MX2017008634A - Metodo para controlar la glicosilacion de glicoproteina recombinante. - Google Patents

Metodo para controlar la glicosilacion de glicoproteina recombinante.

Info

Publication number
MX2017008634A
MX2017008634A MX2017008634A MX2017008634A MX2017008634A MX 2017008634 A MX2017008634 A MX 2017008634A MX 2017008634 A MX2017008634 A MX 2017008634A MX 2017008634 A MX2017008634 A MX 2017008634A MX 2017008634 A MX2017008634 A MX 2017008634A
Authority
MX
Mexico
Prior art keywords
recombinant glycoprotein
regulating
glycosylation
regulating glycosylation
glycoprotein
Prior art date
Application number
MX2017008634A
Other languages
English (en)
Inventor
Young Kim Sun
yong kim Kyu
Hyun Ryu Soo
Sook Seol Sam
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56284687&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017008634(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Publication of MX2017008634A publication Critical patent/MX2017008634A/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1741—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals alpha-Glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La presente invención se refiere a un método para controlar un patrón de glicoproteína recombinante, que comprende cultivar una célula que comprende un polinucleótido que codifica una glicoproteína recombinante en un medio de cultivo que comprende insulina.
MX2017008634A 2014-12-31 2015-12-30 Metodo para controlar la glicosilacion de glicoproteina recombinante. MX2017008634A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020140195976A KR102007930B1 (ko) 2014-12-31 2014-12-31 재조합 당단백질의 글리코실화 조절 방법
PCT/KR2015/014512 WO2016108638A1 (ko) 2014-12-31 2015-12-30 재조합 당단백질의 글리코실화 조절 방법

Publications (1)

Publication Number Publication Date
MX2017008634A true MX2017008634A (es) 2018-04-26

Family

ID=56284687

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017008634A MX2017008634A (es) 2014-12-31 2015-12-30 Metodo para controlar la glicosilacion de glicoproteina recombinante.

Country Status (11)

Country Link
US (1) US10131891B2 (es)
EP (1) EP3241908B1 (es)
JP (1) JP6502505B2 (es)
KR (1) KR102007930B1 (es)
AU (1) AU2015372704B2 (es)
BR (1) BR112017014252A2 (es)
IL (1) IL253217B (es)
MX (1) MX2017008634A (es)
RU (1) RU2670889C9 (es)
SA (1) SA517381863B1 (es)
WO (1) WO2016108638A1 (es)

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
US5705364A (en) * 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
JPH0947284A (ja) 1995-08-07 1997-02-18 Sumitomo Pharmaceut Co Ltd 動物細胞の培養方法
ES2255765T3 (es) 1998-05-29 2006-07-01 Genentech, Inc. Procedimiento de cultivo de celulas para la produccion de glicoproteinas.
US7294481B1 (en) 1999-01-05 2007-11-13 Immunex Corporation Method for producing recombinant proteins
WO2004050679A2 (en) 2001-10-22 2004-06-17 Applied Research Systems Ars Holding N.V. Mutant glycoproteins
TWI364458B (en) 2004-08-27 2012-05-21 Wyeth Res Ireland Ltd Production of tnfr-lg
WO2007034809A1 (ja) 2005-09-20 2007-03-29 Taisho Pharmaceutical Co., Ltd. 組み換え蛋白質産生のための宿主細胞
WO2007070315A2 (en) 2005-12-08 2007-06-21 Amgen Inc. Improved production of glycoproteins using manganese
EP2041270B1 (en) 2006-07-13 2013-11-20 Wyeth LLC Production of glycoproteins
MY185872A (en) 2006-09-13 2021-06-14 Abbvie Inc Cell culture improvements
CA2679941C (en) 2007-03-02 2016-09-20 Wyeth Use of copper and glutamate in cell culture for production of polypeptides
EP2326720B1 (en) 2008-09-15 2018-03-21 F. Hoffmann-La Roche AG Compositions and methods for regulating cell osmolarity
RU2011142230A (ru) 2009-04-20 2013-05-27 Пфайзер Инк. Контроль гликозилирования белка и композиции и способы, касающиеся этого
AU2010254215A1 (en) 2009-05-26 2011-12-01 Momenta Pharmaceuticals, Inc. Production of glycoproteins
US8778659B2 (en) * 2010-02-10 2014-07-15 Biocon Limited Method of reducing glycosylation of proteins, processes and proteins thereof
JP5976549B2 (ja) 2010-02-24 2016-08-24 メルク・シャープ・エンド・ドーム・コーポレイション ピチア・パストリスにおいて産生される治療用糖タンパク質上のｎ−グリコシル化部位占拠を増加させるための方法
KR101868139B1 (ko) 2010-11-30 2018-06-15 주식회사 엘지화학 새로운 융합 프로모터 및 이를 포함하는 재조합 벡터
EP2702077A2 (en) * 2011-04-27 2014-03-05 AbbVie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
IL310968A (en) 2011-07-01 2024-04-01 Amgen Inc Mammalian cell culture
BR112015022529A2 (pt) 2013-03-15 2017-07-18 Genentech Inc meios de cultura de células e processos de produção de anticorpo
WO2014195452A1 (en) 2013-06-07 2014-12-11 Novo Nordisk A/S Method for making mature insulin polypeptides
US20160237399A1 (en) * 2015-02-18 2016-08-18 Biogen Ma Inc. Control of Protein Glycosylation by Culture Medium Supplementation and Cell Culture Process Parameters
EP3916081A3 (en) 2013-08-19 2022-03-23 Biogen MA Inc. Control of protein glycosylation by culture medium supplementation and cell culture process parameters

Also Published As

Publication number Publication date
EP3241908A1 (en) 2017-11-08
AU2015372704A1 (en) 2017-07-20
SA517381863B1 (ar) 2020-06-23
EP3241908A4 (en) 2018-06-20
KR20160081699A (ko) 2016-07-08
EP3241908B1 (en) 2020-08-05
BR112017014252A2 (pt) 2018-01-02
IL253217B (en) 2022-08-01
WO2016108638A1 (ko) 2016-07-07
RU2670889C1 (ru) 2018-10-25
JP6502505B2 (ja) 2019-04-17
US20170342392A1 (en) 2017-11-30
US10131891B2 (en) 2018-11-20
RU2670889C9 (ru) 2018-12-11
JP2018500041A (ja) 2018-01-11
KR102007930B1 (ko) 2019-08-06
IL253217A0 (en) 2017-08-31
AU2015372704B2 (en) 2018-09-20

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