MX2015007365A - Peptidos como agonistas de oxitocina. - Google Patents
Peptidos como agonistas de oxitocina.Info
- Publication number
- MX2015007365A MX2015007365A MX2015007365A MX2015007365A MX2015007365A MX 2015007365 A MX2015007365 A MX 2015007365A MX 2015007365 A MX2015007365 A MX 2015007365A MX 2015007365 A MX2015007365 A MX 2015007365A MX 2015007365 A MX2015007365 A MX 2015007365A
- Authority
- MX
- Mexico
- Prior art keywords
- lower alkyl
- hydroxy
- hydrogen
- cycloalkyl
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychiatry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a compuestos de la fórmula (I) en donde R1 es hidroxi o amino; R2 es sec-butilo o isobutilo; R3 es alquilo inferior, alquilo inferior sustituido por hidroxi, -(CH2)2C(O)-NH2, -(CH2)3-NH2 o -CH2-grupo heterocíclico aromático de cinco miembros; R4 es hidrógeno o alquilo inferior; R5 es hidrógeno o alquilo inferior; o R4 y R5 junto con los átomos de N y C a los que están unidos pueden formar un anillo de pirrolidina, opcionalmente sustituido por hidroxi o halógeno, un anillo de piperidina o un anillo de azetidina; R6 es hidrógeno, alquilo inferior, alquilo inferior sustituido por hidroxi, -(CH2)2C(O)OH, - (CH2)2C(O)NH2, bencilo opcionalmente sustituido por amino o hidroxi, -CH2-grupo heterocíclico aromático de cinco miembros, indolilo, -CH2-ciclo-alquilo, cicloalquilo, -(CH2)2- S-alquilo inferior o es -(CH2)1-4-NH2 R6' es hidrógeno o alquilo inferior; o R6 y R6´ juntos son cicloalquilo; X es - C(O)-CHR-NR´-C(O)-; R/R´ independientemente uno de otro son hidrógeno o alquilo inferior; m es 2; o es 0 ó 1; o a una sal de adición de ácido farmacéuticamente aceptable, a una mezcla racémica o a sus enantiómeros correspondientes y/o isómeros ópticos de los mismos. Ahora se ha encontrado que los compuestos presentes son agonistas de receptores de oxitocina para el tratamiento del autismo, el estrés, incluido el trastorno del estrés postraumático, la ansiedad, incluidos los trastornos de ansiedad y la depresión, la esquizofrenia, los trastornos psiquiátricos y la pérdida de memoria, la abstinencia del alcohol, la adicción a las drogas y para el tratamiento del síndrome de Prader-Willi.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12199012 | 2012-12-21 | ||
| PCT/EP2013/076783 WO2014095773A1 (en) | 2012-12-21 | 2013-12-17 | Peptides as oxytocin agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015007365A true MX2015007365A (es) | 2015-10-14 |
| MX358684B MX358684B (es) | 2018-08-31 |
Family
ID=47471593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015007365A MX358684B (es) | 2012-12-21 | 2013-12-17 | Peptidos como agonistas de oxitocina. |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US9868766B2 (es) |
| EP (1) | EP2935312B1 (es) |
| JP (1) | JP6067878B2 (es) |
| KR (1) | KR101819804B1 (es) |
| CN (1) | CN104870466B (es) |
| AR (1) | AR094225A1 (es) |
| AU (1) | AU2013363768B2 (es) |
| BR (1) | BR112015014010A2 (es) |
| CA (1) | CA2895150C (es) |
| CL (1) | CL2015001724A1 (es) |
| CR (1) | CR20150271A (es) |
| DK (1) | DK2935312T3 (es) |
| EA (1) | EA026687B1 (es) |
| ES (1) | ES2690317T3 (es) |
| HK (1) | HK1208477A1 (es) |
| HR (1) | HRP20181569T1 (es) |
| HU (1) | HUE039848T2 (es) |
| IL (1) | IL239519A (es) |
| LT (1) | LT2935312T (es) |
| MA (1) | MA38272A1 (es) |
| MX (1) | MX358684B (es) |
| MY (1) | MY176398A (es) |
| NZ (1) | NZ708175A (es) |
| PE (1) | PE20151446A1 (es) |
| PH (1) | PH12015501145A1 (es) |
| PL (1) | PL2935312T3 (es) |
| PT (1) | PT2935312T (es) |
| RS (1) | RS57690B1 (es) |
| SG (1) | SG11201504883PA (es) |
| SI (1) | SI2935312T1 (es) |
| TW (1) | TWI558726B (es) |
| UA (1) | UA119034C2 (es) |
| WO (1) | WO2014095773A1 (es) |
| ZA (1) | ZA201504186B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013139861A1 (en) | 2012-03-20 | 2013-09-26 | Luc Montagnier | Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders |
| UA111305C2 (uk) | 2012-12-21 | 2016-04-11 | Пфайзер Інк. | Конденсовані лактами арилу та гетероарилу |
| MY176398A (en) | 2012-12-21 | 2020-08-05 | Hoffmann La Roche | Peptides as oxytocin agonists |
| EA201590943A1 (ru) | 2012-12-21 | 2016-01-29 | Алиос Биофарма, Инк. | Замещенные нуклеозиды, нуклеотиды и их аналоги |
| KR102116107B1 (ko) | 2013-12-30 | 2020-05-28 | 삼성디스플레이 주식회사 | 표시 장치 |
| USRE49816E1 (en) | 2014-01-10 | 2024-01-30 | Cornell University | Dipeptides as inhibitors of human immunoproteasomes |
| WO2015185467A1 (en) | 2014-06-03 | 2015-12-10 | F. Hoffmann-La Roche Ag | Peptides as oxytocin agonists |
| EP3521285A1 (en) | 2014-06-17 | 2019-08-07 | Pfizer Inc | Substituted dihydroisoquinolinone compounds |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| SI3177635T1 (sl) * | 2014-08-07 | 2019-01-31 | F. Hoffmann-La Roche Ag | Postopki za pripravo analogov oksitocina |
| JP6758282B2 (ja) * | 2014-08-18 | 2020-09-23 | コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ | ヒト免疫プロテアソーム阻害剤としてのジペプチド模倣薬 |
| LT3666258T (lt) * | 2014-09-19 | 2024-01-10 | Ferring Bv | Praderio-vilio sindromo gydymo būdas |
| CN108351169B (zh) | 2015-10-15 | 2022-01-28 | 康奈尔大学 | 蛋白酶体抑制剂及其用途 |
| US11203613B2 (en) | 2017-10-11 | 2021-12-21 | Cornell University | Peptidomimetic proteasome inhibitors |
| CN112969450B (zh) | 2018-09-20 | 2023-05-30 | 阿卡蒂亚药品公司 | 卡贝缩宫素药物产品及用于制备其的方法 |
| WO2020061414A1 (en) | 2018-09-20 | 2020-03-26 | Levo Therapeutics, Inc. | Stable intranasal formulations of carbetocin |
| WO2021126990A1 (en) * | 2019-12-16 | 2021-06-24 | The Scripps Research Institute | Oxytocin derivatives with improved properties |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009233429B2 (en) | 2008-03-31 | 2014-02-13 | Ferring B.V. | Oxytocin analogues |
| TWI463990B (zh) * | 2009-09-21 | 2014-12-11 | Ferring Bv | 催產素受體促進劑 |
| US9119805B2 (en) * | 2009-10-01 | 2015-09-01 | The University Of Sydney | Therapy and prevention of problem drinking |
| MY176398A (en) | 2012-12-21 | 2020-08-05 | Hoffmann La Roche | Peptides as oxytocin agonists |
-
2013
- 2013-12-17 MY MYPI2015001585A patent/MY176398A/en unknown
- 2013-12-17 WO PCT/EP2013/076783 patent/WO2014095773A1/en active Application Filing
- 2013-12-17 SG SG11201504883PA patent/SG11201504883PA/en unknown
- 2013-12-17 NZ NZ708175A patent/NZ708175A/en not_active IP Right Cessation
- 2013-12-17 EA EA201591078A patent/EA026687B1/ru not_active IP Right Cessation
- 2013-12-17 KR KR1020157016376A patent/KR101819804B1/ko active IP Right Grant
- 2013-12-17 LT LTEP13814079.3T patent/LT2935312T/lt unknown
- 2013-12-17 JP JP2015548420A patent/JP6067878B2/ja not_active Expired - Fee Related
- 2013-12-17 ES ES13814079.3T patent/ES2690317T3/es active Active
- 2013-12-17 PT PT13814079T patent/PT2935312T/pt unknown
- 2013-12-17 PE PE2015001058A patent/PE20151446A1/es unknown
- 2013-12-17 SI SI201331190T patent/SI2935312T1/sl unknown
- 2013-12-17 BR BR112015014010A patent/BR112015014010A2/pt not_active IP Right Cessation
- 2013-12-17 AU AU2013363768A patent/AU2013363768B2/en not_active Ceased
- 2013-12-17 PL PL13814079T patent/PL2935312T3/pl unknown
- 2013-12-17 RS RS20181124A patent/RS57690B1/sr unknown
- 2013-12-17 EP EP13814079.3A patent/EP2935312B1/en active Active
- 2013-12-17 CA CA2895150A patent/CA2895150C/en not_active Expired - Fee Related
- 2013-12-17 HU HUE13814079A patent/HUE039848T2/hu unknown
- 2013-12-17 UA UAA201506906A patent/UA119034C2/uk unknown
- 2013-12-17 CN CN201380066617.7A patent/CN104870466B/zh not_active Expired - Fee Related
- 2013-12-17 MX MX2015007365A patent/MX358684B/es active IP Right Grant
- 2013-12-17 DK DK13814079.3T patent/DK2935312T3/en active
- 2013-12-17 MA MA38272A patent/MA38272A1/fr unknown
- 2013-12-20 TW TW102147655A patent/TWI558726B/zh not_active IP Right Cessation
- 2013-12-20 AR ARP130104962A patent/AR094225A1/es unknown
-
2015
- 2015-05-21 CR CR20150271A patent/CR20150271A/es unknown
- 2015-05-22 PH PH12015501145A patent/PH12015501145A1/en unknown
- 2015-06-10 ZA ZA2015/04186A patent/ZA201504186B/en unknown
- 2015-06-18 US US14/743,009 patent/US9868766B2/en active Active
- 2015-06-18 IL IL239519A patent/IL239519A/en active IP Right Grant
- 2015-06-18 CL CL2015001724A patent/CL2015001724A1/es unknown
- 2015-09-18 HK HK15109189.5A patent/HK1208477A1/xx not_active IP Right Cessation
-
2018
- 2018-10-02 HR HRP20181569TT patent/HRP20181569T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant or registration |