MX2011011065A - Tia-triaza-ciclopentazulenos como inhibidores de quinasas p13 para el tratamiento del cancer. - Google Patents

Tia-triaza-ciclopentazulenos como inhibidores de quinasas p13 para el tratamiento del cancer.

Info

Publication number
MX2011011065A
MX2011011065A MX2011011065A MX2011011065A MX2011011065A MX 2011011065 A MX2011011065 A MX 2011011065A MX 2011011065 A MX2011011065 A MX 2011011065A MX 2011011065 A MX2011011065 A MX 2011011065A MX 2011011065 A MX2011011065 A MX 2011011065A
Authority
MX
Mexico
Prior art keywords
treatment
cyclopentazulenes
triaza
thia
cancer
Prior art date
Application number
MX2011011065A
Other languages
English (en)
Inventor
Maria Impagnatiello
Lars Van Der Veen
Siegfried Schneider
Tobias Wunberg
Darryl Mcconnell
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2011011065A publication Critical patent/MX2011011065A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención comprende compuestos de fórmula general (1) (ver fórmula (1)) en la que de R1 a R3 y X se definen como en la reivindicación 1, que son adecuados para el tratamiento de enfermedades caracterizadas por una proliferación celular excesiva o anormal, y el uso de los mismos para preparar un medicamento que tenga las propiedades mencionadas anteriormente.
MX2011011065A 2009-04-22 2010-04-21 Tia-triaza-ciclopentazulenos como inhibidores de quinasas p13 para el tratamiento del cancer. MX2011011065A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09158493 2009-04-22
PCT/EP2010/055295 WO2010122071A1 (en) 2009-04-22 2010-04-21 Thia-triaza-cyclopentazulenes as pi3-kinases inhibitors for the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2011011065A true MX2011011065A (es) 2011-11-04

Family

ID=40996623

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011011065A MX2011011065A (es) 2009-04-22 2010-04-21 Tia-triaza-ciclopentazulenos como inhibidores de quinasas p13 para el tratamiento del cancer.

Country Status (21)

Country Link
US (1) US8288379B2 (es)
EP (1) EP2421871B1 (es)
JP (1) JP5658231B2 (es)
KR (1) KR20120014152A (es)
CN (1) CN102459282A (es)
AP (1) AP2011005893A0 (es)
AR (1) AR076364A1 (es)
AU (1) AU2010240965A1 (es)
BR (1) BRPI1016174A2 (es)
CA (1) CA2759595A1 (es)
CO (1) CO6460760A2 (es)
EA (1) EA201101537A1 (es)
EC (1) ECSP11011464A (es)
IL (1) IL215199A0 (es)
MA (1) MA33223B1 (es)
MX (1) MX2011011065A (es)
SG (1) SG175746A1 (es)
TN (1) TN2011000530A1 (es)
TW (1) TW201103942A (es)
UY (1) UY32566A (es)
WO (1) WO2010122071A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160091060A (ko) 2015-01-23 2016-08-02 전관식 약제 분배장치 및 분말약 분배방법
ITRM20150212A1 (it) * 2015-05-15 2016-11-15 Univ Degli Studi Di Palermo 4,5,6,9-tetraidropirrolo[2',3':3,4] cicloepta[1,2-d] isossazoli, procedimento per la loro produzione e loro uso come antitumorali

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9024A (en) * 1852-06-15 Motion of the lay in looms
US5547975A (en) * 1994-09-20 1996-08-20 Talley; John J. Benzopyranopyrazolyl derivatives for the treatment of inflammation
MX2007004051A (es) * 2004-10-07 2007-05-24 Boehringer Ingelheim Int Pi3-quinasas.
UY29149A1 (es) 2004-10-07 2006-05-31 Boehringer Ingelheim Int Tiazolil-dihidro-indazoles
US8779154B2 (en) * 2006-09-26 2014-07-15 Qinglin Che Fused ring compounds for inflammation and immune-related uses
US9243000B2 (en) * 2009-04-22 2016-01-26 Boehringer Ingelheim International Gmbh Thia-triaza-indacenes

Also Published As

Publication number Publication date
SG175746A1 (en) 2011-12-29
EA201101537A1 (ru) 2012-05-30
EP2421871A1 (en) 2012-02-29
US8288379B2 (en) 2012-10-16
UY32566A (es) 2010-11-30
TW201103942A (en) 2011-02-01
ECSP11011464A (es) 2011-12-30
MA33223B1 (fr) 2012-04-02
CA2759595A1 (en) 2010-10-28
CN102459282A (zh) 2012-05-16
IL215199A0 (en) 2011-12-29
BRPI1016174A2 (pt) 2016-04-19
EP2421871B1 (en) 2015-09-16
JP5658231B2 (ja) 2015-01-21
CO6460760A2 (es) 2012-06-15
WO2010122071A1 (en) 2010-10-28
TN2011000530A1 (en) 2013-05-24
KR20120014152A (ko) 2012-02-16
US20110112087A1 (en) 2011-05-12
AR076364A1 (es) 2011-06-08
JP2012524751A (ja) 2012-10-18
AP2011005893A0 (en) 2011-10-31
AU2010240965A1 (en) 2011-10-20

Similar Documents

Publication Publication Date Title
TN2012000369A1 (en) 5-alkynyl-pyrimidines
TN2011000259A1 (en) Substituted pyrimidines for the treatment of diseases such as cancer
MX2009013935A (es) Compuestos quimicos.
TW200726753A (en) 2,4-diamino-pyrimidines as aurora inhibitors
MX2011009780A (es) Pirimidinas sustituidas para el tratamiento del cancer.
MX2013004491A (es) Boronatos como inhibidores de arginasa.
WO2010007116A3 (en) Pyridons as pdk1 inhibitors
MX2013000821A (es) Nuevas aminopirazoloquinazolinas.
MY160468A (en) Novel amino azaheterocyclic carboxamides
WO2009000832A3 (en) Chemical compounds
UA94944C2 (ru) 2,4-диаминопиримидины как ингибиторы киназ, которые принимают участие в регуляции клеточного цикла
MX2012013274A (es) Novedosos derivados de la pirimidina.
MX2012001413A (es) Compuestos azaheterociclicos novedosos.
WO2008152014A3 (en) 3-hetrocyclylidene-indolinone derivatives as inhibitors of specific cell cycle kinases
MX345127B (es) Derivados de tiazol.
MA32505B1 (fr) 5-alcynyl-pyrimidines
MX2011012643A (es) 2,4-diaminopiridinas para el tratamiento de enfermedades caracterizadas por la proliferacion celular excesiva o anormal.
MX2013002851A (es) Inhibidores de tonum pectinacetilesterasa y metodos de su uso.
MX2010009837A (es) Tiazolil-dihidro-indazoles.
TN2011000531A1 (en) 5- alkynyl - pyridines
WO2010012745A3 (en) Benzimidazoles
TN2011000530A1 (en) Thia-triaza-cyclopentazulenes as pi3-kinases inhibitors for the treatment of cancer
MX2014005538A (es) 1-piridazinil-hidroxiimino-3-fenil-propanos como agonistas de proteina g-receptor acoplado a acido biliar 1 (gpbar1).
IN2012DN06600A (es)
TN2011000049A1 (en) 5-alkynyl-pyrimidines

Legal Events

Date Code Title Description
FA Abandonment or withdrawal