MX2016001220A - Procedimiento para preparar un componente neurotoxico altamente puro de una toxina botulinica y usos del mismo. - Google Patents
Procedimiento para preparar un componente neurotoxico altamente puro de una toxina botulinica y usos del mismo.Info
- Publication number
- MX2016001220A MX2016001220A MX2016001220A MX2016001220A MX2016001220A MX 2016001220 A MX2016001220 A MX 2016001220A MX 2016001220 A MX2016001220 A MX 2016001220A MX 2016001220 A MX2016001220 A MX 2016001220A MX 2016001220 A MX2016001220 A MX 2016001220A
- Authority
- MX
- Mexico
- Prior art keywords
- botulinum toxin
- neurotoxic component
- highly pure
- preparing
- pure neurotoxic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/40—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Sustainable Development (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a un procedimiento para preparar un componente neurotóxico altamente puro de una toxina botulínica cultivando Clostridium botulinum bajo condiciones que permitan la producción de una toxina botulínica, y aislar el componente neurotóxico de la toxina botulínica. Además, la presente invención se refiere a un componente neurotóxico altamente puro de una toxina botulínica que se puede obtener mediante el procedimiento de la presente invención y usos del mismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13003792 | 2013-07-30 | ||
PCT/EP2014/002089 WO2015014487A1 (en) | 2013-07-30 | 2014-07-30 | Process for preparing a highly pure neurotoxic component of a botulinum toxin and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016001220A true MX2016001220A (es) | 2016-05-24 |
Family
ID=48906087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016001220A MX2016001220A (es) | 2013-07-30 | 2014-07-30 | Procedimiento para preparar un componente neurotoxico altamente puro de una toxina botulinica y usos del mismo. |
Country Status (13)
Country | Link |
---|---|
US (2) | US9937245B2 (es) |
EP (1) | EP3027641A1 (es) |
JP (1) | JP6517800B2 (es) |
KR (1) | KR102272580B1 (es) |
CN (1) | CN105658662B (es) |
AU (1) | AU2014298922B2 (es) |
BR (1) | BR112016001730B1 (es) |
CA (1) | CA2918233C (es) |
HK (1) | HK1225744A1 (es) |
IL (1) | IL243573B (es) |
MX (1) | MX2016001220A (es) |
RU (1) | RU2663136C2 (es) |
WO (1) | WO2015014487A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR061669A1 (es) * | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
US10792344B2 (en) * | 2006-06-29 | 2020-10-06 | Merz Pharma Gmbh & Co. Kgaa | High frequency application of botulinum toxin therapy |
EP3027641A1 (en) * | 2013-07-30 | 2016-06-08 | Merz Pharma GmbH & Co. KGaA | Process for preparing a highly pure neurotoxic component of a botulinum toxin and uses thereof |
TWI669129B (zh) * | 2014-12-23 | 2019-08-21 | 德商梅茲製藥有限兩合公司 | 預填充式玻璃容器及其套組與使用 |
EP3274044B1 (en) | 2015-03-26 | 2023-03-01 | Vensica Medical Ltd. | Ultrasonic urinary bladder drug delivery |
US11529506B2 (en) | 2018-04-01 | 2022-12-20 | Vensica Medical Ltd. | System and method for ultrasonic bladder therapeutic agent delivery |
JP6875318B2 (ja) * | 2018-04-24 | 2021-05-19 | 株式会社日立産機システム | 安全キャビネット |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19925739A1 (de) * | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
US6903187B1 (en) * | 2000-07-21 | 2005-06-07 | Allergan, Inc. | Leucine-based motif and clostridial neurotoxins |
RU2206337C1 (ru) * | 2002-10-29 | 2003-06-20 | Общество с ограниченной ответственностью "Токсины и сопутствующие продукты" | Лекарственный препарат для лечения мышечных дистоний и способ его получения |
US7339671B2 (en) * | 2004-01-20 | 2008-03-04 | Hong Peng | Apparatus and method for monitoring biological cell culture |
PL1891200T3 (pl) * | 2005-06-17 | 2009-10-30 | Merz Pharma Gmbh & Co Kgaa | Urządzenie i sposób do fermentacyjnego wytwarzania biologicznie aktywnych materiałów |
JP4944896B2 (ja) * | 2005-11-17 | 2012-06-06 | ルバンス セラピュティックス インク. | 低減された非毒素タンパク質を含むボツリヌス毒素の局所適用及び経皮送達のための組成物及び方法 |
AR061669A1 (es) * | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
US8748151B2 (en) * | 2008-08-29 | 2014-06-10 | Merz Pharma Gmbh & Co. Kgaa | Clostridial neurotoxins with altered persistency |
EP2248518B1 (en) * | 2009-04-17 | 2013-01-16 | Merz Pharma GmbH & Co. KGaA | Formulation for stabilizing proteins, peptides or mixtures thereof. |
US8129139B2 (en) * | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
JP2011074025A (ja) * | 2009-09-30 | 2011-04-14 | Chemo-Sero-Therapeutic Research Inst | ボツリヌス毒素の精製方法 |
US20120196349A1 (en) * | 2009-10-21 | 2012-08-02 | Revance Therapeutics, Inc. | Methods and Systems for Purifying Non-Complexed Botulinum Neurotoxin |
US20120189677A1 (en) * | 2011-01-20 | 2012-07-26 | Stephen Tonge | Formulations |
FR2981386B1 (fr) * | 2011-10-14 | 2014-08-22 | Getinge La Calhene | Mecanisme de commande a haut niveau de securite pour un dispositif de transfert etanche entre deux volumes clos |
EP3027641A1 (en) * | 2013-07-30 | 2016-06-08 | Merz Pharma GmbH & Co. KGaA | Process for preparing a highly pure neurotoxic component of a botulinum toxin and uses thereof |
-
2014
- 2014-07-30 EP EP14749719.2A patent/EP3027641A1/en active Pending
- 2014-07-30 JP JP2016530382A patent/JP6517800B2/ja active Active
- 2014-07-30 AU AU2014298922A patent/AU2014298922B2/en active Active
- 2014-07-30 BR BR112016001730-7A patent/BR112016001730B1/pt active IP Right Grant
- 2014-07-30 KR KR1020167004505A patent/KR102272580B1/ko active IP Right Grant
- 2014-07-30 MX MX2016001220A patent/MX2016001220A/es active IP Right Grant
- 2014-07-30 US US14/908,235 patent/US9937245B2/en active Active
- 2014-07-30 WO PCT/EP2014/002089 patent/WO2015014487A1/en active Application Filing
- 2014-07-30 CN CN201480043265.8A patent/CN105658662B/zh active Active
- 2014-07-30 CA CA2918233A patent/CA2918233C/en active Active
- 2014-07-30 RU RU2016103329A patent/RU2663136C2/ru active
-
2016
- 2016-01-11 IL IL243573A patent/IL243573B/en active IP Right Grant
- 2016-12-07 HK HK16113961A patent/HK1225744A1/zh unknown
-
2018
- 2018-01-26 US US15/881,135 patent/US10653754B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2015014487A1 (en) | 2015-02-05 |
CA2918233A1 (en) | 2015-02-05 |
JP2016527257A (ja) | 2016-09-08 |
RU2663136C2 (ru) | 2018-08-01 |
KR20160036581A (ko) | 2016-04-04 |
EP3027641A1 (en) | 2016-06-08 |
IL243573A0 (en) | 2016-03-31 |
AU2014298922B2 (en) | 2018-03-15 |
US20160175407A1 (en) | 2016-06-23 |
BR112016001730B1 (pt) | 2023-04-11 |
CN105658662B (zh) | 2022-05-27 |
IL243573B (en) | 2019-03-31 |
HK1225744A1 (zh) | 2017-09-15 |
US9937245B2 (en) | 2018-04-10 |
JP6517800B2 (ja) | 2019-05-22 |
BR112016001730A2 (pt) | 2017-08-29 |
AU2014298922A1 (en) | 2016-02-18 |
CN105658662A (zh) | 2016-06-08 |
US10653754B2 (en) | 2020-05-19 |
RU2016103329A (ru) | 2017-08-31 |
US20180147266A1 (en) | 2018-05-31 |
CA2918233C (en) | 2022-08-30 |
KR102272580B1 (ko) | 2021-07-05 |
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