WO2019077634A3 - Therapeutic compositions of antimicrobial peptides - Google Patents

Therapeutic compositions of antimicrobial peptides Download PDF

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Publication number
WO2019077634A3
WO2019077634A3 PCT/IN2018/050676 IN2018050676W WO2019077634A3 WO 2019077634 A3 WO2019077634 A3 WO 2019077634A3 IN 2018050676 W IN2018050676 W IN 2018050676W WO 2019077634 A3 WO2019077634 A3 WO 2019077634A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
gram
therapeutic compositions
antimicrobial peptides
curtipes
Prior art date
Application number
PCT/IN2018/050676
Other languages
French (fr)
Other versions
WO2019077634A2 (en
Inventor
Dr. K. Santhosh KUMAR
Original Assignee
Rajiv Gandhi Centre For Biotechnology, An Autonomous Institute Under The Department Of Bio-Technology, Government Of India
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rajiv Gandhi Centre For Biotechnology, An Autonomous Institute Under The Department Of Bio-Technology, Government Of India filed Critical Rajiv Gandhi Centre For Biotechnology, An Autonomous Institute Under The Department Of Bio-Technology, Government Of India
Publication of WO2019077634A2 publication Critical patent/WO2019077634A2/en
Publication of WO2019077634A3 publication Critical patent/WO2019077634A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/463—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from amphibians
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides L-peptides and synthetic D-amino acid substituted peptides isolated, purified and characterized from frogs Clinotarsus curtipes and Hylarana temporalis of the Western Ghats, Kerala region of India. Peptides profiles are herein described according to their killing kinetics of Gram-positive and gram-negative bacteria, red blood cell haemolysis and cytotoxic effect on cultured mammalian cells.
PCT/IN2018/050676 2017-10-20 2018-10-18 Therapeutic compositions of antimicrobial peptides WO2019077634A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201741037147 2017-10-20
IN201741037147 2017-10-20

Publications (2)

Publication Number Publication Date
WO2019077634A2 WO2019077634A2 (en) 2019-04-25
WO2019077634A3 true WO2019077634A3 (en) 2019-08-01

Family

ID=64650452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2018/050676 WO2019077634A2 (en) 2017-10-20 2018-10-18 Therapeutic compositions of antimicrobial peptides

Country Status (1)

Country Link
WO (1) WO2019077634A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113150064B (en) * 2021-04-14 2023-04-11 中山大学 Artificial synthesis method and application of antibacterial and insect-resistant peptide
CN113412833B (en) * 2021-08-23 2021-11-12 山东科金生物发展有限公司 Cryopreservation protective agent for ultralow-temperature damage of mesenchymal stem cells
CN117106050B (en) * 2022-12-30 2024-02-23 好易康生物科技(广州)有限公司 Antibacterial peptide for nonspecific targeted inhibition of pathogenic bacteria and application thereof
CN116535474B (en) * 2023-06-27 2023-09-19 深圳市森盈智能科技有限公司 Anti-adhesion biocompatible antibacterial peptide and application thereof in biological coating

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ABRAHAM PARVIN ET AL: "Novel antibacterial peptides from the skin secretion of the Indian bicoloured frog Clinotarsus curtipes", BIOCHIMIE, MASSON, PARIS, FR, vol. 97, 24 October 2013 (2013-10-24), pages 144 - 151, XP028671648, ISSN: 0300-9084, DOI: 10.1016/J.BIOCHI.2013.10.005 *
PARVIN ABRAHAM ET AL: "Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides", PLOS ONE, vol. 10, no. 5, 21 May 2015 (2015-05-21), pages e0124210, XP055584307, DOI: 10.1371/journal.pone.0124210 *
VINEETH KUMAR ET AL: "Host Defense Peptides from Asian Frogs as Potential Clinical Therapies", ANTIBIOTICS, vol. 4, no. 2, 30 March 2015 (2015-03-30), pages 136 - 159, XP055584338, DOI: 10.3390/antibiotics4020136 *

Also Published As

Publication number Publication date
WO2019077634A2 (en) 2019-04-25

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