MX2013005751A - Quinazolincarboxamida azetidinas. - Google Patents

Quinazolincarboxamida azetidinas.

Info

Publication number
MX2013005751A
MX2013005751A MX2013005751A MX2013005751A MX2013005751A MX 2013005751 A MX2013005751 A MX 2013005751A MX 2013005751 A MX2013005751 A MX 2013005751A MX 2013005751 A MX2013005751 A MX 2013005751A MX 2013005751 A MX2013005751 A MX 2013005751A
Authority
MX
Mexico
Prior art keywords
azetidines
quinazoline carboxamide
quinazoline
carboxamide
cancer
Prior art date
Application number
MX2013005751A
Other languages
English (en)
Other versions
MX355325B (es
Inventor
Donald Bankston
Bayard R Huck
Andreas Goutopoulos
Constantin Neagu
Reinaldo Jones
Yufang Xiao
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2013005751A publication Critical patent/MX2013005751A/es
Publication of MX355325B publication Critical patent/MX355325B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención proporciona nuevos compuestos de quinazolincarboxamida azetidina de acuerdo con la fórmula (I) y su uso para el tratamiento de enfermedades hiperproliferativas tales como el cáncer.
MX2013005751A 2010-11-24 2011-11-11 Quinazolincarboxamida azetidinas. MX355325B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41713110P 2010-11-24 2010-11-24
PCT/EP2011/005691 WO2012069146A1 (en) 2010-11-24 2011-11-11 Quinazoline carboxamide azetidines

Publications (2)

Publication Number Publication Date
MX2013005751A true MX2013005751A (es) 2013-08-01
MX355325B MX355325B (es) 2018-04-16

Family

ID=45001695

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005751A MX355325B (es) 2010-11-24 2011-11-11 Quinazolincarboxamida azetidinas.

Country Status (31)

Country Link
US (1) US8946247B2 (es)
EP (1) EP2643313B9 (es)
JP (1) JP5897590B2 (es)
KR (1) KR101894116B1 (es)
CN (1) CN103228649B (es)
AR (1) AR093725A1 (es)
AU (1) AU2011334173B2 (es)
BR (1) BR112013012488B1 (es)
CA (1) CA2818706C (es)
CL (1) CL2013001459A1 (es)
CO (1) CO6721019A2 (es)
DK (1) DK2643313T3 (es)
EA (1) EA023821B1 (es)
ES (1) ES2594404T3 (es)
HK (1) HK1188444A1 (es)
HR (1) HRP20161183T1 (es)
HU (1) HUE028967T2 (es)
IL (1) IL226233A (es)
LT (1) LT2643313T (es)
MX (1) MX355325B (es)
MY (1) MY186456A (es)
NZ (1) NZ612224A (es)
PE (1) PE20140966A1 (es)
PL (1) PL2643313T3 (es)
PT (1) PT2643313T (es)
RS (1) RS55204B1 (es)
SG (1) SG190318A1 (es)
SI (1) SI2643313T1 (es)
UA (1) UA112167C2 (es)
WO (1) WO2012069146A1 (es)
ZA (1) ZA201304637B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101992505B1 (ko) 2011-09-12 2019-06-24 메르크 파텐트 게엠베하 키나아제 활성의 조절제로서 용도를 위한 아미노피리미딘 유도체
CN104080782B (zh) 2011-09-12 2016-06-01 默克专利有限公司 用作激酶活性调节剂的咪唑胺
CN110078743A (zh) 2012-11-16 2019-08-02 默克专利有限公司 用作激酶活性调节剂的新颖的咪唑-哌啶基衍生物
CA2890288A1 (en) 2012-11-16 2014-05-22 Merck Patent Gmbh Novel heterocyclic derivatives as modulators of kinase activity
NZ706418A (en) 2012-11-29 2019-09-27 Merck Patent Gmbh Azaquinazoline carboxamide derivatives
MX370448B (es) 2013-03-11 2019-12-13 Merck Patent Gmbh Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa.
ES2768900T3 (es) * 2014-04-03 2020-06-24 Merck Patent Gmbh Combinaciones de agentes terapéuticos contra cáncer
EP3229796B1 (en) * 2014-12-11 2023-03-01 Merck Patent GmbH Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a quinazoline derivative
US20190054110A1 (en) * 2016-02-16 2019-02-21 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Modulators of ccr9 for treating tumor resistance to immune responses
EP3416640A1 (en) * 2016-02-16 2018-12-26 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Modulators of tumor immune resistance for the treatment of cancer
US20210017174A1 (en) 2018-03-07 2021-01-21 Bayer Aktiengesellschaft Identification and use of erk5 inhibitor
WO2021094209A1 (en) 2019-11-12 2021-05-20 Bayer Aktiengesellschaft Substituted pyrrolo triazine carboxamide derivatives as prostaglandin ep3 receptor antagonists
KR20230110296A (ko) 2020-11-16 2023-07-21 메르크 파텐트 게엠베하 암 치료를 위한 키나제 억제제 조합
US11866421B2 (en) * 2021-05-31 2024-01-09 Epigen Biosciences, Inc. Pyrimidine and pyridine amine compounds and usage thereof in disease treatment
WO2024033513A1 (en) 2022-08-11 2024-02-15 Diaccurate Compounds for treating cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200306819A (en) 2002-01-25 2003-12-01 Vertex Pharma Indazole compounds useful as protein kinase inhibitors
AU2003252314A1 (en) * 2002-08-09 2004-02-25 Kyorin Pharmaceutical Co., Ltd. 4-substituted quinazoline-8-carboxyamide derivative and pharmaceutically acceptable addition salt thereof
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
CA2522595A1 (en) 2003-04-03 2004-10-28 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
WO2005033086A1 (en) 2003-09-30 2005-04-14 Irm Llc Compounds and compositions as protein kinase inhibitors
CA2541989C (en) 2003-10-24 2013-10-01 Exelixis, Inc. P70s6 kinase modulators and method of use
KR20060117329A (ko) 2003-11-21 2006-11-16 노파르티스 아게 단백질 키나제 저해제로서의 1ｈ-이미다조퀴놀린 유도체
TR200808208T1 (tr) 2003-12-09 2008-12-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bir immün tepkinin bastırılması veya proliferatif bir hastalığın tedavisi
CA2563699C (en) 2004-04-23 2014-03-25 Exelixis, Inc. Kinase modulators and method of use
JP5274842B2 (ja) 2004-12-28 2013-08-28 エグゼリクシス， インコーポレイテッド 免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物
GB0501999D0 (en) 2005-02-01 2005-03-09 Sentinel Oncology Ltd Pharmaceutical compounds
JP2008546751A (ja) 2005-06-22 2008-12-25 アステックス・セラピューティクス・リミテッド 医薬組成物
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Also Published As

Publication number Publication date
IL226233A (en) 2017-07-31
HRP20161183T1 (hr) 2016-11-04
HUE028967T2 (en) 2017-01-30
MX355325B (es) 2018-04-16
ZA201304637B (en) 2014-03-26
MY186456A (en) 2021-07-22
EA023821B1 (ru) 2016-07-29
CO6721019A2 (es) 2013-07-31
HK1188444A1 (zh) 2014-05-02
LT2643313T (lt) 2016-10-25
JP2013544257A (ja) 2013-12-12
SI2643313T1 (sl) 2016-11-30
PE20140966A1 (es) 2014-08-06
JP5897590B2 (ja) 2016-03-30
BR112013012488B1 (pt) 2021-08-31
BR112013012488A2 (pt) 2016-07-19
EA201300610A1 (ru) 2013-12-30
CL2013001459A1 (es) 2013-12-27
CN103228649B (zh) 2015-11-25
PT2643313T (pt) 2016-10-11
EP2643313A1 (en) 2013-10-02
NZ612224A (en) 2015-01-30
KR20130130753A (ko) 2013-12-02
IL226233A0 (en) 2013-07-31
AU2011334173A1 (en) 2013-05-02
CN103228649A (zh) 2013-07-31
EP2643313B9 (en) 2017-02-22
KR101894116B1 (ko) 2018-08-31
EP2643313B1 (en) 2016-06-29
UA112167C2 (uk) 2016-08-10
WO2012069146A1 (en) 2012-05-31
CA2818706C (en) 2019-07-23
CA2818706A1 (en) 2012-05-31
ES2594404T3 (es) 2016-12-20
AR093725A1 (es) 2015-06-24
PL2643313T3 (pl) 2017-03-31
DK2643313T3 (en) 2016-10-24
SG190318A1 (en) 2013-06-28
US20130252942A1 (en) 2013-09-26
AU2011334173B2 (en) 2015-07-16
US8946247B2 (en) 2015-02-03
RS55204B1 (sr) 2017-01-31

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