MX2012003558A - Procedimiento para la purificacion de eritropoyetina humana recombinante (epo), epo asi purificada y composiciones farmaceuticas que la comprenden. - Google Patents
Procedimiento para la purificacion de eritropoyetina humana recombinante (epo), epo asi purificada y composiciones farmaceuticas que la comprenden.Info
- Publication number
- MX2012003558A MX2012003558A MX2012003558A MX2012003558A MX2012003558A MX 2012003558 A MX2012003558 A MX 2012003558A MX 2012003558 A MX2012003558 A MX 2012003558A MX 2012003558 A MX2012003558 A MX 2012003558A MX 2012003558 A MX2012003558 A MX 2012003558A
- Authority
- MX
- Mexico
- Prior art keywords
- epo
- recombinant human
- purified
- purification
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se proporciona un procedimiento para la producción de eritropoyetina (EPO), en particular EPO humana recombinante (rhEPO) con una composición definida de glicoformas en una forma altamente pura, es decir, con una alta cantidad de isoformas de EPO O-glicosiladas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09012120 | 2009-09-23 | ||
PCT/EP2010/005839 WO2011035914A1 (en) | 2009-09-23 | 2010-09-23 | Process for the purification of recombinant human erythropoietin (epo), epo thus purified and pharmaceutical compositions comprising same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012003558A true MX2012003558A (es) | 2012-07-03 |
Family
ID=41566362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012003558A MX2012003558A (es) | 2009-09-23 | 2010-09-23 | Procedimiento para la purificacion de eritropoyetina humana recombinante (epo), epo asi purificada y composiciones farmaceuticas que la comprenden. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20120264688A1 (es) |
EP (1) | EP2480569B1 (es) |
JP (1) | JP5728016B2 (es) |
KR (1) | KR20120117728A (es) |
CN (1) | CN102712688B (es) |
AU (1) | AU2010297530B2 (es) |
BR (1) | BR112012006602A2 (es) |
CA (1) | CA2775012A1 (es) |
EA (1) | EA022396B1 (es) |
IL (1) | IL218721A0 (es) |
MX (1) | MX2012003558A (es) |
UA (1) | UA107678C2 (es) |
WO (1) | WO2011035914A1 (es) |
ZA (1) | ZA201202491B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101443257B1 (ko) * | 2011-10-18 | 2014-09-19 | 주식회사 종근당 | 낮은 등전점을 갖는 에리스로포이에틴 유사체의 정제방법 |
US10066001B2 (en) * | 2013-03-15 | 2018-09-04 | Apotex Inc. | Enhanced liquid formulation stability of erythropoietin alpha through purification processing |
WO2014204023A1 (ko) * | 2013-06-17 | 2014-12-24 | 씨제이헬스케어 주식회사 | 신규한 다베포에틴 알파의 정제 방법 |
CA2920191C (en) | 2013-07-18 | 2022-03-01 | Children's Hospital Medical Center | Methods of improving titer in transfection-based production systems using eukaryotic cells |
US10078081B2 (en) | 2014-03-05 | 2018-09-18 | GlycoScientific LLC | Isotopically labeled glycans and methods for producing the same |
JP6906497B2 (ja) * | 2016-03-09 | 2021-07-21 | Jcrファーマ株式会社 | 変異型ヒトエリスロポエチンの製造方法 |
JP6920280B2 (ja) * | 2016-03-31 | 2021-08-18 | 株式会社カネカ | 精製されたネコ由来エリスロポエチンの製造方法 |
DK3613486T3 (da) * | 2018-08-24 | 2021-01-04 | Uga Biopharma Gmbh | Metode og anlæg til rengøring af epo og/eller et epo-derivat |
CN115015415A (zh) * | 2022-05-30 | 2022-09-06 | 科兴生物制药股份有限公司 | 重组人促红细胞生成素的含量检测方法 |
Family Cites Families (32)
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NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
IL77081A (en) | 1984-12-04 | 1999-10-28 | Genetics Inst | AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin |
US4677195A (en) | 1985-01-11 | 1987-06-30 | Genetics Institute, Inc. | Method for the purification of erythropoietin and erythropoietin compositions |
US4667016A (en) | 1985-06-20 | 1987-05-19 | Kirin-Amgen, Inc. | Erythropoietin purification |
IL79176A (en) | 1985-06-20 | 1992-06-21 | Kirin Amgen Inc | Process for the recovery of erythropoietin from a fluid |
DE3785086T2 (de) | 1986-06-04 | 1993-07-08 | Agency Ind Science Techn | Zubereitung fuer zellkultur und ihre verwendung. |
JP2520681B2 (ja) | 1986-08-04 | 1996-07-31 | ザ ユニバーシティ オブ ニュー サウス ウェールズ | 生合成のヒトの成長ホルモン製品 |
US4954437A (en) | 1986-09-15 | 1990-09-04 | Integrated Genetics, Inc. | Cell encoding recombinant human erythropoietin |
IL87737A (en) | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
EP0343635B1 (en) | 1988-05-25 | 1994-08-24 | Teijin Limited | Process for continuously culturing adherent animal cells |
WO1991005867A1 (en) | 1989-10-13 | 1991-05-02 | Amgen Inc. | Erythropoietin isoforms |
US5856298A (en) * | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
KR0176693B1 (ko) | 1989-12-22 | 1999-04-01 | 레지널드 디. 쇼트보그; 제롬 반 쥘렌 | 조절요소를 사용한 내인성 유전자의 발현을 변형시키는 방법 |
GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
DE4115722A1 (de) | 1991-05-14 | 1992-11-19 | Boehringer Mannheim Gmbh | Serumfreies medium zur kultivierung von saeugerzellen |
NZ245015A (en) | 1991-11-05 | 1995-12-21 | Transkaryotic Therapies Inc | Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production |
IL118201A (en) | 1995-05-11 | 2004-12-15 | Roche Diagnostics Gmbh | Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof |
CA2309810C (en) * | 1997-12-03 | 2014-07-08 | Roche Diagnostics Gmbh | Erythropoietin with high specific activity |
BR9917606A (pt) * | 1998-11-06 | 2002-12-31 | Bio Sidus S A | Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento |
CZ299516B6 (cs) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
ATE291436T2 (de) * | 2000-05-15 | 2005-04-15 | Hoffmann La Roche | Flüssige arzneizubereitung enthaltend ein erythropoietin derivat |
US20020045192A1 (en) * | 2001-09-19 | 2002-04-18 | St. Jude Children's Research Hospital | Arf and HDM2 interaction domains and methods of use thereof |
US6930086B2 (en) * | 2001-09-25 | 2005-08-16 | Hoffmann-La Roche Inc. | Diglycosylated erythropoietin |
BR0214568A (pt) * | 2001-11-28 | 2004-11-03 | Sandoz Ag | Purificação cromatográfica de eritropoietina humana recombinante |
ATE363541T1 (de) | 2002-03-26 | 2007-06-15 | Lek Tovarna Farmacevtskih | Verfahren für die herstellung eines gewünschten profils von erythropoietin glyko-isoformen |
PT1428878E (pt) | 2002-12-13 | 2008-11-18 | Bioceuticals Arzneimittel Ag | Processo para a produção e purificação de eritropoietina |
EP1537876A1 (en) | 2003-12-01 | 2005-06-08 | BioGeneriX AG | Erythropoietin solution formulation |
CA2551916C (en) * | 2003-12-31 | 2014-04-29 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Fc-erythropoietin fusion protein with improved pharmacokinetics |
WO2006079155A1 (en) * | 2005-01-25 | 2006-08-03 | Apollo Life Sciences Limited | Molecules and chimeric molecules thereof |
US20090105462A1 (en) * | 2006-11-09 | 2009-04-23 | Ivarie Robert D | Glycosylated erythropoietin |
KR20090090328A (ko) * | 2006-11-09 | 2009-08-25 | 시나게바 바이오파르마, 코포레이션 | 조류 유래 에리트로포이어틴 |
CN107022020A (zh) * | 2008-09-26 | 2017-08-08 | Ambrx公司 | 修饰的动物促红细胞生成素多肽和其用途 |
-
2010
- 2010-09-23 KR KR1020127009211A patent/KR20120117728A/ko not_active Application Discontinuation
- 2010-09-23 BR BR112012006602A patent/BR112012006602A2/pt not_active IP Right Cessation
- 2010-09-23 CN CN201080051883.9A patent/CN102712688B/zh not_active Expired - Fee Related
- 2010-09-23 EA EA201290135A patent/EA022396B1/ru not_active IP Right Cessation
- 2010-09-23 EP EP10759588.6A patent/EP2480569B1/en active Active
- 2010-09-23 US US13/497,500 patent/US20120264688A1/en not_active Abandoned
- 2010-09-23 JP JP2012530170A patent/JP5728016B2/ja not_active Expired - Fee Related
- 2010-09-23 UA UAA201205042A patent/UA107678C2/uk unknown
- 2010-09-23 AU AU2010297530A patent/AU2010297530B2/en not_active Ceased
- 2010-09-23 MX MX2012003558A patent/MX2012003558A/es not_active Application Discontinuation
- 2010-09-23 WO PCT/EP2010/005839 patent/WO2011035914A1/en active Application Filing
- 2010-09-23 CA CA2775012A patent/CA2775012A1/en not_active Abandoned
-
2012
- 2012-03-19 IL IL218721A patent/IL218721A0/en unknown
- 2012-04-04 ZA ZA2012/02491A patent/ZA201202491B/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112012006602A2 (pt) | 2019-09-24 |
WO2011035914A1 (en) | 2011-03-31 |
KR20120117728A (ko) | 2012-10-24 |
UA107678C2 (uk) | 2015-02-10 |
US20120264688A1 (en) | 2012-10-18 |
CN102712688B (zh) | 2015-06-24 |
JP5728016B2 (ja) | 2015-06-03 |
EP2480569B1 (en) | 2016-04-13 |
CA2775012A1 (en) | 2011-03-31 |
AU2010297530B2 (en) | 2013-12-19 |
CN102712688A (zh) | 2012-10-03 |
EA022396B1 (ru) | 2015-12-30 |
JP2013505276A (ja) | 2013-02-14 |
AU2010297530A1 (en) | 2012-04-26 |
IL218721A0 (en) | 2012-06-28 |
EA201290135A1 (ru) | 2012-10-30 |
EP2480569A1 (en) | 2012-08-01 |
ZA201202491B (en) | 2012-12-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC | Change of company name or juridical status |
Owner name: NERVIANO MEDICAL SCIENCES S.R.L.* Owner name: EVONIK DEGUSSA GMBH |
|
FA | Abandonment or withdrawal |