MX2016009316A - Activacion de las plaquetas y liberacion del factor de crecimiento utilizando pulsos electricos. - Google Patents

Activacion de las plaquetas y liberacion del factor de crecimiento utilizando pulsos electricos.

Info

Publication number
MX2016009316A
MX2016009316A MX2016009316A MX2016009316A MX2016009316A MX 2016009316 A MX2016009316 A MX 2016009316A MX 2016009316 A MX2016009316 A MX 2016009316A MX 2016009316 A MX2016009316 A MX 2016009316A MX 2016009316 A MX2016009316 A MX 2016009316A
Authority
MX
Mexico
Prior art keywords
growth factor
electric pulses
platelet activation
factor release
release
Prior art date
Application number
MX2016009316A
Other languages
English (en)
Inventor
Caiafa Antonio
Bogdan Neculaes Vasile
Lawrence Garner Allen
Soliz Torres Andrew
Duh- Lan Lee Brian
Original Assignee
Gen Electric
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Electric filed Critical Gen Electric
Publication of MX2016009316A publication Critical patent/MX2016009316A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
    • C12Y306/01005—Apyrase (3.6.1.5), i.e. ATP diphosphohydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Ecology (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)

Abstract

Se describen métodos y sistemas para la liberación de factores de crecimiento; en ciertas modalidades, una muestra de sangre se expone a una secuencia de uno o más pulsos eléctricos para desencadenar la liberación de un factor de crecimiento en la muestra; en ciertas modalidades, la liberación del factor de crecimiento no está acompañada de coagulación dentro de la muestra de sangre.
MX2016009316A 2014-01-17 2015-01-09 Activacion de las plaquetas y liberacion del factor de crecimiento utilizando pulsos electricos. MX2016009316A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/157,819 US9452199B2 (en) 2014-01-17 2014-01-17 Platelet activation and growth factor release using electric pulses
PCT/US2015/010817 WO2015108778A1 (en) 2014-01-17 2015-01-09 Platelet activation and growth factor release using electric pulses

Publications (1)

Publication Number Publication Date
MX2016009316A true MX2016009316A (es) 2016-10-13

Family

ID=52424133

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016009316A MX2016009316A (es) 2014-01-17 2015-01-09 Activacion de las plaquetas y liberacion del factor de crecimiento utilizando pulsos electricos.

Country Status (12)

Country Link
US (5) US9452199B2 (es)
EP (2) EP3502690B1 (es)
JP (1) JP6625542B2 (es)
KR (1) KR102277931B1 (es)
CN (1) CN105899949B (es)
AU (2) AU2015206756B2 (es)
CA (1) CA2936230C (es)
ES (1) ES2929394T3 (es)
MX (1) MX2016009316A (es)
RU (1) RU2712234C2 (es)
TW (1) TWI673054B (es)
WO (1) WO2015108778A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9452199B2 (en) * 2014-01-17 2016-09-27 General Electric Company Platelet activation and growth factor release using electric pulses
US9708597B2 (en) * 2014-01-17 2017-07-18 General Electric Company Electric pulse generation systems using capacitive coupling
US9752120B2 (en) 2015-03-31 2017-09-05 General Electric Company Activated platelet composition with tunable growth factor level
US10633645B2 (en) * 2015-12-30 2020-04-28 General Electric Company Calcium controlled activation of platelets via electrical stimulation
KR102516995B1 (ko) * 2016-04-05 2023-03-31 제네럴 일렉트릭 컴퍼니 조정가능한 성장 인자 레벨을 가진 활성화된 혈소판 조성
US10968423B2 (en) 2018-02-26 2021-04-06 General Electric Company System and method for electric pulse based activation of biological samples
US20200000709A1 (en) * 2018-06-29 2020-01-02 Cal-X Stars Business Accelerator, Inc. Combination of bioelectrical stimulator and platelet-rich fibrin for accelerated healing and regeneration
JP7248721B2 (ja) * 2021-02-17 2023-03-29 ゼネラル・エレクトリック・カンパニイ 成長因子レベルを調節可能な活性化血小板組成物

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479896A (en) * 1981-12-11 1984-10-30 Antoniades Harry N Method for extraction localization and direct recovery of platelet derived growth factor
US7053063B2 (en) * 1999-07-21 2006-05-30 The Regents Of The University Of California Controlled electroporation and mass transfer across cell membranes in tissue
CA2378898A1 (en) * 1999-07-23 2001-02-01 The Scripps Research Institute Method for measuring coagulant factor activity in whole blood
US6326177B1 (en) 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
DE10119901A1 (de) 2001-04-23 2002-10-24 Amaxa Gmbh Schaltungsanordnung zur Einbringung von Nukleinsäuren und anderen biologisch aktiven Molekülen in den Kern höherer eukaryontischer Zellen mit Hilfe elektrischen Stroms
US20060269531A1 (en) * 2003-07-18 2006-11-30 Eastern Virginia Medical School Apparatus for generating electrical pulses and methods of using the same
US6897069B1 (en) 2004-06-08 2005-05-24 Ambion, Inc. System and method for electroporating a sample
US7565201B2 (en) 2004-12-17 2009-07-21 Eastern Virginia Medical School Activation of calcium-mediated cell functions in cells and tissues, including aggregation of human platelets. by nanosecond pulsed electric fields
US7923238B2 (en) * 2006-02-10 2011-04-12 Bio-Rad Laboratories, Inc. Multi-channel electroporation system
US7750605B2 (en) * 2006-09-21 2010-07-06 Bio-Rad Laboratories, Inc. Controlling an electrical signal sent to a sample load using a pulse modulated resistance
US8222909B2 (en) * 2008-08-22 2012-07-17 Bio-Rad Laboratories, Inc. Electroporation system with dial-in time constant
JP6034564B2 (ja) * 2008-11-13 2016-11-30 イースタン バージニア メディカル スクール ナノ秒パルス電界による、ヒト血小板の活性化および凝集方法ならびに血小板ゲルの形成方法
JP2012519558A (ja) * 2009-03-10 2012-08-30 モナッシュ ユニヴァーシティ マイクロ流体素子を使用する血小板凝集
JP2012523879A (ja) * 2009-04-15 2012-10-11 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 超音波キャビテーションを使った腫瘍治療
KR101114712B1 (ko) 2009-10-23 2012-02-29 세원셀론텍(주) 염화칼슘용액과 제1형 콜라겐으로 혈소판풍부혈장(ｐｒｐ)을 활성화하여 조직재생을 유도하는 조성물의 제조방법
US8450078B2 (en) * 2009-12-18 2013-05-28 Entegrion, Inc. Portable coagulation monitoring device and method of assessing coagulation response
WO2011088231A1 (en) 2010-01-13 2011-07-21 Apt Therapeutics, Inc. Apyrase therapy for bleeding conditions
US9164079B2 (en) * 2011-03-17 2015-10-20 Greyledge Technologies Llc Systems for autologous biological therapeutics
US9078862B2 (en) * 2013-06-06 2015-07-14 General Electric Company Platelet activation using long electric field pulses
US9452199B2 (en) * 2014-01-17 2016-09-27 General Electric Company Platelet activation and growth factor release using electric pulses

Also Published As

Publication number Publication date
JP2017505608A (ja) 2017-02-23
US10369200B2 (en) 2019-08-06
TW201620529A (zh) 2016-06-16
RU2016126427A3 (es) 2018-07-27
JP6625542B2 (ja) 2019-12-25
AU2020207831A1 (en) 2020-08-13
US11464829B2 (en) 2022-10-11
ES2929394T3 (es) 2022-11-28
TWI673054B (zh) 2019-10-01
US20160367632A1 (en) 2016-12-22
US20230013598A1 (en) 2023-01-19
EP3094970B1 (en) 2019-03-06
US10383915B2 (en) 2019-08-20
RU2712234C2 (ru) 2020-01-27
US20150202264A1 (en) 2015-07-23
US20190336578A1 (en) 2019-11-07
AU2020207831B2 (en) 2022-01-13
CA2936230A1 (en) 2015-07-23
KR102277931B1 (ko) 2021-07-15
CA2936230C (en) 2022-06-14
WO2015108778A1 (en) 2015-07-23
CN105899949A (zh) 2016-08-24
EP3502690B1 (en) 2022-09-07
AU2015206756B2 (en) 2020-05-14
US9452199B2 (en) 2016-09-27
EP3502690A1 (en) 2019-06-26
EP3094970A1 (en) 2016-11-23
KR20160108419A (ko) 2016-09-19
RU2016126427A (ru) 2018-02-20
CN105899949B (zh) 2019-09-03
AU2015206756A1 (en) 2016-07-21
US20160367633A1 (en) 2016-12-22

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