KR20200083503A - Tim-3 경로와 pd-1 경로의 이중 저해제 - Google Patents

Tim-3 경로와 pd-1 경로의 이중 저해제 Download PDF

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Publication number
KR20200083503A
KR20200083503A KR1020207014464A KR20207014464A KR20200083503A KR 20200083503 A KR20200083503 A KR 20200083503A KR 1020207014464 A KR1020207014464 A KR 1020207014464A KR 20207014464 A KR20207014464 A KR 20207014464A KR 20200083503 A KR20200083503 A KR 20200083503A
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South Korea
Prior art keywords
cancer
virus
cell
immune response
leukemia
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Ceased
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KR1020207014464A
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Korean (ko)
Inventor
포타열 고빈단 나이르 사시쿠마
무라리다라 라마찬드라
시싸라마야 세티 수다르샨 나레마데팔리
나가라즈 고다
Original Assignee
오리진 디스커버리 테크놀로지스 리미티드
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Publication of KR20200083503A publication Critical patent/KR20200083503A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020207014464A 2017-11-03 2018-10-31 Tim-3 경로와 pd-1 경로의 이중 저해제 Ceased KR20200083503A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201741039298 2017-11-03
IN201741039298 2017-11-03
PCT/IB2018/058526 WO2019087087A1 (en) 2017-11-03 2018-10-31 Dual inhibitors of tim-3 and pd-1 pathways

Publications (1)

Publication Number Publication Date
KR20200083503A true KR20200083503A (ko) 2020-07-08

Family

ID=65033624

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207014464A Ceased KR20200083503A (ko) 2017-11-03 2018-10-31 Tim-3 경로와 pd-1 경로의 이중 저해제

Country Status (15)

Country Link
US (4) US11497734B2 (https=)
EP (1) EP3703683A1 (https=)
JP (2) JP7378394B2 (https=)
KR (1) KR20200083503A (https=)
CN (1) CN111372584A (https=)
AU (1) AU2018360386B2 (https=)
BR (1) BR112020008537A2 (https=)
CA (1) CA3080098A1 (https=)
EA (1) EA202090746A1 (https=)
IL (2) IL274380A (https=)
MX (1) MX2020004531A (https=)
MY (1) MY206121A (https=)
PH (1) PH12020550511A1 (https=)
SG (1) SG11202003625VA (https=)
WO (1) WO2019087087A1 (https=)

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CN118236374A (zh) * 2018-03-14 2024-06-25 奥瑞基尼肿瘤有限公司 使用1,2,4-噁二唑化合物调节tigit和pd-1信号传导途径的方法
KR20220059517A (ko) 2019-09-30 2022-05-10 메드샤인 디스커버리 아이엔씨. 소분자 pd-1/pd-l1 억제제로서의 화합물 및 이의 용도
CN116916905A (zh) * 2020-12-07 2023-10-20 塞莱斯蒂亚生物技术股份公司 治疗癌症的药物组合
CN114796226B (zh) * 2021-12-17 2023-09-12 新乡医学院 奥拉帕尼在诱导核仁应激中的应用

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MY206121A (en) 2017-11-03 2024-11-29 Aurigene Discovery Tech Ltd Dual inhibitors of tim-3 and pd-1 pathways
AU2018360389B2 (en) 2017-11-06 2024-09-19 Aurigene Oncology Limited Conjoint therapies for immunomodulation

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Publication number Publication date
IL287959A (en) 2022-01-01
US20240100024A1 (en) 2024-03-28
WO2019087087A1 (en) 2019-05-09
AU2018360386B2 (en) 2023-11-09
JP7378394B2 (ja) 2023-11-13
JP2021502965A (ja) 2021-02-04
MX2020004531A (es) 2020-08-03
AU2018360386A1 (en) 2020-05-07
EA202090746A1 (ru) 2020-08-17
IL274380A (en) 2020-06-30
SG11202003625VA (en) 2020-05-28
MY206121A (en) 2024-11-29
EP3703683A1 (en) 2020-09-09
US11497734B2 (en) 2022-11-15
BR112020008537A2 (pt) 2020-10-06
US20230062570A1 (en) 2023-03-02
PH12020550511A1 (en) 2021-05-10
CN111372584A (zh) 2020-07-03
CA3080098A1 (en) 2019-05-09
US20200368210A1 (en) 2020-11-26
US20250144082A1 (en) 2025-05-08
US12226402B2 (en) 2025-02-18
JP2023182598A (ja) 2023-12-26

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