MX2019001834A - Metodos de acoplamiento cruzado. - Google Patents

Metodos de acoplamiento cruzado.

Info

Publication number
MX2019001834A
MX2019001834A MX2019001834A MX2019001834A MX2019001834A MX 2019001834 A MX2019001834 A MX 2019001834A MX 2019001834 A MX2019001834 A MX 2019001834A MX 2019001834 A MX2019001834 A MX 2019001834A MX 2019001834 A MX2019001834 A MX 2019001834A
Authority
MX
Mexico
Prior art keywords
methods
formula
cross coupling
compound
catalyst
Prior art date
Application number
MX2019001834A
Other languages
English (en)
Inventor
Qinhua Huang Peter
Robert Pinchman Joseph
Daniel Hopkins Chad
Duane Bunker Kevin
Original Assignee
Zeno Royalties & Milestones Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeno Royalties & Milestones Llc filed Critical Zeno Royalties & Milestones Llc
Publication of MX2019001834A publication Critical patent/MX2019001834A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/1616—Coordination complexes, e.g. organometallic complexes, immobilised on an inorganic support, e.g. ship-in-a-bottle type catalysts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/821—Ruthenium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/84—Metals of the iron group
    • B01J2531/847—Nickel
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/38—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing five carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Coupling Device And Connection With Printed Circuit (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Flanged Joints, Insulating Joints, And Other Joints (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Los métodos para preparar compuestos de biciclo[1.1.1]pentano sustituido de la Fórmula (I) comprenden hacer reaccionar un compuesto de la Fórmula (A) con un compuesto de la Fórmula (B) en presencia de un primer catalizador de metal de transición seleccionado de un catalizador de paladio y un catalizador de níquel, donde las variables R1, R2, X1 y X2 son como se describen en la presente descripción.
MX2019001834A 2016-08-23 2017-08-22 Metodos de acoplamiento cruzado. MX2019001834A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662378453P 2016-08-23 2016-08-23
PCT/US2017/048021 WO2018039232A1 (en) 2016-08-23 2017-08-22 Methods for cross coupling

Publications (1)

Publication Number Publication Date
MX2019001834A true MX2019001834A (es) 2019-06-06

Family

ID=61245274

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019001834A MX2019001834A (es) 2016-08-23 2017-08-22 Metodos de acoplamiento cruzado.

Country Status (12)

Country Link
US (1) US10793504B2 (es)
EP (1) EP3504217A4 (es)
JP (1) JP7043488B2 (es)
KR (1) KR102444836B1 (es)
CN (1) CN109661399B (es)
AU (1) AU2017316639B2 (es)
BR (1) BR112019003314B1 (es)
CA (1) CA3032734A1 (es)
MX (1) MX2019001834A (es)
NZ (1) NZ750265A (es)
SG (1) SG11201900904PA (es)
WO (1) WO2018039232A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108373461B (zh) * 2018-04-28 2019-08-20 陕西师范大学 一种光/镍协同催化制备氟代联芳烃的方法
US11453678B2 (en) * 2018-10-23 2022-09-27 National University Corporation Hokkaido University Solvent-free cross-coupling reaction, and production method using said reaction
CN110054541B (zh) * 2019-05-16 2022-05-27 安徽秀朗新材料科技有限公司 一种氘代芳香族化合物的制备方法
CN110105179B (zh) * 2019-05-24 2022-04-29 浙江大学 一种钯/咪唑盐催化硝基芳烃和硼酸化合物偶联合成芳香族化合物的方法
JP2022534426A (ja) 2019-05-31 2022-07-29 イケナ オンコロジー， インコーポレイテッド Ｔｅａｄ阻害剤およびその使用
CN114502540A (zh) 2019-05-31 2022-05-13 医肯纳肿瘤学公司 Tead抑制剂和其用途
CN112094165A (zh) * 2019-06-18 2020-12-18 浙江省化工研究院有限公司 一种由Suzuki偶联反应制备联芳烃类化合物的方法
WO2022120353A1 (en) * 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead inhibitors and uses thereof
WO2022170218A1 (en) * 2021-02-05 2022-08-11 The Board Of Regents Of The University Of Texas System Intramolecular cyclization for general synthesis of bicyclic alkyl bioisostere boronates
EP4194089A3 (en) * 2021-07-19 2023-09-06 Heraeus Deutschland GmbH & Co. KG Catalyst system for suzuki cross-coupling reactions comprising a photoredox component

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04500663A (ja) 1988-06-03 1992-02-06 ザ　ユニヴァーシティー　オブ　テキサス　システム ［１．１．１］プロペランに基づく化合物と方法
JP4098368B2 (ja) * 1997-02-13 2008-06-11 チッソ株式会社 ビシクロ〔１．１．１〕ペンタン構造を有する液晶性化合物、液晶組成物及び液晶表示素子
CN101805374B (zh) * 2010-03-19 2012-07-04 郑州泰基鸿诺药物科技有限公司 二茂铁亚胺环钯-膦加合物及其制备和应用
CN101830763B (zh) * 2010-05-05 2013-11-27 中国科学院长春应用化学研究所 一种镍类催化剂在铃木偶联反应中的应用
CN103044469A (zh) * 2012-11-30 2013-04-17 大连联化化学有限公司 一种制备环戊烯/环己烯-1-硼酸频哪醇酯的方法
WO2015089170A1 (en) 2013-12-12 2015-06-18 Kalyra Pharmaceuticals, Inc. Bicyclic alkyl compounds and synthesis
CN113336653A (zh) 2014-03-07 2021-09-03 里科瑞尔姆Ip控股有限责任公司 螺桨烷衍生物及合成
CN105294442A (zh) * 2014-06-03 2016-02-03 上海合全药物研发有限公司 一种双环[1.1.1]戊烷-1,3-二羧酸二甲酯的制备方法
CN104211723B (zh) * 2014-08-07 2016-07-06 沧州普瑞东方科技有限公司 乙烯基硼化试剂的合成及应用
CN109071409B (zh) * 2016-03-14 2021-09-17 斯帕罗化学股份公司 制备取代的双环[1 1 1]戊烷的方法

Also Published As

Publication number Publication date
AU2017316639B2 (en) 2022-09-08
SG11201900904PA (en) 2019-03-28
CN109661399A (zh) 2019-04-19
NZ750265A (en) 2021-03-26
RU2019104463A (ru) 2020-09-25
US20190202769A1 (en) 2019-07-04
BR112019003314B1 (pt) 2023-03-28
KR20190041485A (ko) 2019-04-22
CN109661399B (zh) 2021-09-07
AU2017316639A1 (en) 2019-02-14
JP2019528296A (ja) 2019-10-10
US10793504B2 (en) 2020-10-06
WO2018039232A1 (en) 2018-03-01
EP3504217A4 (en) 2020-04-01
RU2019104463A3 (es) 2020-09-25
JP7043488B2 (ja) 2022-03-29
EP3504217A1 (en) 2019-07-03
CA3032734A1 (en) 2018-03-01
BR112019003314A2 (pt) 2019-06-04
KR102444836B1 (ko) 2022-09-19

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