MX2019014256A - Metodo para producir compuesto opticamente activo. - Google Patents

Metodo para producir compuesto opticamente activo.

Info

Publication number
MX2019014256A
MX2019014256A MX2019014256A MX2019014256A MX2019014256A MX 2019014256 A MX2019014256 A MX 2019014256A MX 2019014256 A MX2019014256 A MX 2019014256A MX 2019014256 A MX2019014256 A MX 2019014256A MX 2019014256 A MX2019014256 A MX 2019014256A
Authority
MX
Mexico
Prior art keywords
salt
compound
optically active
active compound
producing optically
Prior art date
Application number
MX2019014256A
Other languages
English (en)
Inventor
Masato Kitayama
Sayuri Hirano
Yoshiyuki Takeda
Koji Nakamoto
Motoki Ikeuchi
Masatoshi Yamada
Jun-Ichi Kawakami
Original Assignee
Dot Therapeutics 1 Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dot Therapeutics 1 Inc filed Critical Dot Therapeutics 1 Inc
Publication of MX2019014256A publication Critical patent/MX2019014256A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

El propósito de la presente invención es proporcionar un método capaz de producir un derivado de pirimidinamida ópticamente activo en una escala industrial. El compuesto (I) o una sal del mismo se somete a una reacción de reducción asimétrica, el compuesto obtenido (II) o una sal del mismo se somete a una reacción de desprotección, y el compuesto obtenido (III) o una sal del mismo se hace reaccionar con el compuesto (VI) o una sal del mismo para obtener el compuesto (V) o una sal del mismo. (ver fórmulas) en donde cada símbolo se define en la especificación.
MX2019014256A 2017-05-30 2018-05-29 Metodo para producir compuesto opticamente activo. MX2019014256A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017106280 2017-05-30
PCT/IB2018/053822 WO2018220533A2 (ja) 2017-05-30 2018-05-29 光学活性化合物の製造法

Publications (1)

Publication Number Publication Date
MX2019014256A true MX2019014256A (es) 2022-03-31

Family

ID=64454503

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019014256A MX2019014256A (es) 2017-05-30 2018-05-29 Metodo para producir compuesto opticamente activo.

Country Status (12)

Country Link
US (2) US10988469B2 (es)
EP (2) EP4406609A3 (es)
JP (2) JP7102233B2 (es)
KR (1) KR20200013707A (es)
CN (2) CN117447464A (es)
AU (1) AU2018276192B2 (es)
BR (1) BR112019025355A2 (es)
CA (1) CA3065683A1 (es)
EA (1) EA039880B1 (es)
IL (1) IL270983B (es)
MX (1) MX2019014256A (es)
WO (1) WO2018220533A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018220533A2 (ja) 2017-05-30 2018-12-06 ミレニアム ファーマシューティカルズ， インコーポレイテッド 光学活性化合物の製造法
JP2023548600A (ja) * 2020-11-06 2023-11-17 デイ ワン バイオファーマシューティカルズ， インコーポレイテッド 低グレード神経膠腫を処置するためのｒａｆインヒビター
CN114685564B (zh) * 2020-12-27 2023-09-22 西北大学 新型亚磷酰胺配体及其合成方法和应用
CN117567388B (zh) * 2023-11-14 2024-04-16 济南悟通生物科技有限公司 一种2-乙酰基-5-噻唑甲酸的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6764842B2 (en) * 2001-03-28 2004-07-20 Merck & Co., Inc. Enantioselective bioreduction for the preparation of integrin receptor antagonist intermediates
TW200303304A (en) 2002-02-18 2003-09-01 Astrazeneca Ab Chemical compounds
TWI345568B (en) * 2004-04-02 2011-07-21 Mitsubishi Tanabe Pharma Corp Tetrahydronaphthyridine derivatives and a process for preparing the same
CL2008001933A1 (es) 2007-06-29 2009-09-25 Millennium Pharm Inc Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros.
JP2010532381A (ja) * 2007-06-29 2010-10-07 サネシス ファーマシューティカルズ， インコーポレイテッド Ｒａｆキナーゼ阻害剤として有用な複素環式化合物
AU2013232191B2 (en) * 2012-03-14 2017-03-30 Merck Sharp & Dohme Llc Bis-quarternary cinchona alkaloid salts as asymmetric phase transfer catalysts
EP2832738A4 (en) 2012-03-28 2016-02-24 Takeda Pharmaceutical RHODIUM CATALYST AND PROCESS FOR PRODUCING AN AMINO COMPOUND
TWI602803B (zh) * 2013-03-29 2017-10-21 第一三共股份有限公司 光學活性二胺衍生物之製造方法
WO2015178846A1 (en) * 2014-05-20 2015-11-26 Sp Process Development Ab Process for the preparation of chiral amines from prochiral ketones
JP6638363B2 (ja) 2015-12-11 2020-01-29 株式会社大林組 掘削装置および杭孔の拡径方法
CN105524111B (zh) * 2016-01-25 2017-10-27 西北农林科技大学 手性亚磷酰胺单齿配体及其合成方法与应用
WO2018220533A2 (ja) 2017-05-30 2018-12-06 ミレニアム ファーマシューティカルズ， インコーポレイテッド 光学活性化合物の製造法

Also Published As

Publication number Publication date
WO2018220533A3 (ja) 2019-02-28
AU2018276192A1 (en) 2020-01-16
IL270983A (en) 2020-01-30
EP3632441B1 (en) 2024-07-17
WO2018220533A2 (ja) 2018-12-06
US20200317659A1 (en) 2020-10-08
CN117447464A (zh) 2024-01-26
US20210347769A1 (en) 2021-11-11
AU2018276192B2 (en) 2022-05-19
CN111032047A (zh) 2020-04-17
EP3632441C0 (en) 2024-07-17
CN111032047B (zh) 2023-10-27
EP3632441A2 (en) 2020-04-08
CA3065683A1 (en) 2018-12-06
EA039880B1 (ru) 2022-03-23
JP2022116043A (ja) 2022-08-09
US10988469B2 (en) 2021-04-27
KR20200013707A (ko) 2020-02-07
JP2018203733A (ja) 2018-12-27
BR112019025355A2 (pt) 2020-06-23
EP3632441A4 (en) 2021-01-13
JP7420865B2 (ja) 2024-01-23
EP4406609A3 (en) 2024-10-02
EA201992709A1 (ru) 2020-04-23
IL270983B (en) 2022-03-01
EP4406609A2 (en) 2024-07-31
JP7102233B2 (ja) 2022-07-19

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