JP2021502965A - Tim−3およびpd−1経路の二重阻害剤 - Google Patents
Tim−3およびpd−1経路の二重阻害剤 Download PDFInfo
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- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229950001269 taselisib Drugs 0.000 description 1
- 229940126625 tavolimab Drugs 0.000 description 1
- 229940063683 taxotere Drugs 0.000 description 1
- 229960001674 tegafur Drugs 0.000 description 1
- WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 description 1
- 229960004964 temozolomide Drugs 0.000 description 1
- 229960001278 teniposide Drugs 0.000 description 1
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
- 229950003046 tesevatinib Drugs 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 229940022511 therapeutic cancer vaccine Drugs 0.000 description 1
- 229940126622 therapeutic monoclonal antibody Drugs 0.000 description 1
- 229940021747 therapeutic vaccine Drugs 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 229960005062 tinzaparin Drugs 0.000 description 1
- 108010078373 tisagenlecleucel Proteins 0.000 description 1
- 229950005976 tivantinib Drugs 0.000 description 1
- 229960005048 toceranib Drugs 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 239000003558 transferase inhibitor Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 108010075758 trebananib Proteins 0.000 description 1
- IUCJMVBFZDHPDX-UHFFFAOYSA-N tretamine Chemical compound C1CN1C1=NC(N2CC2)=NC(N2CC2)=N1 IUCJMVBFZDHPDX-UHFFFAOYSA-N 0.000 description 1
- 229950001353 tretamine Drugs 0.000 description 1
- KVJXBPDAXMEYOA-CXANFOAXSA-N trilostane Chemical compound OC1=C(C#N)C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@@]32O[C@@H]31 KVJXBPDAXMEYOA-CXANFOAXSA-N 0.000 description 1
- 229960001670 trilostane Drugs 0.000 description 1
- NOYPYLRCIDNJJB-UHFFFAOYSA-N trimetrexate Chemical compound COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 NOYPYLRCIDNJJB-UHFFFAOYSA-N 0.000 description 1
- 229960001099 trimetrexate Drugs 0.000 description 1
- 229960000875 trofosfamide Drugs 0.000 description 1
- UMKFEPPTGMDVMI-UHFFFAOYSA-N trofosfamide Chemical compound ClCCN(CCCl)P1(=O)OCCCN1CCCl UMKFEPPTGMDVMI-UHFFFAOYSA-N 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
- 229940030325 tumor cell vaccine Drugs 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 208000025421 tumor of uterus Diseases 0.000 description 1
- 238000000539 two dimensional gel electrophoresis Methods 0.000 description 1
- TUCIOBMMDDOEMM-RIYZIHGNSA-N tyrphostin B42 Chemical compound C1=C(O)C(O)=CC=C1\C=C(/C#N)C(=O)NCC1=CC=CC=C1 TUCIOBMMDDOEMM-RIYZIHGNSA-N 0.000 description 1
- 229950009811 ubenimex Drugs 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 229960001055 uracil mustard Drugs 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 201000005290 uterine carcinosarcoma Diseases 0.000 description 1
- 206010046885 vaginal cancer Diseases 0.000 description 1
- 208000013139 vaginal neoplasm Diseases 0.000 description 1
- 229940102566 valproate Drugs 0.000 description 1
- 229960000241 vandetanib Drugs 0.000 description 1
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 description 1
- 230000006444 vascular growth Effects 0.000 description 1
- 239000004066 vascular targeting agent Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N verteporfin Chemical compound C=1C([C@@]2([C@H](C(=O)OC)C(=CC=C22)C(=O)OC)C)=NC2=CC(C(=C2C=C)C)=NC2=CC(C(=C2CCC(O)=O)C)=NC2=CC2=NC=1C(C)=C2CCC(=O)OC ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N 0.000 description 1
- 229960003895 verteporfin Drugs 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
- 229940023147 viral vector vaccine Drugs 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
- 229950003684 zibotentan Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Description
式中:
Zは、−OHまたは−NH−Gを表し;
Gは、水素または(C1〜C6)アルキルを表し;
Yは、水素または以下の構造式で表される基を表し、
Ra’は、水素を表し、または、RaおよびRa’は、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を任意により含む5〜6員環を形成し、
Rbは、−C(O)NRxRy、−NRxRy、またはカルボン酸で任意により置換されている(C1〜C6)アルキルを表し、
Rcは、水素を表し、またはRbおよびRcは、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、5〜6員環は、ヒドロキシルで任意によりさらに置換されており、
Rdは、−ORX、カルボン酸、またはアリール−OHで任意により置換されている(C1〜C6)アルキルを表し、
Reは、水素を表し、または、RdおよびReは、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、
RxおよびRyは、独立して水素、(C1〜C6)アルキルまたは(C2〜C6)アシルを表す。
治療方法
Zは、−OHまたは−NH−Gを表し;
Gは、水素または(C1〜C6)アルキルを表し;
Yは、水素または次式で表される基を表し、
Ra’は、水素を表し、または、RaおよびRa’は、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を任意により含む5〜6員環を形成し、
Rbは、−C(O)NRxRy、−NRxRy、またはカルボン酸で任意により置換されている(C1〜C6)アルキルを表し、
Rcは、水素を表し、またはRbおよびRcは、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、5〜6員環は、ヒドロキシルで任意によりさらに置換されており、
Rdは、−ORX、カルボン酸、またはアリール−OHで任意により置換されている(C1〜C6)アルキルを表し、
Reは、水素を表し、または、RdおよびReは、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、
RxおよびRyは、独立して水素、(C1〜C6)アルキルまたは(C2〜C6)アシルを表す。
Zは、−OHまたは−NH−Gを表し;
Gは、水素または(C1〜C6)アルキルを表し;
Yは、以下の構造式で表される基を表し、
Ra’は、水素を表し、または、RaおよびRa’は、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を任意により含む5〜6員環を形成し、
Rbは、−C(O)NRxRyまたはカルボン酸で任意により置換されている(C1〜C6)アルキルを表し;
Rcは、水素を表し、または、RbおよびRcは、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、
Rdは、−ORXで任意により置換されている(C1〜C6)アルキルを表し、
Reは、水素を表し、または、RdおよびReは、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、
RxおよびRyは、独立して水素、(C1〜C6)アルキルまたは(C2〜C6)アシルを表す。
Zは、−OHまたは−NH−Gを表し;
Gは、水素またはメチルを表し、
Yは、水素または以下の構造式で表される基を表し、
Ra’は、水素を表し、または、RaおよびRa’は、それらに結合している原子と一緒になって、シクロペンチル環を形成し、
Rbは、sec−ブチル、−CH2C(O)NH2、−(CH2)4−NH2、−(CH2)4−NH(C(O)CH3)、−CH2C(O)OH、または−(CH2)2C(O)OHを表し、
Rcは、水素を表し、またはRbおよびRcは、それらに結合している原子と一緒になってピロリジン環を形成し、ピロリジン環は、ヒドロキシルで任意によりさらに置換される。
Rdは、イソプロピル、sec−ブチル、−CH2OH、−CH(CH3)OH、−CH(CH3)OCH3、−CH2C(O)OH、または−CH2−(p−OH(フェニル))を表し、
Reは、水素を表し、またはRdおよびReは、それらに結合している原子と一緒になってピロリジン環を形成する。
Zは、−OHまたは−NH−Gを表し;
Gは、水素またはメチルを表し、
Yは、以下の構造式で表される基を表し、
Ra’は、水素を表し、
Rbは、−CH2C(O)NH2、−CH2C(O)OH、または−(CH2)2C(O)OHを表し、
Rcは、水素を表し、またはRbおよびRcは、それらに結合している原子と一緒になってピロリジン環を形成し、
Rdは、sec−ブチル、−CH2OH、または−CH(CH3)OHを表し、
Reは、水素を表す。
使用方法
バイオマーカースクリーニング
a)対象由来の生体試料がガレクチン−9、CDllb+Gr−l+、CEACAM1、HMGB1、ホスファチジルセリン、TIM−3、PD−L1、および/またはPD−L2を過剰発現するかを決定すること、および
b)試料がガレクチン−9、CDllb+Gr−l+、CEACAM1、HMGB1、ホスファチジルセリン、TIM−3、PD−L1、および/またはPD−L2を過剰発現する場合、対象を本明細書に開示の式(I)の化合物と接触させることを含む。
a)対象由来の生体試料がTIM−3を過剰発現するかを決定すること、および
b)試料がTIM−3を過剰発現する場合、対象を本明細書に開示の式(I)の化合物と接触させることを含む。
a)対象由来の生体試料がTIM−3を過剰発現するかを決定すること、および
b)試料がTIM−3を過剰発現する場合、対象を本明細書に開示の式(I)の化合物と接触させることを含む。
a)対象から生体試料を入手するか、または提供されること、
b)対象試料中のTIM−3の量または活性を測定すること、および
c)測定された量または活性を、対照試料中のTIM−3の量または活性と比較することを含み、
対照試料と比較して、対象試料中のTIM−3の量または活性が有意に増加している場合には、対象が式(I)の化合物に応答する可能性が高いと特定し、
対照試料と比較して、対象試料中のTIM−3の量または活性が類似しているか、または減少している場合、対象が式(I)の化合物に応答する可能性が低いと特定する。
a)対象から生体試料を入手するか、または提供されること、
b)対象試料中のTIM−3の量または活性を測定すること、および
c)測定された量または活性を、対照試料中のTIM−3の量または活性と比較することを含み、
対照試料と比較して、対象試料中のTIM−3の活性が類似しているか、または減少している場合、対象が式(I)の化合物に応答する可能性が高いと特定し、
対照試料と比較して、対象試料中のTIM−3の量または活性が高い場合、対象が式(I)の化合物に応答する可能性が低いと特定する。
投与方法
併用療法
併用治療法のための剤
1)アルドステロンシンターゼ阻害剤、
2)ALK阻害剤、アポトーシス誘導剤、
3)アロマターゼ阻害剤、
4)CART細胞(例えば、CD19を標的とするCART細胞)、
5)BCR−ABL阻害剤、
6)BRAF阻害剤、
7)CDK4/6−阻害剤、
8)CEACAM(例えば、CEACAM−1、−3および/または−5)阻害剤、
9)c−KIT阻害剤、
10)c−MET阻害剤、
10)cRAP阻害剤、
11)CTLA4阻害剤、
12)チトクロームP450阻害剤(例えば、CYP17阻害剤)、
13)EGF阻害剤、
14)ERK1/2 ATP阻害剤、
15)FGF阻害剤(例えば、FGFR2またはFGFR4阻害剤)、
16)Flt3阻害剤(例えば、FLK2/STK1)、
17)P−糖タンパク質1阻害剤、
18)HDAC阻害剤、
19)HDM2阻害剤、
20)HER3阻害剤、
21)ヒスタミン放出阻害剤、
22)HSP90阻害剤、
23)IAP阻害剤、
24)IDH阻害剤、
25)IDO阻害剤、
26)IGF−1R阻害剤、
27)鉄キレート剤、
28)ヤヌス阻害剤、
29)LAG−3阻害剤、
30)M−CSF阻害剤、
31)MEK阻害剤、
32)mTOR阻害剤、
33)p53阻害剤(例えば、p53/Mdm2相互作用の阻害剤)、
34)PDGFRβ阻害剤、
35)PKC阻害剤、
36)PI3K阻害剤、
37)PIM阻害剤、
38)PRLR阻害剤、
39)RafキナーゼC阻害剤、
40)平滑化(SMO)受容体阻害剤、
41)ソマトスタチンアゴニストおよび/または成長ホルモン放出阻害剤、
42)形質導入モジュレーターおよび/または血管新生阻害剤、
43)VEGFR−2阻害剤(例えば、FLK−1/KDR)、
44)チロシンキナーゼ阻害剤(例えば、CSF−1Rチロシンキナーゼ)、
45)Wntシグナル伝達阻害剤、
46)Bcl−2阻害剤、
47)Mcl−1阻害剤、
48)BTK阻害剤、
49)CUDC−907(二重PI3K/HDAC阻害剤)などの二重活性分子、
50)BETブロモドメイン阻害剤、
51)アルギナーゼ−1阻害剤、および
52)PD−1阻害剤
1)(S)−N−((S)−1−シクロヘキシル−2−((S)−2−(4−(4−フルオロベンゾイル)チアゾール−2−イル)ピロリジン−1−イル)−2−オキソエチル)−2−(メチルアミノ)プロパンアミド;
2)((1R、9S、12S、15R、16E、18R、19R、21R、23S、24E、26E、28E、30S、32S、35R)−l、18−ジヒドロキシ−12−{(lR)−2−[(lS、3R、4R)−4−(2−ヒドロキシエトキシ)−3−メトキシシクロヘキシル]−l−メチルエチル}−19,30−ジメトキシ−15,17,21,23,29,35−ヘキサメチル−ll、36−ジオキサ−4−アザトリシクロ[30.3.1.04,9]ヘキサトリアコンタ−16,24,26,28−テトラエン−2,3,10,14,20−ペンタオン);
3)(S)−l−(4−クロロフェニル)−7−イソプロポキシ−6−メトキシ−2−(4−{メチル−[4−(4−メチル−3−オキソピペラジン−1−イル)−trans−シクロヘキシルメチル]−アミノ}フェニル)−1,4−ジヒドロ−2H−イソキノリン−3オン;
4)N−(4−((1R,3S,5S)−3−アミノ−5−メチルシクロヘキシル)ピリジン−3−イル)−6−(2,6−ジフルオロフェニル)−5−フルオロピコリンアミド;
5)米国特許第8,735,551号に記載されている、配列番号141のVHおよび配列番号140のVLを含む、抗HER3モノクローナル抗体またはその抗原結合断片;
6)(E)−N−ヒドロキシ−3−(4−(((2−(2−メチル−1H−インドール−3−イル)エチル)アミノ)メチル)フェニル)アクリルアミド;
7)(3R)−3−シクロペンチル−3−[4−(7H−ピロロ−[2,3−d]ピリミジン−4−イル)−1H−ピラゾール−1−イル]プロパンニトリル;および/または
8)8−(2,6−ジフルオロ−3,5−ジメトキシ−フェニル)−キノキサリン−5−カルボン酸(4−ジメチルアミノメチル−1H−イミダゾール−2−イル)−アミド。
1)3−(1H−インドール−3−イル)−4−[2−(4−メチル−1−ピペラジニル)−4−キナゾリニル]−1H−ピロール−2,5−ジアン;
2)5−(2,4−ジヒドロキシ−5−イソプロピルフェニル)−N−エチル−4−(4−(モルホリノメチル)フェニル)イソキサゾール−3−カルボキサミド;
3)2−メチル−2−(4−(3−メチル−2−オキソ−8−(キノリン−3−イル)−2,3−ジヒドロ−1H−イミダゾ[4,5
−c]キノリン−1−イル)フェニル)プロパンニトリル(ダクトリシブ);
4)化合物D(CYP17阻害剤);
5)4−[3,5−ビス(2−ヒドロキシフェニル)−1H−1,2,4−トリアゾール−1−イル]−安息香酸(デファシロクス(defeasirox));
6)4,4’−(1H−1,2,4−トリアゾール−1−イルメチレン)ビス−ベンゾニトリル(レトロゾール);
7)(4S,5R)−3−(2’−アミノ−2−モルホリノ−4’−(トリフルオロメチル)−[4,5’−ビピリミジン]−6−イル)−4−(ヒドロキシメチル)−5−メチルオキサゾリジン−2−オン;
8)(S)−5−(5−クロロ−1−メチル−2−オキソ−1,2−ジヒドロピリジン−3−イル)−6−(4−クロロフェニル)−2−(2,4−ジメトキシピリミジン−5−イル)−l−イソプロピル−5,6−ジヒドロピロロ[3,4−d]イミダゾール−4(1H)−オン;
9)4−[(4−メチル−1−ピペラジニル)メチル]−N−[4−メチル−3−[[4−(3−ピリジニル)−2−ピリミジニル]アミノ]フェニル]−メタンスルホネート−ベンズアミド;
10)4−[(R)−6,7−ジヒドロ−5H−ピロロ[1,2−c]イミダゾール−5−イル]−3−フルオロベンゾニトリル(オシロドロスタット);
11)N−[6−[(2R,6S)−2,6−ジメチル−4−モルホリニル]−3−ピリジニル]−2−メチル−4’(トリフルオロメトキシ)−[1,1’−ビフェニル]−3−カルボキサミド、二リン酸(リン酸ソニデギブ);
12)(R)−2−(5−(4−(6−ベンジル−4,5−ジメチルピリダジン−3−イル)−2−メチルピペラジン−1−イル)ピラジン−2−イル)プロパン−2−オール;
13)化合物M(PRLRに対するヒトモノクローナル抗体);
14)2−(2’,3−ジメチル−[2,4’−ビピリジン]−5−イル)−N−(5−(ピラジン−2−イル)ピリジン−2−イル)アセトアミド;
15)7−シクロペンチル−N,N−ジメチル−2−((5−((1R,6S)−9−メチル−4−オキソ−3,9−ジアザビシクロ[4.2.1]ノナン−3−イル))ピリジン−2−イル)アミノ)−7H−ピロロ[2,3−d]ピリミジン−6−カルボキサミド;
16)化合物P(FGFR2および/またはFGFR4抗体薬物コンジュゲート、mAb12425);
17)化合物Q(M−CSFに対するFabのモノクローナル抗体);
18)N−[(9S,10R,11R,13R)−2,3,10,11,12,13−ヘキサヒドロ−10−メトキシ−9−メチル−1−オキソ−9,13−エポキシ−1H,9H−ジインドロ[1,2,3m]ピロロ[3,4−j][1,7]ベンゾジアゾニン−11−イル]−N−メチル−ベンズアミド(ミドスタウリン);
19)1−メチル−5−((2−(5−(トリフルオロメチル)−1H−イミダゾール−2−イル)ピリジン−4−イル)オキシ)−N−(4−(トリフルオロメチル)フェニル)−1H−ベンゾ[d]イミダゾール−2−アミン;
20)シクロ((4R)−4−(2−アミノエチルカルバモイルオキシ)−L−プロリル−L−フェニルグリシル−D−トリプトフィル−L−リシル−4−0−ベンジル−L−チロシル−L−フェニルアラニル−)(パシレオチドジアスパルテート);
21)1−アミノ−5−フルオロ−3−[6−(4−メチル−1−ピペラジニル)−1H−ベンゾイミダゾール−2−イル]−2(1H)−キノリノン(ドビチニブ);
22)8−(6−メトキシ−ピリジン−3−イル)−3−メチル−1−(4−ピペラジン−1−イル−3−トリフルオロメチル−フェニル)−1,3−ジヒドロ−イミダゾ[4,5−c]キノリン−2−オン;
23)N6−(2−イソプロポキシ−5−メチル−4−(1−メチルピペリジン−4−イル)フェニル)−N4−(2−(イソプロピルスルホニル)フェニル)−1H−ピラゾロ[3,4−d]ピリミジン−4,6−ジアミン;
24)3−(4−(4−((5−クロロ−4−((5−メチル−1H−ピラゾール−3−イル)アミノ)ピリミジン−2−イル)アミノ)−5−フルオロ−2−メチルフェニル1)ピペリジン−1−イル)チエタン1,1−ジオキシド;
25)5−クロロ−N2−(2−フルオロ−5−メチル−4−(1−(テトラヒドロ−2H−ピラン−4−イル)ピペリジン−4−イル)フェニル)−N4−(5−メチル−1H−ピラゾール−3−イル)ピリミジン−2,4−ジアミン;
26)5−クロロ−N2−(4−(1−エチルピペリジン−4−イル)−2−フルオロ−5−メチルフェニル)−N4−(5−メチル−1Hピラゾール−3−イル)ピリミジン−2,4−ジアミン;
27)6−[(2S,4R,6E)−4−メチル−2−(メチルアミノ)−3−オキソ−6−オクテン酸]シクロスポリンD.アムドレー、PSC833、[3’−デソキシ−3’−オキソ−MeBmt]1−[Val]2−シクロスポリン(valspodar);
28)N−(4−クロロフェニル)−4−(4−ピリジニルメチル)−1−フタラジナミンコハク酸塩(バタラニブコハク酸塩);
29)化合物CC(IDH阻害剤);
30)(R)−N−(4−(クロロジフルオロメトキシ)フェニル)−6−(3−ヒドロキシピロリジン−1−イル)−5−(1H−ピラゾール−5−イル)ニコチンアミド;
31)化合物EE(cRAF阻害剤);
32)化合物FF(ERK1/2ATP競合阻害剤);および
33)4−((2−(((1R,2R)−2−ヒドロキシシクロヘキシル)アミノ)ベンゾ[d]チアゾール−6−イル)オキシ)−N−メチルピコリンアミド。例えば、その全体が参照により本明細書に組み込まれるWO2016/100882を参照されたい。
膵悪性腫瘍
CP−675,206、イピリムマブ);AdVtk療法;プロテアソーム阻害剤(例えば、ボルテゾミブ(ベルケイド)、NPI−0052);チアゾリジンジオン(例えば、ピオグリタゾン);NPC−1C;オーロラキナーゼ阻害剤(例えば、R763/AS703569)、CTGF阻害剤(例えば、FG−3019);siG 12D LODER;および放射線療法(例えば、トモセラピー、定位放射線、陽子線治療)、外科手術、ならびにこれらの組み合わせが挙げられる。
小細胞肺癌
非小細胞肺癌
卵巣悪性腫瘍
腎細胞癌
慢性骨髄性白血病
慢性リンパ性白血病
急性リンパ性白血病
急性骨髄性白血病
多発性骨髄腫
前立腺悪性腫瘍
ホジキンリンパ腫
非ホジキンリンパ腫
医薬組成物
実施例
実施例1:組換えPD−L1/PD−L2の存在下でのマウス脾細胞増殖の救済
要件:
プロトコル
脾細胞の調製および培養:
CFSE増殖アッセイ:CFSEは、細胞内に受動的に拡散し、細胞内タンパク質に結合する色素である。1x106細胞/mLの採取した脾細胞を、事前に温めた1xPBS/0.1%BSA溶液中、5μMのCFSEにより37℃で10分間処理した。過剰なCFSEは、細胞に5容量の氷冷培地を使用してクエンチし、氷上で5分間インキュベートした。CFSE標識脾細胞に、氷冷完全RPMI培地で3回洗浄した。MDA−MB231細胞(高グルコースDMEM培地で培養された1x105細胞)または組換えヒトPDL−1(100ng/mL)と試験化合物のいずれかを含むウェルにCFSE標識1x105脾細胞を追加した。脾細胞を抗マウスCD3および抗マウスCD28抗体(それぞれ1μg/mL)で刺激し、培養物をさらに5%CO2で37℃で72時間インキュベートした。細胞を採取し、氷冷FACSバッファーで3回洗浄し、励起488nmおよび発光フィルター521nmのフローサイトメトリーで増殖率%を分析した。
データのコンパイル、処理、および推論:
刺激脾細胞:脾細胞+抗−CD3/CD28刺激
バックグラウンド増殖:脾細胞+抗−CD3/CD28+PD−L1
化合物増殖:脾細胞+抗−CD3/CD28+PD−L1+化合物
リガンド(PDL−1)の存在下で抗CD3/CD28刺激脾細胞に必要な濃度の化合物を添加することにより、化合物の効果を調べる。
実施例2:組換えTIM−3の存在下でのマウス脾細胞増殖のレスキュー
要件:
プロトコル
ヒトPBMC IFN−γ放出アッセイ
Claims (85)
- 細胞におけるT細胞免疫グロブリンおよびムチンドメイン含有−3(TIM−3)活性によって媒介される免疫応答を調節する方法であって、前記方法は、前記細胞を式(I)の化合物またはその薬学的に許容される塩と接触させることを含み、
Zは、−OHまたは−NH−Gを表し;
Gは、水素または(C1〜C6)アルキルを表し;
Yは、水素または以下の構造式で表される基を表し、
Ra’は、水素を表し、または、RaおよびRa’は、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を任意により含む5〜6員環を形成し、
Rbは、−C(O)NRxRy、−NRxRy、またはカルボン酸で任意により置換されている(C1〜C6)アルキルを表し、
Rcは、水素を表し、またはRbおよびRcは、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、前記5〜6員環は、ヒドロキシルで任意によりさらに置換されており、
Rdは、−ORX、カルボン酸、またはアリール−OHで任意により置換されている(C1〜C6)アルキルを表し、
Reは、水素を表し、または、RdおよびReは、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、
RxおよびRyは、独立して水素、(C1〜C6)アルキルまたは(C2〜C6)アシルを表す、方法。 - Zが−NH−Gを表す、請求項1に記載の方法。
- Gが水素またはメチルを表す、請求項1または2に記載の方法。
- Gが水素を表す、請求項1〜3のいずれか一項に記載の方法。
- Zが−OHを表す、請求項1に記載の方法。
- 式中、Raが(C1〜C4)アルキルを表し、(C1〜C4)アルキルが−OH、−NRxRy、−NH−C(=NH)−NH2、−SRX、カルボン酸、またはアリールで置換され、前記アリール基は、ヒドロキシルで任意によりさらに置換される、請求項1〜5のいずれか一項に記載の方法。
- Raが、−OH、−NH2、−NH−C(=NH)−NH2、−SCH3、カルボン酸、フェニル、またはp−OH(フェニル)で置換されている(C1〜C4)アルキルを表し、Ra’が、水素である、請求項1〜6のいずれか一項に記載の方法。
- Raが、−OH、−NH2、−NH−C(=NH)−NH2、カルボン酸、またはフェニルで置換されている(C1〜C4)アルキルを表し、Ra’が、水素である、請求項1〜7のいずれか一項に記載の方法。
- Raが、−CH2OH、−CH(CH3)OH、−(CH2)4−NH2、−(CH2)2−SCH3、−(CH2)2C(O)OH、−(CH2)3−NH−C(=NH)−NH2、−CH2−(フェニル)、または−CH2−(p−OH(フェニル))を表す、請求項1〜8のいずれか一項に記載の方法。
- Raが、−CH2OH、−CH(CH3)OH、−(CH2)4−NH2、−(CH2)2C(O)OH、−(CH2)3−NH−C(=NH)−NH2、または−CH2−(フェニル)を表す、請求項1〜9のいずれか一項に記載の方法。
- Raが、−CH2OHまたは−CH(CH3)OHを表す、請求項1〜10のいずれか一項に記載の方法。
- Raが、−CH2OHを表す、請求項11に記載の方法。
- RaおよびGが、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成する、請求項1または2に記載の方法。
- 前記5〜6員環が、モルホリン環である、請求項13に記載の方法。
- RaおよびRa’が、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を任意により含む5〜6員環を形成する、請求項1〜5のいずれか一項に記載の方法。
- 前記5〜6員環が、シクロペンチル環である、請求項15に記載の方法。
- Rbが、(C1〜C4)アルキルを表し、(C1〜C4)アルキルが−C(O)NRxRy、−NRxRyまたはカルボン酸で任意により置換される、請求項1〜16のいずれか一項に記載の方法。
- Rbが、−C(O)NH2、−NH2、−NH(C(O)CH3)、またはカルボン酸で任意により置換されている(C1〜C4)アルキルを表し、Rcが、水素を表す、請求項1〜17のいずれか一項に記載の方法。
- Rbが、−C(O)NH2、−NH(C(O)CH3)、またはカルボン酸で任意により置換されている(C1〜C4)アルキルを表し、Rcが、水素を表す、請求項1〜18のいずれか一項に記載の方法。
- Rbが、sec−ブチル、−CH2C(O)NH2、−(CH2)4−NH2、−(CH2)4−NH(C(O)CH3)、−CH2C(O)OH、または−(CH2)2C(O)OHを表す、請求項1〜19のいずれか一項に記載の方法。
- Rbが、−CH2C(O)NH2、−(CH2)4−NH2、−(CH2)4−NH(C(O)CH3)、−CH2C(O)OH、または−(CH2)2C(O)OHを表す、請求項1〜20のいずれか一項に記載の方法。
- Rbが、−CH2C(O)NH2、−CH2C(O)OH、または−(CH2)2C(O)OHを表す、請求項1〜21のいずれか一項に記載の方法。
- Rbが、−CH2C(O)OHまたは−(CH2)2C(O)OHを表す、請求項22に記載の方法。
- RbおよびRcが、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、前記5〜6員環が、ヒドロキシルで任意によりさらに置換される、請求項1〜16のいずれか一項に記載の方法。
- 前記5〜6員環が、ピロリジン環であり、前記ピロリジン環が、ヒドロキシルで任意によりさらに置換される、請求項24に記載の方法。
- Rdが、−OH、−OCH3、−C(O)OH、またはp−OH(フェニル)で任意により置換されている(C1〜C4)アルキルを表し、Reが、水素を表す、請求項1〜26のいずれか一項に記載の方法。
- Rdが、イソプロピル、secブチル、−CH2OH、−CH(CH3)OH、−CH(CH3)OCH3、−CH2C(O)OH、または−CH2−(p−OH(フェニル))を表す、請求項1〜27のいずれか一項に記載の方法。
- Rdが、sec−ブチル、−CH2OH、または−CH(CH3)OHを表す、請求項1〜28のいずれか一項に記載の方法。
- Rdが、−CH(CH3)OHを表す、請求項29に記載の方法。
- RdおよびReが、それらに結合している原子と一緒になって、
O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成する、請求項1〜26のいずれか一項に記載の方法。 - 前記5〜6員環が、ピロリジン環である、請求項31に記載の方法。
- Yが、水素を表す、請求項1〜25のいずれか一項に記載の方法。
- 請求項1に記載の方法であって、式中、
Zは、−OHまたは−NH−Gを表し;
Gは、水素または(C1〜C6)アルキルを表し;
Yは、以下の構造式で表される基を表し、
Ra’は、水素を表し、または、RaおよびRa’は、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を任意により含む5〜6員環を形成し、
Rbは、−C(O)NRxRyまたはカルボン酸で任意により置換されている(C1〜C6)アルキルを表し;
Rcは、水素を表し、または、RbおよびRcは、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、
Rdは、−ORXで任意により置換されている(C1〜C6)アルキルを表し、
Reは、水素を表し、または、RdおよびReは、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、
RxおよびRyは、独立して水素、(C1〜C6)アルキルまたは(C2〜C6)アシルを表す、方法。 - 請求項1に記載の方法であって、式中、
Zは、−OHまたは−NH−Gを表し;
Gは、水素またはメチルを表し、
Yは、水素または以下の構造式で表される基を表し、
Ra’は、水素を表し、または、RaおよびRa’は、それらに結合している原子と一緒になって、シクロペンチル環を形成し、
Rbは、sec−ブチル、−CH2C(O)NH2、−(CH2)4−NH2、−(CH2)4−NH(C(O)CH3)、−CH2C(O)OH、または−(CH2)2C(O)OHを表し、
Rcは、水素を表し、またはRbおよびRcは、それらに結合している前記原子と一緒になってピロリジン環を形成し、ピロリジン環は、ヒドロキシルで任意によりさらに置換される。
Rdは、イソプロピル、sec−ブチル、−CH2OH、−CH(CH3)OH、−CH(CH3)OCH3、−CH2C(O)OH、または−CH2−(p−OH(フェニル))を表し、
Reは、水素を表し、またはRdおよびReは、それらに結合している前記原子と一緒になってピロリジン環を形成する、方法。 - 請求項1に記載の方法であって、式中、
Zは、−OHまたは−NH−Gを表し;
Gは、水素またはメチルを表し、
Yは、以下の構造式で表される基を表し、
Ra’は、水素を表し、
Rbは、−CH2C(O)NH2、−CH2C(O)OH、または−(CH2)2C(O)OHを表し、
Rcは、水素を表し、またはRbおよびRcは、それらに結合している前記原子と一緒になってピロリジン環を形成し、
Rdは、sec−ブチル、−CH2OH、または−CH(CH3)OHを表し、
Reは、水素を表す、方法。 - Raは、−CH2OH、−CH(CH3)OH、または−(CH2)3−NH−C(=NH)−NH2を表し、Rbは、−CH2C(O)NH2、−CH2C(O)OH、または−(CH2)2C(O)OHを表し、Rdは、−CH2OHまたは−CH(CH3)OHを表す、請求項34〜36のいずれか一項に記載の方法。
- Raは、−CH2OHまたは−CH(CH3)OHを表し、Rbは、−CH2C(O)OHまたは−(CH2)2C(O)OHを表し、Rdは、−CH(CH3)OHを表す、請求項37に記載の方法。
- Raは、−CH2OHを表し、Rbは、−CH2C(O)OHまたは−(CH2)2C(O)OHを表し、Rdは−CH(CH3)OHを表す、請求項37に記載の方法。
- Raは、−CH(CH3)OHを表し、Rbは、−CH2C(O)NH2を表し、Rdは、−CH2OHを表す、請求項37に記載の方法。
- Raは、−(CH2)3−NH−C(=NH)−NH2を表し、Rbは、−CH2C(O)NH2を表し、Rdは、−CH2OHを表す、請求項37に記載の方法。
- 前記免疫応答が、プログラムされた細胞死1(PD−1)シグナル伝達経路によってさらに媒介される、請求項1〜44のいずれか一項に記載の方法。
- 前記免疫応答がTIM−3剤によってさらに媒介される、請求項1〜45のいずれか一項に記載の方法。
- 前記TIM−3剤が、ガレクチン−9、癌胎児性抗原関連細胞接着分子1(CEACAM1)、高移動度グループボックス1(HMGB1)、白血球免疫グロブリン様受容体A3(LILRA3)、およびホスファチジルセリンから選択される、請求項46に記載の方法。
- 前記細胞と接触することが、それを必要とする対象で起こり、それにより悪性腫瘍、免疫障害、免疫不全障害、炎症性障害、感染症、および移植拒絶から選択される疾患または障害を治療する、請求項1〜47のいずれか一項に記載の方法。
- 前記疾患または障害が悪性腫瘍である、請求項48記載の方法。
- 前記悪性腫瘍が、悪性腫瘍細胞、悪性腫瘍幹細胞または免疫細胞上でのTIM−3および/またはTIM−3剤および/またはそれらの組み合わせの直接発現によって媒介される、請求項49に記載の方法。
- 前記TIM−3剤が、ガレクチン−9、癌胎児性抗原関連細胞接着分子1(CEACAM1)、高移動度グループボックス1(HMGB1)、白血球免疫グロブリン様受容体A3(LILRA3)、白血球免疫グロブリン様受容体B2(LILRB2)、またはホスファチジルセリンから選択される、請求項50に記載の方法。
- 前記細胞と接触することがそれを必要とする対象で起こり、それにより疾患または障害を治療し、前記細胞が悪性腫瘍細胞、悪性腫瘍幹細胞、および免疫細胞から選択される、請求項1〜47のいずれか一項に記載の方法。
- 疾患または障害の前記治療が、腫瘍細胞の成長および/または転移を阻害することを含む、請求項48に記載の方法。
- 前記腫瘍細胞が、乳悪性腫瘍、結腸悪性腫瘍、肝悪性腫瘍、卵巣悪性腫瘍、前立腺悪性腫瘍、腎悪性腫瘍、または子宮悪性腫瘍から選択される悪性腫瘍に由来する、請求項53に記載の方法。
- 前記腫瘍細胞が、造血器悪性腫瘍に由来する、請求項53に記載の方法。
- 前記造血器悪性腫瘍は、リンパ腫、B細胞リンパ腫、T細胞リンパ腫、バーキットリンパ腫、ホジキンリンパ腫、非ホジキンリンパ腫、白血病、骨髄腫、急性骨髄性白血病(AML)、急性リンパ芽球性白血病(ALL)、慢性骨髄性白血病(CML)、慢性リンパ芽球性白血病(CLL)、慢性骨髄単球性白血病(CMML)、多発性骨髄腫、骨髄異形成症候群(MDS)、および形質細胞腫から選択される、請求項55に記載の方法。
- 卵巣悪性腫瘍、結腸悪性腫瘍、乳悪性腫瘍、肺悪性腫瘍、骨髄腫、神経芽細胞由来のCNS腫瘍、単球性白血病、B細胞由来白血病、T細胞由来白血病、B細胞由来リンパ腫、T細胞由来リンパ腫、およびマスト細胞由来の腫瘍から選択される、請求項53に記載の方法。
- 前記腫瘍細胞が、細胞腫、乳悪性腫瘍、上皮性悪性腫瘍、結腸悪性腫瘍、肺悪性腫瘍、黒色腫、前立腺悪性腫瘍、腎悪性腫瘍、骨悪性腫瘍、膵悪性腫瘍、皮膚悪性腫瘍、頭頸部悪性腫瘍、子宮悪性腫瘍、卵巣悪性腫瘍、直腸結腸悪性腫瘍、直腸悪性腫瘍、肛門部の悪性腫瘍、腹膜悪性腫瘍、結合組織悪性腫瘍、眼悪性腫瘍、咽喉悪性腫瘍、口腔悪性腫瘍、胆道悪性腫瘍、胃悪性腫瘍、精巣悪性腫瘍、卵管癌、子宮内膜悪性腫瘍、子宮頸悪性腫瘍、膣悪性腫瘍、外陰悪性腫瘍、食道悪性腫瘍、小腸悪性腫瘍、内分泌系悪性腫瘍、甲状腺悪性腫瘍、副甲状腺悪性腫瘍、副腎悪性腫瘍、肉腫、尿道悪性腫瘍、陰茎悪性腫瘍、慢性または急性白血病、急性リンパ性白血病(ALL)、急性骨髄性白血病(AML)、慢性リンパ性白血病(CLL)、慢性骨髄性白血病(CML)、骨髄増殖性疾患/新生物(MPDS)、骨髄異形成症候群、単球性白血病、B細胞由来白血病、T細胞由来白血病、小児の固形腫瘍、B細胞由来リンパ腫、T細胞由来リンパ腫、ホジキンリンパ腫、緩慢で攻撃的な非ホジキンリンパ腫、バーキットリンパ腫、濾胞性リンパ腫、中皮腫、胸腺癌、骨髄腫、多発性骨髄腫、巨細胞骨髄腫、重鎖骨髄腫、軽鎖またはベンス−ジョーンズ骨髄腫、マスト細胞由来腫瘍、平滑筋腫、平滑筋肉腫、神経膠腫、膀胱悪性腫瘍、尿管悪性腫瘍、腎盂癌、肝悪性腫瘍、膵悪性腫瘍、移植後リンパ増殖性疾患(PTLD)、神経芽細胞由来CNS腫瘍、中枢神経系(CNS)の新生物、腫瘍血管新生、脊髄腫瘍、脳幹神経膠腫、下垂体腺腫、類表皮性悪性腫瘍、唾液腺癌、扁平上皮悪性腫瘍、ファコマトーシスに関連する異常な血管増殖、浮腫(脳腫瘍に関連するものなど)、メイグス症候群、メルケル細胞癌、および環境的に誘発された悪性腫瘍から選択される癌由来である、請求項53に記載の方法。
- 前記疾患または障害が感染症である、請求項48に記載の方法。
- 前記感染症が細菌感染、ウイルス感染、真菌感染、または寄生虫感染である、請求項59に記載の方法。
- 前記感染症は、炭疽菌、桿菌、ボルデテラ、ボレリア、ボツリヌス中毒、ブルセラ、バークホルデリア、カンピロバクター、クラミジア、コレラ、クロストリジウム、ゴノコッカス、コリネバクテリウム、ジフテリア、エンテロバクター、エンテロコッカス、エルウィニア、エスケリキア、フランシセラ、ヘモフィルス、ヘリオバクター、クレブシエラ、レジオネラ、レプトスピラ、レプトスピラ症、リステリア、ライム病、髄膜炎菌、マイコバクテリウム、マイコプラズマ、ナイセリア、パスツレラ、ペロバクター、ペスト、肺炎球菌、プロテウス、シュードモナス、リケッチア、サルモネラ、セラチア、赤痢菌、ブドウ球菌、連鎖球菌、破傷風、トレポネーマ、ビブリオ、エルシニアおよびキサントモナスから選択される少なくとも1つの細菌;アルボウイルス脳炎ウイルス、アデノウイルス、単純ヘルペスI型、単純ヘルペス2型、水痘帯状疱疹ウイルス、エプスタインバーウイルス、サイトメガロウイルス、ヘルペスウイルス8型、パピローマウイルス、BKウイルス、コロナウイルス、エコーウイルス、JCウイルス、天然痘、B型肝炎、ボカウイルス、パルボウイルスB19、アストロウイルス、ノーウォークウイルス、コクサッキーウイルス、A型肝炎、ポリオウイルス、ライノウイルス、重症急性呼吸器症候群ウイルス、C型肝炎、黄熱病、デング熱ウイルス、ウエストナイルウイルス、風疹、E型肝炎、ヒト免疫不全ウイルス(HIV)、ヒトT細胞リンパ好性ウイルス(HTLV)、インフルエンザ、グアナリトウイルス、フニンウイルス、ラッサウイルス、マチュポウイルス、サビアウイルス、クリミア−コンゴ出血熱ウイルス、エボラウイルス、マールブルグウイルス、麻疹ウイルス、軟体動物ウイルス、ムンプスウイルス、パラインフルエンザ、RSウイルス、ヒトメタニューモウイルス、ヘンドラウイルス、ニパウイルス、狂犬病、D型肝炎、ロタウイルス、オルビウイルス、コルチウイルス、ワクシニアウイルス、およびバンナウイルスから選択される少なくとも1つのウイルス;カンジダ症、アスペルギルス(フミガーツス、ニガーなど)、ブラストミセス・デルマチチジス、カンジダ(アルビカンス、クルセイ、グラブラータ、トロピカリスなど)、コクシディオイデス・イミティス、クリプトコッカス(ネオフォルマンスなど)、ヒストプラズマ・カプスラーツム、ケカビ目(ムコール、アブシディア、クモノスカビ)、パラコクシジオイデス・ブラジリエンシス、スポロトリコーシス、スポロトリックス・シェンキイ、接合菌症、クロモブラストミコーシス、ロボミコーシス、菌腫、爪真菌症、毛幹癜風(piedra pityriasis versicolor)、白癬性毛瘡、頭部白癬、体部白癬、股部白癬、黄癬、黒癬、足白癬、耳真菌症、黒色菌糸症、およびリノスポリジウム症から選択される真菌感染症;ならびにアカントアメーバ、Babesia microti、大腸バランジウム、赤痢アメーバ原虫、ランブル鞭毛虫、Cryptosporidium muris、Trypanosomatida gambiense、Trypanosomatida rhodesiense、ブルーストリパノソーマ、クルーズトリパノソーマ、メキシコリーシュマニア、ブラジルリーシュマニア、熱帯リーシュマニア、ドノヴァンリーシュマニア、トキソプラズマ原虫、三日熱マラリア、卵型マラリア原虫、四日熱マラリア原虫、熱帯熱マラリア原虫、ニューモシスチス・カリニ、膣トリコモナス、ヒストモナス・メレアグリディス、双腺綱、鞭虫、ヒトカイチュウ、ヒトギョウチュウ、十二指腸鉤虫、フォーラーネグレリア、アメリカ鉤虫、ブラジル鉤虫、糞線虫、バンクロフト糸状虫、メジナ虫、住血吸虫、肝吸虫、腸管吸虫、肺吸虫、マンソン住血吸虫、ビルハルツ住血吸虫、日本住血吸虫、肝蛭、巨大肝蛭、異形吸虫、およびウェステルマン肺吸虫から選択される少なくとも1つの寄生虫から選択される、請求項48に記載の方法。
- 前記疾患または障害が免疫障害、免疫不全障害、または炎症性疾患である、請求項48に記載の方法。
- 前記免疫障害、免疫不全障害または炎症性疾患は、腸粘膜炎症、大腸炎に関連する消耗性疾患、多発性硬化症、全身性エリテマトーデス、関節リウマチ、I型糖尿病、変形性関節症、乾癬、クローン病、アテローム性動脈硬化症、アレルギー状態、および糸球体腎炎、ならびに炎症性腸疾患から選択される、請求項62に記載の方法。
- 前記免疫障害または炎症性疾患が、多発性硬化症、関節リウマチ、I型糖尿病、クローン病、アテローム性動脈硬化症、アレルギー状態、および糸球体腎炎から選択される、請求項63に記載の方法。
- 対象における免疫応答を調節する方法であって、
a)対象由来の生体試料がTIM−3を過剰発現するかを決定すること、および
b)前記試料が、TIM−3を過剰発現する場合、請求項1〜44のいずれか一項で定義された化合物と前記対象を接触させることを含む、方法。 - 前記試料が、PD−L1またはPD−L2を過剰発現するかどうかを決定し、前記試料が、TIM−3およびPD−L1またはPD−L2のいずれかを過剰発現する場合、前記対象を前記化合物と接触させることをさらに含む、請求項65に記載の方法。
- 前記生体試料が、全血、血漿、血清、細胞(例えば、腫瘍細胞)、唾液、尿、便および組織から選択される、請求項65または66に記載の方法。
- 前記対象が悪性腫瘍を有し、任意により、前記試料が前記悪性腫瘍由来の1つ以上の細胞を含む、請求項65〜67のいずれか一項に記載の方法。
- TIM−3発現悪性腫瘍細胞が、造血器悪性腫瘍細胞、固形腫瘍細胞、および悪性腫瘍幹細胞(CSC)から選択される、請求項65〜68のいずれか一項に記載の方法。
- 前記対象が、細菌感染症、ウイルス感染症、真菌感染症、および寄生虫感染症から選択される感染症を有する、請求項65〜67のいずれか一項に記載の方法。
- 前記対照試料が、前記対象が式(I)の化合物を受ける前に得られ、前記対象試料が、前記対象が式(I)の化合物を受けた後に得られる、請求項65〜70のいずれか一項に記載の方法。
- 薬学的に許容される担体または賦形剤および少なくとも1つの式(I)の化合物、またはその薬学的に許容される塩を含む医薬組成物であって、式(I)の化合物が、
Zは、−OHまたは−NH−Gを表し;
Gは、水素または(C1〜C6)アルキルを表し;
Yは、水素または以下の構造式で表される基を表し、
Ra’は、水素を表し、または、RaおよびRa’は、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を任意により含む5〜6員環を形成し、
Rbは、−C(O)NRxRy、−NRxRy、またはカルボン酸で任意により置換されている(C1〜C6)アルキルを表し、
Rcは、水素を表し、またはRbおよびRcは、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、5〜6員環は、ヒドロキシルで任意によりさらに置換されており、
Rdは、−ORX、カルボン酸、またはアリール−OHで任意により置換されている(C1〜C6)アルキルを表し、
Reは、水素を表し、または、RdおよびReは、それらに結合している原子と一緒になって、O、NまたはSから選択される1〜3個のヘテロ原子を含む5〜6員環を形成し、
RxおよびRyは、独立して水素、(C1〜C6)アルキルまたは(C2〜C6)アシルを表す、医薬組成物。 - 抗悪性腫瘍剤、化学療法剤、または抗増殖性化合物のうちの少なくとも1つをさらに含む、請求項72に記載の医薬組成物。
- 悪性腫瘍を治療する方法であって、それを必要とする対象に請求項72に記載の医薬組成物の治療的有効量を投与することを含む方法。
- 前記腫瘍細胞が、乳悪性腫瘍、結腸悪性腫瘍、肝悪性腫瘍、卵巣悪性腫瘍、前立腺悪性腫瘍、腎悪性腫瘍、または子宮悪性腫瘍から選択される悪性腫瘍に由来する、請求項74に記載の方法。
- 前記腫瘍細胞が、造血器悪性腫瘍に由来する、請求項74に記載の方法。
- 前記造血器悪性腫瘍は、リンパ腫、B細胞リンパ腫、T細胞リンパ腫、バーキットリンパ腫、ホジキンリンパ腫、非ホジキンリンパ腫、白血病、骨髄腫、急性骨髄性白血病(AML)、急性リンパ芽球性白血病(ALL)、慢性骨髄性白血病(CML)、慢性リンパ芽球性白血病(CLL)、慢性骨髄単球性白血病(CMML)、多発性骨髄腫、骨髄異形成症候群(MDS)、および形質細胞腫から選択される、請求項76に記載の方法。
- 前記腫瘍細胞は、卵巣悪性腫瘍、結腸悪性腫瘍、乳悪性腫瘍、肺悪性腫瘍、骨髄腫、神経芽細胞由来のCNS腫瘍、単球性白血病、B細胞由来白血病、T細胞由来白血病、B細胞由来リンパ腫、T細胞由来リンパ腫、およびマスト細胞由来の腫瘍から選択される、請求項74に記載の方法。
- 前記腫瘍細胞が、細胞腫、乳悪性腫瘍、上皮性悪性腫瘍、結腸悪性腫瘍、肺悪性腫瘍、黒色腫、前立腺悪性腫瘍、腎悪性腫瘍、骨悪性腫瘍、膵悪性腫瘍、皮膚悪性腫瘍、頭頸部悪性腫瘍、子宮悪性腫瘍、卵巣悪性腫瘍、直腸結腸悪性腫瘍、直腸悪性腫瘍、肛門部の悪性腫瘍、腹膜悪性腫瘍、結合組織悪性腫瘍、眼悪性腫瘍、咽喉悪性腫瘍、口腔悪性腫瘍、胆道悪性腫瘍、胃悪性腫瘍、精巣悪性腫瘍、卵管癌、子宮内膜悪性腫瘍、子宮頸悪性腫瘍、膣悪性腫瘍、外陰悪性腫瘍、食道悪性腫瘍、小腸悪性腫瘍、内分泌系悪性腫瘍、甲状腺悪性腫瘍、副甲状腺悪性腫瘍、副腎悪性腫瘍、肉腫、尿道悪性腫瘍、陰茎悪性腫瘍、慢性または急性白血病、急性リンパ性白血病(ALL)、急性骨髄性白血病(AML)、慢性リンパ性白血病(CLL)、慢性骨髄性白血病(CML)、骨髄増殖性疾患/新生物(MPDS)、骨髄異形成症候群、単球性白血病、B細胞由来白血病、T細胞由来白血病、小児の固形腫瘍、B細胞由来リンパ腫、T細胞由来リンパ腫、ホジキンリンパ腫、緩慢で攻撃的な非ホジキンリンパ腫、バーキットリンパ腫、濾胞性リンパ腫、中皮腫、胸腺癌、胸腺腫、骨髄腫、多発性骨髄腫、巨細胞骨髄腫、重鎖骨髄腫、軽鎖またはベンス−ジョーンズ骨髄腫、マスト細胞由来腫瘍、平滑筋腫、平滑筋肉腫、神経膠腫、膀胱悪性腫瘍、尿管悪性腫瘍、腎盂癌、肝悪性腫瘍、膵悪性腫瘍、移植後リンパ増殖性疾患(PTLD)、神経芽細胞由来CNS腫瘍、中枢神経系(CNS)の新生物、腫瘍血管新生、脊髄腫瘍、脳幹神経膠腫、下垂体腺腫、類表皮性悪性腫瘍、唾液腺癌、扁平上皮癌、ファコマトーシスに関連する異常な血管増殖、浮腫(脳腫瘍に関連するものなど)、メイグス症候群、メルケル細胞癌、および環境的に誘発された悪性腫瘍から選択される悪性腫瘍由来である、請求項74に記載の方法。
- 感染症を治療する方法であって、それを必要とする対象に請求項72に記載の医薬組成物の治療的有効量を投与することを含む方法。
- 前記感染症が細菌感染、ウイルス感染、真菌感染、または寄生虫感染である、請求項80に記載の方法。
- 前記感染症は、前記感染症は、炭疽菌、桿菌、ボルデテラ、ボレリア、ボツリヌス中毒、ブルセラ、バークホルデリア、カンピロバクター、クラミジア、コレラ、クロストリジウム、ゴノコッカス、コリネバクテリウム、ジフテリア、エンテロバクター、エンテロコッカス、エルウィニア、エスケリキア、フランシセラ、ヘモフィルス、ヘリオバクター、クレブシエラ、レジオネラ、レプトスピラ、レプトスピラ症、リステリア、ライム病、髄膜炎菌、マイコバクテリウム、マイコプラズマ、ナイセリア、パスツレラ、ペロバクター、ペスト、肺炎球菌、プロテウス、シュードモナス、リケッチア、サルモネラ、セラチア、赤痢菌、ブドウ球菌、連鎖球菌、破傷風、トレポネーマ、ビブリオ、エルシニアおよびキサントモナスから選択される少なくとも1つの細菌;アルボウイルス脳炎ウイルス、アデノウイルス、単純ヘルペスI型、単純ヘルペス2型、水痘帯状疱疹ウイルス、エプスタインバーウイルス、サイトメガロウイルス、ヘルペスウイルス8型、パピローマウイルス、BKウイルス、コロナウイルス、エコーウイルス、JCウイルス、天然痘、B型肝炎、ボカウイルス、パルボウイルスB19、アストロウイルス、ノーウォークウイルス、コクサッキーウイルス、A型肝炎、ポリオウイルス、ライノウイルス、重症急性呼吸器症候群ウイルス、C型肝炎、黄熱病、デング熱ウイルス、ウエストナイルウイルス、風疹、E型肝炎、ヒト免疫不全ウイルス(HIV)、ヒトT細胞リンパ好性ウイルス(HTLV)、インフルエンザ、グアナリトウイルス、フニンウイルス、ラッサウイルス、マチュポウイルス、サビアウイルス、クリミア−コンゴ出血熱ウイルス、エボラウイルス、マールブルグウイルス、麻疹ウイルス、軟体動物ウイルス、ムンプスウイルス、パラインフルエンザ、RSウイルス、ヒトメタニューモウイルス、ヘンドラウイルス、ニパウイルス、狂犬病、D型肝炎、ロタウイルス、オルビウイルス、コルチウイルス、ワクシニアウイルス、およびバンナウイルスから選択される少なくとも1つのウイルス;カンジダ症、アスペルギルス(フミガーツス、ニガーなど)、ブラストミセス・デルマチチジス、カンジダ(アルビカンス、クルセイ、グラブラータ、トロピカリスなど)、コクシディオイデス・イミティス、クリプトコッカス(ネオフォルマンスなど)、ヒストプラズマ・カプスラーツム、ケカビ目(ムコール、アブシディア、クモノスカビ)、パラコクシジオイデス・ブラジリエンシス、スポロトリコーシス、スポロトリックス・シェンキイ、接合菌症、クロモブラストミコーシス、ロボミコーシス、菌腫、爪真菌症、毛幹癜風(piedra pityriasis versicolor)、白癬性毛瘡、頭部白癬、体部白癬、股部白癬、黄癬、黒癬、足白癬、耳真菌症、黒色菌糸症、およびリノスポリジウム症から選択される少なくとも1つの真菌症;ならびにアカントアメーバ、Babesia microti、大腸バランジウム、赤痢アメーバ原虫、ランブル鞭毛虫、Cryptosporidium muris、Trypanosomatida gambiense、Trypanosomatida rhodesiense、ブルーストリパノソーマ、クルーズトリパノソーマ、メキシコリーシュマニア、ブラジルリーシュマニア、熱帯リーシュマニア、ドノヴァンリーシュマニア、トキソプラズマ原虫、三日熱マラリア、卵型マラリア原虫、四日熱マラリア原虫、熱帯熱マラリア原虫、ニューモシスチス・カリニ、膣トリコモナス、ヒストモナス・メレアグリディス、双腺綱、鞭虫、ヒトカイチュウ、ヒトギョウチュウ、十二指腸鉤虫、フォーラーネグレリア、アメリカ鉤虫、ブラジル鉤虫、糞線虫、バンクロフト糸状虫、メジナ虫、住血吸虫、肝吸虫、腸管吸虫、肺吸虫、マンソン住血吸虫、ビルハルツ住血吸虫、日本住血吸虫、肝蛭、巨大肝蛭、異形吸虫、およびウェステルマン肺吸虫から選択されるから選択される少なくとも1つの寄生虫から選択される、請求項80に記載の方法。
- 自己免疫疾患または炎症性疾患を治療する方法であって、それを必要とする対象に治療有効量の請求項72に記載の医薬組成物を投与することを含む方法。
- 前記自己免疫疾患または炎症性疾患は、腸粘膜炎症、大腸炎に関連する消耗性疾患、多発性硬化症、全身性エリテマトーデス、関節リウマチ、I型糖尿病、変形性関節症、乾癬、クローン病、アテローム性動脈硬化症、アレルギー状態、および糸球体腎炎、ならびに炎症性腸疾患から選択される、請求項83に記載の方法。
- 前記自己免疫疾患または炎症性疾患が、多発性硬化症、関節リウマチ、I型糖尿病、クローン病、アテローム性動脈硬化症、アレルギー状態、および糸球体腎炎から選択される、請求項84に記載の方法。
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Publication number | Priority date | Publication date | Assignee | Title |
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SG11201601682RA (en) | 2013-09-06 | 2016-04-28 | Aurigene Discovery Tech Ltd | 1,2,4-oxadiazole derivatives as immunomodulators |
MY196130A (en) | 2015-03-10 | 2023-03-16 | Aurigene Discovery Tech Ltd | 1,2,4-Oxadiazole and Thiadiazole Compounds as Immunomodulators |
WO2019061324A1 (en) | 2017-09-29 | 2019-04-04 | Curis Inc. | CRYSTALLINE FORMS OF IMMUNOMODULATORS |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016142833A1 (en) * | 2015-03-10 | 2016-09-15 | Aurigene Discovery Technologies Limited | 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
WO2016142886A2 (en) * | 2015-03-10 | 2016-09-15 | Aurigene Discovery Technologies Limited | 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
JP2016532710A (ja) * | 2013-09-06 | 2016-10-20 | オーリジーン ディスカバリー テクノロジーズ リミテッドAurigene Discovery Technologies Limited | 免疫調節剤としての1,2,4−オキサジアゾール誘導体 |
Family Cites Families (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3227725A (en) | 1962-04-17 | 1966-01-04 | Union Carbide Corp | Certain 3,5-disubstituted 1,2,4-oxadiazole compounds |
US4172896A (en) | 1978-06-05 | 1979-10-30 | Dainippon Pharmaceutical Co., Ltd. | Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
TW201311B (ja) | 1991-06-17 | 1993-03-01 | Hoffmann La Roche | |
GB9217295D0 (en) | 1992-08-14 | 1992-09-30 | Wellcome Found | Controlled released tablets |
GB9315856D0 (en) | 1993-07-30 | 1993-09-15 | Wellcome Found | Stabilized pharmaceutical |
US5541231A (en) | 1993-07-30 | 1996-07-30 | Glaxo Wellcome Inc. | Stabilized Pharmaceutical |
US5358970A (en) | 1993-08-12 | 1994-10-25 | Burroughs Wellcome Co. | Pharmaceutical composition containing bupropion hydrochloride and a stabilizer |
CA2143246C (en) | 1994-03-16 | 2000-08-22 | Thierry Godel | Imidazodiazepines |
US5811097A (en) | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
CN1229110C (zh) | 1997-07-29 | 2005-11-30 | 阿尔康实验室公司 | 含半乳甘露聚糖聚合物和硼酸盐的眼用组合物 |
JP2002501892A (ja) | 1998-01-29 | 2002-01-22 | セプラコア インコーポレーテッド | 光学的に純粋な(−)−ビュープロピオンの薬学的使用 |
PT1210428E (pt) | 1999-08-23 | 2015-07-21 | Genetics Inst Llc | Pd-1, um recetor para b7-4 e suas utilizações |
US8889112B2 (en) | 1999-09-16 | 2014-11-18 | Ocularis Pharma, Llc | Ophthalmic formulations including selective alpha 1 antagonists |
AU2002240818C1 (en) | 2001-03-14 | 2008-11-06 | Agilent Technologies, Inc. | MHC molecule constructs and their uses for diagnosis and therapy |
CA2442066C (en) | 2001-04-02 | 2005-11-01 | Wyeth | Pd-1, a receptor for b7-4, and uses therefor |
US7794710B2 (en) | 2001-04-20 | 2010-09-14 | Mayo Foundation For Medical Education And Research | Methods of enhancing T cell responsiveness |
WO2003042402A2 (en) | 2001-11-13 | 2003-05-22 | Dana-Farber Cancer Institute, Inc. | Agents that modulate immune cell activation and methods of use thereof |
GB0204159D0 (en) | 2002-02-22 | 2002-04-10 | British Biotech Pharm | Metalloproteinase inhibitors |
EP3287144A1 (en) | 2002-07-03 | 2018-02-28 | ONO Pharmaceutical Co., Ltd. | Immunopotentiating compositions |
CN101899114A (zh) | 2002-12-23 | 2010-12-01 | 惠氏公司 | 抗pd-1抗体及其用途 |
US6933289B2 (en) | 2003-07-01 | 2005-08-23 | Allergan, Inc. | Inhibition of irritating side effects associated with use of a topical ophthalmic medication |
BRPI0413381A (pt) | 2003-08-07 | 2006-10-17 | Allergan Inc | composições para liberação de compostos terapêuticos nos olhos e processos para fabricação e uso das mesmas |
US20050059744A1 (en) | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
TW200524601A (en) | 2003-12-05 | 2005-08-01 | Bristol Myers Squibb Co | Heterocyclic anti-migraine agents |
US7585881B2 (en) | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
EP1593671A1 (en) | 2004-03-05 | 2005-11-09 | Graffinity Pharmaceuticals AG | DPP-IV inhibitors |
US8193359B2 (en) | 2004-12-24 | 2012-06-05 | Prosidion Limited | G-protein coupled receptor agonists |
CA2970873C (en) | 2005-05-09 | 2022-05-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
US20090170907A1 (en) | 2005-06-06 | 2009-07-02 | Smithkline Beecham Corporation | Chemical Compounds |
US20090042926A1 (en) | 2005-12-20 | 2009-02-12 | Jason Imbriglio | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment |
EP1999119A2 (en) | 2006-02-15 | 2008-12-10 | Abbott Laboratories | Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome |
BRPI0713187A2 (pt) | 2006-07-20 | 2012-10-16 | Mehmet Kahraman | método de inibir rho-quinase, método de tratamento de doença mediada por rho-quinase, composto e composição farmacêutica |
MX344418B (es) | 2006-09-25 | 2016-12-15 | Ptc Therapeutics Inc | Formas cristalinas del acido 3-[5- 2- fluorofenil)- [1,2,4] oxadiazol-3-il]- benzoico. |
EP3222634A1 (en) | 2007-06-18 | 2017-09-27 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor pd-1 |
EP2178531A4 (en) | 2007-07-02 | 2012-01-11 | Yu Ming | METHODS AND COMPOSITIONS, TARGETS FOR COMBINED CANCER TREATMENTS |
US7868001B2 (en) | 2007-11-02 | 2011-01-11 | Hutchison Medipharma Enterprises Limited | Cytokine inhibitors |
BRPI0908849A2 (pt) | 2008-02-22 | 2015-08-25 | Irm Llc | Composto e composições como c-kit e inibidores de pdgfr quinase |
WO2010033701A2 (en) | 2008-09-19 | 2010-03-25 | Genzyme Corporation | Inhibitors of sphingosine kinase 1 |
WO2010051447A1 (en) | 2008-10-30 | 2010-05-06 | Elixir Pharmaceuticals, Inc. | Sulfonamide containing compounds and uses thereof |
PE20120341A1 (es) | 2008-12-09 | 2012-04-24 | Genentech Inc | Anticuerpos anti-pd-l1 y su uso para mejorar la funcion de celulas t |
KR101573109B1 (ko) | 2009-11-24 | 2015-12-01 | 메디뮨 리미티드 | B7―h1에 대한 표적화된 결합 물질 |
US20130022629A1 (en) | 2010-01-04 | 2013-01-24 | Sharpe Arlene H | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof |
WO2011137587A1 (en) | 2010-05-06 | 2011-11-10 | Hutchison Medipharma Limited | Cytokine inhibitors |
US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
EA036314B1 (ru) | 2010-08-20 | 2020-10-26 | Новартис Аг | Выделенные антитела к рецептору эпидермального фактора роста-3 (her3) и их фрагменты, фармацевтическая композиция, содержащая эти антитела и фрагменты, и их применение для лечения рака |
WO2012129564A2 (en) | 2011-03-24 | 2012-09-27 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Proteasome chymotrypsin-like inhibition using pi-1833 analogs |
WO2012168944A1 (en) | 2011-06-08 | 2012-12-13 | Aurigene Discovery Technologies Limited | Therapeutic compounds for immunomodulation |
AU2012313888B2 (en) | 2011-09-27 | 2016-03-31 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH |
EP2822957A1 (en) | 2012-03-07 | 2015-01-14 | Aurigene Discovery Technologies Limited | Peptidomimetic compounds as immunomodulators |
CA2868408A1 (en) | 2012-03-29 | 2013-10-03 | Aurigene Discovery Technologies Limited | Immunomodulating cyclic compounds from the bc loop of human pd1 |
WO2014055897A2 (en) | 2012-10-04 | 2014-04-10 | Dana-Farber Cancer Institute, Inc. | Human monoclonal anti-pd-l1 antibodies and methods of use |
ES2824024T3 (es) | 2012-10-10 | 2021-05-11 | Sangamo Therapeutics Inc | Compuestos modificadores de células T y usos de los mismos |
AR093984A1 (es) | 2012-12-21 | 2015-07-01 | Merck Sharp & Dohme | Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano |
AU2014205317B2 (en) | 2013-01-09 | 2016-11-24 | Gilead Sciences, Inc. | 5-membered heteroaryls and their use as antiviral agents |
AP2015008707A0 (en) | 2013-03-14 | 2015-09-30 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
WO2014147586A1 (en) | 2013-03-22 | 2014-09-25 | Novartis Ag | 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh |
PL3021869T3 (pl) | 2013-07-16 | 2020-11-16 | F. Hoffmann-La Roche Ag | Sposoby leczenia nowotworu z użyciem antagonistów wiązania osi PD-1 i inhibitorów TIGIT |
CA2920113A1 (en) | 2013-08-20 | 2015-02-26 | Merck Sharp & Dohme Corp. | Treating cancer with a combination of a pd-1 antagonist and dinaciclib |
RS57559B1 (sr) | 2013-09-06 | 2018-10-31 | Aurigene Discovery Tech Ltd | 1,3,4-oksadiazol i 1,3,4-tiadiazol derivativi kao imunomodulatori |
AU2013400609B9 (en) | 2013-09-13 | 2020-03-05 | Beigene Switzerland Gmbh | Anti-PD1 antibodies and their use as therapeutics and diagnostics |
KR20160093012A (ko) | 2013-11-05 | 2016-08-05 | 코그네이트 바이오서비시즈, 인코포레이티드 | 암 치료를 위한 체크포인트 억제제 및 치료제의 배합물 |
GB2516515B8 (en) | 2013-12-04 | 2016-10-05 | Intelligent Growth Solutions Ltd | Automated arrangement to grow plants under lighting in a vertical tower |
US20160303231A1 (en) | 2013-12-11 | 2016-10-20 | Robert Iannone | Treating cancer with a combination of a pd-1 antagonist and a vegfr inhibitor |
WO2015097536A2 (en) | 2013-12-24 | 2015-07-02 | Janssen Pharmaceutical Nv | Anti-vista antibodies and fragments |
JP2016021697A (ja) | 2014-07-15 | 2016-02-04 | 株式会社日立製作所 | 通信システム、通信装置、及び、制御装置 |
EP3191126B1 (en) | 2014-09-13 | 2020-05-13 | Novartis AG | Combination therapies of alk inhibitors |
AU2015327868A1 (en) | 2014-10-03 | 2017-04-20 | Novartis Ag | Combination therapies |
WO2016073470A1 (en) | 2014-11-04 | 2016-05-12 | The University Of Kansas | Lkb1-ampk activators for therapeutic use in polycystic kidney disease |
WO2016100882A1 (en) | 2014-12-19 | 2016-06-23 | Novartis Ag | Combination therapies |
CN107405336A (zh) | 2015-03-10 | 2017-11-28 | 奥瑞基尼探索技术有限公司 | 作为免疫调节剂的1,3,4‑噁二唑和噻二唑化合物 |
WO2018047143A1 (en) | 2016-09-12 | 2018-03-15 | Aurigene Discovery Technologies Limited | Vista signaling pathway inhibitory compounds useful as immunomodulators |
WO2018051254A1 (en) * | 2016-09-14 | 2018-03-22 | Aurigene Discovery Technologies Limited | Cyclic substituted-1,2,4-oxadiazole compounds as immunomodulators |
SG10202010584XA (en) | 2016-10-20 | 2020-12-30 | Aurigene Discovery Tech Ltd | Dual inhibitors of vista and pd-1 pathways |
WO2019061324A1 (en) | 2017-09-29 | 2019-04-04 | Curis Inc. | CRYSTALLINE FORMS OF IMMUNOMODULATORS |
KR20200068659A (ko) | 2017-10-11 | 2020-06-15 | 오리진 디스커버리 테크놀로지스 리미티드 | 3-치환된 1,2,4-옥사다이아졸의 결정질 형태 |
JP7378394B2 (ja) | 2017-11-03 | 2023-11-13 | オーリジーン オンコロジー リミテッド | Tim-3およびpd-1経路の二重阻害剤 |
EP3706798A1 (en) | 2017-11-06 | 2020-09-16 | Aurigene Discovery Technologies Limited | Conjoint therapies for immunomodulation |
-
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2016532710A (ja) * | 2013-09-06 | 2016-10-20 | オーリジーン ディスカバリー テクノロジーズ リミテッドAurigene Discovery Technologies Limited | 免疫調節剤としての1,2,4−オキサジアゾール誘導体 |
WO2016142833A1 (en) * | 2015-03-10 | 2016-09-15 | Aurigene Discovery Technologies Limited | 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
WO2016142886A2 (en) * | 2015-03-10 | 2016-09-15 | Aurigene Discovery Technologies Limited | 3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators |
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CN111372584A (zh) | 2020-07-03 |
MX2020004531A (es) | 2020-08-03 |
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US20200368210A1 (en) | 2020-11-26 |
CA3080098A1 (en) | 2019-05-09 |
BR112020008537A2 (pt) | 2020-10-06 |
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IL287959A (en) | 2022-01-01 |
EP3703683A1 (en) | 2020-09-09 |
IL274380A (en) | 2020-06-30 |
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US11497734B2 (en) | 2022-11-15 |
AU2018360386A1 (en) | 2020-05-07 |
AU2018360386B2 (en) | 2023-11-09 |
US20240100024A1 (en) | 2024-03-28 |
EA202090746A1 (ru) | 2020-08-17 |
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