MX2022012013A - Composiciones y metodos para transduccion de tumores. - Google Patents

Composiciones y metodos para transduccion de tumores.

Info

Publication number
MX2022012013A
MX2022012013A MX2022012013A MX2022012013A MX2022012013A MX 2022012013 A MX2022012013 A MX 2022012013A MX 2022012013 A MX2022012013 A MX 2022012013A MX 2022012013 A MX2022012013 A MX 2022012013A MX 2022012013 A MX2022012013 A MX 2022012013A
Authority
MX
Mexico
Prior art keywords
transduction
tumors
compositions
methods
cancer cells
Prior art date
Application number
MX2022012013A
Other languages
English (en)
Inventor
Roy Lobb
Paul Rennert
Original Assignee
Aleta Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aleta Biotherapeutics Inc filed Critical Aleta Biotherapeutics Inc
Publication of MX2022012013A publication Critical patent/MX2022012013A/es

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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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Abstract

La invención se refiere a agentes terapéuticos contra el cáncer, en particular, el sistema de generación de células cancerosas más susceptibles a células efectos mediante la introducción de dianas de tratamiento celular en las células cancerosas.
MX2022012013A 2015-10-30 2018-04-26 Composiciones y metodos para transduccion de tumores. MX2022012013A (es)

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US201562249183P 2015-10-30 2015-10-30

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MX2022012013A true MX2022012013A (es) 2022-10-21

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MX2018005348A MX2018005348A (es) 2015-10-30 2016-10-28 Composiciones y metodos para transduccion de tumores.
MX2022012013A MX2022012013A (es) 2015-10-30 2018-04-26 Composiciones y metodos para transduccion de tumores.

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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2018005315A (es) 2015-10-30 2018-08-14 Aleta Biotherapeutics Inc Composiciones y metodos para el tratamiento del cancer.
AU2016343805A1 (en) 2015-10-30 2018-06-07 Aleta Biotherapeutics Inc. Compositions and methods for tumor transduction
TWI676483B (zh) * 2017-08-06 2019-11-11 強普生技股份有限公司 醫藥套組及其用途
WO2019035938A1 (en) 2017-08-16 2019-02-21 Elstar Therapeutics, Inc. MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF
KR102847676B1 (ko) * 2017-12-15 2025-08-21 알레타 바이오쎄라퓨틱스, 인크. Cd19 변이체
US20240182529A1 (en) * 2017-12-19 2024-06-06 Beijing Zeqin Biomedical Co., Ltd Ph low insertion peptide and composition thereof
CN110824158A (zh) * 2018-08-07 2020-02-21 上海恒润达生生物科技有限公司 一种检测cart细胞针对靶抗原细胞因子的分泌的方法
SG11202108924RA (en) * 2019-02-20 2021-09-29 Res Inst Nationwide Childrens Hospital Cancer-targeted, virus-encoded, regulatable t (catvert) or nk cell (catvern) linkers
CN112480263A (zh) * 2019-09-12 2021-03-12 普米斯生物技术(苏州)有限公司 一种双特异t细胞激活器活化t细胞的设计及其应用
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
KR20230069961A (ko) 2020-09-14 2023-05-19 보르 바이오파마 인크. Cd33에 대한 단일 도메인 항체
EP4507794A1 (en) 2022-04-11 2025-02-19 Vor Biopharma Inc. Binding agents and methods of use thereof
WO2024238565A1 (en) 2023-05-15 2024-11-21 Vor Biopharma Inc. Egf-like module containing mucin-like hormone-like 2 (erm2) binding agents and methods of use thereof

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US6352694B1 (en) * 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
ZA932522B (en) 1992-04-10 1993-12-20 Res Dev Foundation Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
US5614191A (en) * 1995-03-15 1997-03-25 The United States Of America As Represented By The Department Of Health And Human Services IL-13 receptor specific chimeric proteins and uses thereof
EP0922105B1 (en) 1996-07-17 2005-12-07 THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Infectious papillomavirus pseudoviral particles
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
PT1012259E (pt) 1997-06-04 2009-11-06 Oxford Biomedica Ltd Vector dirigido a tumor
DE122007000015I2 (de) 1997-09-05 2008-01-24 Medimmune Inc Methode zur in Vitro auseinander- und wiederzusammensetzung von Papillomavirus virusähnlichen Teilchen (vlps)
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
JP2003516124A (ja) 1999-10-15 2003-05-13 ユニバーシティー オブ マサチューセッツ 標的とした遺伝的干渉の手段としてのｒｎａ干渉経路遺伝子
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
WO2001096584A2 (en) 2000-06-12 2001-12-20 Akkadix Corporation Materials and methods for the control of nematodes
CA2412901A1 (en) * 2000-06-22 2001-12-27 Idec Pharmaceutical Corporation Bispecific fusion protein and method of use for enhancing effector cell killing of target cells
JP5312721B2 (ja) 2000-11-07 2013-10-09 シティ・オブ・ホープ Ｃｄ１９特異的再指向免疫細胞
CN1114690C (zh) 2001-05-15 2003-07-16 乔良 乳头瘤假病毒及其制备方法
GB0209893D0 (en) * 2002-04-30 2002-06-05 Molmed Spa Conjugate
US7235641B2 (en) * 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
JP4384723B2 (ja) 2004-03-08 2009-12-16 ニチコン株式会社 電解コンデンサ用エッチング箔の製造装置
AU2006218489B2 (en) * 2005-03-02 2011-02-24 Biogen Ma Inc. KIM-1 antibodies for treatment of Th2-mediated conditions
WO2007002905A1 (en) 2005-06-29 2007-01-04 University Of Miami Antibody-immune cell ligand fusion protein for cancer therapy
US20070274908A1 (en) 2006-04-07 2007-11-29 The Board Of Regents Of The University Of Texas System Methods and compositions related to adenoassociated virus-phage particles
PT2145189E (pt) 2007-05-08 2016-06-16 Us Health Pseudovírus de papilomavírus para deteção e terapêutica de tumores
JP6035009B2 (ja) 2007-08-22 2016-11-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用
US20110070191A1 (en) 2008-03-19 2011-03-24 Wong Hing C T cell receptor fusions and conjugates and methods of use there of
MX2011002250A (es) * 2008-08-25 2011-08-17 Amplimmune Inc Antagonistas de muerte celular programada-1 y métodos de uso de los mismos.
CA2742777A1 (en) 2008-11-06 2010-05-14 University Of Guelph Methods of improving the therapeutic efficacy and utility of antibody fragments
EP3543256A1 (en) 2009-01-12 2019-09-25 Cytomx Therapeutics Inc. Modified antibody compositions, methods of making and using thereof
EP2398494A4 (en) 2009-02-23 2015-10-28 Cytomx Therapeutics Inc Proproteins and their methods of use
PL2542590T5 (pl) 2010-03-05 2020-08-10 The Johns Hopkins University Kompozycje i sposoby dla ukierunkowanych immunomodulatorowych przeciwciał i białek fuzyjnych
EP2760886B1 (en) * 2011-09-26 2019-10-02 Philogen S.p.A. Immunocytokine combination therapy
GB201203442D0 (en) 2012-02-28 2012-04-11 Univ Birmingham Immunotherapeutic molecules and uses
PE20150605A1 (es) 2012-04-27 2015-05-28 Cytomx Therapeutics Inc Anticuerpos activables que se unen al receptor del factor de crecimiento epidermico
BR112014031689A2 (pt) 2012-06-22 2017-07-25 Cytomx Therapeutics Inc anticorpos reativos cruzados anti-jagged 1/jagged 2, anticorpos anti-jagged ativáveis e métodos de uso deles
US9487590B2 (en) 2012-09-25 2016-11-08 Cytomx Therapeutics, Inc. Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
US10117896B2 (en) * 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
BR112015028387B1 (pt) 2013-05-13 2023-04-11 Cellectis Receptor antigênico quimérico específico para cd19, polinucleotídeo, vetor de expressão, método in vitro para manipulação e uso de uma célula imune
CN105612180B (zh) 2013-07-19 2019-11-12 弗拉芒区生物技术研究所 经靶向修饰的il-1家族成员
CN105829349B (zh) * 2013-10-15 2023-02-03 斯克利普斯研究所 肽嵌合抗原受体t细胞开关和其用途
US10494434B2 (en) 2013-12-20 2019-12-03 Fred Hutchinson Cancer Research Center Tagged chimeric effector molecules and receptors thereof
ES2939760T3 (es) 2014-03-15 2023-04-26 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico para antígenos
WO2015142661A1 (en) * 2014-03-15 2015-09-24 Novartis Ag Regulatable chimeric antigen receptor
KR102329836B1 (ko) 2015-01-26 2021-11-19 셀렉티스 암 면역치료를 위한 항-CLL1 특이적 단일-체인 키메라 항원 수용체들(scCARS)
EP3283113A4 (en) 2015-04-15 2018-12-05 The California Institute for Biomedical Research Optimized pne-based chimeric receptor t cell switches and uses thereof
WO2017222593A1 (en) 2016-06-24 2017-12-28 Icell Gene Therapeutics Llc Chimeric antigen receptors (cars), compositions and methods thereof
JP2018522907A (ja) 2015-08-11 2018-08-16 セレクティスＣｅｌｌｅｃｔｉｓ Ｃｄ３８抗原を標的とするためおよびｃｄ３８遺伝子を不活化するために操作された、免疫療法用の細胞
MX2018005315A (es) * 2015-10-30 2018-08-14 Aleta Biotherapeutics Inc Composiciones y metodos para el tratamiento del cancer.
AU2016343805A1 (en) 2015-10-30 2018-06-07 Aleta Biotherapeutics Inc. Compositions and methods for tumor transduction
WO2017125830A1 (en) 2016-01-21 2017-07-27 Pfizer Inc. Chimeric antigen receptors targeting epidermal growth factor receptor variant iii
AU2017229370B2 (en) 2016-03-08 2021-03-11 Ventana Medical Systems, Inc. Multiplexed immunohistochemistry using recombinant antibodies with epitope tags

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WO2017075533A1 (en) 2017-05-04
US10066023B2 (en) 2018-09-04
CL2018001108A1 (es) 2018-11-16
KR20180083868A (ko) 2018-07-23
EP3368077A1 (en) 2018-09-05
CN108472365A (zh) 2018-08-31
CA3003144A1 (en) 2017-05-04
US20170260288A1 (en) 2017-09-14
US20180022821A1 (en) 2018-01-25
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BR112018008390A2 (pt) 2018-11-27
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