BR112021025948A2 - Polipeptídeos antimicrobianos derivados de bacteriófagos e seu uso contra bactérias gram-negativas e ácido-resistentes - Google Patents
Polipeptídeos antimicrobianos derivados de bacteriófagos e seu uso contra bactérias gram-negativas e ácido-resistentesInfo
- Publication number
- BR112021025948A2 BR112021025948A2 BR112021025948A BR112021025948A BR112021025948A2 BR 112021025948 A2 BR112021025948 A2 BR 112021025948A2 BR 112021025948 A BR112021025948 A BR 112021025948A BR 112021025948 A BR112021025948 A BR 112021025948A BR 112021025948 A2 BR112021025948 A2 BR 112021025948A2
- Authority
- BR
- Brazil
- Prior art keywords
- negative
- acid
- gram
- fast bacteria
- chp
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/14011—Details ssDNA Bacteriophages
- C12N2795/14211—Microviridae
- C12N2795/14222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
polipeptídeos antimicrobianos derivados de bacteriófagos e seu uso contra bactérias gram- negativas e ácido-resistentes. referência cruzada a pedidos relacionados. a presente invenção refere-se a composições farmacêuticas que compreendem uma quantidade eficaz de um peptídeo de chp isolado tendo uma sequência de aminoácidos selecionada do grupo consistindo em seq id nºs: 81-91 e 94-102, ou um peptídeo de chp modificado tendo cerca de 80% de identidade da sequência com ela, em que o peptídeo de chp modificado inibe o crescimento, reduz a população ou mata pelo menos uma espécie de bactérias gram-negativas ou ácido-resistentes; e um carreador farmaceuticamente aceitável. ainda são descritos no presente documento peptídeos de chp isolados, bem como vetores que compreendem uma molécula de ácido nucleico que codifica os peptídeos de chp e células hospedeiras que compreendem um vetor. também são descritos no presente documento métodos de inibição do crescimento, redução da população ou morte de pelo menos uma espécie de bactérias gram-negativas ou ácido-resistentes, métodos de tratamento de uma infecção bacteriana em um paciente e métodos para prevenção, rompimento ou tratamento de uma biopelícula compreendendo uma bactéria gram-negativa.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962870908P | 2019-07-05 | 2019-07-05 | |
| US201962892783P | 2019-08-28 | 2019-08-28 | |
| US201962911900P | 2019-10-07 | 2019-10-07 | |
| US201962948052P | 2019-12-13 | 2019-12-13 | |
| US202062964743P | 2020-01-23 | 2020-01-23 | |
| PCT/US2020/040714 WO2021007107A1 (en) | 2019-07-05 | 2020-07-02 | Antimicrobial, bacteriophage-derived polypeptides and their use against gram-negative and acid-fast bacteria |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021025948A2 true BR112021025948A2 (pt) | 2022-02-08 |
Family
ID=74114204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021025948A BR112021025948A2 (pt) | 2019-07-05 | 2020-07-02 | Polipeptídeos antimicrobianos derivados de bacteriófagos e seu uso contra bactérias gram-negativas e ácido-resistentes |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220401514A1 (pt) |
| EP (1) | EP3993821A4 (pt) |
| JP (1) | JP2022539383A (pt) |
| KR (1) | KR20220029746A (pt) |
| CN (1) | CN114401735A (pt) |
| AU (1) | AU2020310107A1 (pt) |
| BR (1) | BR112021025948A2 (pt) |
| CA (1) | CA3145990A1 (pt) |
| IL (1) | IL289412A (pt) |
| MX (1) | MX2021015563A (pt) |
| WO (1) | WO2021007107A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019245333A1 (en) * | 2018-03-29 | 2020-10-29 | Contrafect Corporation | Antimicrobial, bacteriophage-derived polypeptides and their use against gram-negative bacteria |
| SG11202105401TA (en) * | 2018-12-27 | 2021-07-29 | Johnson & Johnson Consumer Inc | Device and method for selective application of topical composition using dynamic threshold values |
| US12011561B2 (en) | 2020-08-03 | 2024-06-18 | Johnson & Johnson Consumer Inc. | System and method for selective application of cosmetic composition to impart undereye brightening |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5741697A (en) * | 1995-11-30 | 1998-04-21 | University Of Rochester | Bacteriophage of chlamydia psittaci |
| WO2002095413A2 (en) * | 2001-05-23 | 2002-11-28 | The University Of British Columbia | Diagnosis of vascular disease susceptibility using bacteriophage phi-cpn1 host chlamydia |
| CA3095484A1 (en) * | 2018-03-29 | 2019-10-03 | Contrafect Corporation | Lysin-antimicrobial peptide (amp) polypeptide constructs, lysins, isolated polynucleotides encoding same and uses thereof |
| AU2019245333A1 (en) * | 2018-03-29 | 2020-10-29 | Contrafect Corporation | Antimicrobial, bacteriophage-derived polypeptides and their use against gram-negative bacteria |
| MX2020010076A (es) * | 2018-08-23 | 2021-01-08 | Contrafect Corp | Construcciones de polipeptido de lisina-peptido anti-microbiano (amp), lisinas, polinucleotidos aislados que codifican para estas, y sus usos. |
-
2020
- 2020-07-02 KR KR1020227004002A patent/KR20220029746A/ko unknown
- 2020-07-02 BR BR112021025948A patent/BR112021025948A2/pt unknown
- 2020-07-02 CA CA3145990A patent/CA3145990A1/en active Pending
- 2020-07-02 MX MX2021015563A patent/MX2021015563A/es unknown
- 2020-07-02 US US17/621,357 patent/US20220401514A1/en active Pending
- 2020-07-02 EP EP20836436.4A patent/EP3993821A4/en not_active Withdrawn
- 2020-07-02 AU AU2020310107A patent/AU2020310107A1/en not_active Abandoned
- 2020-07-02 JP JP2021577691A patent/JP2022539383A/ja active Pending
- 2020-07-02 CN CN202080062511.XA patent/CN114401735A/zh active Pending
- 2020-07-02 WO PCT/US2020/040714 patent/WO2021007107A1/en unknown
-
2021
- 2021-12-27 IL IL289412A patent/IL289412A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL289412A (en) | 2022-02-01 |
| CN114401735A (zh) | 2022-04-26 |
| CA3145990A1 (en) | 2021-01-14 |
| WO2021007107A1 (en) | 2021-01-14 |
| EP3993821A1 (en) | 2022-05-11 |
| US20220401514A1 (en) | 2022-12-22 |
| EP3993821A4 (en) | 2023-07-19 |
| KR20220029746A (ko) | 2022-03-08 |
| MX2021015563A (es) | 2022-03-17 |
| AU2020310107A1 (en) | 2022-01-20 |
| JP2022539383A (ja) | 2022-09-08 |
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