MX2019008501A - Soluciones de preservacion y/o perfusion de organos. - Google Patents
Soluciones de preservacion y/o perfusion de organos.Info
- Publication number
- MX2019008501A MX2019008501A MX2019008501A MX2019008501A MX2019008501A MX 2019008501 A MX2019008501 A MX 2019008501A MX 2019008501 A MX2019008501 A MX 2019008501A MX 2019008501 A MX2019008501 A MX 2019008501A MX 2019008501 A MX2019008501 A MX 2019008501A
- Authority
- MX
- Mexico
- Prior art keywords
- solution
- organ
- organ preservation
- perfusion
- glucose
- Prior art date
Links
- 239000000082 organ preservation Substances 0.000 title abstract 3
- 230000010412 perfusion Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 abstract 4
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 2
- 229920002307 Dextran Polymers 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 2
- 229910001424 calcium ion Inorganic materials 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 abstract 2
- 210000000056 organ Anatomy 0.000 abstract 2
- 230000001954 sterilising effect Effects 0.000 abstract 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 238000011010 flushing procedure Methods 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/721—Dextrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/08—Tubes; Storage means specially adapted therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/12—Blood circulatory system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Mechanical Engineering (AREA)
- Thermal Sciences (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Abstract
Se proporciona una solución de preservación y/o perfusión de órganos para un tejido u órgano aislado. La solución comprende dextrano, glucosa, iones de calcio, un amortiguador y agua, tiene un PH de 6.6 a 7.8 y es estéril debido a que se ha sometido a esterilización por calor. Asimismo se proporciona un método para preparar la solución. El método comprende combinar dextrano, glucosa, iones de calcio, amortiguador y agua para obtener una solución inicial, ajustar el pH de la solución inicial a un pH de 7.0 a 7.8 si se necesita, y someter la solución inicial a esterilización por calor, obteniendo de esta manera la solución de preservación y/o perfusión de órganos. Asimismo se proporciona un método de preservación y/o perfusión de un tejido u órgano aislado. Asimismo se proporciona un método para lavar, almacenar y/o transportar un pulmón aislado después de removerlo de un donante y prepararlo para trasplante eventual en un receptor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2017/050881 WO2018133921A1 (en) | 2017-01-17 | 2017-01-17 | Organ preservation and/or perfusion solutions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019008501A true MX2019008501A (es) | 2019-12-09 |
Family
ID=57851065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019008501A MX2019008501A (es) | 2017-01-17 | 2017-01-17 | Soluciones de preservacion y/o perfusion de organos. |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US20180199566A1 (es) |
| EP (1) | EP3448149B1 (es) |
| JP (2) | JP7164531B2 (es) |
| KR (1) | KR102700330B1 (es) |
| CN (1) | CN110267534B (es) |
| AU (1) | AU2017393861B2 (es) |
| BR (1) | BR112019014644B1 (es) |
| CA (1) | CA3047360C (es) |
| DK (1) | DK3448149T3 (es) |
| ES (1) | ES2751767T3 (es) |
| HU (1) | HUE046233T2 (es) |
| MX (1) | MX2019008501A (es) |
| PL (1) | PL3448149T3 (es) |
| PT (1) | PT3448149T (es) |
| RU (1) | RU2737147C1 (es) |
| SI (1) | SI3448149T1 (es) |
| WO (1) | WO2018133921A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019014644B1 (pt) | 2017-01-17 | 2022-07-05 | Xvivo Perfusion Ab | Soluções de perfusão e/ou preservação de órgãos |
| IT202000027050A1 (it) * | 2020-11-12 | 2022-05-12 | S A L F S P A Laboratorio Farm | Soluzione colloidale per la perfusione e la conservazione ex-vivo dei polmoni |
| WO2022233642A1 (en) | 2021-05-06 | 2022-11-10 | Xvivo Perfusion Ab | Methods for removing leucocytes from isolated organs |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58192545A (ja) * | 1982-05-04 | 1983-11-10 | 科研製薬株式会社 | 角膜移植用眼球保存液 |
| US4879283A (en) * | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
| JP2949843B2 (ja) * | 1989-12-13 | 1999-09-20 | 吉富製薬株式会社 | 臓器保存液及び臓器保存法 |
| CA2066374C (en) | 1991-04-19 | 2002-01-29 | Paul E. Segall | Solution for perfusing primates |
| US5654266A (en) * | 1992-02-10 | 1997-08-05 | Chen; Chung-Ho | Composition for tissues to sustain viability and biological functions in surgery and storage |
| US5552267A (en) | 1992-04-03 | 1996-09-03 | The Trustees Of Columbia University In The City Of New York | Solution for prolonged organ preservation |
| US5945272A (en) * | 1993-06-04 | 1999-08-31 | Biotime, Incorporated | Plasma expanders and blood substitutes |
| SE505499C2 (sv) | 1995-12-15 | 1997-09-08 | Stiftelsen Facthor | Förvaringslösning för organ och vävnad eller delar därav från människor och djur innehållande kalcium och nitroglycerin, användning därav samt förfarande för förvaring därmed |
| US6492103B1 (en) * | 2000-01-31 | 2002-12-10 | Organ Recovery Systems, Inc. | System for organ and tissue preservation and hypothermic blood substitution |
| EP1339279B2 (en) | 2000-11-03 | 2010-11-17 | XVIVO Perfusion AB | Evaluation and preservation solution |
| US9060507B2 (en) * | 2010-09-01 | 2015-06-23 | Perfusion Fluid Technologies Inc | Perfusion solution |
| GB201020300D0 (en) | 2010-11-30 | 2011-01-12 | Vitrolife Sweden Ab | Product |
| CN103841824B (zh) | 2011-04-14 | 2016-12-14 | 特兰斯迈迪茨公司 | 用于供体肺的离体机器灌注的器官护理溶液 |
| US20140303254A1 (en) * | 2013-04-08 | 2014-10-09 | InnoPharma Licensing LLC | Process Of Manufacturing A Stable, Ready To Use Infusion Bag For An Oxidation Sensitive Formulation |
| CN104013955B (zh) * | 2014-06-18 | 2016-02-24 | 中国科学院过程工程研究所 | 一种不含表面活性剂的水包油乳液及其用途 |
| CN105918308A (zh) * | 2016-04-28 | 2016-09-07 | 上海市胸科医院 | 一种用于移植供肺灌流的肺灌流液及其制备方法 |
| BR112019014644B1 (pt) | 2017-01-17 | 2022-07-05 | Xvivo Perfusion Ab | Soluções de perfusão e/ou preservação de órgãos |
-
2017
- 2017-01-17 BR BR112019014644-0A patent/BR112019014644B1/pt active IP Right Grant
- 2017-01-17 RU RU2019125025A patent/RU2737147C1/ru active
- 2017-01-17 WO PCT/EP2017/050881 patent/WO2018133921A1/en unknown
- 2017-01-17 JP JP2019538494A patent/JP7164531B2/ja active Active
- 2017-01-17 HU HUE17700817A patent/HUE046233T2/hu unknown
- 2017-01-17 KR KR1020197023748A patent/KR102700330B1/ko active IP Right Grant
- 2017-01-17 AU AU2017393861A patent/AU2017393861B2/en active Active
- 2017-01-17 DK DK17700817T patent/DK3448149T3/da active
- 2017-01-17 PL PL17700817T patent/PL3448149T3/pl unknown
- 2017-01-17 PT PT177008174T patent/PT3448149T/pt unknown
- 2017-01-17 CN CN201780083518.8A patent/CN110267534B/zh active Active
- 2017-01-17 MX MX2019008501A patent/MX2019008501A/es unknown
- 2017-01-17 EP EP17700817.4A patent/EP3448149B1/en active Active
- 2017-01-17 CA CA3047360A patent/CA3047360C/en active Active
- 2017-01-17 ES ES17700817T patent/ES2751767T3/es active Active
- 2017-01-17 SI SI201730115T patent/SI3448149T1/sl unknown
- 2017-07-20 US US15/654,763 patent/US20180199566A1/en not_active Abandoned
-
2018
- 2018-11-06 US US16/181,659 patent/US20190069538A1/en not_active Abandoned
-
2022
- 2022-03-18 US US17/655,485 patent/US11849721B2/en active Active
- 2022-07-22 JP JP2022116936A patent/JP2022145712A/ja not_active Withdrawn
-
2023
- 2023-11-13 US US18/507,677 patent/US20240081322A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2751767T3 (es) | 2020-04-01 |
| SI3448149T1 (sl) | 2019-12-31 |
| US20220202006A1 (en) | 2022-06-30 |
| PT3448149T (pt) | 2019-11-04 |
| JP2022145712A (ja) | 2022-10-04 |
| KR102700330B1 (ko) | 2024-08-30 |
| PL3448149T3 (pl) | 2020-01-31 |
| DK3448149T3 (da) | 2019-11-04 |
| BR112019014644A2 (pt) | 2020-05-26 |
| EP3448149A1 (en) | 2019-03-06 |
| US20240081322A1 (en) | 2024-03-14 |
| AU2017393861B2 (en) | 2020-06-04 |
| AU2017393861A1 (en) | 2019-07-11 |
| CA3047360A1 (en) | 2018-07-26 |
| EP3448149B1 (en) | 2019-08-21 |
| CA3047360C (en) | 2023-09-26 |
| HUE046233T2 (hu) | 2020-02-28 |
| KR20190104213A (ko) | 2019-09-06 |
| US20180199566A1 (en) | 2018-07-19 |
| RU2737147C1 (ru) | 2020-11-25 |
| CN110267534A (zh) | 2019-09-20 |
| BR112019014644B1 (pt) | 2022-07-05 |
| JP2020505351A (ja) | 2020-02-20 |
| WO2018133921A1 (en) | 2018-07-26 |
| US11849721B2 (en) | 2023-12-26 |
| US20190069538A1 (en) | 2019-03-07 |
| CN110267534B (zh) | 2021-11-16 |
| JP7164531B2 (ja) | 2022-11-01 |
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