MX2020004531A - Inhibidores dobles de tim-3 y las vias de pd-1. - Google Patents
Inhibidores dobles de tim-3 y las vias de pd-1.Info
- Publication number
- MX2020004531A MX2020004531A MX2020004531A MX2020004531A MX2020004531A MX 2020004531 A MX2020004531 A MX 2020004531A MX 2020004531 A MX2020004531 A MX 2020004531A MX 2020004531 A MX2020004531 A MX 2020004531A MX 2020004531 A MX2020004531 A MX 2020004531A
- Authority
- MX
- Mexico
- Prior art keywords
- tim
- pathways
- dual inhibitors
- inhibitors
- dual
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 230000009977 dual effect Effects 0.000 title abstract 2
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 title 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 title 1
- 230000037361 pathway Effects 0.000 title 1
- 102100040678 Programmed cell death protein 1 Human genes 0.000 abstract 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 abstract 3
- -1 3-substituted 1,2,4-oxadiazole compounds Chemical class 0.000 abstract 1
- 108010074708 B7-H1 Antigen Proteins 0.000 abstract 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 abstract 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 abstract 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 abstract 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 abstract 1
- 108091054435 TIM family Proteins 0.000 abstract 1
- 102000043124 TIM family Human genes 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201741039298 | 2017-11-03 | ||
| PCT/IB2018/058526 WO2019087087A1 (en) | 2017-11-03 | 2018-10-31 | Dual inhibitors of tim-3 and pd-1 pathways |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020004531A true MX2020004531A (es) | 2020-08-03 |
Family
ID=65033624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020004531A MX2020004531A (es) | 2017-11-03 | 2018-10-31 | Inhibidores dobles de tim-3 y las vias de pd-1. |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US11497734B2 (https=) |
| EP (1) | EP3703683A1 (https=) |
| JP (2) | JP7378394B2 (https=) |
| KR (1) | KR20200083503A (https=) |
| CN (1) | CN111372584A (https=) |
| AU (1) | AU2018360386B2 (https=) |
| BR (1) | BR112020008537A2 (https=) |
| CA (1) | CA3080098A1 (https=) |
| EA (1) | EA202090746A1 (https=) |
| IL (2) | IL274380A (https=) |
| MX (1) | MX2020004531A (https=) |
| MY (1) | MY206121A (https=) |
| PH (1) | PH12020550511A1 (https=) |
| SG (1) | SG11202003625VA (https=) |
| WO (1) | WO2019087087A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE038169T2 (hu) | 2013-09-06 | 2018-09-28 | Aurigene Discovery Tech Ltd | 1,2,4-Oxadiazol származékok mint immunomodulátorok |
| KR102894264B1 (ko) | 2015-03-10 | 2025-12-02 | 오리진 온콜로지 리미티드 | 면역조절제로서의 1,2,4-옥사다이아졸 및 티아다이아졸 화합물 |
| WO2019061324A1 (en) | 2017-09-29 | 2019-04-04 | Curis Inc. | CRYSTALLINE FORMS OF IMMUNOMODULATORS |
| EP3694841A1 (en) | 2017-10-11 | 2020-08-19 | Aurigene Discovery Technologies Limited | Crystalline forms of 3-substituted 1,2,4-oxadiazole |
| MY206121A (en) | 2017-11-03 | 2024-11-29 | Aurigene Discovery Tech Ltd | Dual inhibitors of tim-3 and pd-1 pathways |
| AU2018360389B2 (en) | 2017-11-06 | 2024-09-19 | Aurigene Oncology Limited | Conjoint therapies for immunomodulation |
| CN118236374A (zh) * | 2018-03-14 | 2024-06-25 | 奥瑞基尼肿瘤有限公司 | 使用1,2,4-噁二唑化合物调节tigit和pd-1信号传导途径的方法 |
| KR20220059517A (ko) | 2019-09-30 | 2022-05-10 | 메드샤인 디스커버리 아이엔씨. | 소분자 pd-1/pd-l1 억제제로서의 화합물 및 이의 용도 |
| CN116916905A (zh) * | 2020-12-07 | 2023-10-20 | 塞莱斯蒂亚生物技术股份公司 | 治疗癌症的药物组合 |
| CN114796226B (zh) * | 2021-12-17 | 2023-09-12 | 新乡医学院 | 奥拉帕尼在诱导核仁应激中的应用 |
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| KR20170066546A (ko) | 2014-10-03 | 2017-06-14 | 노파르티스 아게 | 조합 요법 |
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| KR102894264B1 (ko) * | 2015-03-10 | 2025-12-02 | 오리진 온콜로지 리미티드 | 면역조절제로서의 1,2,4-옥사다이아졸 및 티아다이아졸 화합물 |
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| AU2017345500B2 (en) | 2016-10-20 | 2022-03-10 | Aurigene Oncology Limited | Dual inhibitors of vista and PD-1 pathways |
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| EP3694841A1 (en) | 2017-10-11 | 2020-08-19 | Aurigene Discovery Technologies Limited | Crystalline forms of 3-substituted 1,2,4-oxadiazole |
| MY206121A (en) | 2017-11-03 | 2024-11-29 | Aurigene Discovery Tech Ltd | Dual inhibitors of tim-3 and pd-1 pathways |
| AU2018360389B2 (en) | 2017-11-06 | 2024-09-19 | Aurigene Oncology Limited | Conjoint therapies for immunomodulation |
-
2018
- 2018-10-31 MY MYPI2020002161A patent/MY206121A/en unknown
- 2018-10-31 US US16/761,162 patent/US11497734B2/en active Active
- 2018-10-31 CN CN201880075325.2A patent/CN111372584A/zh active Pending
- 2018-10-31 BR BR112020008537-5A patent/BR112020008537A2/pt not_active Application Discontinuation
- 2018-10-31 WO PCT/IB2018/058526 patent/WO2019087087A1/en not_active Ceased
- 2018-10-31 MX MX2020004531A patent/MX2020004531A/es unknown
- 2018-10-31 CA CA3080098A patent/CA3080098A1/en active Pending
- 2018-10-31 JP JP2020526224A patent/JP7378394B2/ja active Active
- 2018-10-31 EP EP18836390.7A patent/EP3703683A1/en not_active Withdrawn
- 2018-10-31 KR KR1020207014464A patent/KR20200083503A/ko not_active Ceased
- 2018-10-31 SG SG11202003625VA patent/SG11202003625VA/en unknown
- 2018-10-31 AU AU2018360386A patent/AU2018360386B2/en not_active Expired - Fee Related
- 2018-10-31 EA EA202090746A patent/EA202090746A1/ru unknown
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2020
- 2020-04-29 PH PH12020550511A patent/PH12020550511A1/en unknown
- 2020-04-30 IL IL274380A patent/IL274380A/en unknown
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2021
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2022
- 2022-10-07 US US17/962,096 patent/US20230062570A1/en not_active Abandoned
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2023
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- 2023-11-21 US US18/516,458 patent/US12226402B2/en active Active
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2025
- 2025-01-09 US US19/015,100 patent/US20250144082A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL287959A (en) | 2022-01-01 |
| US20240100024A1 (en) | 2024-03-28 |
| WO2019087087A1 (en) | 2019-05-09 |
| KR20200083503A (ko) | 2020-07-08 |
| AU2018360386B2 (en) | 2023-11-09 |
| JP7378394B2 (ja) | 2023-11-13 |
| JP2021502965A (ja) | 2021-02-04 |
| AU2018360386A1 (en) | 2020-05-07 |
| EA202090746A1 (ru) | 2020-08-17 |
| IL274380A (en) | 2020-06-30 |
| SG11202003625VA (en) | 2020-05-28 |
| MY206121A (en) | 2024-11-29 |
| EP3703683A1 (en) | 2020-09-09 |
| US11497734B2 (en) | 2022-11-15 |
| BR112020008537A2 (pt) | 2020-10-06 |
| US20230062570A1 (en) | 2023-03-02 |
| PH12020550511A1 (en) | 2021-05-10 |
| CN111372584A (zh) | 2020-07-03 |
| CA3080098A1 (en) | 2019-05-09 |
| US20200368210A1 (en) | 2020-11-26 |
| US20250144082A1 (en) | 2025-05-08 |
| US12226402B2 (en) | 2025-02-18 |
| JP2023182598A (ja) | 2023-12-26 |
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