MX2015007291A - Derivados de tiazol como inhibidores de la tirosina cinasa de bruton. - Google Patents

Derivados de tiazol como inhibidores de la tirosina cinasa de bruton.

Info

Publication number
MX2015007291A
MX2015007291A MX2015007291A MX2015007291A MX2015007291A MX 2015007291 A MX2015007291 A MX 2015007291A MX 2015007291 A MX2015007291 A MX 2015007291A MX 2015007291 A MX2015007291 A MX 2015007291A MX 2015007291 A MX2015007291 A MX 2015007291A
Authority
MX
Mexico
Prior art keywords
bruton
inhibitors
compounds
tyrosine kinase
btk
Prior art date
Application number
MX2015007291A
Other languages
English (en)
Inventor
Francisco Javier Lopez-Tapia
Sung-Sau So
Nicholas John Silvestre Huby
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2015007291A publication Critical patent/MX2015007291A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Esta solicitud describe compuestos de acuerdo con la f6rmula genérica I: en la que todas las variables se definen como se describe en el presente documento, que inhiben la Btk. Los compuestos descritos en el presente documento son útiles para modular la actividad de Btk y tratar enfermedades asociadas con la excesiva actividad de Btk. Los compuestos son útiles además para tratar enfermedades inflamatorias y autoinmunes asociadas con la proliferación aberrante de células B tales como la artritis reumatoide. También se describen composiciones que contienen compuestos de Fórmula I y por lo menos un vehículo, diluyente o excipiente.
MX2015007291A 2012-12-13 2013-12-09 Derivados de tiazol como inhibidores de la tirosina cinasa de bruton. MX2015007291A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261736631P 2012-12-13 2012-12-13
PCT/EP2013/075887 WO2014090715A1 (en) 2012-12-13 2013-12-09 Thiazole derivatives as inhibitors of bruton's tyrosine kinase

Publications (1)

Publication Number Publication Date
MX2015007291A true MX2015007291A (es) 2015-09-10

Family

ID=49765484

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015007291A MX2015007291A (es) 2012-12-13 2013-12-09 Derivados de tiazol como inhibidores de la tirosina cinasa de bruton.

Country Status (12)

Country Link
US (1) US9359345B2 (es)
EP (1) EP2931721B1 (es)
JP (1) JP6154482B2 (es)
KR (1) KR101707761B1 (es)
CN (1) CN104837837B (es)
BR (1) BR112015013762A2 (es)
CA (1) CA2893637A1 (es)
ES (1) ES2607635T3 (es)
HK (1) HK1212975A1 (es)
MX (1) MX2015007291A (es)
RU (1) RU2015126293A (es)
WO (1) WO2014090715A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019106146A1 (en) * 2017-11-30 2019-06-06 Step Pharma S.A.S. Compounds
EP3492454A1 (en) * 2017-11-30 2019-06-05 Step Pharma S.A.S. Compounds
EP3717459A1 (en) * 2017-11-30 2020-10-07 Step Pharma S.A.S. Compounds
JP7084586B2 (ja) 2018-01-15 2022-06-15 国立研究開発法人産業技術総合研究所 単結晶ダイヤモンド基板を含む積層体
FI3870574T3 (fi) 2018-10-23 2023-04-03 Step Pharma S A S Aminopyrimidiini/pyratsiini-johdannaiset ctps1-inhibiittoreina
CA3160447A1 (en) * 2019-11-06 2021-05-14 Albert Einstein College Of Medicine Small molecule prostagladin transport inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010011375A2 (en) * 2008-04-21 2010-01-28 Merck & Co., Inc. Inhibitors of janus kinases
WO2010068788A1 (en) 2008-12-10 2010-06-17 Cgi Pharmaceuticals, Inc. Heterocyclic amides as btk inhibitors

Also Published As

Publication number Publication date
US20150353534A1 (en) 2015-12-10
CN104837837A (zh) 2015-08-12
EP2931721A1 (en) 2015-10-21
CA2893637A1 (en) 2014-06-19
KR20150093238A (ko) 2015-08-17
CN104837837B (zh) 2017-04-05
BR112015013762A2 (pt) 2017-07-11
WO2014090715A1 (en) 2014-06-19
EP2931721B1 (en) 2016-10-26
KR101707761B1 (ko) 2017-02-16
JP2016502988A (ja) 2016-02-01
ES2607635T3 (es) 2017-04-03
HK1212975A1 (zh) 2016-06-24
RU2015126293A (ru) 2017-01-19
JP6154482B2 (ja) 2017-06-28
US9359345B2 (en) 2016-06-07

Similar Documents

Publication Publication Date Title
SG194728A1 (en) Inhibitors of bruton's tyrosine kinase
MX2014001653A (es) Inhibidores de la tirosina-cinasa de bruton.
MX2011008643A (es) Inhibidores de tirosina cinasa de bruton.
WO2014064131A3 (en) Inhibitors of bruton's tyrosine kinase
EA201390207A1 (ru) Ингибиторы тирозинкиназы брутона
MX2015010466A (es) Inhibidores de tirosina cinasa de bruton.
NZ601700A (en) 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives as inhibitors of Bruton's Tyrosine Kinase (Btk)
PH12018501268A1 (en) Compounds useful as kinase inhibitors
PH12016500531A1 (en) Compound inhibiting activities of btk and/or jak3 kinases
SG11201806930PA (en) Novel condensed pyrimidine compound or salt thereof
MX2015010983A (es) Inhibidores de tirosina-cinasa de bruton.
MY158411A (en) Novel pyridinones and pyridazinones
GEP20156285B (en) Compounds and compositions as trk inhibitors
MX2014002442A (es) Inhibidores de pirrolopirazina cinasa.
BR112015010693A2 (pt) inibidores de tirosina quinase de bruton
MX2015007291A (es) Derivados de tiazol como inhibidores de la tirosina cinasa de bruton.
PH12017501043A1 (en) 2-amino-5,5-difluoro-6-(fluoromethyl)-6-phenyl-3,4,5,6-tetrahydropyridines as bace1 inhibitors
SG10201805392YA (en) 1,2,4-triazine-6-carboxamide kinase inhibitors
TW201613896A (en) Novel 2,5-substituted pyrimidines
MX2016006744A (es) Inhibidores de tirosina cinasa de bruton.
MX370010B (es) Inhibidores de tirosina cinasa de bruton.
MX366840B (es) Pirimidinas novedosas 2,5-sustituidas como inhibidores de pde.
MX2015013685A (es) Inhibidores de tirosina cinasa de bruton.
MX2016006351A (es) Inhibidores de tirosina cinasa de bruton.
MX2015010820A (es) Inhibidores de tirosina cinasa de bruton.