AU2018360386B2 - Dual inhibitors of TIM-3 and PD-1 pathways - Google Patents

Dual inhibitors of TIM-3 and PD-1 pathways Download PDF

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Publication number
AU2018360386B2
AU2018360386B2 AU2018360386A AU2018360386A AU2018360386B2 AU 2018360386 B2 AU2018360386 B2 AU 2018360386B2 AU 2018360386 A AU2018360386 A AU 2018360386A AU 2018360386 A AU2018360386 A AU 2018360386A AU 2018360386 B2 AU2018360386 B2 AU 2018360386B2
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AU
Australia
Prior art keywords
cancer
inhibitor
cell
tim
disease
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Expired - Fee Related
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AU2018360386A
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English (en)
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AU2018360386A1 (en
Inventor
Nagaraj GOWDA
Seetharamaiah Setty Sudarshan Naremaddepalli
Muralidhara Ramachandra
Pottayil Govindan Nair Sasikumar
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Aurigene Oncology Ltd
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Aurigene Oncology Ltd
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Publication of AU2018360386A1 publication Critical patent/AU2018360386A1/en
Assigned to AURIGENE ONCOLOGY LIMITED reassignment AURIGENE ONCOLOGY LIMITED Amend patent request/document other than specification (104) Assignors: AURIGENE DISCOVERY TECHNOLOGIES LIMITED
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Publication of AU2018360386B2 publication Critical patent/AU2018360386B2/en
Expired - Fee Related legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2018360386A 2017-11-03 2018-10-31 Dual inhibitors of TIM-3 and PD-1 pathways Expired - Fee Related AU2018360386B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201741039298 2017-11-03
IN201741039298 2017-11-03
PCT/IB2018/058526 WO2019087087A1 (en) 2017-11-03 2018-10-31 Dual inhibitors of tim-3 and pd-1 pathways

Publications (2)

Publication Number Publication Date
AU2018360386A1 AU2018360386A1 (en) 2020-05-07
AU2018360386B2 true AU2018360386B2 (en) 2023-11-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018360386A Expired - Fee Related AU2018360386B2 (en) 2017-11-03 2018-10-31 Dual inhibitors of TIM-3 and PD-1 pathways

Country Status (15)

Country Link
US (4) US11497734B2 (https=)
EP (1) EP3703683A1 (https=)
JP (2) JP7378394B2 (https=)
KR (1) KR20200083503A (https=)
CN (1) CN111372584A (https=)
AU (1) AU2018360386B2 (https=)
BR (1) BR112020008537A2 (https=)
CA (1) CA3080098A1 (https=)
EA (1) EA202090746A1 (https=)
IL (2) IL274380A (https=)
MX (1) MX2020004531A (https=)
MY (1) MY206121A (https=)
PH (1) PH12020550511A1 (https=)
SG (1) SG11202003625VA (https=)
WO (1) WO2019087087A1 (https=)

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* Cited by examiner, † Cited by third party
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NZ734650A (en) 2015-03-10 2023-07-28 Aurigene Oncology Ltd 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
IL273896B2 (en) 2017-10-11 2025-08-01 Aurigene Oncology Ltd Crystalline forms of 3-substituted 1,2,4-oxadiazole
AU2018360386B2 (en) 2017-11-03 2023-11-09 Aurigene Oncology Limited Dual inhibitors of TIM-3 and PD-1 pathways
CN111386128A (zh) 2017-11-06 2020-07-07 奥瑞基尼探索技术有限公司 用于免疫调节的联合疗法
WO2019175799A2 (en) * 2018-03-14 2019-09-19 Aurigene Discovery Technologies Limited Method of modulating tigit and pd-1 signalling pathways using 1,2,4-oxadiazole compounds
US20220402917A1 (en) 2019-09-30 2022-12-22 Medshine Discovery Inc. Compound as small molecule inhibitor pd-1/pd-l1 and application thereof
CN116916905A (zh) * 2020-12-07 2023-10-20 塞莱斯蒂亚生物技术股份公司 治疗癌症的药物组合
CN114796226B (zh) * 2021-12-17 2023-09-12 新乡医学院 奥拉帕尼在诱导核仁应激中的应用

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MX2020004531A (es) 2020-08-03
IL274380A (en) 2020-06-30
US20230062570A1 (en) 2023-03-02
US11497734B2 (en) 2022-11-15
EP3703683A1 (en) 2020-09-09
CA3080098A1 (en) 2019-05-09
BR112020008537A2 (pt) 2020-10-06
JP2021502965A (ja) 2021-02-04
JP7378394B2 (ja) 2023-11-13
US20240100024A1 (en) 2024-03-28
WO2019087087A1 (en) 2019-05-09
EA202090746A1 (ru) 2020-08-17
JP2023182598A (ja) 2023-12-26
US12226402B2 (en) 2025-02-18
PH12020550511A1 (en) 2021-05-10
CN111372584A (zh) 2020-07-03
IL287959A (en) 2022-01-01
SG11202003625VA (en) 2020-05-28
AU2018360386A1 (en) 2020-05-07
MY206121A (en) 2024-11-29
US20250144082A1 (en) 2025-05-08
KR20200083503A (ko) 2020-07-08
US20200368210A1 (en) 2020-11-26

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HB Alteration of name in register

Owner name: AURIGENE ONCOLOGY LIMITED

Free format text: FORMER NAME(S): AURIGENE DISCOVERY TECHNOLOGIES LIMITED

MK25 Application lapsed reg. 22.2i(2) - failure to pay acceptance fee