MX2016012934A - Composicion solida que comprende sofosbuvir amorfo. - Google Patents
Composicion solida que comprende sofosbuvir amorfo.Info
- Publication number
- MX2016012934A MX2016012934A MX2016012934A MX2016012934A MX2016012934A MX 2016012934 A MX2016012934 A MX 2016012934A MX 2016012934 A MX2016012934 A MX 2016012934A MX 2016012934 A MX2016012934 A MX 2016012934A MX 2016012934 A MX2016012934 A MX 2016012934A
- Authority
- MX
- Mexico
- Prior art keywords
- sofosbuvir
- solid composition
- weight
- amorphous sofosbuvir
- matrix compound
- Prior art date
Links
- TTZHDVOVKQGIBA-IQWMDFIBSA-N sofosbuvir Chemical compound N1([C@@H]2O[C@@H]([C@H]([C@]2(F)C)O)CO[P@@](=O)(N[C@@H](C)C(=O)OC(C)C)OC=2C=CC=CC=2)C=CC(=O)NC1=O TTZHDVOVKQGIBA-IQWMDFIBSA-N 0.000 title abstract 6
- 229960002063 sofosbuvir Drugs 0.000 title abstract 6
- 239000008247 solid mixture Substances 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000011159 matrix material Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/222—Amides of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una composición sólida, la cual comprende sofosbuvir y cuando menos un compuesto de matriz farmacéuticamente aceptable, en donde cuando menos el 99 por ciento en peso del sofosbuvir comprendido en la composición está presente en una forma amorfa, cuando menos el 99 por ciento en peso de la composición sólida consiste en el sofosbuvir y el cuando menos un compuesto de matriz, y en donde la composición sólida contiene el sofosbuvir en una cantidad de cuando menos el 55 por ciento en peso, basándose en el peso combinado del sofosbuvir y el cuando menos un compuesto de matriz.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14163434 | 2014-04-03 | ||
PCT/EP2015/057411 WO2015150561A2 (en) | 2014-04-03 | 2015-04-02 | Solid composition comprising amorphous sofosbuvir |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016012934A true MX2016012934A (es) | 2016-12-07 |
Family
ID=50397065
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016012934A MX2016012934A (es) | 2014-04-03 | 2015-04-02 | Composicion solida que comprende sofosbuvir amorfo. |
MX2019009842A MX2019009842A (es) | 2014-04-03 | 2016-09-30 | Composicion solida que comprende sofosbuvir amorfo. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019009842A MX2019009842A (es) | 2014-04-03 | 2016-09-30 | Composicion solida que comprende sofosbuvir amorfo. |
Country Status (10)
Country | Link |
---|---|
US (2) | US10493089B2 (es) |
EP (1) | EP3125868A2 (es) |
JP (1) | JP2017512811A (es) |
KR (1) | KR20160142342A (es) |
CN (1) | CN106163529A (es) |
AU (1) | AU2015239018A1 (es) |
CA (1) | CA2943574A1 (es) |
MX (2) | MX2016012934A (es) |
RU (1) | RU2016142819A (es) |
WO (1) | WO2015150561A2 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3524234T1 (sl) | 2014-06-13 | 2021-05-31 | Ratiopharm Gmbh | Trdne oblike sofosbuvira |
WO2016038542A2 (en) * | 2014-09-10 | 2016-03-17 | Mylan Laboratories Limited | Polymorphic forms of sofosbuvir |
CZ2015443A3 (cs) * | 2015-06-26 | 2017-01-04 | Zentiva, K.S. | Farmaceutická formulace sofosbuviru |
AU2016336244A1 (en) * | 2015-10-07 | 2018-04-12 | Sandoz Ag | Solid pharmaceutical composition comprising amorphous sofosbuvir |
CZ2016257A3 (cs) * | 2016-05-05 | 2017-11-15 | Zentiva, K.S. | Amorfní forma sofosbuviru, způsob její přípravy a její stabilizace |
CN106083963A (zh) * | 2016-06-08 | 2016-11-09 | 上海现代制药海门有限公司 | 一种索非布韦晶型6的制备方法 |
CN109862884A (zh) * | 2016-08-12 | 2019-06-07 | 桑多斯股份公司 | 包含无定形索非布韦的固体药物组合物 |
CZ2016553A3 (cs) | 2016-09-09 | 2018-03-21 | Zentiva, K.S. | Pevná farmaceutická dávková forma obsahující sofosbuvir |
WO2018078536A1 (en) | 2016-10-26 | 2018-05-03 | Lupin Limited | Stable solid dispersion of sofosbuvir and process for preparation thereof |
CN108210509A (zh) * | 2016-12-13 | 2018-06-29 | 南京圣和药业股份有限公司 | 新的核苷氨基磷酸脂化合物的组合物及其制备方法 |
RU2659693C1 (ru) * | 2017-06-30 | 2018-07-03 | Общество с ограниченной ответственностью "Изварино Фарма" | Фармацевтическая композиция, обладающая активностью против ВИЧ-инфекции |
WO2019134971A1 (en) * | 2018-01-04 | 2019-07-11 | Sandoz Ag | Encapsulated particles comprising a pharmaceutically active ingredient |
US20210380422A1 (en) | 2018-10-05 | 2021-12-09 | Fuji Chemical Industries Co., Ltd. | Porous silica particle composition |
CN111040010A (zh) * | 2019-12-23 | 2020-04-21 | 上海红蓝医药科技有限公司 | 一种索非布韦中间体的合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0008058A (pt) * | 1999-12-08 | 2002-03-26 | Pharmacia Corp | Forma de estado sólido de celecoxib tendo biodisposnibilidade melhorada |
CN1200262C (zh) | 2003-01-10 | 2005-05-04 | 清华大学 | 测量粉末吸附气体量的方法和设备 |
WO2010017965A2 (en) | 2008-08-11 | 2010-02-18 | Merck Serono S.A. | SOLID LIPID MICROCAPSULES CONTAINING hGH |
TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
BR112012024884A2 (pt) | 2010-03-31 | 2016-10-18 | Gilead Pharmasset Llc | síntese estereosseletiva de ativos contendo fósforo |
MX2014008008A (es) * | 2011-12-29 | 2014-08-21 | Abbvie Inc | Composiciones solidas que comprenden un inhibidor del virus de la hepatitis c. |
CA2862229A1 (en) * | 2011-12-30 | 2013-07-04 | Chevron U.S.A. Inc. | Process, method, and system for removing heavy metals from fluids |
ES2792503T3 (es) * | 2013-08-27 | 2020-11-11 | Gilead Pharmasset Llc | Formulación combinada de dos compuestos antivirales |
-
2015
- 2015-04-02 KR KR1020167030432A patent/KR20160142342A/ko unknown
- 2015-04-02 US US15/129,149 patent/US10493089B2/en not_active Expired - Fee Related
- 2015-04-02 EP EP15713526.0A patent/EP3125868A2/en not_active Withdrawn
- 2015-04-02 JP JP2016560461A patent/JP2017512811A/ja not_active Ceased
- 2015-04-02 AU AU2015239018A patent/AU2015239018A1/en not_active Abandoned
- 2015-04-02 CN CN201580018422.4A patent/CN106163529A/zh not_active Withdrawn
- 2015-04-02 CA CA2943574A patent/CA2943574A1/en not_active Abandoned
- 2015-04-02 WO PCT/EP2015/057411 patent/WO2015150561A2/en active Application Filing
- 2015-04-02 RU RU2016142819A patent/RU2016142819A/ru not_active Application Discontinuation
- 2015-04-02 MX MX2016012934A patent/MX2016012934A/es unknown
-
2016
- 2016-09-30 MX MX2019009842A patent/MX2019009842A/es unknown
-
2019
- 2019-08-23 US US16/550,057 patent/US20190381085A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP3125868A2 (en) | 2017-02-08 |
US20190381085A1 (en) | 2019-12-19 |
AU2015239018A1 (en) | 2016-10-13 |
US20170100422A1 (en) | 2017-04-13 |
JP2017512811A (ja) | 2017-05-25 |
CA2943574A1 (en) | 2015-10-08 |
RU2016142819A (ru) | 2018-05-10 |
US10493089B2 (en) | 2019-12-03 |
WO2015150561A2 (en) | 2015-10-08 |
RU2016142819A3 (es) | 2018-05-10 |
KR20160142342A (ko) | 2016-12-12 |
CN106163529A (zh) | 2016-11-23 |
WO2015150561A3 (en) | 2016-01-28 |
MX2019009842A (es) | 2019-10-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2019009842A (es) | Composicion solida que comprende sofosbuvir amorfo. | |
HK1251901A1 (zh) | 烯基取代的2,5-哌嗪二酮和其在組合物中用於向個體或細胞遞送藥劑的用途 | |
WO2015200902A8 (en) | Endophytes, associated compositions, and methods of use thereof | |
MY191035A (en) | Affinity-oligonucleotide conjugates and uses thereof | |
IL274297A (en) | Pyrazolo-piperidine-converted indole-2-carboxamides, preparations containing them and their uses | |
WO2016066453A3 (en) | Heterophasic polypropylene with improved impact strength/stiffness balance, improved powder flowability, reduced emissions and low shrinkage | |
MX2017005051A (es) | Polipropileno heterofasico con equilibrio mejorado de rigidez/impacto. | |
SG10201803042PA (en) | Anti-tim-3 antibodies | |
IL247836B (en) | 1, 3-benzodioxole derivatives, preparations containing them and their uses | |
WO2015082046A3 (de) | Substituierte oxepine | |
NZ728483A (en) | Endophytes, associated compositions, and methods of use thereof | |
MX2017007645A (es) | Composiciones inhibidoras de nitrificacion y metodos para preparar las mismas. | |
MX2015009104A (es) | Composiciones en solución sólida y uso en el tratamiento de enfermedades cardiovasculares. | |
EP3254667A4 (en) | Light-curable composition, denture, and plate denture | |
MX2019010594A (es) | Beta-caseina a2 y prevencion de la inflamacion del intestino. | |
WO2016108927A3 (en) | Nitrification inhibitor compositions and methods for preparing the same | |
MX2017008390A (es) | Uretanos funcionalizados con alcoxisilano y funcionalizados con alofanato. | |
SG11201908281VA (en) | Phenalene-1-one-containing photosensitizer composition, phenalene-1-one compound and the use thereof | |
MX2020002123A (es) | Sales de ribociclib y formas en estado sólido de las mismas. | |
WO2018127612A3 (en) | Compositions comprising lespedeza plant extract | |
GEP201706739B (en) | Compositions comprising vortioxetine and donepezil | |
GB2576614B (en) | Compositions, uses and methods | |
GB201901099D0 (en) | Methods, uses and compositions | |
EP3449924A4 (en) | COMPOSITION, ACTIVE SITE OF CROCINES, AND USES THEREOF | |
HK1254884A1 (zh) | 用於減弱運動後表現下降的細菌組合物 |