006098A
MX2020006098A MX2020006098A MX2020006098A MX2020006098A MX 2020006098 A MX2020006098 A MX 2020006098A MX 2020006098 A MX2020006098 A MX 2020006098A MX 2020006098 A MX2020006098 A MX 2020006098A MX 2020006098 A MX2020006098 A MX 2020006098A
Authority
MX
Mexico
Prior art keywords
lysins
derivatives
identification
gram
activity against
Prior art date
Application number
MX2020006098A
Other languages
English (en)
Inventor
Raymond Schuch
Chiara Indiani
Original Assignee
Contrafect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Contrafect Corp filed Critical Contrafect Corp
Publication of MX2020006098A publication Critical patent/MX2020006098A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Virology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se describen nuevos polipéptidos de lisina activos contra bacterias Gramnegativas, particularmente P. aeruginosa, composiciones farmacéuticas que los contienen y métodos para su uso para tratar infecciones bacterianas Gramnegativas y, más generalmente para inhibir el crecimiento, o reducir la población, o matar bacterias Gramnegativas, incluyendo, pero sin limitarse a, alterar las biopelículas formadas por dichas bacterias. Algunas de las lisinas descritas se han modificado en la secuencia de aminoácidos en comparación con la de las lisinas mediante el reemplazo de ciertos aminoácidos cargados con aminoácidos no cargados y/o mediante fusión en la terminal N- o C- con secuencias de péptidos antibacterianos con o sin un en lazador de intervención.
MX2020006098A 2017-12-12 2018-12-12 Lisinas y sus derivados con actividad bactericida contra pseudomona aeruginosa, en la presencia de suero humano. MX2020006098A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762597577P 2017-12-12 2017-12-12
US201862721969P 2018-08-23 2018-08-23
PCT/US2018/065265 WO2019118632A1 (en) 2017-12-12 2018-12-12 Identification of lysins and derivatives thereof with bacterial activity against pseudomonas aeruginosa

Publications (1)

Publication Number Publication Date
MX2020006098A true MX2020006098A (es) 2020-08-24

Family

ID=66819724

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006098A MX2020006098A (es) 2017-12-12 2018-12-12 Lisinas y sus derivados con actividad bactericida contra pseudomona aeruginosa, en la presencia de suero humano.

Country Status (11)

Country Link
US (1) US12121568B2 (es)
EP (1) EP3723789A4 (es)
JP (2) JP2021506769A (es)
KR (1) KR20200098615A (es)
CN (1) CN111971058A (es)
AU (1) AU2018384790B2 (es)
BR (1) BR112020011433A2 (es)
CA (1) CA3085644A1 (es)
IL (2) IL275060B2 (es)
MX (1) MX2020006098A (es)
WO (1) WO2019118632A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111971058A (zh) 2017-12-12 2020-11-20 康特拉费克特公司 对铜绿假单胞菌具有细菌活性的溶素及其衍生物的鉴定
EP3727451B1 (en) * 2017-12-22 2023-05-10 The Rockefeller University Recombinant pseudomonas aeruginosa lysins
US11773140B2 (en) 2018-03-29 2023-10-03 Contrafect Corporation Gram-negative lysin-antimicrobial peptide (AMP) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof in human serum
US10988520B2 (en) * 2018-03-29 2021-04-27 Contrafect Corporation Lysin-antimicrobial peptide (AMP) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof
WO2020046747A1 (en) * 2018-08-23 2020-03-05 Contrafect Corporation Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof
US20220160843A1 (en) * 2019-04-05 2022-05-26 Contrafect Corporation Lysins and derivatives thereof with bactericidal activity against pseudomonas aeruginosa, in the presence of human serum
KR102225240B1 (ko) * 2019-07-03 2021-03-10 경북대학교 산학협력단 다제내성 병원성 세균을 효과적으로 사멸시키는 재조합 항균 단백질 Ablysin의 용도
US20220411473A1 (en) * 2019-11-14 2022-12-29 Contrafect Corporation Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof
WO2023034646A2 (en) * 2021-09-03 2023-03-09 Aanika Biosciences, Inc. Lysecd7 variants and methods of using the same
CN114410670B (zh) * 2022-01-29 2024-01-23 福建医科大学附属口腔医院 一种溶菌酶及其在口腔护理用品中的应用
CN117660413B (zh) * 2023-12-15 2024-06-07 华南理工大学 一种内溶素Lys009及其工程改造和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0815484D0 (en) 2008-08-26 2008-10-01 Univ Leuven Kath Antibacterial agents
CA3019013C (en) 2009-02-06 2020-12-15 Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa Antibacterial phage, phage peptides and methods of use thereof
CA2780079A1 (en) * 2009-11-18 2011-05-26 Basf Plant Science Company Gmbh Process for the production of fine chemicals
CA2794603C (en) * 2010-04-27 2019-05-21 Lysando Ag Method of reducing biofilms
GB201018518D0 (en) 2010-11-03 2010-12-15 Univ Leuven Kath Novel endolysin
WO2012145630A2 (en) 2011-04-21 2012-10-26 The Rockefeller University Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria
WO2015070912A1 (en) 2013-11-14 2015-05-21 Lysando Ag Modified el188 endolysin sequence
WO2015200783A2 (en) 2014-06-26 2015-12-30 The Rockefeller University Acinetobacter lysins
BR112018005316A2 (pt) 2015-09-17 2018-12-11 Contrafect Corporation ?uso de lisina para restabelecer/aumentar a atividade antibacteriana na presença de surfactante pulmonar de antibióticos inibidos desse modo?
CN111971058A (zh) 2017-12-12 2020-11-20 康特拉费克特公司 对铜绿假单胞菌具有细菌活性的溶素及其衍生物的鉴定
CN108103050A (zh) 2018-02-11 2018-06-01 中国医药集团总公司四川抗菌素工业研究所 一种铜绿假单胞菌噬菌体裂解酶、其编码基因、重组表达载体及其制备方法和应用
US11773140B2 (en) 2018-03-29 2023-10-03 Contrafect Corporation Gram-negative lysin-antimicrobial peptide (AMP) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof in human serum
WO2020046747A1 (en) 2018-08-23 2020-03-05 Contrafect Corporation Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof

Also Published As

Publication number Publication date
US12121568B2 (en) 2024-10-22
RU2020118691A (ru) 2022-01-13
CA3085644A1 (en) 2019-06-20
BR112020011433A2 (pt) 2020-12-01
CN111971058A (zh) 2020-11-20
IL275060B1 (en) 2023-06-01
IL275060A (en) 2020-07-30
EP3723789A4 (en) 2021-12-01
AU2018384790A1 (en) 2020-07-30
AU2018384790B2 (en) 2024-10-17
KR20200098615A (ko) 2020-08-20
IL303122A (en) 2023-07-01
US20210085758A1 (en) 2021-03-25
JP2021506769A (ja) 2021-02-22
IL275060B2 (en) 2023-10-01
EP3723789A1 (en) 2020-10-21
WO2019118632A1 (en) 2019-06-20
JP2024010053A (ja) 2024-01-23

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