SG11201900904PA - Methods for cross coupling - Google Patents

Methods for cross coupling

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Publication number
SG11201900904PA
SG11201900904PA SG11201900904PA SG11201900904PA SG11201900904PA SG 11201900904P A SG11201900904P A SG 11201900904PA SG 11201900904P A SG11201900904P A SG 11201900904PA SG 11201900904P A SG11201900904P A SG 11201900904PA SG 11201900904P A SG11201900904P A SG 11201900904PA
Authority
SG
Singapore
Prior art keywords
international
suite
california
cure
road
Prior art date
Application number
SG11201900904PA
Inventor
Joseph Robert Pinchman
Chad Daniel Hopkins
Kevin Duane Bunker
Peter Qinhua Huang
Original Assignee
Zeno Royalties & Milestones Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeno Royalties & Milestones Llc filed Critical Zeno Royalties & Milestones Llc
Publication of SG11201900904PA publication Critical patent/SG11201900904PA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/1616—Coordination complexes, e.g. organometallic complexes, immobilised on an inorganic support, e.g. ship-in-a-bottle type catalysts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/821—Ruthenium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/84—Metals of the iron group
    • B01J2531/847—Nickel
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/38—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing five carbon atoms

Abstract

PUBLISHEDUNDER THE PATENT COOPERATION TREATY (PCT) IiiiimmomiolollmonoloollloonoloillooloinovoimIE () International Publication Number WO 2018/039232 Al WIPO I PCT (12) INTERNATIONAL APPLICATION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) (51) International Patent Classification: C07F 5/04 (2006.01) CO7D 239/26 (2006.01) CO7C 13/36 (2006.01) CO7D 263/56 (2006.01) CO7C 67/333 (2006.01) CO7D 413/08 (2006.01) CO7C 6 9 / 753 (2006.01) CO7F 5/02 (2006.01) CO7D 213/26 (2006.01) (21) International Application Number: PCT/US2017/048021 (22) International Filing Date: 22 August 2017 (22.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/378,453 23 August 2016 (23.08.2016) US (71) Applicant: KALYRA PHARMACEUTICALS, INC. [US/US]; 10835 Road to the Cure, Suite 205, San Diego, California 92121 (US). (72) Inventors: PINCHMAN, Joseph Robert; 10835 Road to the Cure, Suite 205, San Diego, California 92121 (US). HOPKINS, Chad Daniel; 10835 Road to the Cure, Suite 205, San Diego, California 92121 (US). BUNKER, Kevin Duane; 10835 Road to the Cure, Suite 205, San Diego, Cal- ifornia 92121 (US). HUANG, Peter Qinhua; 10835 Road to the Cure, Suite 205, San Diego, California 92121 (US). (74) Agent: MILLER, Kimberly J.; Knobbe, Martens, Olson & Bear, LLP, 2040 Main Street, 14th Floor, Irvine, California 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 2 I (3)) 1-1 0 (57) : Methods of preparing substituted bicyclo[1.1.1]pentane compounds of Formula (I) comprise reacting a compound of \" Formula (A) with a compound of Formula (B) in the presence of a first transition metal catalyst selected from a palladium catalyst and C a nickel catalyst, where the variables R 1 , R 2 , X and X 1 2 are as described herein. (54) Title: METHODS FOR CROSS COUPLING
SG11201900904PA 2016-08-23 2017-08-22 Methods for cross coupling SG11201900904PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662378453P 2016-08-23 2016-08-23
PCT/US2017/048021 WO2018039232A1 (en) 2016-08-23 2017-08-22 Methods for cross coupling

Publications (1)

Publication Number Publication Date
SG11201900904PA true SG11201900904PA (en) 2019-03-28

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ID=61245274

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201900904PA SG11201900904PA (en) 2016-08-23 2017-08-22 Methods for cross coupling

Country Status (12)

Country Link
US (1) US10793504B2 (en)
EP (1) EP3504217A4 (en)
JP (1) JP7043488B2 (en)
KR (1) KR102444836B1 (en)
CN (1) CN109661399B (en)
AU (1) AU2017316639B2 (en)
BR (1) BR112019003314B1 (en)
CA (1) CA3032734A1 (en)
MX (1) MX2019001834A (en)
NZ (1) NZ750265A (en)
SG (1) SG11201900904PA (en)
WO (1) WO2018039232A1 (en)

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Publication number Priority date Publication date Assignee Title
CN108373461B (en) * 2018-04-28 2019-08-20 陕西师范大学 A kind of method that light/nickel concerted catalysis prepares fluoro biaryl
JP7023019B2 (en) * 2018-10-23 2022-02-21 国立大学法人北海道大学 Cross-coupling reaction without solvent and manufacturing method using the reaction
CN110054541B (en) * 2019-05-16 2022-05-27 安徽秀朗新材料科技有限公司 Preparation method of deuterated aromatic compound
CN110105179B (en) * 2019-05-24 2022-04-29 浙江大学 Method for synthesizing aromatic compound by coupling nitroarene and boric acid compound under catalysis of palladium/imidazolium salt
TW202108571A (en) 2019-05-31 2021-03-01 美商醫肯納腫瘤學公司 Tead inhibitors and uses thereof
CA3141826A1 (en) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Tead inhibitors and uses thereof
CN112094165A (en) * 2019-06-18 2020-12-18 浙江省化工研究院有限公司 Method for preparing biaryl compound by Suzuki coupling reaction
WO2022120353A1 (en) * 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead inhibitors and uses thereof
WO2022170218A1 (en) * 2021-02-05 2022-08-11 The Board Of Regents Of The University Of Texas System Intramolecular cyclization for general synthesis of bicyclic alkyl bioisostere boronates
EP4194089A3 (en) * 2021-07-19 2023-09-06 Heraeus Deutschland GmbH & Co. KG Catalyst system for suzuki cross-coupling reactions comprising a photoredox component

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KR900701960A (en) 1988-06-03 1990-12-05 한스 마크 [1,1,1] propane based compounds and preparation methods
AU5880598A (en) 1997-02-13 1998-09-08 Chisso Corporation Liquid-crystalline compounds having bicyclo{1.1.1}pentane structure, liquid-crystal composition, and liquid-crystal display element
CN101805374B (en) * 2010-03-19 2012-07-04 郑州泰基鸿诺药物科技有限公司 Ferrocenyl cycloimine palladium-phosphine adduct and preparation and application therefore
CN101830763B (en) * 2010-05-05 2013-11-27 中国科学院长春应用化学研究所 Application of nickel catalyst in suzuki-miyaura coupling reaction
CN103044469A (en) * 2012-11-30 2013-04-17 大连联化化学有限公司 Method for preparing cyclopentene/cyclohexene-1-boronic acid pinacol ester
CN105814013A (en) * 2013-12-12 2016-07-27 卡利拉制药公司 Bicyclic alkyl compounds and synthesis
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CN105294442A (en) * 2014-06-03 2016-02-03 上海合全药物研发有限公司 Preparation method for bicyclo [1.1.1] pentane-1,3-dicarboxylic acid dimethylester
CN104211723B (en) * 2014-08-07 2016-07-06 沧州普瑞东方科技有限公司 The synthesis of vinyl borating agent and application
ES2916099T3 (en) 2016-03-14 2022-06-28 Spirochem Ag Preparation method of substituted bicyclo[1.1.1]pentanes

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Publication number Publication date
BR112019003314B1 (en) 2023-03-28
KR20190041485A (en) 2019-04-22
JP2019528296A (en) 2019-10-10
CN109661399B (en) 2021-09-07
WO2018039232A1 (en) 2018-03-01
US10793504B2 (en) 2020-10-06
AU2017316639B2 (en) 2022-09-08
KR102444836B1 (en) 2022-09-19
EP3504217A4 (en) 2020-04-01
NZ750265A (en) 2021-03-26
RU2019104463A (en) 2020-09-25
AU2017316639A1 (en) 2019-02-14
CN109661399A (en) 2019-04-19
JP7043488B2 (en) 2022-03-29
US20190202769A1 (en) 2019-07-04
EP3504217A1 (en) 2019-07-03
RU2019104463A3 (en) 2020-09-25
MX2019001834A (en) 2019-06-06
BR112019003314A2 (en) 2019-06-04
CA3032734A1 (en) 2018-03-01

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