MX2012014443A - Composiciones oftalmicas para la administracion de ingredientes activos liposolubles. - Google Patents

Composiciones oftalmicas para la administracion de ingredientes activos liposolubles.

Info

Publication number
MX2012014443A
MX2012014443A MX2012014443A MX2012014443A MX2012014443A MX 2012014443 A MX2012014443 A MX 2012014443A MX 2012014443 A MX2012014443 A MX 2012014443A MX 2012014443 A MX2012014443 A MX 2012014443A MX 2012014443 A MX2012014443 A MX 2012014443A
Authority
MX
Mexico
Prior art keywords
liposoluble
compositions
aqueous phase
administration
ophthalmic compositions
Prior art date
Application number
MX2012014443A
Other languages
English (en)
Inventor
Danilo Aleo
Sergio Mangiafico
Melina Cro
Maria Grazia Antonietta Saita
Original Assignee
Medivis S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivis S R L filed Critical Medivis S R L
Publication of MX2012014443A publication Critical patent/MX2012014443A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a composiciones farmacéuticas oftálmicas en microemulsión capaz de portar ingredientes activos liposolubles o pobremente solubles en agua, que contienen un agente emulsificante que consiste de un succinato de polietilenglicol d-a-tocoferílico 1000 (TPGS), un componente oleoso que consiste de triglicéridos de cadena media (MCT) y una fase acuosa oftalmológicamente aceptable. La invención además se refiere a composiciones oftálmicas para usar un sustituto de lágrimas, formulado similarmente a las composiciones previas pero sin un ingrediente farmacéuticamente activo y que contiene, en la fase acuosa, polímeros de polisacáridos o derivados de celulosa conocidos como componentes para lágrimas artificiales, las preparaciones descritas son sistemas auto-emulsionantes (SMEDDS) caracterizados por una alta estabilidad y por una concentración particularmente baja de agente tensioactivo y son adecuadas para administración ocular tópica.
MX2012014443A 2010-06-11 2011-06-13 Composiciones oftalmicas para la administracion de ingredientes activos liposolubles. MX2012014443A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2010A000322A IT1404931B1 (it) 2010-06-11 2010-06-11 Composizioni oftalmiche per la somministrazione di principi attivi liposolubili .
PCT/IT2011/000196 WO2011154985A1 (en) 2010-06-11 2011-06-13 Ophthalmic compositions for the administration of liposoluble acitve ingredients

Publications (1)

Publication Number Publication Date
MX2012014443A true MX2012014443A (es) 2013-05-01

Family

ID=43740390

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012014443A MX2012014443A (es) 2010-06-11 2011-06-13 Composiciones oftalmicas para la administracion de ingredientes activos liposolubles.

Country Status (8)

Country Link
US (1) US20130108674A1 (es)
EP (1) EP2579845B1 (es)
CN (1) CN103079543A (es)
CA (1) CA2802162A1 (es)
IT (1) IT1404931B1 (es)
MX (1) MX2012014443A (es)
RU (1) RU2013100984A (es)
WO (1) WO2011154985A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013179253A1 (en) * 2012-06-02 2013-12-05 Micro Labs Limited Dose combination comprising nsaid and steroidal anti-inflammatory agent for treating post operative ocular inflammation
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
RU2746083C2 (ru) 2015-03-05 2021-04-06 Аллерган, Инк. Самоэмульгирующиеся системы доставки лекарств (sedds) для доставки офтальмологического лекарства
KR101635915B1 (ko) * 2016-02-15 2016-07-04 삼천당제약주식회사 사이클로스포린과 히알루론산 또는 이의 염을 포함하는 수용액 형태의 안과용 조성물
ITUA20162425A1 (it) * 2016-04-08 2017-10-08 Medivis S R L Composizione oftalmica che comprende PVP-I
GB2550346B (en) * 2016-05-13 2021-02-24 Phytoceutical Ltd Micelles
PT3266446T (pt) * 2016-07-07 2019-01-30 Salvat Lab Sa Composição oftálmica compreendendo óleo de rícino e triglicérido de cadeia média
WO2019043723A1 (en) * 2017-08-30 2019-03-07 Tathagata Dutta EMULSIONS FOR OPHTHALMIC ADMINISTRATION OF ANTIOXIDANTS
DK3673896T3 (da) * 2018-12-28 2022-02-07 Dr Rolf Lambert Pharma Consulting Gmbh Liposomal øjendråbeopløsning og anvendelser deraf til behandling af tørre øjne.
CN114245737A (zh) 2019-06-11 2022-03-25 司斐股份有限公司 微乳剂组合物
CN110237233B (zh) * 2019-07-30 2021-01-15 沈阳兴齐眼药股份有限公司 一种含有环孢素的眼用药物组合物、其制备方法及用途
WO2021119822A1 (en) * 2019-12-18 2021-06-24 National Research Council Of Canada Emulsions of bioactive lipophilic compounds including oils
IT202000015583A1 (it) * 2020-06-30 2021-12-30 Iromed Group S R L Composizione oftalmica
IT202100006839A1 (it) 2021-03-22 2022-09-22 Omisan Farm S R L Preparato topico oftalmico idrosolubile contenente luteina e relativo metodo di produzione
CN113750043A (zh) * 2021-09-18 2021-12-07 山东省药学科学院 一种塞来昔布自乳化口服液及其制备方法
DE102021212692A1 (de) * 2021-11-11 2023-05-11 Ursapharm Arzneimittel Gmbh Selbstemulgierende öl-in wasser-mikro- oder nanoemulsion so-wie emulgierende zusammensetzung
CN114601798B (zh) * 2022-03-23 2023-08-25 北京电子科技职业学院 含天然产物的眼用纳米脂肪乳及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2013755C (en) 1989-04-05 1993-11-30 Simon Benita Medicinal emulsions
CA2166722A1 (en) 1994-05-06 1995-11-16 Manoj L. Maniar Use of vitamin e tocopheryl derivatives in ophthalmic compositions
EP0825849A1 (en) * 1995-05-19 1998-03-04 Abbott Laboratories Self-emulsifying formulations of lipophilic drugs
US6479540B1 (en) * 1999-09-27 2002-11-12 Sonus Pharmaceuticals, Inc. Compositions of tocol-soluble therapeutics
CN1274294C (zh) * 2001-10-19 2006-09-13 伊索泰克尼卡股份有限公司 环孢菌素类似物微乳液预浓缩物
US20040185068A1 (en) * 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
DE602004023106D1 (de) * 2003-11-07 2009-10-22 Senju Pharma Co Pharmazeutische zusammensetzung mit prostaglandin
AU2005304035B2 (en) 2004-11-09 2010-07-22 Santen Sas Ophthalmic oil-in-water type emulsion with stable positive zeta potential
EP2129364B1 (en) * 2006-12-21 2020-04-15 Santen SAS Process for manufacturing ophthalmic oil-in-water emulsions
CN101918019B (zh) 2007-10-08 2014-11-26 奥里尼亚制药有限公司 包含钙调神经磷酸酶抑制剂或mTOR抑制剂的眼科组合物
WO2010045292A2 (en) * 2008-10-15 2010-04-22 The University Of North Carolina At Chapel Hill Nanoparticle compositions comprising liquid oil cores
EP2504351A4 (en) * 2009-11-23 2013-10-30 Palatin Technologies Inc MELANOCORTIN-1 RECEPTOR-SPECIFIC LINEAR PEPTIDE

Also Published As

Publication number Publication date
IT1404931B1 (it) 2013-12-09
WO2011154985A1 (en) 2011-12-15
CN103079543A (zh) 2013-05-01
US20130108674A1 (en) 2013-05-02
EP2579845B1 (en) 2020-04-29
EP2579845A1 (en) 2013-04-17
CA2802162A1 (en) 2011-12-15
RU2013100984A (ru) 2014-08-20
ITRM20100322A1 (it) 2011-12-12

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