DK3350318T3 - Fremgangsmåder relateret til aktiverede dendritiske cellesammensætninger til individer med fremskredne cancersygdomme - Google Patents

Fremgangsmåder relateret til aktiverede dendritiske cellesammensætninger til individer med fremskredne cancersygdomme Download PDF

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DK3350318T3
DK3350318T3 DK16847253.8T DK16847253T DK3350318T3 DK 3350318 T3 DK3350318 T3 DK 3350318T3 DK 16847253 T DK16847253 T DK 16847253T DK 3350318 T3 DK3350318 T3 DK 3350318T3
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dendritic cell
methods related
cell compositions
activated dendritic
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DK16847253.8T
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Marnix L Bosch
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Northwest Biotherapeutics Inc
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    • A61K35/15Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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DK16847253.8T 2015-09-15 2016-09-14 Fremgangsmåder relateret til aktiverede dendritiske cellesammensætninger til individer med fremskredne cancersygdomme DK3350318T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562219058P 2015-09-15 2015-09-15
PCT/US2016/051781 WO2017048875A1 (en) 2015-09-15 2016-09-14 Methods relating to activated dendritic cell compositions and immunotherapeutic treatments for subjects with advanced cancers

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DK3350318T3 true DK3350318T3 (da) 2022-07-11

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US (1) US20190046568A1 (da)
EP (2) EP3350318B1 (da)
JP (3) JP6980650B2 (da)
KR (1) KR20180044430A (da)
CN (2) CN108291204A (da)
AU (2) AU2016323066B2 (da)
BR (1) BR112018005180B1 (da)
CA (1) CA2998614A1 (da)
DK (1) DK3350318T3 (da)
ES (1) ES2923769T3 (da)
HK (1) HK1258885A1 (da)
HU (1) HUE059560T2 (da)
IL (2) IL258071B (da)
MX (2) MX2018003197A (da)
PL (1) PL3350318T3 (da)
RU (1) RU2749610C2 (da)
WO (1) WO2017048875A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190076473A1 (en) * 2017-09-14 2019-03-14 Cellular Approaches, Inc. Autologous and allogenic macrophages and monocytes for use in therapeutic methods
CN110106145B (zh) * 2019-06-12 2021-02-12 蓝莲(杭州)生物科技有限公司 一种未成熟树突状细胞培养液及其未成熟树突状细胞的制备方法
AU2020363707A1 (en) * 2019-10-07 2022-04-28 Northwest Biotherapeutics, Inc. In vitro methods and compositions for enhancing the activation of dendritic cells and t cells, and for inducing a th-1 immune response

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633929B1 (en) 1992-04-01 2004-03-03 The Rockefeller University METHOD FOR $i(IN VITRO) PROLIFERATION OF DENDRITIC CELL PRECURSORS AND THEIR USE TO PRODUCE IMMUNOGENS
US7659119B2 (en) 1996-02-12 2010-02-09 Argos Therapeutics, Inc. Method and compositions for obtaining mature dendritic cells
US6558951B1 (en) * 1999-02-11 2003-05-06 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds
US20020094545A1 (en) 2000-11-30 2002-07-18 Harris Paul E. Growth of human dendritic cells for cancer immunotherapy in closed system using microcarrier beads
WO2003010292A2 (en) 2001-07-25 2003-02-06 Northwest Biotherapeutics, Inc. Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors
US7695627B2 (en) 2002-06-19 2010-04-13 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment
WO2004039968A1 (ja) * 2002-10-30 2004-05-13 Japan Science And Technology Agency 骨髄由来の不死化樹状細胞株
CN102600461B (zh) 2002-12-06 2017-07-14 西北生物治疗药物公司 给予体外部分成熟的树突细胞治疗肿瘤
AU2004214896A1 (en) * 2003-02-27 2004-09-10 Northwest Biotherapeutics, Inc. Generation of dendritic cells from monocytic dendritic precursor cells with GM-CSF in the absence of additional cytokines
US20060257359A1 (en) * 2005-02-28 2006-11-16 Cedric Francois Modifying macrophage phenotype for treatment of disease
KR20080109717A (ko) * 2005-12-08 2008-12-17 노쓰웨스트 바이오써라퓨틱스, 인크. 미성숙 단핵구성 수지상 세포의 활성화를 유도하기 위한조성물 및 방법
WO2009034961A1 (ja) * 2007-09-10 2009-03-19 Riken ヒト樹状細胞の評価方法およびヒト細胞免疫療法剤
EP2072617A1 (en) * 2007-12-12 2009-06-24 Trimed Biotech GmbH Method for producing dendritic cells
WO2010132867A1 (en) * 2009-05-15 2010-11-18 Irx Therapeutics, Inc. Vaccine immunotherapy
CN103638517A (zh) * 2013-12-04 2014-03-19 深圳市合一康生物科技有限公司 人树突状细胞疫苗制备的专用试剂盒
WO2016048872A1 (en) * 2014-09-23 2016-03-31 Neostem Oncology, Llc Compositions, methods and kits used to determine potency of dendritic cells in cancer immunitherpay

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CN116413420A (zh) 2023-07-11
US20190046568A1 (en) 2019-02-14
HK1258885A1 (zh) 2019-11-22
EP3350318A1 (en) 2018-07-25
JP2024019229A (ja) 2024-02-08
MX2018003197A (es) 2018-09-26
EP3971285A3 (en) 2022-06-22
JP6980650B2 (ja) 2021-12-15
EP3971285A2 (en) 2022-03-23
JP2018537949A (ja) 2018-12-27
KR20180044430A (ko) 2018-05-02
ES2923769T3 (es) 2022-09-30
RU2749610C2 (ru) 2021-06-16
CA2998614A1 (en) 2017-03-23
IL286225A (en) 2021-10-31
MX2022008806A (es) 2022-08-11
AU2016323066B2 (en) 2023-04-27
EP3350318B1 (en) 2022-04-13
AU2023208190A1 (en) 2023-08-17
PL3350318T3 (pl) 2022-08-16
RU2018113435A3 (da) 2020-03-25
WO2017048875A1 (en) 2017-03-23
CN108291204A (zh) 2018-07-17
IL258071A (en) 2018-05-31
RU2018113435A (ru) 2019-10-16
AU2016323066A1 (en) 2018-05-10
JP2022028818A (ja) 2022-02-16
IL258071B (en) 2021-09-30
BR112018005180B1 (pt) 2023-11-28
HUE059560T2 (hu) 2022-11-28
BR112018005180A2 (da) 2018-10-02

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