MX2013009377A - Metodos, sistemas y aparato para realizar citometrias de flujo. - Google Patents

Metodos, sistemas y aparato para realizar citometrias de flujo.

Info

Publication number
MX2013009377A
MX2013009377A MX2013009377A MX2013009377A MX2013009377A MX 2013009377 A MX2013009377 A MX 2013009377A MX 2013009377 A MX2013009377 A MX 2013009377A MX 2013009377 A MX2013009377 A MX 2013009377A MX 2013009377 A MX2013009377 A MX 2013009377A
Authority
MX
Mexico
Prior art keywords
sample
flow path
interrogation region
analyte
collector element
Prior art date
Application number
MX2013009377A
Other languages
English (en)
Other versions
MX338778B (es
Inventor
Mark Luscher
Randall Marks
Original Assignee
Microbix Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbix Biosystems Inc filed Critical Microbix Biosystems Inc
Publication of MX2013009377A publication Critical patent/MX2013009377A/es
Publication of MX338778B publication Critical patent/MX338778B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/0612—Germ cells sorting of gametes, e.g. according to sex or motility
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/061—Sperm cells, spermatogonia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N15/1436—Optical arrangements the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4915—Blood using flow cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Ecology (AREA)
  • Reproductive Health (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Un aparato para la detección de un analito en una muestra incluye una fuente de iluminación para generar energía electromagnética para iluminar la muestra en una región de interrogación, un elemento colector cóncavo que tiene un eje óptico y un punto focal, la región de interrogación coincide con el punto focal del elemento colector cóncavo, una celda de flujo cerrado que tiene una trayectoria de flujo definida entre una entrada de muestras y una salida de muestras, la trayectoria de flujo pasa a través de la región de interrogación y una región de clasificación dispuesta aguas abajo de la región de interrogación. La porción de la trayectoria de flujo que pasa a través de la región de interrogación está alineada coaxialmente con el eje óptico del elemento colector cóncavo. El aparato incluye además la muestra la cual comprende o se sospecha comprende el analito y circula en la trayectoria de flujo, donde el analito genera una señal detectable como respuesta a la iluminación. El aparato incluye además un detector para detectar la señal detectable.
MX2013009377A 2011-02-15 2012-02-15 Metodos, sistemas y aparato para realizar citometrias de flujo. MX338778B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161443178P 2011-02-15 2011-02-15
US201161443174P 2011-02-15 2011-02-15
US201161482504P 2011-05-04 2011-05-04
PCT/US2012/025176 WO2012112641A1 (en) 2011-02-15 2012-02-15 Methods, systems, and apparatus for performing flow cytometry

Publications (2)

Publication Number Publication Date
MX2013009377A true MX2013009377A (es) 2014-03-27
MX338778B MX338778B (es) 2016-05-02

Family

ID=45888465

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2013009377A MX338778B (es) 2011-02-15 2012-02-15 Metodos, sistemas y aparato para realizar citometrias de flujo.
MX2016016037A MX353585B (es) 2011-02-15 2012-02-15 Métodos, sistemas y aparato para realizar citometrías de flujo.
MX2015001617A MX346463B (es) 2011-02-15 2012-02-15 Métodos, sistemas y aparato para realizar citometrías de flujo.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2016016037A MX353585B (es) 2011-02-15 2012-02-15 Métodos, sistemas y aparato para realizar citometrías de flujo.
MX2015001617A MX346463B (es) 2011-02-15 2012-02-15 Métodos, sistemas y aparato para realizar citometrías de flujo.

Country Status (13)

Country Link
US (2) US9556416B2 (es)
EP (1) EP2676121A1 (es)
CN (1) CN103477203B (es)
AR (1) AR085246A1 (es)
AU (3) AU2012217757B2 (es)
BR (1) BR112013020636A2 (es)
CA (2) CA2826914C (es)
CO (1) CO6811818A2 (es)
MX (3) MX338778B (es)
RU (2) RU2708095C2 (es)
TW (1) TWI612287B (es)
UA (1) UA114173C2 (es)
WO (1) WO2012112641A1 (es)

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CN103477203A (zh) 2013-12-25
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AU2018200249B2 (en) 2020-03-05
AU2012217757A1 (en) 2013-08-29
RU2016118296A3 (es) 2019-10-01
AU2016201015A1 (en) 2016-03-10
US9556416B2 (en) 2017-01-31
TW201248133A (en) 2012-12-01
EP2676121A1 (en) 2013-12-25
AU2018200249A1 (en) 2018-02-15
MX338778B (es) 2016-05-02
RU2586406C2 (ru) 2016-06-10
AR085246A1 (es) 2013-09-18
CA2826914A1 (en) 2012-08-23
MX346463B (es) 2017-03-21
BR112013020636A2 (pt) 2017-09-05
CA2991625A1 (en) 2012-08-23
US20140030696A1 (en) 2014-01-30
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CO6811818A2 (es) 2013-12-16
RU2013138620A (ru) 2015-03-27
US10465163B2 (en) 2019-11-05
RU2708095C2 (ru) 2019-12-04
NZ614034A (en) 2015-04-24
CN103477203B (zh) 2019-11-22
US20170137780A1 (en) 2017-05-18
RU2016118296A (ru) 2018-10-29
WO2012112641A1 (en) 2012-08-23
UA114173C2 (uk) 2017-05-10
AU2012217757B2 (en) 2015-12-03
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MX353585B (es) 2018-01-19
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