MX2014016119A - Regimenes novedosos de cebadura-refuerzo que implican polipeptidos inmunogenicos codificados por polinucleotidos. - Google Patents

Regimenes novedosos de cebadura-refuerzo que implican polipeptidos inmunogenicos codificados por polinucleotidos.

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Publication number
MX2014016119A
MX2014016119A MX2014016119A MX2014016119A MX2014016119A MX 2014016119 A MX2014016119 A MX 2014016119A MX 2014016119 A MX2014016119 A MX 2014016119A MX 2014016119 A MX2014016119 A MX 2014016119A MX 2014016119 A MX2014016119 A MX 2014016119A
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Mexico
Prior art keywords
polynucleotides
immunogenic polypeptides
polypeptides encoded
regimens involving
boosting regimens
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MX2014016119A
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English (en)
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MX365391B (es
Inventor
Alfredo Nicosia
Ricardo Cortese
Alessandra Vitelli
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Glaxosmithkline Biolog Sa
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Publication date
Application filed by Glaxosmithkline Biolog Sa filed Critical Glaxosmithkline Biolog Sa
Publication of MX2014016119A publication Critical patent/MX2014016119A/es
Publication of MX365391B publication Critical patent/MX365391B/es

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    • AHUMAN NECESSITIES
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/155Paramyxoviridae, e.g. parainfluenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
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    • A61K39/12Viral antigens
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    • AHUMAN NECESSITIES
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    • A61K39/12Viral antigens
    • A61K39/275Poxviridae, e.g. avipoxvirus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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Abstract

La presente invención se refiere a regímenes de administración que son particularmente adecuados para una composición de vacuna que comprende polinucleótidos que codifican polipéptidos inmunogénicos. Estos regímenes de administración involucran la administración repetida de una composición de vacuna y mejoran la respuesta inmunitaria contra el polipéptido inmunogénico.
MX2014016119A 2012-07-05 2013-07-05 Regimenes novedosos de cebadura-refuerzo que implican polipeptidos inmunogenicos codificados por polinucleotidos. MX365391B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2012/063196 WO2014005643A1 (en) 2012-07-05 2012-07-05 Novel prime-boosting regimens involving immunogenic polypeptides encoded by polynucleotides
PCT/EP2013/064286 WO2014006191A1 (en) 2012-07-05 2013-07-05 Novel prime-boosting regimens involving immunogenic polypeptides encoded by polynucleotides

Publications (2)

Publication Number Publication Date
MX2014016119A true MX2014016119A (es) 2015-09-23
MX365391B MX365391B (es) 2019-05-31

Family

ID=48746554

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014016119A MX365391B (es) 2012-07-05 2013-07-05 Regimenes novedosos de cebadura-refuerzo que implican polipeptidos inmunogenicos codificados por polinucleotidos.

Country Status (19)

Country Link
US (3) US20150209420A1 (es)
JP (1) JP6244358B2 (es)
KR (1) KR20150038010A (es)
CN (1) CN104780937A (es)
AU (1) AU2013285398A1 (es)
BR (1) BR112014033077A2 (es)
CA (1) CA2878367A1 (es)
DK (1) DK2869841T3 (es)
EA (1) EA201492230A1 (es)
ES (1) ES2895070T3 (es)
HU (1) HUE056675T2 (es)
IL (1) IL236414A0 (es)
IN (1) IN2014KN03063A (es)
LT (1) LT2869841T (es)
MX (1) MX365391B (es)
PT (1) PT2869841T (es)
SG (1) SG11201408746XA (es)
WO (2) WO2014005643A1 (es)
ZA (1) ZA201500102B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2015008815A0 (en) 2013-04-25 2015-10-31 Crucell Holland Bv Stabilized soluble prefusion rsv f polypeptides
EP3154576A1 (en) * 2014-06-13 2017-04-19 GlaxoSmithKline Biologicals S.A. Immunogenic combinations
PT3188753T (pt) 2014-09-03 2020-03-25 Bavarian Nordic As Métodos e composições para induzir imunidade protetora contra infeção por filovírus
AP2017009822A0 (en) 2014-09-03 2017-03-31 Bavarian Nordic As Methods and compositions for enhancing immune responses
US9630994B2 (en) 2014-11-03 2017-04-25 University Of Washington Polypeptides for use in self-assembling protein nanostructures
US11559570B2 (en) 2015-05-15 2023-01-24 CureVac SE Prime-boost regimens involving administration of at least one mRNA construct
CN116059336A (zh) 2015-07-07 2023-05-05 扬森疫苗与预防公司 针对rsv的疫苗
WO2017005848A1 (en) 2015-07-07 2017-01-12 Janssen Vaccines & Prevention B.V. Stabilized soluble pre-fusion rsv f polypeptides
KR102401247B1 (ko) 2016-04-05 2022-05-25 얀센 백신스 앤드 프리벤션 비.브이. Rsv에 대한 백신
SI3439672T1 (sl) 2016-04-05 2021-02-26 Janssen Vaccines & Prevention B.V. Stabiliziran topen pre-fuzijski F protein RSV za uporabo v profilaksi okužbe z RSV
MX2018013340A (es) * 2016-05-02 2019-08-21 Janssen Vaccines & Prevention Bv Combinaciones de vacunas terapeuticas para el vph.
MX2018014699A (es) 2016-05-30 2019-02-28 Janssen Vaccines & Prevention Bv Proteinas f de prefusion del vrs estabilizadas.
US10925956B2 (en) 2016-07-15 2021-02-23 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against a marburg virus infection
US11192926B2 (en) 2017-04-04 2021-12-07 University Of Washington Self-assembling protein nanostructures displaying paramyxovirus and/or pneumovirus F proteins and their use
EP3606553A1 (en) 2017-04-06 2020-02-12 Janssen Vaccines & Prevention B.V. Mva-bn and ad26.zebov or ad26.filo prime-boost regimen
AU2018267971A1 (en) 2017-05-17 2019-11-07 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against RSV infection
WO2018210871A1 (en) * 2017-05-17 2018-11-22 Janssen Vaccines & Prevention B.V. Methods and compositions for inducing protective immunity against rsv infection
EA202090738A1 (ru) 2017-09-15 2020-06-10 Янссен Вэксинс Энд Превеншн Б.В. Способ безопасного индуцирования иммунитета против rsv
SG11202003609VA (en) * 2017-10-25 2020-05-28 Nouscom Ag Eukaryotic cell line
WO2019094396A1 (en) * 2017-11-07 2019-05-16 Nektar Therapeutics Immunotherapeutic combination for treating cancer
CA3095216A1 (en) 2018-02-28 2019-09-06 University Of Washington Self-asssembling nanostructure vaccines
GB201910794D0 (en) * 2019-07-29 2019-09-11 Pirbright Inst Vaccine
CN112220921B (zh) * 2020-08-25 2022-08-16 北京交通大学 一种针对呼吸道合胞病毒感染的组合疫苗
CN117304280B (zh) * 2023-11-28 2024-04-16 江苏瑞科生物技术股份有限公司 一种重组rsv f蛋白及其应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511845B1 (en) * 1992-08-07 2003-01-28 Alan R. Davis Methods for producing an immune response against HIV-1
US6180398B1 (en) * 1996-07-12 2001-01-30 Virogeneitics Corporation Two-step immunization procedure against the pyramyxoviridae family of viruses using recombinant virus and subunit protein preparation
GB9711957D0 (en) * 1997-06-09 1997-08-06 Isis Innovation Methods and reagents for vaccination
CA2526120A1 (en) * 2003-06-03 2005-02-24 Cell Genesys, Inc. Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site
PL1711518T3 (pl) 2004-01-23 2010-06-30 St Di Richerche Di Biologia Molecolare P Angeletti S P A Nośniki szczepionek pochodzące od szympansich adenowirusów
CA2645507A1 (en) * 2006-03-10 2007-09-20 The Regents Of The University Of California Vaccine for viruses that cause persistent or latent infections
US20070292922A1 (en) * 2006-03-31 2007-12-20 Cell Genesys, Inc. Regulated expression of recombinant proteins from adeno-associated viral vectors
US8206978B2 (en) * 2007-01-05 2012-06-26 Inseron, Inc. Green fluorescent protein optimized for expression with self-cleaving polypeptides
GB0706914D0 (en) * 2007-04-10 2007-05-16 Isis Innovation Novel adenovirus vectors
WO2009025770A2 (en) * 2007-08-17 2009-02-26 Wyeth A heterologous prime-boost immunization regimen
CL2007002710A1 (es) * 2007-09-20 2008-01-04 Univ Pontificia Catolica Chile Formulacion inmunogenica que confiere proteccion contra la infeccion o patologia causada por el virus respiratorio sincicial (vrs) que comprende una cepa recombinante atenuada de mycobacterium; y uso de la formulacion inmunogenica para preparar una vacuna para prevenir, tratar o atenuar infecciones del vrs.
US7863425B2 (en) * 2007-09-26 2011-01-04 Cornell University Compositions and methods for inhibiting Yersinia pestis infection
GB0823497D0 (en) * 2008-12-24 2009-01-28 Isis Innovation Immunogenic composition and use thereof
BRPI1008018A2 (pt) 2009-02-02 2016-03-15 Okairos Ag ácidos nucleicos de adenovírus símio e sequências de aminoácidos, vetores contendo os mesmos e uso dos mesmos
US20120141525A1 (en) * 2009-05-18 2012-06-07 Panacea Biotec Limited Universal influenza vaccine based on recombinant modified vaccine ankara virus (mva)
US9095546B2 (en) * 2009-07-20 2015-08-04 National Health Research Institutes Human respiratory syncytial virus (RSV) vaccine
WO2012021730A2 (en) 2010-08-11 2012-02-16 Genvec, Inc. Respiratory syncytial virus (rsv) vaccine
WO2012085936A2 (en) * 2010-12-20 2012-06-28 Panacea Biotech Ltd Recombinant respiratory syncytial virus plasmids and vaccines
US9119813B2 (en) * 2012-03-22 2015-09-01 Crucell Holland B.V. Vaccine against RSV

Also Published As

Publication number Publication date
EA201492230A1 (ru) 2015-06-30
ES2895070T3 (es) 2022-02-17
PT2869841T (pt) 2021-10-28
SG11201408746XA (en) 2015-01-29
JP2015526403A (ja) 2015-09-10
MX365391B (es) 2019-05-31
ZA201500102B (en) 2017-09-27
IN2014KN03063A (es) 2015-05-08
LT2869841T (lt) 2021-11-25
WO2014005643A1 (en) 2014-01-09
KR20150038010A (ko) 2015-04-08
DK2869841T3 (da) 2021-10-25
US20150209420A1 (en) 2015-07-30
HUE056675T2 (hu) 2022-02-28
CN104780937A (zh) 2015-07-15
JP6244358B2 (ja) 2017-12-06
CA2878367A1 (en) 2014-01-09
BR112014033077A2 (pt) 2017-08-01
US20240091338A1 (en) 2024-03-21
US20180256704A1 (en) 2018-09-13
WO2014006191A1 (en) 2014-01-09
IL236414A0 (en) 2015-02-26
AU2013285398A1 (en) 2015-02-05

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