MX2013008189A - Composiciones de alta penetracion y metodos para tratar lesiones en los tejidos inducidas por agentes patogenos. - Google Patents

Composiciones de alta penetracion y metodos para tratar lesiones en los tejidos inducidas por agentes patogenos.

Info

Publication number
MX2013008189A
MX2013008189A MX2013008189A MX2013008189A MX2013008189A MX 2013008189 A MX2013008189 A MX 2013008189A MX 2013008189 A MX2013008189 A MX 2013008189A MX 2013008189 A MX2013008189 A MX 2013008189A MX 2013008189 A MX2013008189 A MX 2013008189A
Authority
MX
Mexico
Prior art keywords
methods
treatment
benzocaine
compositions
treatment composition
Prior art date
Application number
MX2013008189A
Other languages
English (en)
Other versions
MX336765B (es
Inventor
B Ron Johnson
James P Mccarthy
Original Assignee
Quadex Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quadex Pharmaceuticals Llc filed Critical Quadex Pharmaceuticals Llc
Publication of MX2013008189A publication Critical patent/MX2013008189A/es
Publication of MX336765B publication Critical patent/MX336765B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Anesthesiology (AREA)
  • Virology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Composiciones y métodos para tratar trastornos en tejidos, tales como los ocasionados por agentes patógenos y/o toxinas. Las composiciones de tratamiento incluyen un agente antiinfeccioso activo, un portador líquido y benzocaína en cantidad suficiente para que la composición de tratamiento penetre más rápidamente en el tejido con trastorno en comparación con la misma composición de tratamiento en ausencia de la benzocaína. Además, la benzocaína puede aumentar el tiempo de contacto del agente antiinfeccioso activo en el área de tratamiento. El agente antiinfeccioso activo preferido puede ser un organohaluro, tal como un compuesto haluro de amonio cuaternario, un ejemplo del cual es el cloruro de benzalconio. Las composiciones y los métodos de tratamiento pueden utilizar un aplicador adaptado para su uso en la promoción de la penetración de la composición de tratamiento y/o la agitación del tejido con trastorno para incrementar aún más la penetración.
MX2013008189A 2011-01-24 2012-01-19 Composiciones de alta penetracion y metodos para tratar lesiones en los tejidos inducidas por agentes patogenos. MX336765B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/012,719 US8846725B2 (en) 2011-01-24 2011-01-24 Highly penetrating compositions and methods for treating pathogen-induced disordered tissues
PCT/US2012/021877 WO2012102936A1 (en) 2011-01-24 2012-01-19 Highly penetrating compositions and methods for treating pathogen-induced disordered tissues

Publications (2)

Publication Number Publication Date
MX2013008189A true MX2013008189A (es) 2013-08-21
MX336765B MX336765B (es) 2016-01-29

Family

ID=45563563

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008189A MX336765B (es) 2011-01-24 2012-01-19 Composiciones de alta penetracion y metodos para tratar lesiones en los tejidos inducidas por agentes patogenos.

Country Status (12)

Country Link
US (4) US8846725B2 (es)
EP (1) EP2667865A1 (es)
JP (1) JP6039584B2 (es)
KR (2) KR20140005996A (es)
AU (1) AU2012209412B2 (es)
BR (1) BR112013018901A2 (es)
CA (1) CA2824766A1 (es)
IL (1) IL227566A0 (es)
MX (1) MX336765B (es)
RU (1) RU2586969C2 (es)
TW (1) TWI503133B (es)
WO (1) WO2012102936A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8846725B2 (en) 2011-01-24 2014-09-30 Quadex Pharmaceuticals, Llc Highly penetrating compositions and methods for treating pathogen-induced disordered tissues
US9125911B2 (en) * 2013-03-14 2015-09-08 Quadex Pharmaceuticals, Llc Combined systemic and topical treatment of disordered tissues
US9463180B2 (en) 2013-03-14 2016-10-11 Quadex Pharmaceuticals, Llc Treatment of molluscum contagiosum
US9549930B2 (en) 2013-03-14 2017-01-24 Quadex Pharmaceuticals, Llc Combined systemic and topical treatment of disordered and/or prodromal stage tissue
US11759418B1 (en) * 2016-07-15 2023-09-19 Chrism Products, Inc. Composition for treating wounds, dermatitis, inflammation, and irritation
EP3585226A4 (en) * 2017-02-22 2020-11-18 Dermal Biomics, Inc. NON-WOVEN WIPES, CLEANING COMPOSITIONS AND RELATED PACKAGING
US10478407B2 (en) 2018-02-23 2019-11-19 The Administrators Of The Tulane Educational Fund Pharmaceutical composition for viral infections

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US4199574A (en) 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
GB1574302A (en) 1977-06-27 1980-09-03 Scherico Ltd Stable sprayable anesthetic solution
US4176197A (en) 1978-02-03 1979-11-27 Dominion Pharmacal, Inc. Method for treating acne vulgaris
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Also Published As

Publication number Publication date
TW201309342A (zh) 2013-03-01
US20180028666A1 (en) 2018-02-01
US8846725B2 (en) 2014-09-30
US20140364496A1 (en) 2014-12-11
US20120190715A1 (en) 2012-07-26
EP2667865A1 (en) 2013-12-04
US9314526B2 (en) 2016-04-19
KR20180077306A (ko) 2018-07-06
BR112013018901A2 (pt) 2017-03-28
AU2012209412B2 (en) 2016-09-15
RU2586969C2 (ru) 2016-06-10
MX336765B (es) 2016-01-29
KR20140005996A (ko) 2014-01-15
JP2014503603A (ja) 2014-02-13
RU2013139163A (ru) 2015-03-10
US20140364495A1 (en) 2014-12-11
IL227566A0 (en) 2013-09-30
CA2824766A1 (en) 2012-08-02
NZ613262A (en) 2015-10-30
WO2012102936A1 (en) 2012-08-02
TWI503133B (zh) 2015-10-11
JP6039584B2 (ja) 2016-12-07

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