MX2012004995A - Piridinas biciclicas y analogos como moduladores de sirtuina. - Google Patents
Piridinas biciclicas y analogos como moduladores de sirtuina.Info
- Publication number
- MX2012004995A MX2012004995A MX2012004995A MX2012004995A MX2012004995A MX 2012004995 A MX2012004995 A MX 2012004995A MX 2012004995 A MX2012004995 A MX 2012004995A MX 2012004995 A MX2012004995 A MX 2012004995A MX 2012004995 A MX2012004995 A MX 2012004995A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- substituted
- fluoro
- sirtuin
- compound
- Prior art date
Links
- -1 Bicyclic pyridines Chemical class 0.000 title claims description 176
- 102000011990 Sirtuin Human genes 0.000 title description 354
- 108050002485 Sirtuin Proteins 0.000 title description 354
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- 125000000217 alkyl group Chemical group 0.000 claims description 224
- 125000000623 heterocyclic group Chemical group 0.000 claims description 82
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 46
- 229910052757 nitrogen Inorganic materials 0.000 claims description 45
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 41
- 239000001257 hydrogen Substances 0.000 claims description 36
- 229910052739 hydrogen Inorganic materials 0.000 claims description 36
- 125000001424 substituent group Chemical group 0.000 claims description 36
- 125000005843 halogen group Chemical group 0.000 claims description 33
- 150000003839 salts Chemical class 0.000 claims description 28
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 25
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 25
- 150000002431 hydrogen Chemical group 0.000 claims description 22
- 125000001153 fluoro group Chemical group F* 0.000 claims description 19
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 18
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 17
- 229910052799 carbon Inorganic materials 0.000 claims description 16
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 16
- 125000004432 carbon atom Chemical group C* 0.000 claims description 15
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 15
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- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims description 7
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- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 6
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Landscapes
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| PCT/US2010/054880 WO2011059839A1 (en) | 2009-10-29 | 2010-10-29 | Bicyclic pyridines and analogs as sirtuin modulators |
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| MX2012004995A MX2012004995A (es) | 2009-10-29 | 2010-10-29 | Piridinas biciclicas y analogos como moduladores de sirtuina. |
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| EA017919B1 (ru) | 2007-12-10 | 2013-04-30 | Новартис Аг | Производные пиразин-2-карбоксамида для лечения заболеваний, которые поддаются лечению путем блокирования эпителиальных натриевых каналов |
| KR101679089B1 (ko) | 2008-09-29 | 2016-11-23 | 서트리스 파마슈티컬즈, 인코포레이티드 | 시르투인 조절제로서의 크로메논 유사체 |
| CA2869730A1 (en) | 2012-04-25 | 2013-10-31 | Takeda Pharmaceutical Company Limited | Nitrogenated heterocyclic compound |
| US9394315B2 (en) | 2012-05-08 | 2016-07-19 | Lycera Corporation | Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
| AU2013259737A1 (en) | 2012-05-08 | 2014-10-02 | Lycera Corporation | Tetrahydronaphthyridine and related bicyclic compounds for inhibition of RORgamma activity and the treatment of disease |
| EP2873669A4 (en) | 2012-07-13 | 2015-11-25 | Takeda Pharmaceutical | HETEROCYCLIC CONNECTION |
| WO2014033196A1 (en) * | 2012-08-30 | 2014-03-06 | F. Hoffmann-La Roche Ag | Dioxino- and oxazin-[2,3-d]pyrimidine pi3k inhibitor compounds and methods of use |
| CN102977117A (zh) * | 2012-11-26 | 2013-03-20 | 盛世泰科生物医药技术(苏州)有限公司 | 一种6-溴-2,2-二甲基-2h-吡啶并[3,2-b][1,4]恶嗪-3(4h)-酮的合成方法 |
| GEP201606554B (en) * | 2012-12-26 | 2016-10-10 | Takeda Pharmaceuticals Co | Nitrogenated heterocyclic compound |
| US9834520B2 (en) | 2013-03-14 | 2017-12-05 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| BR112015028613A2 (pt) * | 2013-05-13 | 2017-07-25 | Glaxosmithkline Llc | análogos de uréia com ligações por pontes substituída como moduladores de sirtuína |
| WO2016081692A2 (en) * | 2014-11-19 | 2016-05-26 | Glaxosmithkline Llc | Substituted bridged urea analogs as sirtuin modulators |
| US10472376B2 (en) | 2013-07-03 | 2019-11-12 | Takeda Pharmaceutical Company Limited | Amide compound |
| WO2015002231A1 (ja) | 2013-07-03 | 2015-01-08 | 武田薬品工業株式会社 | 複素環化合物 |
| LT3929196T (lt) | 2013-09-24 | 2023-09-25 | Fujifilm Corporation | Farmacinė kompozicija junginio, kurio sudėtyje yra azotas arba jo druska, arba jo metalo kompleksas |
| US10172915B2 (en) | 2013-10-20 | 2019-01-08 | Duke University | Methods and compositions for activation of sirtuins with Annexin A1 peptides |
| BR112016008276B1 (pt) | 2013-10-25 | 2021-03-02 | Novartis Ag | derivados bicíclicos de piridila fundidos ao anel, seus usos e seu intermediário, e composição farmacêutica |
| WO2015095788A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| WO2015095792A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Carbamate benzoxaxine propionic acids and acid derivatives for modulation of rorgamma activity and the treatment of disease |
| WO2015095795A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| JP6510539B2 (ja) * | 2014-01-09 | 2019-05-08 | ザ ジェイ． デヴィッド グラッドストーン インスティテューツ， ア テスタメンタリー トラスト エスタブリッシュド アンダー ザ ウィル オブ ジェイ． デヴィッド グラッドストーン | 置換ベンゾオキサジン及び関連化合物 |
| US10532088B2 (en) | 2014-02-27 | 2020-01-14 | Lycera Corporation | Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma and related therapeutic methods |
| JP2017114764A (ja) * | 2014-04-25 | 2017-06-29 | 武田薬品工業株式会社 | 片頭痛治療剤 |
| CA2947290A1 (en) | 2014-05-05 | 2015-11-12 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| US10189777B2 (en) | 2014-05-05 | 2019-01-29 | Lycera Corporation | Benzenesulfonamido and related compounds for use as agonists of RORγ and the treatment of disease |
| US10316054B2 (en) | 2014-06-02 | 2019-06-11 | Glaxosmithkline Intellectual Property (No. 2) Limited | Preparation and use of crystalline beta-D-nicotinamide riboside |
| EP3152220A1 (en) | 2014-06-06 | 2017-04-12 | Glaxosmithkline Intellectual Property (No. 2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
| ES2756748T3 (es) | 2014-10-03 | 2020-04-27 | Novartis Ag | Uso de derivados de piridilo bicíclicos de anillo fusionado como inhibidores de fgfr4 |
| KR20170087907A (ko) * | 2014-11-19 | 2017-07-31 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 시르투인 조정제로서의 치환된 가교된 우레아 유사체 |
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-
2010
- 2010-10-29 EP EP10830519.4A patent/EP2493888B1/en active Active
- 2010-10-29 AU AU2010319842A patent/AU2010319842A1/en not_active Abandoned
- 2010-10-29 KR KR1020127013635A patent/KR20120092141A/ko not_active Ceased
- 2010-10-29 CA CA2779303A patent/CA2779303A1/en not_active Abandoned
- 2010-10-29 MX MX2012004995A patent/MX2012004995A/es not_active Application Discontinuation
- 2010-10-29 ES ES10830519.4T patent/ES2574927T3/es active Active
- 2010-10-29 US US13/504,134 patent/US9556201B2/en not_active Expired - Fee Related
- 2010-10-29 RU RU2012122065/04A patent/RU2550821C2/ru not_active IP Right Cessation
- 2010-10-29 JP JP2012537157A patent/JP2013509442A/ja not_active Ceased
- 2010-10-29 IN IN3799DEN2012 patent/IN2012DN03799A/en unknown
- 2010-10-29 WO PCT/US2010/054880 patent/WO2011059839A1/en not_active Ceased
- 2010-10-29 CN CN201080060180.2A patent/CN102725291B/zh not_active Expired - Fee Related
- 2010-10-29 BR BR112012010010A patent/BR112012010010A2/pt not_active IP Right Cessation
-
2012
- 2012-04-23 IL IL219372A patent/IL219372A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2493888A1 (en) | 2012-09-05 |
| US20120252780A1 (en) | 2012-10-04 |
| CA2779303A1 (en) | 2011-05-19 |
| EP2493888A4 (en) | 2013-05-01 |
| US9556201B2 (en) | 2017-01-31 |
| JP2013509442A (ja) | 2013-03-14 |
| AU2010319842A1 (en) | 2012-05-17 |
| CN102725291A (zh) | 2012-10-10 |
| WO2011059839A1 (en) | 2011-05-19 |
| CN102725291B (zh) | 2016-12-21 |
| RU2012122065A (ru) | 2013-12-10 |
| ES2574927T3 (es) | 2016-06-23 |
| RU2550821C2 (ru) | 2015-05-20 |
| BR112012010010A2 (pt) | 2018-03-20 |
| KR20120092141A (ko) | 2012-08-20 |
| IN2012DN03799A (OSRAM) | 2015-08-28 |
| EP2493888B1 (en) | 2016-04-06 |
| IL219372A0 (en) | 2012-06-28 |
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