MX2013001427A - 2-sustituido-8-alquil-7-oxo-7,8-dihidropirido[2,3-d]pirimidina-6- carbonitrilos y sus usos. - Google Patents
2-sustituido-8-alquil-7-oxo-7,8-dihidropirido[2,3-d]pirimidina-6- carbonitrilos y sus usos.Info
- Publication number
- MX2013001427A MX2013001427A MX2013001427A MX2013001427A MX2013001427A MX 2013001427 A MX2013001427 A MX 2013001427A MX 2013001427 A MX2013001427 A MX 2013001427A MX 2013001427 A MX2013001427 A MX 2013001427A MX 2013001427 A MX2013001427 A MX 2013001427A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- formula
- cancer
- further characterized
- pyrimidine
- Prior art date
Links
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37094610P | 2010-08-05 | 2010-08-05 | |
| PCT/US2011/044807 WO2012018540A1 (en) | 2010-08-05 | 2011-07-21 | 2-substituted-8-alkyl-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidine-6-carbonitriles and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2013001427A true MX2013001427A (es) | 2013-06-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| MX2013001427A MX2013001427A (es) | 2010-08-05 | 2011-07-21 | 2-sustituido-8-alquil-7-oxo-7,8-dihidropirido[2,3-d]pirimidina-6- carbonitrilos y sus usos. |
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| EP (1) | EP2600719B1 (enExample) |
| JP (1) | JP5512894B2 (enExample) |
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| BR (1) | BR112013002375B1 (enExample) |
| CA (1) | CA2807498C (enExample) |
| DK (1) | DK2600719T3 (enExample) |
| EA (1) | EA022527B1 (enExample) |
| ES (1) | ES2525866T3 (enExample) |
| IL (1) | IL224555A (enExample) |
| MX (1) | MX2013001427A (enExample) |
| NZ (1) | NZ606281A (enExample) |
| PL (1) | PL2600719T3 (enExample) |
| PT (1) | PT2600719E (enExample) |
| WO (1) | WO2012018540A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA022527B1 (ru) * | 2010-08-05 | 2016-01-29 | Темпл Юниверсити - Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | 2-ЗАМЕЩЕННЫЕ-8-АЛКИЛ-7-ОКСО-7,8-ДИГИДРОПИРИДО[2,3-d]ПИРИМИДИН-6-КАРБОНИТРИЛЫ И ИХ ПРИМЕНЕНИЕ |
| WO2014031571A1 (en) * | 2012-08-21 | 2014-02-27 | Icahn School Of Medicine At Mount Sinai | Treatment of viral infections |
| EP2968331B1 (en) | 2013-03-14 | 2020-07-01 | Icahn School of Medicine at Mount Sinai | Pyrimidine compounds as kinase inhibitors |
| CA2946538A1 (en) | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| WO2016015597A1 (en) | 2014-07-26 | 2016-02-04 | Sunshine Lake Pharma Co., Ltd. | Compounds as cdk small-molecule inhibitors and uses thereof |
| CN104447739B (zh) * | 2014-11-07 | 2016-02-17 | 郑州泰基鸿诺药物科技有限公司 | 一种氘代Palbociclib衍生物、制备方法及应用 |
| CN104447743B (zh) * | 2014-11-26 | 2016-03-02 | 苏州明锐医药科技有限公司 | 帕博西尼的制备方法 |
| CN104496983B (zh) | 2014-11-26 | 2016-06-08 | 苏州明锐医药科技有限公司 | 一种帕博西尼的制备方法 |
| CN104478874B (zh) * | 2014-12-08 | 2016-03-02 | 新发药业有限公司 | 一种帕博赛布的制备方法 |
| CN104610254B (zh) * | 2015-01-26 | 2017-02-01 | 新发药业有限公司 | 一种帕博赛布的低成本制备方法 |
| CN105111205B (zh) * | 2015-09-12 | 2017-01-04 | 山东罗欣药业集团股份有限公司 | 一种帕博西尼的制备方法 |
| CN110382495B (zh) | 2016-12-16 | 2022-04-05 | 基石药业（苏州）有限公司 | Cdk4/6抑制剂 |
| MA51846A (fr) | 2018-02-15 | 2021-04-21 | Nuvation Bio Inc | Composés hétérocycliques utilisés en tant qu'inhibiteurs de kinases |
| KR102286701B1 (ko) * | 2018-09-28 | 2021-08-06 | 재단법인 대구경북첨단의료산업진흥재단 | 피리도[2,3-d]피리미딘 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 |
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| TWI818930B (zh) * | 2018-11-12 | 2023-10-21 | 美商昂可諾法治療股份有限公司 | 8-環戊基-7-側氧基-2-(4-哌嗪-1-基-苯基胺基)-7,8-二氫-吡啶[2,3-d]嘧啶-6-氰基及其用於治療增生性疾病的用途 |
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| CA2659746A1 (en) | 2006-08-02 | 2008-02-07 | Temple University - Of The Commonwealth System Of Higher Education | Aryl vinyl sulfides, sulfones, sulfoxides and sulfonamides, derivatives thereof and therapeutic uses thereof |
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| KR101754664B1 (ko) | 2009-12-18 | 2017-07-06 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 치환된 피리도〔2,3-ｄ〕피리미딘-7(8ｈ)-온스 및 이의 치료 용도 |
| EA022527B1 (ru) * | 2010-08-05 | 2016-01-29 | Темпл Юниверсити - Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн | 2-ЗАМЕЩЕННЫЕ-8-АЛКИЛ-7-ОКСО-7,8-ДИГИДРОПИРИДО[2,3-d]ПИРИМИДИН-6-КАРБОНИТРИЛЫ И ИХ ПРИМЕНЕНИЕ |
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| BR112013002375B1 (pt) | 2020-05-12 |
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