MX2019015156A - Dispositivo de control y sensor de poro dual. - Google Patents

Dispositivo de control y sensor de poro dual.

Info

Publication number
MX2019015156A
MX2019015156A MX2019015156A MX2019015156A MX2019015156A MX 2019015156 A MX2019015156 A MX 2019015156A MX 2019015156 A MX2019015156 A MX 2019015156A MX 2019015156 A MX2019015156 A MX 2019015156A MX 2019015156 A MX2019015156 A MX 2019015156A
Authority
MX
Mexico
Prior art keywords
chamber
nanopore
target
control
sensing
Prior art date
Application number
MX2019015156A
Other languages
English (en)
Inventor
William B Dunbar
Reto Stamm
Michael Summers
Eric Thorne
Original Assignee
Ontera Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ontera Inc filed Critical Ontera Inc
Publication of MX2019015156A publication Critical patent/MX2019015156A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Food Science & Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Se describen dispositivos de dos poros y método para secuenciación. Un dispositivo de dos poros puede incluir una primera cámara, una segunda cámara, y una tercera cámara, en donde la primera cámara está en comunicación con la segunda cámara a través de un primer nanoporo, y en donde la segunda cámara está en comunicación con la tercera cámara a través de un segundo nanoporo. El dispositivo también puede incluir circuitería de detección para medir señales eléctricas asociadas con un objetivo en un nanoporo, y circuitería de control para controlar el movimiento del objetivo en un nanoporo. El dispositivo puede incluir y/o cambiar entre modos de detección y control para cada uno del primer nanoporo y el segundo nanoporo. Los métodos de secuenciación pueden implementar un dispositivo de dos poros con relación a la translocación de un objetivo a través de uno o más nanoporos, cambiar entre modos de detección y control según sea apropiado, y medir aspectos del objetivo utilizando modos de detección.
MX2019015156A 2017-06-21 2018-06-14 Dispositivo de control y sensor de poro dual. MX2019015156A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762523228P 2017-06-21 2017-06-21
PCT/US2018/037634 WO2018236673A1 (en) 2017-06-21 2018-06-14 DOUBLE PORE DETECTION AND CONTROL DEVICE

Publications (1)

Publication Number Publication Date
MX2019015156A true MX2019015156A (es) 2020-08-17

Family

ID=64692458

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019015156A MX2019015156A (es) 2017-06-21 2018-06-14 Dispositivo de control y sensor de poro dual.

Country Status (8)

Country Link
US (2) US11099169B2 (es)
EP (1) EP3642607A4 (es)
JP (2) JP7038147B2 (es)
KR (2) KR102315815B1 (es)
CN (1) CN111065917A (es)
CA (1) CA3067993C (es)
MX (1) MX2019015156A (es)
WO (1) WO2018236673A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
CN111065917A (zh) * 2017-06-21 2020-04-24 奥特拉公司 双孔－控制和传感器设备
US11789006B2 (en) 2019-03-12 2023-10-17 Oxford Nanopore Technologies Plc Nanopore sensing device, components and method of operation
EP3980557A4 (en) * 2019-06-07 2023-07-26 Applied Materials, Inc. METHODS OF MAKING TWO-PORE SENSORS
EP4010492A4 (en) * 2019-08-06 2024-04-03 Nooma Bio Inc LOGIC-CONTROLLED POLYNUCLEOTIDE SCANNING FOR FEATURE IMAGING IN A NANOPORE DEVICE
CN112708544A (zh) * 2019-10-25 2021-04-27 成都今是科技有限公司 基因测序的测量装置及其测量方法
CN110823773A (zh) * 2019-11-22 2020-02-21 瑞芯智造(深圳)科技有限公司 用于测量微纳颗粒的装置及方法
US11536708B2 (en) 2020-01-09 2022-12-27 Applied Materials, Inc. Methods to fabricate dual pore devices
US20230349882A1 (en) * 2020-07-17 2023-11-02 Oxford Nanopore Technologies Plc Nanopore sensing device
JP2024512838A (ja) * 2021-03-31 2024-03-21 イルミナ インコーポレイテッド 分子検出のためのスケーラブル回路

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US7250115B2 (en) * 2003-06-12 2007-07-31 Agilent Technologies, Inc Nanopore with resonant tunneling electrodes
EP1912062B1 (en) * 2006-10-13 2010-09-08 Sabanci Universitesi A biosensor and chemical sensor implementation using RF and microwave device, circuits and systems
US8294092B2 (en) * 2009-03-23 2012-10-23 Yale University System and method for trapping and measuring a charged particle in a liquid
KR101559096B1 (ko) * 2011-07-20 2015-10-08 더 리전트 오브 더 유니버시티 오브 캘리포니아 나노포어 폴리뉴클레오티드 서열분석용 보상 패치-클램프 증폭기 및 기타 용도
CN104774757B (zh) * 2011-07-20 2017-03-01 加利福尼亚大学董事会 双孔装置
IN2014DN00221A (es) * 2011-07-25 2015-06-05 Oxford Nanopore Tech Ltd
US9696277B2 (en) 2011-11-14 2017-07-04 The Regents Of The University Of California Two-chamber dual-pore device
US20140099726A1 (en) * 2012-10-10 2014-04-10 Two Pore Guys, Inc. Device for characterizing polymers
JP2016512605A (ja) * 2013-03-13 2016-04-28 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ 転位制御のためのシステム、デバイス、および方法
ES2704902T3 (es) 2013-05-06 2019-03-20 Two Pore Guys Inc Un método de detección de objetivos biológicos usando un nanoporo y un agente de unión a proteínas de fusión
KR102245192B1 (ko) * 2013-05-06 2021-04-29 온테라 인크. 나노포어를 이용한 표적 검출
WO2016154337A2 (en) 2015-03-23 2016-09-29 The University Of North Carolina At Chapel Hill Method for identification and enumeration of nucleic acid sequences, expression, splice variant, translocation, copy, or dna methylation changes using combined nuclease, ligase, polymerase, terminal transferase, and sequencing reactions
EP3303620A1 (en) 2015-06-02 2018-04-11 Nanopore Diagnostics LLC Nucleic acid detection
WO2018093976A1 (en) 2016-11-16 2018-05-24 Nanopore Diagnostics, Llc Analysis of nucleic acids using probe with non-linear tag
CN111065917A (zh) * 2017-06-21 2020-04-24 奥特拉公司 双孔－控制和传感器设备

Also Published As

Publication number Publication date
US20180372713A1 (en) 2018-12-27
KR102377508B1 (ko) 2022-03-23
EP3642607A4 (en) 2021-04-14
EP3642607A1 (en) 2020-04-29
KR20200042894A (ko) 2020-04-24
WO2018236673A1 (en) 2018-12-27
US11099169B2 (en) 2021-08-24
JP2020524801A (ja) 2020-08-20
CN111065917A (zh) 2020-04-24
CA3067993C (en) 2024-02-27
CA3067993A1 (en) 2018-12-27
US20210405020A1 (en) 2021-12-30
KR20210129726A (ko) 2021-10-28
KR102315815B1 (ko) 2021-10-25
JP7038147B2 (ja) 2022-03-17
JP2022088415A (ja) 2022-06-14

Similar Documents

Publication Publication Date Title
MX2019015156A (es) Dispositivo de control y sensor de poro dual.
AU2016363000B2 (en) Open-top microfluidic device with structural anchors
WO2017120623A3 (en) Modular sensing device for controlling a self-propelled device
AU2018270075A1 (en) Transmembrane pore consisting of two CsgG pores
EP3446113A4 (en) NANOPORE SENSOR, STRUCTURE AND DEVICE WITH THE SENSOR AND METHOD FOR SHAPING AND USE THEREOF
MX2017012142A (es) Pedales de vehiculo de deteccion autonoma.
WO2013019069A3 (ko) 삼킴 장애 측정 및 치료 장치
WO2017106185A8 (en) Dual controls for therapeutic cell activation or elimination
WO2013136181A3 (en) Reduced pressure apparatus and methods
EP3556802A4 (en) POROUS POLYTETRAFLUOROETHYLENE MEMBRANE, WATERPROOF BREATHABLE MEMBRANE AND WATERPROOF BREATHABLE MEMBER USING THE SAME
EP4006030A3 (en) Methods and compositions for inhibiting the interaction of menin with mll proteins
WO2016014987A3 (en) Long-term implantable monitoring system & methods of use
MX342019B (es) Circuito de control de un dispositivo quirurgico con un conmutador y metodo para determinar el estado del conmutador.
EP3257449A3 (en) Control systems for surgical instruments
MX358328B (es) Método y aparato para controlar la agregación de celdas.
MX2016007886A (es) Sistema de control de fontaneria con señal de socorro.
EP3376888A4 (en) CLOTHING WITH PRESSURE SENSOR CONTROL
MX351678B (es) Aparato de iluminación para vehículos con control de proximidad multizona.
TW201614428A (en) Wearable device, method of controlling the same, and mobile device configured to control the same
EP3311140B8 (en) Determining extracellular analyte concentration with nanoplasmonic sensors
GB2540089A (en) Wireless electrical stimulation system
PL3423591T3 (pl) Wrażliwe enzymy, elektrody i czujniki zależne od NAD i sposoby ich wytwarzania oraz zastosowania
WO2020095052A8 (en) Pore
MX2018009323A (es) Estireno funcionalizado con [bis(trihidrocarbilsilil)aminosililo] y un metodo para su preparacion.
NZ733931A (en) Methods of detecting a quantity of water in a humidifier