MX2014004086A - Compuestos de pirrolopirimidina para el tratamiento del cancer. - Google Patents

Compuestos de pirrolopirimidina para el tratamiento del cancer.

Info

Publication number
MX2014004086A
MX2014004086A MX2014004086A MX2014004086A MX2014004086A MX 2014004086 A MX2014004086 A MX 2014004086A MX 2014004086 A MX2014004086 A MX 2014004086A MX 2014004086 A MX2014004086 A MX 2014004086A MX 2014004086 A MX2014004086 A MX 2014004086A
Authority
MX
Mexico
Prior art keywords
compound
alkyl
further characterized
cancer
mmol
Prior art date
Application number
MX2014004086A
Other languages
English (en)
Spanish (es)
Inventor
Xiaodong Wang
Jing Liu
Weihe Zhang
Stepen Frye
Dmitri Kireev
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Publication of MX2014004086A publication Critical patent/MX2014004086A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MX2014004086A 2011-10-03 2012-10-01 Compuestos de pirrolopirimidina para el tratamiento del cancer. MX2014004086A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161542392P 2011-10-03 2011-10-03
US201161547183P 2011-10-14 2011-10-14
PCT/US2012/058298 WO2013052417A1 (en) 2011-10-03 2012-10-01 Pyrrolopyrimidine compounds for the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2014004086A true MX2014004086A (es) 2014-09-22

Family

ID=48044101

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014004086A MX2014004086A (es) 2011-10-03 2012-10-01 Compuestos de pirrolopirimidina para el tratamiento del cancer.

Country Status (13)

Country Link
US (3) US9273056B2 (enExample)
EP (1) EP2763988B1 (enExample)
JP (2) JP2014532060A (enExample)
KR (1) KR102063098B1 (enExample)
CN (1) CN103958510B (enExample)
AU (1) AU2012318896B2 (enExample)
BR (1) BR112014007788A2 (enExample)
CA (1) CA2850617A1 (enExample)
ES (1) ES2650630T3 (enExample)
IL (1) IL231835A0 (enExample)
MX (1) MX2014004086A (enExample)
RU (1) RU2631655C2 (enExample)
WO (1) WO2013052417A1 (enExample)

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RU2014145121A (ru) 2012-05-22 2016-07-10 Зэ Юниверсити Оф Норд Каролина Эт Чапел Хилл Пиримидиновые соединения для лечения злокачественной опухоли
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US9771330B2 (en) 2012-11-27 2017-09-26 The University Of North Carolina At Chapel Hill Pyrimidine compounds for the treatment of cancer
US9649309B2 (en) 2014-04-11 2017-05-16 The University Of North Carolina At Chapel Hill Therapeutic uses of selected pyrimidine compounds with anti-Mer tyrosine kinase activity
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US10709708B2 (en) 2016-03-17 2020-07-14 The University Of North Carolina At Chapel Hill Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor
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CN112043710A (zh) * 2020-09-28 2020-12-08 广州智睿医药科技有限公司 一种治疗或预防与lrrk2激酶或异常lrrk2突变激酶活性相关疾病的药物
CN115073469B (zh) * 2021-03-15 2023-12-22 药雅科技(上海)有限公司 吡咯并嘧啶类化合物作为激酶抑制剂的制备及其应用
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Also Published As

Publication number Publication date
EP2763988A4 (en) 2015-06-03
US10179133B2 (en) 2019-01-15
US20140243315A1 (en) 2014-08-28
BR112014007788A2 (pt) 2017-04-18
RU2014115847A (ru) 2015-11-10
CN103958510A (zh) 2014-07-30
IL231835A0 (en) 2014-05-28
KR102063098B1 (ko) 2020-01-08
JP2017101043A (ja) 2017-06-08
RU2631655C2 (ru) 2017-09-26
KR20140095471A (ko) 2014-08-01
CN103958510B (zh) 2016-10-19
CA2850617A1 (en) 2013-04-11
EP2763988A1 (en) 2014-08-13
US9273056B2 (en) 2016-03-01
US20180104247A1 (en) 2018-04-19
EP2763988B1 (en) 2017-09-20
US9795606B2 (en) 2017-10-24
WO2013052417A1 (en) 2013-04-11
US20160151372A1 (en) 2016-06-02
JP6316925B2 (ja) 2018-04-25
AU2012318896B2 (en) 2017-03-02
JP2014532060A (ja) 2014-12-04
ES2650630T3 (es) 2018-01-19
HK1201256A1 (en) 2015-08-28
AU2012318896A1 (en) 2014-05-22

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