MX2013005200A - Derivados de acido hidroxamico y su so en el tratamiento de infecciones bacterianas. - Google Patents

Derivados de acido hidroxamico y su so en el tratamiento de infecciones bacterianas.

Info

Publication number
MX2013005200A
MX2013005200A MX2013005200A MX2013005200A MX2013005200A MX 2013005200 A MX2013005200 A MX 2013005200A MX 2013005200 A MX2013005200 A MX 2013005200A MX 2013005200 A MX2013005200 A MX 2013005200A MX 2013005200 A MX2013005200 A MX 2013005200A
Authority
MX
Mexico
Prior art keywords
hydroxymethyl
methyl
diinyl
buta
hydroxyamino
Prior art date
Application number
MX2013005200A
Other languages
English (en)
Spanish (es)
Inventor
Ramesh Kasar
James Bradley Aggen
Martin Sheringham Linsell
Qing Jane Lu
Dan Wang
Tim Church
Heinz E Moser
Phillip A Patten
Original Assignee
Achaogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achaogen Inc filed Critical Achaogen Inc
Publication of MX2013005200A publication Critical patent/MX2013005200A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MX2013005200A 2010-11-10 2011-11-04 Derivados de acido hidroxamico y su so en el tratamiento de infecciones bacterianas. MX2013005200A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41231110P 2010-11-10 2010-11-10
PCT/US2011/059280 WO2012154204A1 (en) 2010-11-10 2011-11-04 Hydroxamic acid derivatives and their use in the treatment of bacterial infections

Publications (1)

Publication Number Publication Date
MX2013005200A true MX2013005200A (es) 2013-06-28

Family

ID=46317476

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005200A MX2013005200A (es) 2010-11-10 2011-11-04 Derivados de acido hidroxamico y su so en el tratamiento de infecciones bacterianas.

Country Status (14)

Country Link
EP (1) EP2638006A1 (zh)
JP (1) JP2014501716A (zh)
KR (1) KR20140023869A (zh)
CN (1) CN103298780A (zh)
AR (1) AR083760A1 (zh)
AU (1) AU2011367819A1 (zh)
BR (1) BR112013011693A2 (zh)
CA (1) CA2817211A1 (zh)
EA (1) EA201390626A1 (zh)
IL (1) IL226270A0 (zh)
MX (1) MX2013005200A (zh)
SG (1) SG190243A1 (zh)
TW (1) TW201249786A (zh)
WO (1) WO2012154204A1 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107021895A (zh) 2007-06-12 2017-08-08 尔察祯有限公司 抗菌剂
EP2847162A1 (en) * 2012-05-09 2015-03-18 Achaogen, Inc. Antibacterial agents
EP2847168A1 (en) 2012-05-10 2015-03-18 Achaogen, Inc. Antibacterial agents
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
TR201807881T4 (tr) 2013-12-19 2018-06-21 Idorsia Pharmaceuticals Ltd Antibakteriyel 1h-ındazol ve 1h-ındol türevleri.
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
US9539305B1 (en) 2014-03-14 2017-01-10 Fleurir Abx Llc Pristinamycin compositions, LpxC compositions, their improvements, and combinations thereof
AR100428A1 (es) 2014-05-16 2016-10-05 Actelion Pharmaceuticals Ltd Derivados antibacterianos quinazolina-4(3h)-ona
CN107001300A (zh) 2014-11-19 2017-08-01 埃科特莱茵药品有限公司 抗菌性苯并噻唑衍生物
LT3233843T (lt) 2014-12-16 2019-12-10 Novartis Ag Izoksazolo hidroksamido rūgšties junginiai, kaip lpxc inhibitoriai
ES2961564T3 (es) 2016-04-25 2024-03-12 Univ Duke Derivados de benzoilglicina y métodos de preparación y uso de los mismos
ES2820502T3 (es) 2016-06-14 2021-04-21 Novartis Ag Forma cristalina de (R)-4-(5-(ciclopropiletilinil)isoxazol-3-il)-N-hidroxi-2-metil-2-(metilsulfonil)butanamida como agente antibacteriano
WO2017223349A1 (en) 2016-06-23 2017-12-28 Achaogen, Inc. Antibacterial agents
BR112020016270A2 (pt) * 2018-02-10 2020-12-15 Kbp Biosciences Co., Ltd. Composto atuando como antibióticos
CN110563611B (zh) * 2019-09-19 2021-02-02 中国医学科学院医药生物技术研究所 一种异羟肟酸类衍生物及其制备方法和应用
CN113957098A (zh) * 2021-09-13 2022-01-21 湖南工业大学 普罗威登斯属细菌菌株在制备二价锰氧化剂中的应用
CN116730870B (zh) * 2023-08-08 2023-10-13 中国医学科学院医药生物技术研究所 异羟肟酸类化合物或其可药用盐、及其用途和制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925659A (en) 1996-05-07 1999-07-20 Merck & Co., Inc. Antibacterial agents
WO1998018754A1 (en) 1996-10-28 1998-05-07 Versicor, Inc. Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
JP2002541197A (ja) 1999-04-09 2002-12-03 ブリティッシュ バイオテック ファーマシューティカルズ リミテッド 抗菌剤
EP2295402B1 (en) * 2003-01-08 2015-08-12 The University of Washington Antibacterial agents
DE102006032709A1 (de) 2006-07-14 2008-01-17 BSH Bosch und Siemens Hausgeräte GmbH Luftschallgedämmte Lebensmittelmühle
CN101209974A (zh) * 2006-12-31 2008-07-02 天津药物研究院 异羟肟酸类衍生物及其用途
CN107021895A (zh) * 2007-06-12 2017-08-08 尔察祯有限公司 抗菌剂
WO2011005355A1 (en) * 2009-05-07 2011-01-13 Achaogen, Inc. Combinations comprising a lpxc inhibitor and an antibiotic for use in the treatment of infections caused by gram-negative bacteria
SI2562155T1 (sl) * 2010-04-20 2019-08-30 Fujifilm Toyama Chemical Co., Ltd. Derivat hidroksamske kisline

Also Published As

Publication number Publication date
KR20140023869A (ko) 2014-02-27
AU2011367819A1 (en) 2013-05-02
JP2014501716A (ja) 2014-01-23
IL226270A0 (en) 2013-07-31
CA2817211A1 (en) 2012-11-15
AR083760A1 (es) 2013-03-20
TW201249786A (en) 2012-12-16
EA201390626A1 (ru) 2013-12-30
WO2012154204A1 (en) 2012-11-15
SG190243A1 (en) 2013-06-28
BR112013011693A2 (pt) 2016-08-09
CN103298780A (zh) 2013-09-11
EP2638006A1 (en) 2013-09-18

Similar Documents

Publication Publication Date Title
MX2013005200A (es) Derivados de acido hidroxamico y su so en el tratamiento de infecciones bacterianas.
US9701622B2 (en) Antibacterial agents
TWI574941B (zh) 抗菌劑
JP5550650B2 (ja) 細菌感染症処置に適用するための有機化合物
CA2819880C (en) Substituted 1-benzylcycloalkylcarboxlic acids and use thereof
WO2014165075A1 (en) Antibacterial agents
JP6715772B2 (ja) １２−ｅｐｉ−プロイロムチリン
TW201100076A (en) Substituted aminopropionic derivatives as neprilysin inhibitors
BG107229A (bg) Циклопентил-заместени глутарамидни производни като инхибитори на неутрална ендопептидаза
US20150175530A1 (en) Antibacterial agents
US9303027B2 (en) Kappa opioid receptor agonists
KR20180111776A (ko) 마크로시클릭 광범위 항생제
WO2013039947A1 (en) Polymorphs of n-((s)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1r,2r)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide
TW201319036A (zh) 苯基衍生物
HUE035856T2 (hu) Fluor-helyettesített (3R,4R,5S)-5-guanidino-4-acilamino-3-(pentán-3-iloxi)ciklohexén-1-karbonsavak, azok észterei és azok alkalmazási módszerei
JP2013534917A (ja) 自己免疫障害、アレルギー、及び慢性疼痛状態、等の治療に有用な新規カテプシンｓプロテアーゼ阻害剤
JP2013028536A (ja) 環状アミン−１−カルボン酸エステル誘導体およびそれを含有する医薬組成物
JP2794341B2 (ja) シクロアルキルヒドロキシ尿素類及びそれらのリポキシゲナーゼ阻害物質としての用途

Legal Events

Date Code Title Description
FA Abandonment or withdrawal