MX2018003197A - Métodos relacionados a composiciones de células dentríticas activadas y tratamientos inmunoterapéuticos para sujetos con cánceres avanzados. - Google Patents

Métodos relacionados a composiciones de células dentríticas activadas y tratamientos inmunoterapéuticos para sujetos con cánceres avanzados.

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Publication number
MX2018003197A
MX2018003197A MX2018003197A MX2018003197A MX2018003197A MX 2018003197 A MX2018003197 A MX 2018003197A MX 2018003197 A MX2018003197 A MX 2018003197A MX 2018003197 A MX2018003197 A MX 2018003197A MX 2018003197 A MX2018003197 A MX 2018003197A
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Mexico
Prior art keywords
activated dendritic
cytokines
dendritic cell
subjects
methods relating
Prior art date
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MX2018003197A
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English (en)
Inventor
L Bosch Marnix
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Northwest Biotherapeutics Inc
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Publication date
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Publication of MX2018003197A publication Critical patent/MX2018003197A/es

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4615—Dendritic cells
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    • G01N33/56966—Animal cells
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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Abstract

La presente descripción proporciona células dendríticas activadas y parcialmente maduras que producen niveles de citoquinas/quimiocinas, por ejemplo, uno o cualquier combinación de, y/o todos de IL-6, IL-8, IL-12 y/o TNFa, que se correlacionan con el resultado clínico mejorado, veces de sobrevivencia significativamente incrementadas y veces significativamente incrementadas para recurrencia de tumor o cáncer. Las cantidades de umbral determinadas de estas citoquinas pueden utilizarse para (i) una prueba de potencia inmunoterapéutica para células dendríticas activadas, (ii) seleccionar pacientes que responden, (iii) rechazar pacientes sin respuesta y (iv) detectar la activación de célula dendrítica o agentes de maduración que también pueden inducir la producción de la cantidad de umbral de las citoquinas/quimiocinas.
MX2018003197A 2015-09-15 2016-09-14 Métodos relacionados a composiciones de células dentríticas activadas y tratamientos inmunoterapéuticos para sujetos con cánceres avanzados. MX2018003197A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562219058P 2015-09-15 2015-09-15
PCT/US2016/051781 WO2017048875A1 (en) 2015-09-15 2016-09-14 Methods relating to activated dendritic cell compositions and immunotherapeutic treatments for subjects with advanced cancers

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MX2018003197A true MX2018003197A (es) 2018-09-26

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MX2018003197A MX2018003197A (es) 2015-09-15 2016-09-14 Métodos relacionados a composiciones de células dentríticas activadas y tratamientos inmunoterapéuticos para sujetos con cánceres avanzados.
MX2022008806A MX2022008806A (es) 2015-09-15 2018-03-14 Metodos relacionados a composiciones de celulas dendriticas activadas y tratamientos inmunoterapeuticos para sujetos con canceres avanzados.

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US (1) US20190046568A1 (es)
EP (2) EP3350318B1 (es)
JP (3) JP6980650B2 (es)
KR (1) KR20180044430A (es)
CN (2) CN108291204A (es)
AU (2) AU2016323066B2 (es)
BR (1) BR112018005180B1 (es)
CA (1) CA2998614A1 (es)
DK (1) DK3350318T3 (es)
ES (1) ES2923769T3 (es)
HK (1) HK1258885A1 (es)
HU (1) HUE059560T2 (es)
IL (2) IL258071B (es)
MX (2) MX2018003197A (es)
PL (1) PL3350318T3 (es)
RU (1) RU2749610C2 (es)
WO (1) WO2017048875A1 (es)

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MX2022008806A (es) 2022-08-11
ES2923769T3 (es) 2022-09-30
JP2018537949A (ja) 2018-12-27
HK1258885A1 (zh) 2019-11-22
US20190046568A1 (en) 2019-02-14
EP3350318B1 (en) 2022-04-13
DK3350318T3 (da) 2022-07-11
CA2998614A1 (en) 2017-03-23
AU2016323066A1 (en) 2018-05-10
JP2024019229A (ja) 2024-02-08
RU2749610C2 (ru) 2021-06-16
EP3350318A4 (en) 2019-11-13
HUE059560T2 (hu) 2022-11-28
IL258071A (en) 2018-05-31
RU2018113435A3 (es) 2020-03-25
KR20180044430A (ko) 2018-05-02
AU2023208190A1 (en) 2023-08-17
IL286225A (en) 2021-10-31
PL3350318T3 (pl) 2022-08-16
WO2017048875A1 (en) 2017-03-23
EP3971285A3 (en) 2022-06-22
AU2016323066B2 (en) 2023-04-27
JP2022028818A (ja) 2022-02-16
CN116413420A (zh) 2023-07-11
EP3350318A1 (en) 2018-07-25
CN108291204A (zh) 2018-07-17
BR112018005180B1 (pt) 2023-11-28
RU2018113435A (ru) 2019-10-16
IL258071B (en) 2021-09-30
EP3971285A2 (en) 2022-03-23
BR112018005180A2 (es) 2018-10-02
JP6980650B2 (ja) 2021-12-15

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