MX2019014286A - Metodos y composiciones para promover la produccion de proteinas que contienen aminoacidos no naturales. - Google Patents

Metodos y composiciones para promover la produccion de proteinas que contienen aminoacidos no naturales.

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Publication number
MX2019014286A
MX2019014286A MX2019014286A MX2019014286A MX2019014286A MX 2019014286 A MX2019014286 A MX 2019014286A MX 2019014286 A MX2019014286 A MX 2019014286A MX 2019014286 A MX2019014286 A MX 2019014286A MX 2019014286 A MX2019014286 A MX 2019014286A
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MX
Mexico
Prior art keywords
compositions
methods
amino acid
protein production
containing protein
Prior art date
Application number
MX2019014286A
Other languages
English (en)
Inventor
Tian Feng
Chen Sigeng
Lu Yingchun
Original Assignee
Ambrx Inc
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Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Publication of MX2019014286A publication Critical patent/MX2019014286A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
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    • C12Y—ENZYMES
    • C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/48—Regulators of apoptosis
    • C—CHEMISTRY; METALLURGY
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/106—Plasmid DNA for vertebrates
    • C12N2800/107—Plasmid DNA for vertebrates for mammalian

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En la presente se describen métodos y composiciones para la generación de líneas celulares para promover la producción de proteínas que contienen aminoácido no natural usando tecnologías de modificación de ingeniería.
MX2019014286A 2017-06-02 2018-06-02 Metodos y composiciones para promover la produccion de proteinas que contienen aminoacidos no naturales. MX2019014286A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762514754P 2017-06-02 2017-06-02
PCT/US2018/035764 WO2018223108A1 (en) 2017-06-02 2018-06-02 Methods and compositions for promoting non-natural amino acid-containing protein production

Publications (1)

Publication Number Publication Date
MX2019014286A true MX2019014286A (es) 2020-01-27

Family

ID=62749186

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019014286A MX2019014286A (es) 2017-06-02 2018-06-02 Metodos y composiciones para promover la produccion de proteinas que contienen aminoacidos no naturales.
MX2023004927A MX2023004927A (es) 2017-06-02 2019-11-28 Metodos y composiciones para promover la produccion de proteinas que contienen aminoacidos no naturales.

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Application Number Title Priority Date Filing Date
MX2023004927A MX2023004927A (es) 2017-06-02 2019-11-28 Metodos y composiciones para promover la produccion de proteinas que contienen aminoacidos no naturales.

Country Status (21)

Country Link
US (2) US11851662B2 (es)
EP (2) EP3630977B1 (es)
JP (2) JP7245786B2 (es)
KR (2) KR20240063184A (es)
CN (2) CN117286182A (es)
AU (1) AU2018275152A1 (es)
BR (1) BR112019025476A2 (es)
CA (1) CA3065137A1 (es)
DK (1) DK3630977T3 (es)
FI (1) FI3630977T3 (es)
HR (1) HRP20240344T1 (es)
IL (1) IL270906A (es)
LT (1) LT3630977T (es)
MX (2) MX2019014286A (es)
MY (1) MY202215A (es)
NZ (1) NZ760107A (es)
PL (1) PL3630977T3 (es)
PT (1) PT3630977T (es)
RS (1) RS65370B1 (es)
SI (1) SI3630977T1 (es)
WO (1) WO2018223108A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019191728A1 (en) 2018-03-29 2019-10-03 Ambrx, Inc. Humanized anti-prostate-specific membrane antigen (psma) antibody drug conjugates
CN111117944B (zh) * 2019-11-22 2022-05-24 中农威特生物科技股份有限公司 一种用于规模化悬浮培养的抗凋亡mdck宿主细胞株及其建立方法
CN112375774A (zh) * 2020-10-26 2021-02-19 浙江新码生物医药有限公司 一种重组蛋白表达用工程菌株的构建方法
CN112575005A (zh) * 2021-01-04 2021-03-30 昆明理工大学 一种提高烟草重金属镉胁迫抗性和降低镉富集的方法
WO2023202967A1 (en) * 2022-04-19 2023-10-26 F. Hoffmann-La Roche Ag Improved production cells

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AU2002303431C1 (en) 2001-04-19 2008-03-06 The Regents Of The University Of California Methods and composition for the production of orthoganal tRNA-aminoacyltRNA synthetase pairs
EP1583816A4 (en) 2002-12-22 2007-06-13 Scripps Research Inst PROTEIN NETWORKS
CN101160525A (zh) 2003-06-18 2008-04-09 斯克利普斯研究院 非天然活性氨基酸遗传密码增加
EP1636340A4 (en) 2003-06-18 2009-02-11 Scripps Research Inst COMPLEMENTS TO THE GENETIC CODE OF UNNATURATIVE REACTIVE AMINO ACIDS
CN102732588B (zh) 2004-12-22 2015-01-07 Ambrx公司 氨酰基-tRNA合成酶的组合物及其用途
WO2007021297A1 (en) 2005-08-18 2007-02-22 Ambrx, Inc. COMPOSITIONS OF tRNA AND USES THEREOF
JP2009520949A (ja) * 2005-11-16 2009-05-28 アンブルックス，インコーポレイテッド 非天然アミノ酸を含んでいる組成物および方法
US20080317670A1 (en) 2005-12-14 2008-12-25 Ambrx, Inc. Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides
CA2662755C (en) 2006-09-08 2017-04-04 Ambrx, Inc. Suppressor trna transcription in vertebrate cells
ES2457527T3 (es) 2006-09-08 2014-04-28 Ambrx, Inc. ARNt Supresor hibrido en células de vertebrados
EP2064316B1 (en) * 2006-09-08 2012-01-25 Ambrx, Inc. Site specific incorporation of non-natural amino acids by vertebrate cells
CN101535338A (zh) 2006-10-18 2009-09-16 斯克利普斯研究院 在哺乳动物细胞中将非天然氨基酸遗传掺入蛋白质
CA2683960A1 (en) * 2007-04-13 2008-10-23 The Salk Institute For Biological Studies Methods of genetically encoding unnatural amino acids in eukaryotic cells using orthogonal trna/synthetase pairs
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GB0721291D0 (en) * 2007-10-30 2007-12-12 Medical Res Council Methods and compositions
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WO2013130814A1 (en) 2012-02-29 2013-09-06 Ambrx, Inc. Novel prodrug containing molecule compostions and their uses
EP2858676B1 (en) 2012-06-07 2019-03-13 Ambrx, Inc. Prostate-specific membrane antigen antibody drug conjugates
CN104619350A (zh) 2012-06-14 2015-05-13 Ambrx公司 结合到核受体配体多肽的抗psma抗体
MX359449B (es) 2012-06-19 2018-09-28 Ambrx Inc Conjugados de anticuerpo fármaco anti-cd70.
GB201419109D0 (en) 2014-10-27 2014-12-10 Medical Res Council Incorporation of unnatural amino acids into proteins

Also Published As

Publication number Publication date
KR20200011979A (ko) 2020-02-04
PL3630977T3 (pl) 2024-06-24
JP7245786B2 (ja) 2023-03-24
JP2023075254A (ja) 2023-05-30
US11851662B2 (en) 2023-12-26
CN117286182A (zh) 2023-12-26
LT3630977T (lt) 2024-04-25
MX2023004927A (es) 2023-05-17
BR112019025476A2 (pt) 2020-06-23
CN110959041A (zh) 2020-04-03
AU2018275152A1 (en) 2020-01-16
US20210017527A1 (en) 2021-01-21
US20240167044A1 (en) 2024-05-23
HRP20240344T1 (hr) 2024-05-24
FI3630977T3 (fi) 2024-04-24
CN110959041B (zh) 2023-09-29
KR102662379B1 (ko) 2024-04-29
NZ760107A (en) 2024-03-22
WO2018223108A1 (en) 2018-12-06
EP3630977A1 (en) 2020-04-08
PT3630977T (pt) 2024-04-24
EP3630977B1 (en) 2024-02-21
IL270906A (en) 2020-01-30
SI3630977T1 (sl) 2024-05-31
DK3630977T3 (da) 2024-04-15
MY202215A (en) 2024-04-17
RS65370B1 (sr) 2024-04-30
JP2020522247A (ja) 2020-07-30
CA3065137A1 (en) 2018-12-06
EP4382124A2 (en) 2024-06-12
KR20240063184A (ko) 2024-05-09

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